PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8422666-2 1993 Here we characterize the rIL-2 requirements for the generation of enhanced antitumor cytotoxicity by L-PAM TuB thymocytes relative to normal thymocytes upon in vitro stimulation with MOPC-315 tumor cells. Melphalan 101-106 tubby bipartite transcription factor Mus musculus 107-110 8422666-4 1993 However, even when rIL-2 was added on day 2 after culture initiation, thymocytes from L-PAM TuB mice generated a more potent antitumor cytotoxicity than did thymocytes from normal mice. Melphalan 86-91 tubby bipartite transcription factor Mus musculus 92-95 8422666-7 1993 The same low concentration of rIL-2 was also sufficient for restoring the generation of antitumor cytotoxicity by cultures of L-PAM TuB thymocytes, but not normal thymocytes, from which the rIL-2-containing medium was removed 1 day earlier. Melphalan 126-131 tubby bipartite transcription factor Mus musculus 132-135 8422666-8 1993 At the same time, conditioned medium from stimulation cultures of L-PAM TuB thymocytes was not superior to conditioned medium from stimulation cultures of normal thymocytes in supporting the generation of antitumor cytotoxicity by either normal or L-PAM TuB thymocytes. Melphalan 66-71 tubby bipartite transcription factor Mus musculus 72-75 1760820-3 1991 In addition, the ability of melphalan TuB thymocytes to generate an enhanced level of anti-MOPC-315 cytotoxicity correlated with their ability to proliferate more readily than thymocytes from untreated tumor-bearing mice and thymocytes from untreated or melphalan-treated normal mice in response to stimulation with MOPC-315 tumor cells plus a low concentration of rIL-2. Melphalan 28-37 tubby bipartite transcription factor Mus musculus 38-41