PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8760140-4	1996	Stimulation with IL-1 beta and TNF-alpha plus H2O2 or IL-1 beta and LPS plus H2O2 increased the synthesis of NO2- and NO3- by 3.8- and 3.5-fold, respectively.	Nitrogen Dioxide	109-112	interleukin 1 beta	Rattus norvegicus	17-26	
12132579-3	2002	NO production (NO2-), indicating iNOS activity, was much higher in the young rat hepatocytes following stimulation with LPS or IL-1beta.	Nitrogen Dioxide	15-18	interleukin 1 beta	Rattus norvegicus	127-135	
11229466-9	2001	In the same way, the amino sugar reduced NO2- and PGE2 production induced by IL-1beta.	Nitrogen Dioxide	41-44	interleukin 1 beta	Rattus norvegicus	77-85	
10086983-3	1999	In such rats, IL-1beta (10 microgram/kg) induced a biphasic pressor response, with a rise in the plasma concentration of NOx (NO2(-) and NO3(-): metabolites of NO) during the second phase.	Nitrogen Dioxide	126-129	interleukin 1 beta	Rattus norvegicus	14-22	
9698594-7	1998	Both types of asbestos fibers (chrysotile > crocidolite) upregulated the formation of NO2- in mesothelial cells costimulated with IL-1beta in a concentration-dependent and time-dependent fashion.	Nitrogen Dioxide	89-92	interleukin 1 beta	Rattus norvegicus	133-141	
9134219-9	1997	The effect of staurosporine on both basal and IL-1 beta-stimulated NO2- production was concentration-dependent with an apparent maximum at 3 nM.	Nitrogen Dioxide	67-70	interleukin 1 beta	Rattus norvegicus	46-55	
8897830-7	1996	The addition of the glycolytic end product, pyruvate, completely blocked the 2-DG inhibition of IL-1 beta-stimulated NO2- production [7.4 +/- 0.4 nmol.	Nitrogen Dioxide	117-120	interleukin 1 beta	Rattus norvegicus	96-105	
8760140-2	1996	Stimulation of rat pleural mesothelial cells with combinations of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and LPS induced the synthesis of nitric oxide as measured by the oxidation products nitrite (NO2-) and nitrate (NO3-).	Nitrogen Dioxide	262-265	interleukin 1 beta	Rattus norvegicus	66-84	
11016861-4	2000	NO2- production stimulated by IL-1beta + TGFalpha was significantly reduced by N(G)-nitro-L-arginine methyl ester (L-NAME) or aminoguanidine, yet not by D-NAME.	Nitrogen Dioxide	0-3	interleukin 1 beta	Rattus norvegicus	30-38	
9602105-3	1998	Intraperitoneally administered IL-1 beta produced a significant increase in both NO2- and NO3- levels in the PVN region.	Nitrogen Dioxide	81-84	interleukin 1 beta	Rattus norvegicus	31-40	
8897830-3	1996	Removal of glucose from the media partially inhibited IL-1 beta-stimulated nitrite (NO2-) production [8.1 +/- 0.3 vs. 4.4 +/- 0.6 nmol.	Nitrogen Dioxide	84-87	interleukin 1 beta	Rattus norvegicus	54-63	
8897830-5	1996	The glycolytic inhibitor 2-deoxy-D-glucose (2-DG) completely inhibited IL-1 beta-stimulated NO2- production [0.7 +/- 0.5 nmol.	Nitrogen Dioxide	92-95	interleukin 1 beta	Rattus norvegicus	71-80	
8760140-4	1996	Stimulation with IL-1 beta and TNF-alpha plus H2O2 or IL-1 beta and LPS plus H2O2 increased the synthesis of NO2- and NO3- by 3.8- and 3.5-fold, respectively.	Nitrogen Dioxide	109-112	interleukin 1 beta	Rattus norvegicus	54-63	
8594915-2	1995	Maximal nitrite (NO2(-)) production by cultured neonatal rat cardiac myocytes was achieved with 500 U/ml interleukin-1 beta (IL-1 beta) for 48 h (4.6 +/- 0.3 nmol/1.25 x 10(5) cells; n = 12).	Nitrogen Dioxide	17-20	interleukin 1 beta	Rattus norvegicus	105-123	
8594915-2	1995	Maximal nitrite (NO2(-)) production by cultured neonatal rat cardiac myocytes was achieved with 500 U/ml interleukin-1 beta (IL-1 beta) for 48 h (4.6 +/- 0.3 nmol/1.25 x 10(5) cells; n = 12).	Nitrogen Dioxide	17-20	interleukin 1 beta	Rattus norvegicus	125-134	
8594915-5	1995	The addition of FSK or DBcAMP to IL-1 beta significantly increased NO2-) levels vs. IL-1 beta alone (9.7 +/- 0.6 and 10.9 +/- 0.8 vs. 4.6 +/- 0.3 nmol/1.25 x 10(5) cells per 48 h, respectively; P < 0.01; n = 12).	Nitrogen Dioxide	67-70	interleukin 1 beta	Rattus norvegicus	33-42	
7686532-3	1993	Interleukin-1 beta dose dependently (1 to 20 ng/mL) stimulated NO2-/NO3- production as a function of time.	Nitrogen Dioxide	63-66	interleukin 1 beta	Rattus norvegicus	0-18	
7686532-5	1993	NG-Monomethyl L-arginine completely blocked the interleukin-1 beta-induced NO2-/NO3- production, the effect of which was reversed by L-arginine but not by D-arginine.	Nitrogen Dioxide	75-78	interleukin 1 beta	Rattus norvegicus	48-66	
28986735-9	2017	Furthermore, NO2 exposure promoted the increase in the expression of mucin gene (MUC5AC) and pro-inflammatory factors [interleukin (IL)-1beta, intercellular adhesion molecule-1 (ICAM-1), and IL-6] as well as serum OVA-specific immunoglobulin E (IgE) production.	Nitrogen Dioxide	13-16	interleukin 1 beta	Rattus norvegicus	119-141	
27872853-5	2016	ELISA showed that HA-CS-IL-1Ra microspheres inhibited IL-1beta-induced inflammation by attenuating increases in NO2- and prostaglandin E2 levels as well as increase in glycosaminoglycan release.	Nitrogen Dioxide	112-115	interleukin 1 beta	Rattus norvegicus	54-62