PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30421459-7 2019 The level of E6 directly correlated with the extent of cisplatin sensitivity and was shown to be increased in newly established drug-resistant cell line variants, while reducing E6 expression using Brd4-inhibitors enhanced chemoresponse when co-delivered with cisplatin. Cisplatin 260-269 bromodomain containing 4 Homo sapiens 198-202 30421459-8 2019 Inhibition of Brd4 could represent a new therapeutic option by increasing treatment response in cervical cancer cells and might allow lower cisplatin dosages, thus reducing negative side effects. Cisplatin 140-149 bromodomain containing 4 Homo sapiens 14-18 35167374-0 2022 BRD4 promotes the migration and invasion of bladder cancer through the Sonic hedgehog signaling pathway and enhances cisplatin resistance. Cisplatin 117-126 bromodomain containing 4 Homo sapiens 0-4 35167374-6 2022 We further found that cisplatin (DDP) suppressed the migration and invasion of BCa cells in vitro and inhibited tumor growth in vivo; however overexpression of BRD4 weakened the pharmacological effects of DDP. Cisplatin 22-31 bromodomain containing 4 Homo sapiens 160-164 35083874-7 2022 RESULTS: BRD4 inhibitors JQ1 and ARV-771 were identified as the most promising drugs both in the cisplatin and radiation screening projects in two NSCLC cell lines. Cisplatin 97-106 bromodomain containing 4 Homo sapiens 9-13 35403781-5 2022 Gene expression of HDAC1, HDAC2, SIRT1, MTA1, KAT2B, KAT6A, KAT6B, and BRD4 indicated the cisplatin activates the epigenetic machinery. Cisplatin 90-99 bromodomain containing 4 Homo sapiens 71-75