PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1730428-3 1992 Therefore, a phase I study of intravenous melphalan utilizing GM-CSF (recombinant granulocyte-macrophage colony-stimulating factor) support was initiated. Melphalan 42-51 colony stimulating factor 2 Homo sapiens 82-130 1730428-2 1992 It was postulated that GM-CSF would permit the use of higher dose melphalan with only moderate myelosuppression easily manageable in an outpatient setting. Melphalan 66-75 colony stimulating factor 2 Homo sapiens 23-29 1730428-3 1992 Therefore, a phase I study of intravenous melphalan utilizing GM-CSF (recombinant granulocyte-macrophage colony-stimulating factor) support was initiated. Melphalan 42-51 colony stimulating factor 2 Homo sapiens 62-68 9053491-0 1997 Prospective randomized placebo-controlled study of granulocyte-macrophage colony-stimulating factor without stem-cell transplantation after high-dose melphalan in patients with multiple myeloma. Melphalan 150-159 colony stimulating factor 2 Homo sapiens 51-99 1730428-8 1992 Utilizing 20 micrograms/kg/day GM-CSF, the maximum tolerated dose (MTD) of melphalan is 30 mg/m2 and, with 10 mg/kg/day GM-CSF, the maximum tolerated melphalan dose is only 20 mg/m2. Melphalan 75-84 colony stimulating factor 2 Homo sapiens 31-37 2200536-2 1990 In an attempt to stimulate earlier granulocyte recovery, recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) was administered subcutaneously to 23 patients with refractory myeloma who had been treated with melphalan at a high dose of 100 mg/m2. Melphalan 230-239 colony stimulating factor 2 Homo sapiens 75-123 2200536-8 1990 These results support the usefulness of low-dose GM-CSF (0.25 mg/m2) in stimulating marrow recovery in selected patients with adequate marrow reserve treated with high-dose melphalan for refractory multiple myeloma. Melphalan 173-182 colony stimulating factor 2 Homo sapiens 49-55 1692472-0 1990 Granulocyte-macrophage colony stimulating factor (GM-CSF) after high-dose melphalan in patients with advanced colon cancer. Melphalan 74-83 colony stimulating factor 2 Homo sapiens 0-48 1692472-0 1990 Granulocyte-macrophage colony stimulating factor (GM-CSF) after high-dose melphalan in patients with advanced colon cancer. Melphalan 74-83 colony stimulating factor 2 Homo sapiens 50-56