PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2670202-0 1989 Absence of phorbol ester-induced down-regulation of myc protein in the phorbol ester-tolerant mutant of HL-60 promyelocytes. Phorbol Esters 11-24 MYC proto-oncogene, bHLH transcription factor Homo sapiens 52-55 2670202-0 1989 Absence of phorbol ester-induced down-regulation of myc protein in the phorbol ester-tolerant mutant of HL-60 promyelocytes. Phorbol Esters 71-84 MYC proto-oncogene, bHLH transcription factor Homo sapiens 52-55 2670202-7 1989 In this paper, we show that exposing phorbol ester-sensitive (S) HL-60 cells to TPA caused the disappearance of the c-myc protein antigen (detected on Western blots) in 4 h, whereas TPA had no effect on the c-myc protein content of PET cells. Phorbol Esters 37-50 MYC proto-oncogene, bHLH transcription factor Homo sapiens 116-121 3126739-7 1988 Phorbol diesters also caused interruption of transcription of c-myc. Phorbol Esters 0-16 MYC proto-oncogene, bHLH transcription factor Homo sapiens 62-67 2496772-0 1989 Rapid expression of protooncogenes c-fos and c-myc in B-chronic lymphocytic leukemia cells during differentiation induced by phorbol ester and calcium ionophore. Phorbol Esters 125-138 MYC proto-oncogene, bHLH transcription factor Homo sapiens 45-50 3287279-5 1988 Addition of phorbol ester tumour promoters, either at the time of plating or as late as after one week, efficiently rescued focus formation by myc-transformed cells. Phorbol Esters 12-25 MYC proto-oncogene, bHLH transcription factor Homo sapiens 143-146 3357885-0 1988 Phorbol ester-induced terminal differentiation is inhibited in human U-937 monoblastic cells expressing a v-myc oncogene. Phorbol Esters 0-13 MYC proto-oncogene, bHLH transcription factor Homo sapiens 108-111 2653649-11 1989 Phorbol esters also stimulated similar gene expression; however, cyclic AMP analog inhibited phorbol ester or ligand-induced c-myc expression and ODC mRNA accumulation. Phorbol Esters 0-14 MYC proto-oncogene, bHLH transcription factor Homo sapiens 125-130 3152600-0 1988 Modulation of c-myc oncogene expression by phorbol ester and interferon-gamma: appraisal by flow cytometry. Phorbol Esters 43-56 MYC proto-oncogene, bHLH transcription factor Homo sapiens 14-19 3152600-8 1988 The extent and kinetics of c-myc oncoprotein induction have been determined following phorbol ester, 12-O tetradecanoylphorbol 13 acetate (TPA) and interferon-gamma (IFN-gamma) exposure of both HL-60 and Daudi cells. Phorbol Esters 86-99 MYC proto-oncogene, bHLH transcription factor Homo sapiens 27-32 3422230-0 1988 Dioctanoylglycerol and phorbol esters regulate transcription of c-myc in human promyelocytic leukemia cells. Phorbol Esters 23-37 MYC proto-oncogene, bHLH transcription factor Homo sapiens 64-69 3128958-4 1988 c-myc mRNA expression was induced both by the phorbol ester and by IL-2, provided that receptors were present. Phorbol Esters 46-59 MYC proto-oncogene, bHLH transcription factor Homo sapiens 0-5 3077555-10 1988 Phorbol esters also stimulated similar gene expression; however, cAMP analogue inhibited phorbol ester- or ligand-induced c-myc expression. Phorbol Esters 0-14 MYC proto-oncogene, bHLH transcription factor Homo sapiens 122-127 3215049-0 1988 Differentiation associated c-myc expression in phorbol ester and lymphokine stimulated B-type chronic lymphocytic leukemia cells. Phorbol Esters 47-60 MYC proto-oncogene, bHLH transcription factor Homo sapiens 27-32 3077555-10 1988 Phorbol esters also stimulated similar gene expression; however, cAMP analogue inhibited phorbol ester- or ligand-induced c-myc expression. Phorbol Esters 89-102 MYC proto-oncogene, bHLH transcription factor Homo sapiens 122-127 3325877-6 1987 Unlike the phosphorylation studies, bryostatin treatment, over a 1-100 nM concentration