PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34746018-0 2021 LncRNA OTUD6B-AS1 Induces Cisplatin Resistance in Cervical Cancer Cells Through Up-Regulating Cyclin D2 via miR-206. Cisplatin 26-35 microRNA 206 Homo sapiens 108-115 27014910-0 2016 miR-206 regulates cisplatin resistance and EMT in human lung adenocarcinoma cells partly by targeting MET. Cisplatin 18-27 microRNA 206 Homo sapiens 0-7 27014910-2 2016 The aims of this study were to explore the potential role of miR-206 in governing cisplatin resistance and EMT in lung cancer cells. Cisplatin 82-91 microRNA 206 Homo sapiens 61-68 27014910-4 2016 Ectopic expression of miR-206 mimics inhibited cisplatin resistance, reversed the EMT phenotype, decreased the migration and invasion in these DDP-resistant cells. Cisplatin 47-56 microRNA 206 Homo sapiens 22-29 27014910-5 2016 In contrast, miR-206 inhibitors increased cisplatin resistance, EMT, cell migration and invasion in non-DDP-resistant cells. Cisplatin 42-51 microRNA 206 Homo sapiens 13-20 27014910-9 2016 In lung adenocarcinoma tissues, we demonstrated that low expression of miR-206 were also correlated with increased cisplatin resistance and MET expression. Cisplatin 115-124 microRNA 206 Homo sapiens 71-78 27014910-10 2016 In addition, we revealed that miR-206 overexpression reduced cisplatin resistance and EMT in DDP-resistant cells, partly due to inactivation of MET/PI3K/AKT/mTOR signaling pathway, and subsequent downregulation of MDR1, ZEB1 and Snail expression. Cisplatin 61-70 microRNA 206 Homo sapiens 30-37 27014910-12 2016 Taken together, our study implied that activation of miR-206 or inactivation of its target gene pathway could serve as a novel approach to reverse cisplatin resistance in lung adenocarcinomas cells. Cisplatin 147-156 microRNA 206 Homo sapiens 53-60 28713273-7 2017 Interestingly, we found that the upregulation of 6PGD in cisplatin-resistant cells was due to the decreased expression of miR-206 and miR-613, which we found to target this enzyme. Cisplatin 57-66 microRNA 206 Homo sapiens 122-129 28713273-8 2017 We further demonstrate that suppressing 6PGD using shRNA, inhibitor or miR-206/miR-613, either as single agents or in combination, could sensitize cisplatin-resistant cancer cells to cisplatin treatment and thereby improving the therapeutic efficacy of cisplatin. Cisplatin 147-156 microRNA 206 Homo sapiens 71-78 28713273-8 2017 We further demonstrate that suppressing 6PGD using shRNA, inhibitor or miR-206/miR-613, either as single agents or in combination, could sensitize cisplatin-resistant cancer cells to cisplatin treatment and thereby improving the therapeutic efficacy of cisplatin. Cisplatin 183-192 microRNA 206 Homo sapiens 71-78 28713273-8 2017 We further demonstrate that suppressing 6PGD using shRNA, inhibitor or miR-206/miR-613, either as single agents or in combination, could sensitize cisplatin-resistant cancer cells to cisplatin treatment and thereby improving the therapeutic efficacy of cisplatin. Cisplatin 183-192 microRNA 206 Homo sapiens 71-78 34746018-5 2021 Our qRT-PCR assays verified that miR-206 levels were down-regulated in cisplatin-resistant cervical cancer cells. Cisplatin 71-80 microRNA 206 Homo sapiens 33-40 34746018-6 2021 The introduction of miR-206 sensitized cisplatin-resistant cervical cancer cells to cisplatin. Cisplatin 39-48 microRNA 206 Homo sapiens 20-27 34746018-6 2021 The introduction of miR-206 sensitized cisplatin-resistant cervical cancer cells to cisplatin. Cisplatin 84-93 microRNA 206 Homo sapiens 20-27 34746018-12 2021 Taken together, these results suggest that OTUD6B-AS1-mediated down-regulation of miR-206 increases CCND2 expression, leading to cisplatin resistance. Cisplatin 129-138 microRNA 206 Homo sapiens 82-89 33292230-12 2020 Overexpression of miR-206 in cisplatin-sensitive EOC cell lines significantly increased cell viability, migration and invasion in the presence of cisplatin and decreased cisplatin-induced apoptosis. Cisplatin 29-38 microRNA 206 Homo sapiens 18-25 33292230-12 2020 Overexpression of miR-206 in cisplatin-sensitive EOC cell lines significantly increased cell viability, migration and invasion in the presence of cisplatin and decreased cisplatin-induced apoptosis. Cisplatin 146-155 microRNA 206 Homo sapiens 18-25 33292230-12 2020 Overexpression of miR-206 in cisplatin-sensitive EOC cell lines significantly increased cell viability, migration and invasion in the presence of cisplatin and decreased cisplatin-induced apoptosis. Cisplatin 146-155 microRNA 206 Homo sapiens 18-25