PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31764352-4	2019	QUESTIONS/PURPOSES: Using human OA knee chondrocytes in vitro, we asked, does chloramphenicol (1) activate autophagy in chondrocytes; (2) protect chondrocytes from IL-1beta-induced apoptosis; and (3) reduce the expression of matrix metallopeptidase (MMP)-13 and IL-6 (markers associated with articular cartilage degradation and joint inflammation).	Chloramphenicol	78-93	matrix metallopeptidase 13	Homo sapiens	225-257	
20338993-10	2010	These findings suggest that chloramphenicol-induced PI-3K/Akt, JNK phosphorylation, and activator protein 1 activation might function as a novel mitochondrial stress signal that result in an increase of MMP-13 expression and MMP-13-associated cancer cell invasion.	Chloramphenicol	28-43	matrix metallopeptidase 13	Homo sapiens	203-209	
20338993-10	2010	These findings suggest that chloramphenicol-induced PI-3K/Akt, JNK phosphorylation, and activator protein 1 activation might function as a novel mitochondrial stress signal that result in an increase of MMP-13 expression and MMP-13-associated cancer cell invasion.	Chloramphenicol	28-43	matrix metallopeptidase 13	Homo sapiens	225-231	
20338993-0	2010	Chloramphenicol causes mitochondrial stress, decreases ATP biosynthesis, induces matrix metalloproteinase-13 expression, and solid-tumor cell invasion.	Chloramphenicol	0-15	matrix metallopeptidase 13	Homo sapiens	81-108	
20338993-4	2010	We found that chloramphenicol can induce matrix metalloproteinase (MMP)-13 expression and increase MMP-13 protein in conditioned medium, resulting in an increase in cancer cell invasion.	Chloramphenicol	14-29	matrix metallopeptidase 13	Homo sapiens	41-74	
20338993-4	2010	We found that chloramphenicol can induce matrix metalloproteinase (MMP)-13 expression and increase MMP-13 protein in conditioned medium, resulting in an increase in cancer cell invasion.	Chloramphenicol	14-29	matrix metallopeptidase 13	Homo sapiens	99-105	
20338993-7	2010	Both the SP 600125 (JNK inhibitor) and LY 294002 (PI-3K/Akt inhibitor) can inhibit chloramphenicol-induced c-Jun phosphorylation, MMP-13 expression, and cell invasion.	Chloramphenicol	83-98	matrix metallopeptidase 13	Homo sapiens	130-136