range and for varying lengths of time, did not affect HL-60 c-myc RNA levels, while phorbol ester treatment rapidly decreased c-myc RNA levels. Phorbol Esters 172-185 MYC proto-oncogene, bHLH transcription factor Homo sapiens 214-219 3118872-0 1987 The effects of phorbol ester and Ca ionophore on c-fos and c-myc expression and on DNA synthesis in human lymphocytes are not directly related. Phorbol Esters 15-28 MYC proto-oncogene, bHLH transcription factor Homo sapiens 59-64 3118872-2 1987 Phorbol ester and calcium ionophore A 23187 induce c-fos and c-myc expression in these cells as shown by the measure of the specific mRNA levels and of the c-fos nuclear protein amount. Phorbol Esters 0-13 MYC proto-oncogene, bHLH transcription factor Homo sapiens 61-66 3118872-4 1987 Lymphocyte stimulation by phorbol ester for a short time induces c-fos and c-myc expression, but has no effect on [3H]thymidine incorporation. Phorbol Esters 26-39 MYC proto-oncogene, bHLH transcription factor Homo sapiens 75-80 3115797-3 1987 The phorbol ester TPA and the adenylate cyclase activator forskolin reduced the c-myc RNA, levels and after 3 days of treatment a proportion of the cells accumulated in G1. Phorbol Esters 4-17 MYC proto-oncogene, bHLH transcription factor Homo sapiens 80-85 3855302-0 1985 Phorbol esters increase calcitonin gene transcription and decrease c-myc mRNA levels in cultured human medullary thyroid carcinoma. Phorbol Esters 0-14 MYC proto-oncogene, bHLH transcription factor Homo sapiens 67-72 3325885-0 1987 Different regulation of N- and c-myc expression during phorbol ester-induced maturation of human SH-SY5Y neuroblastoma cells. Phorbol Esters 55-68 MYC proto-oncogene, bHLH transcription factor Homo sapiens 31-36 3098506-0 1986 Expression of c-myc and c-fos during phorbol ester induced differentiation of B-type chronic lymphocytic leukemia cells. Phorbol Esters 37-50 MYC proto-oncogene, bHLH transcription factor Homo sapiens 14-19 3333275-5 1987 We have used this assay to estimate the number of c-myc molecules in a range of normal and transformed cells of human, murine, and feline origin; to monitor increases in c-myc expression when quiescent cells are stimulated with growth factors; and to follow the decrease in c-myc protein levels when HL60 promyelocytic leukaemia cells are induced to differentiate with dimethylsulphoxide or phorbol esters. Phorbol Esters 391-405 MYC proto-oncogene, bHLH transcription factor Homo sapiens 50-55 3541926-2 1986 Induction of HL-60 cells by phorbol esters to undergo monocytic differentiation results in the suppression of c-myc, but the activation of c-fos gene transcription. Phorbol Esters 28-42 MYC proto-oncogene, bHLH transcription factor Homo sapiens 110-115 3022291-7 1986 Serum and the phorbol ester tumor promoter phorbol 12-myristate 13-acetate also enhanced c-myc expression in cardiac myocyte cultures. Phorbol Esters 14-27 MYC proto-oncogene, bHLH transcription factor Homo sapiens 89-94 3095123-0 1986 Modulation of c-fos and c-myc mRNA levels in normal human lymphocytes by calcium ionophore A23187 and phorbol ester. Phorbol Esters 102-115 MYC proto-oncogene, bHLH transcription factor Homo sapiens 24-29 3000601-4 1985 Bradykinin and phorbol esters stimulated the same magnitude of c-myc expression as PDGF but elicited less than one-tenth the PDGF-induced mitogenic response. Phorbol Esters 15-29 MYC proto-oncogene, bHLH transcription factor Homo sapiens 63-68 3855302-4 1985 We found that the phorbol esters, 12-O-tetradecanoyl phorbol 13-acetate and phorbol 12,13-dibutyrate 1) altered the morphology of the TT cells towards that of high-calcitonin-containing cells; 2) enhanced calcitonin secretion 7-fold; 3) increased calcitonin production at the transcriptional level by 2-fold; 4) inhibited cellular proliferation; and 