PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7585502-5	1995	A direct correlation (P < 0.01) between intracellular GSH levels and the LD99 dose of melphalan was observed, signifying that elevation of the thiol secondary to GCS expression is sufficient to confer the resistance phenotype.	Melphalan	89-98	glutamate-cysteine ligase catalytic subunit	Homo sapiens	165-168	
7513621-1	1994	Levels of intracellular glutathione (GSH) and the GSH-related enzymes gamma-glutamylcysteine synthetase (gamma-GCS) and gamma-glutamyltranspeptidase (gamma-GT) were measured in the melphalan-resistant human multiple myeloma cell line 8226/LR-5 and were compared to those measured in the drug-sensitive 8226/S and doxorubicin-resistant 8226/Dox40 cell lines.	Melphalan	181-190	glutamate-cysteine ligase catalytic subunit	Homo sapiens	70-103	
7513621-2	1994	Both GSH and gamma-GCS activity, the rate-limiting step in the de novo synthesis of GSH, were elevated by a factor of approximately 2 in the melphalan-resistant 8226/LR-5 cells relative to the other two lines.	Melphalan	141-150	glutamate-cysteine ligase catalytic subunit	Homo sapiens	13-22	
7969079-3	1994	Using melphalan-resistant DU 145/M4.5 human prostate carcinoma cells, which express elevated GSH levels, GCS enzyme activity, and GCS mRNA levels, we sought to determine the mechanism(s) responsible for the increased GCS mRNA expression.	Melphalan	6-15	glutamate-cysteine ligase catalytic subunit	Homo sapiens	105-108	
7969079-3	1994	Using melphalan-resistant DU 145/M4.5 human prostate carcinoma cells, which express elevated GSH levels, GCS enzyme activity, and GCS mRNA levels, we sought to determine the mechanism(s) responsible for the increased GCS mRNA expression.	Melphalan	6-15	glutamate-cysteine ligase catalytic subunit	Homo sapiens	130-133	
7969079-3	1994	Using melphalan-resistant DU 145/M4.5 human prostate carcinoma cells, which express elevated GSH levels, GCS enzyme activity, and GCS mRNA levels, we sought to determine the mechanism(s) responsible for the increased GCS mRNA expression.	Melphalan	6-15	glutamate-cysteine ligase catalytic subunit	Homo sapiens	130-133