PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15389577-0 2005 Studies of the roles of ADP-ribosylation factors and phospholipase D in phorbol ester-induced membrane ruffling. Phorbol Esters 72-85 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 53-68 16341931-1 2005 Stable overexpression of myristoylated alanine-rich C-kinase substrate (MARCKS) is known to enhance phorbol ester stimulation of phospholipase D (PLD) activity and protein kinase Calpha (PKCalpha) levels in SK-N-MC neuroblastoma cells. Phorbol Esters 100-113 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 129-144 16341931-1 2005 Stable overexpression of myristoylated alanine-rich C-kinase substrate (MARCKS) is known to enhance phorbol ester stimulation of phospholipase D (PLD) activity and protein kinase Calpha (PKCalpha) levels in SK-N-MC neuroblastoma cells. Phorbol Esters 100-113 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 146-149 15843515-8 2005 Phorbol ester, which did not stimulate degranulation by itself, restored degranulation when used in combination with thapsigargin whether PLD function was disrupted with 1-butanol or the small inhibitory RNAs. Phorbol Esters 0-13 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 138-141 15081395-0 2004 Expression and regulation of phospholipase D isoforms in sphingosine and phorbol ester-stimulated glioma C6 cells. Phorbol Esters 73-86 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 29-44 15556619-0 2004 Phorbol ester-induced differentiation of L6 myogenic cells involves phospholipase D activation. Phorbol Esters 0-13 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 68-83 15081395-5 2004 On the contrary, phorbol ester (12-O-tetradecanoylphorbol-13-acetate, TPA)-mediated PLD activity was enhanced by GTPgammaS and was only partially decreased by methyl-beta-cyclodextrin. Phorbol Esters 17-30 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 84-87 10597278-7 1999 This increase did not result from activation of phospholipase D (PLD), although the enzyme was activatable by treatment with phorbol ester Thus, a phosphohydrolase-mediated DAG synthesis from PLD-produced PA can be excluded. Phorbol Esters 125-138 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 192-195 14646617-4 2003 Melanoma cell lines showed phosphatidylcholine-hydrolysing, phosphatidylinositol 4,5-bisphosphate-dependent PLD activity, which was activated by phorbol ester and a non-hydrolysable guanosine triphosphate (GTP) analogue in a dose-dependent and synergistic manner, whereas primary melanocytes exhibited only low PLD activity compared with the melanoma cell lines. Phorbol Esters 145-158 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 108-111 14646617-4 2003 Melanoma cell lines showed phosphatidylcholine-hydrolysing, phosphatidylinositol 4,5-bisphosphate-dependent PLD activity, which was activated by phorbol ester and a non-hydrolysable guanosine triphosphate (GTP) analogue in a dose-dependent and synergistic manner, whereas primary melanocytes exhibited only low PLD activity compared with the melanoma cell lines. Phorbol Esters 145-158 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 311-314 14646617-8 2003 We conclude that in human melanoma cells, the PLD activity that is stimulated by phorbol ester requires ADP-ribosylation factor, protein kinase C and Rho proteins for full activity, and most probably represents the isoenzyme PLD1. Phorbol Esters 81-94 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 46-49 11687572-2 2001 We previously showed that in resting epithelial HT29-cl19A cells, PLD is implicated in the control of constitutive protein transit, from the trans-Golgi network to the plasma membrane, and that phorbol ester stimulation of protein transit is correlated with PLD activation (Auger, R., Robin, P., Camier, B., Vial, G., Rossignol, B., Tenu, J.-P., and Raymond, M.-N. (1999) J. Biol. Phorbol Esters 194-207 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 258-261 11380624-1 2001 BACKGROUND: Treatment of many cell types with phorbol esters stimulates phospholipase D (PLD) activity implying regulation of the enzyme by protein kinase C. Studies of the effects of several protein-tyrosine kinase (PTK) inhibitors have suggested that PTK(s) play some roles in the phorbol ester-induced PLD activation, but it remains unclear how and which PTK(s) is involved in this pathway. Phorbol Esters 46-60 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 89-92 11380624-1 2001 BACKGROUND: Treatment of many cell types with phorbol esters stimulates phospholipase D (PLD) activity implying regulation of the enzyme by protein kinase C. Studies of the effects of several protein-tyrosine kinase (PTK) inhibitors have suggested that PTK(s) play some roles in the phorbol ester-induced PLD activation, but it remains unclear how and which PTK(s) is involved in this pathway. Phorbol Esters 46-60 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 305-308 11380624-1 2001 BACKGROUND: Treatment of many cell types with phorbol esters stimulates phospholipase D (PLD) activity implying regulation of the enzyme by protein kinase