PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8657115-1 1996 Previous studies have indicated that the expression of viral oncoproteins, cell transformation, or phorbol ester treatment of cells can inhibit alpha/beta interferon (IFN-alpha/beta)-induced gene expression. Phorbol Esters 99-112 interferon alpha 1 Homo sapiens 167-170 10022868-7 1999 Coinciding with the induction of histone acetylases, phorbol ester markedly enhanced IFN-alpha-stimulated gene expression in U937 cells. Phorbol Esters 53-66 interferon alpha 1 Homo sapiens 85-94 8657115-4 1996 Phorbol ester treatment of monocytes inhibited IFN alpha-stimulated tyrosine phosphorylation of the transcription factors Stat1alpha, Stat2, and Stat3 and of the tyrosine kinase Tyk2 but had no effect on IFN-gamma activation of Stat1alpha. Phorbol Esters 0-13 interferon alpha 1 Homo sapiens 47-56 2127700-2 1990 Phorbol esters can inhibit IFN-induced expression of some of these RNAs, including ISG-54K. Phorbol Esters 0-14 interferon alpha 1 Homo sapiens 27-30 1406637-2 1992 In addition, phorbol esters may promote cell growth by the inhibition of expression of cellular gene products regulated by antiproliferative agents such as interferons (IFN)s. In human diploid fibroblasts, phorbol 12-myristate 13-acetate (PMA) selectively inhibits the IFN-alpha-induced cellular gene ISG54. Phorbol Esters 13-27 interferon alpha 1 Homo sapiens 269-278 1628655-0 1992 Transcriptional activation of human (2"-5")oligoadenylate synthetase gene expression by the phorbol ester 12-O-tetradecanoyl-phorbol 13-acetate in type-I-interferon-treated HL-60 and HeLa cells. Phorbol Esters 92-105 interferon alpha 1 Homo sapiens 154-164 8289823-3 1994 IFN-alpha-stimulated formation of ISGF3 and subsequent gene expression can be inhibited by phorbol esters or expression of the adenovirus E1A protein. Phorbol Esters 91-105 interferon alpha 1 Homo sapiens 0-9 1655906-0 1991 Phorbol ester-mediated inhibition of IFN-alpha/beta gene transcription in blood mononuclear leukocytes. Phorbol Esters 0-13 interferon alpha 1 Homo sapiens 37-46 1655906-1 1991 The phorbol ester PMA efficiently inhibits the in vitro IFN-alpha and -beta responses in human blood monocytes induced by Sendai virus and in natural IFN-producing cells induced by glutaraldehyde-fixed herpes simplex virus-infected human amnion (WISH) cells. Phorbol Esters 4-17 interferon alpha 1 Homo sapiens 56-75 2127700-3 1990 The actions of phorbol esters on IFN-activated ISG-54K transcription are cell specific and are reversed by inhibitors of protein synthesis. Phorbol Esters 15-29 interferon alpha 1 Homo sapiens 33-36 2127700-4 1990 In those cell lines in which phorbol esters inhibit IFN-induced ISG-54K transcription, prolonged IFN exposure also induces a "desensitized state" such that further IFN exposure no longer induces ISG-54K expression. Phorbol Esters 29-43 interferon alpha 1 Homo sapiens 52-55 2127700-6 1990 Experiments are described to determine whether the mechanism by which phorbol esters inhibit IFN-activated ISG-54K expression is the same as the mechanism by which prolonged exposure to IFN makes cells refractory to further induction of ISG-54K expression. Phorbol Esters 70-84 interferon alpha 1 Homo sapiens 93-96 18635599-7 2008 We show that lipid rafts are required for enterocyte migration, that IFN displaces Cx43 from lipid rafts, and that the phorbol ester phorbol 12-myristate 13-acetate (PMA) restores Cx43 to lipid rafts after treatment with IFN in a protein kinase C-dependent manner. Phorbol Esters 119-132 interferon alpha 1 Homo sapiens 221-224 2470148-4 1989 In contrast, interferon alpha (IFN-alpha) inhibited the release of reverse transcriptase and viral antigens into the culture supernatant after phorbol ester stimulation of both cell lines. Phorbol Esters 143-156 interferon alpha 1 Homo sapiens 13-40 2470148-6 1989 Also, after phorbol ester stimulation of ACH-2 cells, IFN-alpha reduced the number of infectious viral particles secreted into the culture supernatant, but had no effect on the infectivity of cell-associated virus. Phorbol Esters 12-25 interferon alpha 1 Homo sapiens 54-63 2494657-6 1989 These findings suggest the existence of a phorbol ester-sensitive factor, inducible in MOLT-4 and constitutively expressed or modified in YHHH, which operates in the pathway of induction of class I HLA by IFN-alpha but not in the pathway used by IFN-gamma. Phorbol Esters 42-55 interferon alpha 1 Homo sapiens 205-214 2464596-2 1989 Experiments reported here indicate that phorbol esters can also specifically inhibit the expression of an IFN-induced RNA (IFN-IND-1). Phorbol Esters 40-54 interferon alpha 1 Homo sapiens 106-109 2464596-2 1989 Experiments reported here indicate that phorbol esters can also specifically inhibit the expression of an IFN-induced RNA (IFN-IND-1). Phorbol Esters 40-54 interferon alpha 1 Homo sapiens 123-126 2464596-3 1989 Phorbol esters exert their effects by inhibiting IFN-induced transcription of the gene that encodes IFN-IND-1 (ISG-54K); inhibitors of protein synthesis reverse the effects of these compounds. Phorbol Esters 0-14 interferon alpha 1 Homo sapiens 49-52 2464596-3 1989 Phorbol esters exert their effects by inhibiting IFN-induced transcription of the gene that encodes IFN-IND-1 (ISG-54K); inhibitors of protein synthesis reverse the effects of these compounds. Phorbol Esters 0-14 interferon alpha 1 Homo sapiens 100-103 2464596-4 1989 The actions of phorbol esters are only seen in those types of cultured cells where cycloheximide in the presence of IFN prevents long term IFN treatment of cells from inducing a "desensitized state." Phorbol Esters 15-29 interferon alpha 1 Homo sapiens 116-119 2464596-4 1989 The actions of phorbol esters are only seen in those types of cultured cells where cycloheximide in the presence of IFN prevents long term IFN treatment of cells from inducing a "desensitized state." Phorbol Esters 15-29 interferon alpha 1 Homo sapiens 139-142 2439242-0 1987 Release of arachidonic acid metabolites by human monocytes or lymphocytes: effect of treatment with interferon on stimulation by phorbol ester or calcium ionophore. Phorbol Esters 129-142 interferon alpha 1 Homo sapiens 100-110 6501944-0 1984 Enhancement by phorbol esters of cell growth inhibiting action of interferon. Phorbol Esters 15-29 interferon alpha 1 Homo sapiens 66-76 6201264-14 1984 If this mechanism is counteracted by addition of anti-IFN serum, the phorbol esters can provide an alternative activation signal. Phorbol Esters 69-83 interferon alpha 1 Homo sapiens 54-57