PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22673883-2	2012	The IL-18 receptor (IL-18R) is expressed on these cells in cisplatin-induced acute kidney injury, but the role of IL-18R is unknown.	Cisplatin	59-68	interleukin 18	Mus musculus	4-9	
31405732-4	2019	Caspase-11 knockout mice after cisplatin treatment exhibited attenuated deterioration of renal functional, reduced tubular damage, reduced macrophage and neutrophil infiltration, and decreased urinary IL-18 excretion.	Cisplatin	31-40	interleukin 18	Mus musculus	201-206	
31405732-5	2019	Mechanistically, the upregulation of caspase-11 by either cisplatin or ischemia-reperfusion cleaved gasdermin D (GSDMD) into GSDMD-N, which translocated onto the plasma membrane, thus triggering cell pyroptosis and facilitated IL-18 release in primary cultured renal tubular cells.	Cisplatin	58-67	interleukin 18	Mus musculus	227-232	
31405732-7	2019	Furthermore, deficiency of GSDMD significantly suppressed cisplatin-induced IL-18 release but not the transcription and maturation level of IL-18 in tubular cells.	Cisplatin	58-67	interleukin 18	Mus musculus	76-81	
31014901-6	2019	Urolithin A attenuated cisplatin-induced pro-inflammatory cytokine/chemokine tumor necrosis factor alpha (TNFalpha), interleukin 23 (IL-23), interleukin 18 (IL-18) and macrophage inflammatory protein 2 (MIP2).	Cisplatin	23-32	interleukin 18	Mus musculus	141-155	
31014901-6	2019	Urolithin A attenuated cisplatin-induced pro-inflammatory cytokine/chemokine tumor necrosis factor alpha (TNFalpha), interleukin 23 (IL-23), interleukin 18 (IL-18) and macrophage inflammatory protein 2 (MIP2).	Cisplatin	23-32	interleukin 18	Mus musculus	157-162	
28831294-10	2017	Daidzein attenuated cisplatin-induced inflammatory cytokines tumor necrosis factor alpha (TNFalpha), interleukin 10 (IL-10), interleukin 18 (IL-18), and monocyte chemoattractant protein-1 (MCP-1).	Cisplatin	20-29	interleukin 18	Mus musculus	125-139	
28831294-10	2017	Daidzein attenuated cisplatin-induced inflammatory cytokines tumor necrosis factor alpha (TNFalpha), interleukin 10 (IL-10), interleukin 18 (IL-18), and monocyte chemoattractant protein-1 (MCP-1).	Cisplatin	20-29	interleukin 18	Mus musculus	141-146	
22543082-0	2012	Cisplatin-induced acute renal failure in mice is mediated by chymase-activated angiotensin-aldosterone system and interleukin-18.	Cisplatin	0-9	interleukin 18	Mus musculus	114-128	
22543082-3	2012	Administration of recombinant IL-18 prior to cisplatin restored acute renal failure in IL-18KO mice.	Cisplatin	45-54	interleukin 18	Mus musculus	30-35	
22543082-8	2012	These results show that IL-18, aldosterone and angiotensin II synergistically act to prolong the accumulation of cisplatin in the kidney, leading to acute renal failure.	Cisplatin	113-122	interleukin 18	Mus musculus	24-29	
17400889-0	2007	Cisplatin-induced acute renal failure is associated with an increase in the cytokines interleukin (IL)-1beta, IL-18, IL-6, and neutrophil infiltration in the kidney.	Cisplatin	0-9	interleukin 18	Mus musculus	110-115	
17400889-9	2007	In summary, our data demonstrated that cisplatin-induced ARF is associated with increases in the cytokines IL-1beta, IL-18, and IL-6 and neutrophil infiltration in the kidney.	Cisplatin	39-48	interleukin 18	Mus musculus	117-122