C. Studies of the effects of several protein-tyrosine kinase (PTK) inhibitors have suggested that PTK(s) play some roles in the phorbol ester-induced PLD activation, but it remains unclear how and which PTK(s) is involved in this pathway. Phorbol Esters 46-59 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 89-92 11380624-1 2001 BACKGROUND: Treatment of many cell types with phorbol esters stimulates phospholipase D (PLD) activity implying regulation of the enzyme by protein kinase C. Studies of the effects of several protein-tyrosine kinase (PTK) inhibitors have suggested that PTK(s) play some roles in the phorbol ester-induced PLD activation, but it remains unclear how and which PTK(s) is involved in this pathway. Phorbol Esters 46-59 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 305-308 11380624-2 2001 In this study, we investigated the roles of Syk and other PTKs for the phorbol esters, 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced PLD activation in K562 and DT40 cells. Phorbol Esters 71-85 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 138-141 11336804-8 2001 PLD activity was furthermore increased by 8Br-cAMP and following acute (30 min) stimulation of protein kinase C (PKC) with a phorbol ester (PMA). Phorbol Esters 125-138 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 11314048-8 2001 Furthermore, in all cell lines tested, a chronic exposure of the cells to HePC abrogates PLD activation by either phorbol esters or HePC itself with no effect on total cellular PLD levels. Phorbol Esters 114-128 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 89-92 11018470-2 2000 In SK-N-MC human neuroblastoma cells, phorbol ester (TPA) activation of PLD was enhanced by overexpressing myristoylated alanine-rich C kinase substrate (MARCKS). Phorbol Esters 38-51 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 72-75 10830309-6 2000 PLD activity was also potently stimulated by treatment with phorbol esters, but this activity was only partially inhibited by brefeldin A or by the overexpression of ARF dominant negative mutants. Phorbol Esters 60-74 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 10709112-10 2000 Finally, in vivo experiments have confirmed previous results showing that activation of PLD by phorbol esters is markedly potentiated in the MDR cells. Phorbol Esters 95-109 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 88-91 9516439-13 1998 In conclusion, the data presented indicate that TcdB-1470 and TcsL selectively interfere with phorbol ester stimulation of PLD and suggest an essential role of Ral proteins in PKC signaling to PLD in HEK-293 cells. Phorbol Esters 94-107 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 123-126 10049738-8 1999 Depleting cells of PKC by long term phorbol ester treatment actually increased PLD activity in v-Raf-transformed cells, indicating that v-Raf-induced PLD activity is not dependent on PKC. Phorbol Esters 36-49 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 79-82 9593849-0 1998 Phorbol ester stimulation of phosphatidylcholine synthesis requires expression of both protein kinase C-alpha and phospholipase D. Phorbol Esters 0-13 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 114-129 9572295-5 1998 The activation of PLD by [Pro9]SP was sensitive to external calcium and required an active protein kinase C because the inhibition of this kinase (Ro 31-8220) or its down-regulation (long-term treatment with a phorbol ester) abolished the response. Phorbol Esters 210-223 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 18-21 9516439-0 1998 Specific inhibition of phorbol ester-stimulated phospholipase D by Clostridium sordellii lethal toxin and Clostridium difficile toxin B-1470 in HEK-293 cells. Phorbol Esters 23-36 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 48-63 10049506-0 1999 Overexpression of protein kinase C-epsilon and its regulatory domains in fibroblasts inhibits phorbol ester-induced phospholipase D activity. Phorbol Esters 94-107 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 116-131 9873009-0 1999 Phospholipase D mediates matrix metalloproteinase-9 secretion in phorbol ester-stimulated human fibrosarcoma cells. Phorbol Esters 65-78 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 9639664-3 1998 Hydrolysis of PtdCho by phospholipase D (PLD) and resynthesis of PtdCho from labeled choline were stimulated 2- to 4-fold by PKC activation with the phorbol ester, 4beta-12-O-tetradecanoylphorbol-13-acetate (beta-TPA), in all cells except those from heterozygous X-ALD individuals. Phorbol Esters 149-162 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 24-39 9639664-3 1998 Hydrolysis of PtdCho by phospholipase D (PLD) and resynthesis of PtdCho from labeled choline were stimulated 2- to 4-fold by PKC activation with the phorbol ester, 4beta-12-O-tetradecanoylphorbol-13-acetate (beta-TPA), in all cells except those from heterozygous X-ALD individuals. Phorbol Esters 149-162 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 41-44 9395070-0 1997 Ro31-8220 inhibits protein kinase C to block the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells: