PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31887787-0 2020 MicroRNA26a inhibits cisplatin-induced renal tubular epithelial cells apoptosis through suppressing the expression of transient receptor potential channel 6 mediated dynamin-related protein 1. Cisplatin 21-30 dynamin 1 like Homo sapiens 166-191 35538029-8 2022 Confocal imaging showed that knockdown of Mff inhibits the mitochondrial fission and downregulates the expression of GTPase dynamin-related protein 1 (Drp1) in cisplatin-resistant Huh-7/DDP cells. Cisplatin 160-169 dynamin 1 like Homo sapiens 151-155 33302576-0 2020 Inhibition of Drp1 Sensitizes Cancer Cells to Cisplatin-Induced Apoptosis through Transcriptional Inhibition of c-FLIP Expression. Cisplatin 46-55 dynamin 1 like Homo sapiens 14-18 31887787-14 2020 We further verified that miR-26a protected cisplatin-induced apoptosis by target transient receptor potential channel 6 (TRPC6) which can regulate the expression of dynamic-related protein 1 (DRP1) and inhibit the mitochondrial apoptosis pathway. Cisplatin 43-52 dynamin 1 like Homo sapiens 165-190 31887787-14 2020 We further verified that miR-26a protected cisplatin-induced apoptosis by target transient receptor potential channel 6 (TRPC6) which can regulate the expression of dynamic-related protein 1 (DRP1) and inhibit the mitochondrial apoptosis pathway. Cisplatin 43-52 dynamin 1 like Homo sapiens 192-196 31887787-15 2020 Thus, miR-26a/TRPC6/DRP1 is a new protective pathway in cisplatin-induced AKI and may be targeted for the prevention and treatment of drug-related acute kidney injury. Cisplatin 56-65 dynamin 1 like Homo sapiens 20-24 31887787-10 2020 We further verified that miR-26a protected against cisplatin-induced cell apoptosis by acting on transient receptor potential channel 6 (TRPC6) which can regulate the expression of dynamin-related protein 1 (DRP1), thus inhibited the mitochondrial apoptosis pathway. Cisplatin 51-60 dynamin 1 like Homo sapiens 181-206 31887787-10 2020 We further verified that miR-26a protected against cisplatin-induced cell apoptosis by acting on transient receptor potential channel 6 (TRPC6) which can regulate the expression of dynamin-related protein 1 (DRP1), thus inhibited the mitochondrial apoptosis pathway. Cisplatin 51-60 dynamin 1 like Homo sapiens 208-212 31887787-11 2020 Therefore, the study unveiled that miR-26a/TRPC6/DRP1 is a novel protective pathway in cisplatin-induced AKI and may be targeted for the prevention and treatment of drug-related renal injury. Cisplatin 87-96 dynamin 1 like Homo sapiens 49-53 23792636-6 2013 Further, PXN mutants, through their interactions with BCL-2 and DRP-1, could regulate cisplatin drug resistance in human lung cancer cells. Cisplatin 86-95 dynamin 1 like Homo sapiens 64-69 28423497-0 2017 Drp1-dependent mitophagy protects against cisplatin-induced apoptosis of renal tubular epithelial cells by improving mitochondrial function. Cisplatin 42-51 dynamin 1 like Homo sapiens 0-4 28423497-11 2017 Suppression of mitochondrial fission by knockdown of its main regulator dynamin-related protein-1 (Drp1) decreased cisplatin-induced mitophagy. Cisplatin 115-124 dynamin 1 like Homo sapiens 72-97 28423497-11 2017 Suppression of mitochondrial fission by knockdown of its main regulator dynamin-related protein-1 (Drp1) decreased cisplatin-induced mitophagy. Cisplatin 115-124 dynamin 1 like Homo sapiens 99-103 28423497-12 2017 Meanwhile, Drp1 suppression protected against cisplatin-induced cells injury by inhibiting mitochondrial dysfunction. Cisplatin 46-55 dynamin 1 like Homo sapiens 11-15 28423497-13 2017 Our results provide evidence that Drp1-depedent mitophagy has potential as renoprotective targets for the treatment of cisplatin-induced AKI. Cisplatin 119-128 dynamin 1 like Homo sapiens 34-38 32433544-0 2020 Drp1-dependent remodeling of mitochondrial morphology triggered by EBV-LMP1 increases cisplatin resistance. Cisplatin 86-95 dynamin 1 like Homo sapiens 0-4 32433544-10 2020 In addition, EBV-LMP1 regulates Drp1 through two oncogenic signaling axes, AMPK and cyclin B1/Cdk1, which promote cell survival and cisplatin resistance in NPC. Cisplatin 132-141 dynamin 1 like Homo sapiens 32-36 32020220-6 2020 Accordingly, cisplatin induced mitophagy in surviving HCC cells by activating DRP1. Cisplatin 13-22 dynamin 1 like Homo sapiens 78-82 32020220-7 2020 The DRP1 inhibitor (Mdivi-1) increased the apoptosis of cisplatin-treated HCC cells by targeting mitophagy. Cisplatin 56-65 dynamin 1 like Homo sapiens 4-8 32020220-10 2020 Our results indicate that targeting cisplatin-mediated mitophagy increases HCC apoptosis via DRP1 inhibition, providing preclinical proof of concept for combination therapy targeting mitophagy to potentiate the efficacy of chemotherapy. Cisplatin 36-45 dynamin 1 like Homo sapiens 93-97 19525928-11 2009 Antibodies specific to DRP1 co-precipitated a human homologue of yeast Rad23 protein A (hHR23A) and silencing of hHR23A decreased the nuclear DRP1 level and cisplatin resistance. Cisplatin 157-166 dynamin 1 like Homo sapiens 23-27