PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8262669-0 1994 Receptor-mediated cytotoxicity of alpha-MSH fragments containing melphalan in a human melanoma cell line. Melphalan 65-74 proopiomelanocortin Homo sapiens 34-43 8019062-1 1994 Two different chlorinated drugs, chlorambucil and melphalan, have been linked to the carrier alpha-melanocyte-stimulating hormone at the end of the solid-phase peptide synthesis of the hormone. Melphalan 50-59 proopiomelanocortin Homo sapiens 93-129 1668532-0 1991 Human melanoma targeting with alpha-MSH-melphalan conjugate. Melphalan 40-49 proopiomelanocortin Homo sapiens 30-39 1668532-6 1991 alpha-MSH receptor recognition properties also remained unchanged with a better apparent affinity of the conjugate probably due to the alkylating activity of melphalan itself. Melphalan 158-167 proopiomelanocortin Homo sapiens 0-9 1668532-7 1991 Using human melanoma dendritic cells expressing more than 10,000 alpha-MSH binding sites per cell as an in vitro model, we were able to demonstrate higher cytotoxicities as compared to melphalan-treated cells. Melphalan 185-194 proopiomelanocortin Homo sapiens 65-74 2171755-1 1990 alpha-MSH fragments containing melphalan were tested in vivo on L1210 leukemia and on human amelanotic melanoma xenograft in mice and in vitro on human amelanotic melanoma cell lines. Melphalan 31-40 proopiomelanocortin Homo sapiens 0-9 2177734-1 1990 For chemical affinity labeling of the melanotropin receptor several alpha-MSH fragments containing phenylalanine mustard were synthesized in solution. Melphalan 99-120 proopiomelanocortin Homo sapiens 68-77