p70 S6 kinase and MAPKAP kinase-1beta do not function downstream of PKC in activating PLD. Phorbol Esters 49-62 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 231-234 9395070-5 1997 The PI-3 kinase inhibitor, wortmannin, inhibits the phorbol ester-stimulated release of ethanolamine- but not choline-metabolites from C6 cells suggesting that different PLD isoforms regulate the turnover of PtdEth and PtdCho in C6 cells. Phorbol Esters 52-65 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 170-173 9395070-3 1997 Here we show that the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells due to phospholipid hydrolysis by phospholipase D (PLD) is not inhibited by rapamycin or PD98059, specific inhibitors respectively of p70 S6 kinase and MAPKK (MEK) and thus of MAPKAP kinase-1beta but is still completely blocked by Ro31-8220. Phorbol Esters 22-35 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 151-166 9395070-3 1997 Here we show that the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells due to phospholipid hydrolysis by phospholipase D (PLD) is not inhibited by rapamycin or PD98059, specific inhibitors respectively of p70 S6 kinase and MAPKK (MEK) and thus of MAPKAP kinase-1beta but is still completely blocked by Ro31-8220. Phorbol Esters 22-35 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 168-171 9346296-2 1997 In the present study, performed in cell-free preparations, we have characterized and compared the regulation of HEK cell PLD activity by the stable GTP analogue, guanosine 5"-O-[gamma-thio]triphosphate (GTP[S]), and the phorbol ester, phorbol 12-myristate 13-acetate (PMA). Phorbol Esters 220-233 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 121-124 9346296-10 1997 The results indicate that phorbol ester stimulation of PLD activity in HEK cells apparently occurs by a phosphorylation-dependent mechanism involving membrane-associated PKC isozymes but not ARF proteins, the major targets of GTP[S]" action. Phorbol Esters 26-39 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 55-58 9001386-0 1997 Inhibition of phorbol ester-stimulated phospholipase D activity by chronic tamoxifen treatment in breast cancer cells. Phorbol Esters 14-27 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 39-54 9143362-1 1997 We studied the relationships between the activation of phospholipase D (PLD) by guanine nucleotides and phorbol esters in permeabilized U937 promonocytes and in solubilized extracts prepared from U937 cell membranes. Phorbol Esters 104-118 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 55-70 9143362-1 1997 We studied the relationships between the activation of phospholipase D (PLD) by guanine nucleotides and phorbol esters in permeabilized U937 promonocytes and in solubilized extracts prepared from U937 cell membranes. Phorbol Esters 104-118 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 72-75 9143362-12 1997 These results suggest that the assembly of active RhoA/PLD signaling complexes on membranes involves a phorbol ester/calphostin-binding protein, but is not dependent on PKC-type catalytic activity. Phorbol Esters 103-116 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 55-58 9052757-9 1997 Phorbol diesters also activated PLD, but estrogen had no influence. Phorbol Esters 0-16 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 32-35 9052757-10 1997 Pretreatment of cells with phorbol dibutyrate (PKC down-regulation protocol) blocked phorbol diester- and tamoxifen-induced PLD activity. Phorbol Esters 85-100 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 124-127 9001386-2 1997 TAM caused these inhibitory effects without inducing membrane translocation or down-regulation of protein kinase C-alpha, the major mediator of phorbol ester effects on PLD activation. Phorbol Esters 144-157 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 169-172 9256242-0 1997 Alkyl lysophospholipids inhibit phorbol ester-stimulated phospholipase D activity and DNA synthesis in fibroblasts. Phorbol Esters 32-45 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 57-72 7559408-5 1995 Both fMLP and active phorbol esters induced a 2-3-fold increase in GTP gamma S-stimulated PLD in HL-60 membranes. Phorbol Esters 21-35 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 90-93 8955215-6 1996 The P2zR-mediated PLD activity was distinguished from phorbol ester-stimulated PLD activity because the latter was slowly activated (t(1/2) > 15 min), unaffected by oxidized ATP or KN-62, and completely inhibited by bisindolylmaleimide. Phorbol Esters 54-67 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 79-82 8910539-0 1996 Protein kinase Calpha is a major mediator of the stimulatory effect of phorbol ester on phospholipase D-mediated hydrolysis of phosphatidylethanolamine. Phorbol Esters 71-84 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 88-103 8898346-6 1996 TPA, a phorbol ester which induced a rapid and important redistribution of PKC, although unable to elicit PLC or PLA2 stimulation, specifically provoked PLD activation in a PKC-dependent but Ca(2+)-independent