PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10484133-1 1999 The involvement of tetrodotoxin-sensitive Na+ channels and receptor-operated nonspecific Ca2+ channels, and the effects of short-chain fatty acids, on growth hormone (GH) release induced by GH-releasing hormone (GHRH) were investigated in cultured and freshly isolated caprine anterior pituitary cells. Fatty Acids, Volatile 123-146 somatoliberin Capra hircus 212-216 10843791-1 2000 The effects of short-chain fatty acids (SCFA: acetate, propionate, and butyrate) on growth hormone (GH)-releasing hormone (GHRH)-induced GH secretion from pituitary somatotrophs were assessed on isolated anterior pituitary cells of goats. Fatty Acids, Volatile 15-38 somatoliberin Capra hircus 84-121 10843791-1 2000 The effects of short-chain fatty acids (SCFA: acetate, propionate, and butyrate) on growth hormone (GH)-releasing hormone (GHRH)-induced GH secretion from pituitary somatotrophs were assessed on isolated anterior pituitary cells of goats. Fatty Acids, Volatile 15-38 somatoliberin Capra hircus 123-127 10843791-1 2000 The effects of short-chain fatty acids (SCFA: acetate, propionate, and butyrate) on growth hormone (GH)-releasing hormone (GHRH)-induced GH secretion from pituitary somatotrophs were assessed on isolated anterior pituitary cells of goats. Fatty Acids, Volatile 40-44 somatoliberin Capra hircus 84-121 10843791-4 2000 However, in cells cultured in the presence of either propionate (3 or 10 mM) or butyrate (1, 3, or 10 mM), the addition of SCFA to the medium during GHRH stimulation significantly reduced the GHRH-induced GH release. Fatty Acids, Volatile 123-127 somatoliberin Capra hircus 149-153 10843791-4 2000 However, in cells cultured in the presence of either propionate (3 or 10 mM) or butyrate (1, 3, or 10 mM), the addition of SCFA to the medium during GHRH stimulation significantly reduced the GHRH-induced GH release. Fatty Acids, Volatile 123-127 somatoliberin Capra hircus 192-196 10484133-7 1999 From these findings we conclude that tetrodotoxin-sensitive Na+ channels and voltage-dependent L-type Ca2+ channels are involved in the cellular mechanism for GHRH-induced GH release, and that short-chain fatty acids such as propionate and butyrate have a direct action on somatotrophs to reduce basal and GHRH-induced GH release, in caprine somatotrophs. Fatty Acids, Volatile 193-216 somatoliberin Capra hircus 159-163 10484133-7 1999 From these findings we conclude that tetrodotoxin-sensitive Na+ channels and voltage-dependent L-type Ca2+ channels are involved in the cellular mechanism for GHRH-induced GH release, and that short-chain fatty acids such as propionate and butyrate have a direct action on somatotrophs to reduce basal and GHRH-induced GH release, in caprine somatotrophs. Fatty Acids, Volatile 193-216 somatoliberin Capra hircus 306-310