5) decreased, by 80%, the levels of the c-myc gene mRNA. Phorbol Esters 18-32 MYC proto-oncogene, bHLH transcription factor Homo sapiens 390-395 9461566-8 1998 Assaying ERK5 activity in immune complexes with one of these substrates, c-Myc, we determined that the ERK5 catalytic domain is activated by V12 H-Ras and to a lesser extent by phorbol ester but not by constitutively active mutants of Raf-1. Phorbol Esters 177-190 MYC proto-oncogene, bHLH transcription factor Homo sapiens 73-78 11598794-0 2001 Down-modulation of c-myc expression by phorbol ester protects CEM T leukaemia cells from starvation-induced apoptosis: role of ornithine decarboxylase and polyamines. Phorbol Esters 39-52 MYC proto-oncogene, bHLH transcription factor Homo sapiens 19-24 10339499-0 1999 Posttranslational regulation of Myc function in response to phorbol ester/interferon-gamma-induced differentiation of v-Myc-transformed U-937 monoblasts. Phorbol Esters 60-73 MYC proto-oncogene, bHLH transcription factor Homo sapiens 32-35 10339499-0 1999 Posttranslational regulation of Myc function in response to phorbol ester/interferon-gamma-induced differentiation of v-Myc-transformed U-937 monoblasts. Phorbol Esters 60-73 MYC proto-oncogene, bHLH transcription factor Homo sapiens 120-123 10339499-2 1999 Constitutive expression of v-Myc blocks phorbol ester (TPA)-induced differentiation of human U-937 monoblasts. Phorbol Esters 40-53 MYC proto-oncogene, bHLH transcription factor Homo sapiens 29-32 23509080-3 2013 Addition of phorbol esters to RPTCs not only increased c-Myc binding to the GRK4 promoter but also increased both phospho-c-Myc and GRK4 expression. Phorbol Esters 12-26 MYC proto-oncogene, bHLH transcription factor Homo sapiens 55-60 23509080-3 2013 Addition of phorbol esters to RPTCs not only increased c-Myc binding to the GRK4 promoter but also increased both phospho-c-Myc and GRK4 expression. Phorbol Esters 12-26 MYC proto-oncogene, bHLH transcription factor Homo sapiens 122-127 23509080-4 2013 The phorbol ester-mediated increase in GRK4 expression was completely blocked by the c-Myc inhibitor, 10074-G5, indicating that GRK4 is downstream of phospho-c-Myc. Phorbol Esters 4-17 MYC proto-oncogene, bHLH transcription factor Homo sapiens 85-90 23509080-4 2013 The phorbol ester-mediated increase in GRK4 expression was completely blocked by the c-Myc inhibitor, 10074-G5, indicating that GRK4 is downstream of phospho-c-Myc. Phorbol Esters 4-17 MYC proto-oncogene, bHLH transcription factor Homo sapiens 158-163 14757441-5 2004 Furthermore, when HL-60 myeloid leukemic cells were differentiated with phorbol ester (TPA), PBK/TOPK protein expression was strongly down-regulated by 24 h. Under these same conditions, phosphorylated c-Myc was rapidly down-regulated (by 4 h), while the levels of cyclin D1 and phosphorylated p38 were constant. Phorbol Esters 72-85 MYC proto-oncogene, bHLH transcription factor Homo sapiens 202-207 11236937-2 2001 We have previously shown that IFN-gamma restores phorbol ester-induced differentiation and cell cycle arrest in v-myc transformed human U-937 monoblasts. Phorbol Esters 49-62 MYC proto-oncogene, bHLH transcription factor Homo sapiens 114-117 10931849-0 2000 Regulation of c-myc mRNA decay in vitro by a phorbol ester-inducible, ribosome-associated component in differentiating megakaryoblasts. Phorbol Esters 45-58 MYC proto-oncogene, bHLH transcription factor Homo sapiens 14-19 9378547-6 1997 In contrast, incubation of U937 cells with phorbol ester was associated with progressive down-regulation of c-myc protein. Phorbol Esters 43-56 MYC proto-oncogene, bHLH transcription factor Homo sapiens 108-113 9000576-0 1997 Defects in p21WAF1/CIP1, Rb, and c-myc signaling in phorbol ester-resistant cancer cells. Phorbol Esters 52-65 MYC proto-oncogene, bHLH transcription