manner. Phorbol Esters 7-20 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 153-156 8626805-5 1996 Stimulation of PLD by purified PKCalpha or recombinant PKCalpha (rPKCalpha) occurred in the absence of any nucleotide and required activators such as Ca2+ or phorbol ester. Phorbol Esters 158-171 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 15-18 8579603-0 1996 Involvement of vicinal dithiols in differential regulation of fMLP and phorbol ester-activated phospholipase D in stimulated human neutrophils. Phorbol Esters 71-84 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 95-110 8579603-2 1996 An opposite regulation was observed with phorbol ester PMA, since the phospholipase D activity was mostly calcium insensitive, tyrosine kinase independent, but protein kinase C dependent. Phorbol Esters 41-54 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 70-85 8855796-12 1996 In cultured dog thyrocytes, phorbol esters, and STSP induced DNA synthesis and dedifferentiation, whereas thapsigargin inhibited TSH-induced growth and killed phorbol esters stimulated cells, suggesting a positive role of PLD stimulation towards dedifferentiated growth and of simultaneously raised [Ca2+)i and stimulated protein kinase C-PLD towards growth arrest and cellular death. Phorbol Esters 28-42 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 339-342 8753793-4 1996 Moreover, they demonstrated increased PLD activity when stimulated with lysophosphatidic acid, platelet-derived growth factor, and phorbol ester, compared with vector-transfected cells. Phorbol Esters 131-144 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 38-41 7559408-13 1995 We propose that ARF, upon stimulation with agonists such as fMLP or phorbol esters, is translocated to the membrane and in concert with other protein components of the 50-kDa fraction enhances PLD activity. Phorbol Esters 68-82 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 193-196 7945188-0 1994 Phorbol ester selectively stimulates the phospholipase D-mediated hydrolysis of phosphatidylethanolamine in multidrug-resistant MCF-7 human breast carcinoma cells. Phorbol Esters 0-13 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 41-56 7755632-2 1995 In streptolysin-Q-permeabilized HL-60 cells, phorbol ester or diacylglycerol enhanced greatly this PLD activation in the presence of ATP-Mg2+. Phorbol Esters 45-58 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 99-102 7755632-4 1995 This phorbol-ester-induced PLD activation was completely counteracted not only by protein kinase C (PKC) inhibitors but also by tyrosine kinase inhibitors. Phorbol Esters 5-18 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 7890622-10 1995 In parallel, the anti-PtdIns 4-kinase fully inhibited the activation of PLD by GTP gamma S and caused a 60% inhibition of PLD activation by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate, indicating that elevated PtdIns-4,5-P2 levels are required for PLD activation. Phorbol Esters 144-157 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 122-125 7890622-10 1995 In parallel, the anti-PtdIns 4-kinase fully inhibited the activation of PLD by GTP gamma S and caused a 60% inhibition of PLD activation by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate, indicating that elevated PtdIns-4,5-P2 levels are required for PLD activation. Phorbol Esters 144-157 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 122-125 11550712-0 1994 Effect of interleukin 1, lipopolysaccharide and phorbol esters on phospholipase D activity in chondrocytes. Phorbol Esters 48-62 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 66-81 8110192-7 1994 Both granulocytic and monocytic differentiation of myelomonoblastic lines (e.g. HL-60) induced by dimethyl sulphoxide or phorbol diester respectively was accompanied by a 2-3-fold increase in GPI-PLD activity. Phorbol Esters 121-136 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 192-199 7916902-3 1994 Unlike receptor-mediated PLD activation, ketoepoxides were poor inhibitors of phorbol ester-induced PLD activity in granulocytes (IC50 = 43 microM for SCH 49210). Phorbol Esters 78-91 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 100-103 8053546-5 1994 Phorbol ester and vasopressin increased PLD activity in intact A7r5 vascular smooth muscle cells, as measured by an isotopic labeling method. Phorbol Esters 0-13 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 40-43 8053546-6 1994 Using the in vitro fluorescent assay, enhanced PLD activity was detected in membranes prepared from A7r5 cells that had been treated with phorbol ester or vasopressin. Phorbol Esters 138-151 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 47-50 8129736-1 1994 Protein kinase C (PKC), an enzyme which is believed to mediate the stimulatory effects of the PKC activator phorbol 12-myristate 13-acetate (PMA) on phospholipase D (PLD) activity, has a zinc-dependent structure required for phorbol ester binding. Phorbol Esters 225-238 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 166-169 8392931-7 1993 Long-term phorbol ester treatment blocks bradykinin-induced activation of PLD and consequent bisPA formation, thereby unveiling rapid formation of DG. Phorbol Esters 10-23 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 74-77 1905330-5 1991 Additional experiments characterized the activation of PLD by receptor-independent pathways at different stages of differentiation; these included studies of phorbol ester action in intact cells and GTP gamma S action in electropermeabilized cells. Phorbol Esters 158-171 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 55-58 8338512-0 1993 GTP gamma S and phorbol ester act synergistically to stimulate both Ca(2+)-independent secretion and phospholipase D activity in permeabilized human platelets. Phorbol Esters 16-29 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 101-116 1727727-1 1992 Our recent studies have demonstrated the presence in neonatal islet cells and intact adult islets of a phosphatidylcholine-directed phospholipase D (PLD) which is activated after phorbol ester stimulation. Phorbol Esters 179-192 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 132-147 1727727-1 1992 Our recent studies have demonstrated the presence in neonatal islet cells and intact adult islets of a phosphatidylcholine-directed phospholipase D (PLD) which is activated after phorbol ester stimulation. Phorbol Esters 179-192 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 149-152 8504157-0 1993 Phospholipase D activity of human amnion cells stimulated with phorbol ester and bradykinin. Phorbol Esters 63-76 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 2498324-5 1989 We now report that biologically active phorbol esters, a cell-permeable diacylglycerol, 1-oleoyl-2-acetylglycerol (OAG), and calcium ionophore A23187 are also potent inducers of PLD in these HL-60 granulocytes. Phorbol Esters 39-53 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 178-181 2002344-0 1991 Stimulation of phospholipase D activity in human neuroblastoma (LA-N-2) cells by activation of muscarinic acetylcholine receptors or by phorbol esters: relationship to phosphoinositide turnover. Phorbol Esters 136-150 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 15-30 2222456-0 1990 Evidence for protein kinase C independent activation of phospholipase D by phorbol esters in lymphocytes. Phorbol Esters 75-89 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 56-71 2222456-1 1990 Recently it was reported that tumor-promoting phorbol esters stimulate the production of phosphatidylethanol (PEt) in lymphocytes through the activation of phospholipase D (PLD). Phorbol Esters 46-60 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 156-171 2222456-1 1990 Recently it was reported that tumor-promoting phorbol esters stimulate the production of phosphatidylethanol (PEt) in lymphocytes through the activation of phospholipase D (PLD). Phorbol Esters 46-60 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 173-176 2753160-0 1989 Differential activation by fMet-Leu-Phe and phorbol ester of a plasma membrane phosphatidylcholine-specific phospholipase D in human neutrophil. Phorbol Esters 44-57 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 108-123 2498324-14 1989 We conclude that phorbol esters, OAG, and A23187 activate PLD in HL-60 granulocytes via protein kinase-independent as well as protein kinase-dependent mechanisms. Phorbol Esters 17-31 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 58-61 2498324-9 1989 In the presence of 0.5% ethanol, phorbol esters, OAG, and A23187 also induce formation of alkyl-[32P]PEt, demonstrating that the activated PLD catalyzes transphosphatidylation between the phosphatidyl moiety of the alkyl-[32P]PC and ethanol. Phorbol Esters 33-47 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 139-142 25137020-13 2014 Phorbol ester treatment over 3h increased Etn metabolite release from the metastatic PC3 cell line and the benign cell lines PNT2C2 and PNT1A but not from the tumour-derived cell lines P4E6 and LNCaP; this effect was blocked by Ro31-8220 and GF109203X as well as by D609, which inhibited PLD in a transphosphatidylation reaction. Phorbol Esters 0-13 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 288-291 31311871-8 2019 Strikingly, the fluorescent reporter lipids initially produced at the plasma membrane (PM) induced by phorbol ester stimulation of PLD were rapidly internalized via apparent nonvesicular pathways rather than endocytosis, suggesting applications of this activity-based imaging toolset for probing mechanisms of intracellular phospholipid transport. Phorbol Esters 102-115 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 131-134 24830864-7 2014 We subsequently examined the association of CHS1 with PLD, and showed that expression of a truncated mutant of CHS1 in 293T cells induced abnormally rapid activation of PLD after phorbol ester stimulation. Phorbol Esters 179-192 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 169-172 18523140-4 2008 HA-PLD2 confers PLD activity that is activated by phorbol ester, ionomycin, and okadaic acid. Phorbol Esters 50-63 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 3-6