factor Homo sapiens 33-38 1501891-3 1992 In addition, constitutive expression of exogenous myc inhibited induced differentiation of these cells by a variety of treatments including addition to the medium of lipopolysaccharide (LPS) or the phorbol ester 12-O-tetradecanoyl phorbol 13-acetate (TPA) as well as complete withdrawal of serum from the medium. Phorbol Esters 198-211 MYC proto-oncogene, bHLH transcription factor Homo sapiens 50-53 8912151-8 1996 This inhibitory effect of insulin or phorbol esters on PEPCK gene expression was accompanied by an increase in the rate of transcription and mRNA content of nuclear factors such as c-fos and c-myc, the expression of C/EBPs remaining essentially unmodified. Phorbol Esters 37-51 MYC proto-oncogene, bHLH transcription factor Homo sapiens 191-196 1927975-2 1991 These cells can be induced to undergo macrophage differentiation by phorbol esters, which results in suppression of c-myc expression and cessation of cell proliferation. Phorbol Esters 68-82 MYC proto-oncogene, bHLH transcription factor Homo sapiens 116-121 1743296-6 1991 Taken together, these findings suggest that phorbol esters have a biphasic effect on c-myc expression. Phorbol Esters 44-58 MYC proto-oncogene, bHLH transcription factor Homo sapiens 85-90 1743296-7 1991 Whereas the activation of protein kinase C by phorbol esters may be associated with an increase in c-myc gene expression, the subsequent partial down-regulation of kinase activity may initiate a cascade of events resulting in the down-modulation of c-myc expression. Phorbol Esters 46-60 MYC proto-oncogene, bHLH transcription factor Homo sapiens 99-104 1593910-11 1992 In contrast, c-myc was expressed at high levels in UCSD/AML1 cells and showed evidence for specific regulation in response to cycloheximide, phorbol ester, and GM-CSF withdrawal and restimulation. Phorbol Esters 141-154 MYC proto-oncogene, bHLH transcription factor Homo sapiens 13-18 1705899-3 1991 This inhibitor selectively blocks the mRNA expression of the proto-oncogene c-myc in response to the phorbol ester, PMA. Phorbol Esters 101-114 MYC proto-oncogene, bHLH transcription factor Homo sapiens 61-81 1703181-4 1991 The induction of c-myc mRNA by anti-IgM or anti-CD20 is blocked by inhibitors of protein kinase C (PKC) such as staurosporine and by pretreatment of B cells with phorbol esters to reduce cellular PKC levels. Phorbol Esters 162-176 MYC proto-oncogene, bHLH transcription factor Homo sapiens 17-22 1978839-5 1990 Northern blot analysis of a number of transcripts showed that the steady-state levels of c-myc and transforming growth factor beta 1 (TGF-beta 1) messages increased only after 3 h of phorbol ester treatment and returned to normal levels after 24 h. C-fos, albumin, and alphafetoprotein messages were not affected, suggesting the differentiation state of the cells was not altered. Phorbol Esters 183-196 MYC proto-oncogene, bHLH transcription factor Homo sapiens 89-94 2191300-8 1990 Transfection of thymidine kinase-chloramphenicol acetyltransferase constructs containing the 21-bp c-myc sequence into Jurkat cells demonstrated increased chloramphenicol acetyltransferase activity upon phorbol ester and phytohemagglutinin treatment. Phorbol Esters 203-216 MYC proto-oncogene, bHLH transcription factor Homo sapiens 99-104 1688464-10 1990 These data suggest that cAMP, phorbol esters, and PDGF act independently to stimulate c-myc RNA expression in MG-63 cells. Phorbol Esters 30-44 MYC proto-oncogene, bHLH transcription factor Homo sapiens 86-91 1688464-11 1990 However, nuclear runoff experiments and RNA half-life measurements demonstrated that PDGF, phorbol ester, and cAMP all act to increase the transcription of the MYC gene. Phorbol Esters 91-104 MYC proto-oncogene, bHLH transcription factor Homo sapiens 160-163