PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7524571-11 1994 Addition of IFN-gamma (250 to 500 IU/ml) synergistically enhanced the formation of NO2- induced by chrysotile and crocidolite. Nitrogen Dioxide 83-86 interferon gamma Rattus norvegicus 12-21 8292382-5 1994 IFN-gamma (1,000 U)-induced increases in lambda 0 were concentration-dependently inhibited by NG-monomethyl-L-arginine (L-NMMA) with complete inhibition of a concentration of 10(-4) M and were also completely inhibited by either methylene blue (10(-5) M) or KT 5823 (10(-5) M), a specific inhibitor of protein kinase G. IFN-gamma (1,000 U) caused significant nitrite (NO2-) production from the control values of 0.2 +/- 0.1 to 10.0 +/- 0.2 microM/24 h per 10(6) cells (P < 0.001, n = 10), and this increase in NO2- production by IFN-gamma (1,000 U) was completely inhibited by L-NMMA (10(-4) M). Nitrogen Dioxide 368-371 interferon gamma Rattus norvegicus 0-9 8370073-7 1993 Addition of 1 to 50 U/ml IFN-gamma induced a dose-dependent increase in NO2- production, with the maximal level approximating that found in suppressed cocultures; TNF-alpha, IL-2, or LPS did not synergize with IFN-gamma to enhance NO2- production. Nitrogen Dioxide 72-75 interferon gamma Rattus norvegicus 25-34 8370073-7 1993 Addition of 1 to 50 U/ml IFN-gamma induced a dose-dependent increase in NO2- production, with the maximal level approximating that found in suppressed cocultures; TNF-alpha, IL-2, or LPS did not synergize with IFN-gamma to enhance NO2- production. Nitrogen Dioxide 231-234 interferon gamma Rattus norvegicus 25-34 8102159-4 1993 Stimuli such as PMA, LPS, and/or IFN-gamma induce micromolar concentrations of NO2- within 24 h. TNF-alpha increases IFN gamma but not LPS-induced NO2- production. Nitrogen Dioxide 79-82 interferon gamma Rattus norvegicus 33-42 8102159-4 1993 Stimuli such as PMA, LPS, and/or IFN-gamma induce micromolar concentrations of NO2- within 24 h. TNF-alpha increases IFN gamma but not LPS-induced NO2- production. Nitrogen Dioxide 79-82 interferon gamma Rattus norvegicus 117-126 1729374-9 1992 Neutralizing antibodies against mouse TNF-alpha inhibited also the release of NO2- by rIFN-gamma-activated macrophages almost completely. Nitrogen Dioxide 78-81 interferon gamma Rattus norvegicus 86-96 7688152-4 1993 METHODS: RPASM, preincubated in the presence of antisense and sense oligodeoxynucleotide to the first 18 bases after the initiation codon of iNOS mRNA, was exposed to interferon-gamma and tumor necrosis factor-alpha to induce NO production (as measured by NO2-, the stable end product of NO formation). Nitrogen Dioxide 256-259 interferon gamma Rattus norvegicus 167-215 7688152-5 1993 RESULTS: Interferon-gamma and tumor necrosis factor-alpha induced NO production in RPASM: The antisense probe caused up to a 36% decrease in cytokine-induced NO2- production in a concentration-dependent manner (1 to 10 mumol/L). Nitrogen Dioxide 158-161 interferon gamma Rattus norvegicus 9-57 7681038-4 1993 Like M phi, these clones were found to release high levels of NO2- in response to recombinant interferon-gamma (rIFN-gamma) as a priming signal together with either bacterial lipopolysaccharide (LPS) or exogenous recombinant tumor necrosis factor-alpha (rTNF-alpha). Nitrogen Dioxide 62-65 interferon gamma Rattus norvegicus 112-122 1478682-2 1992 A single intravenous injection of 1 x 10(6) U or three injections of 2 x 10(5) U recombinant IFN-gamma (rIFN-gamma) induced optimal activation of resident and exudate peritoneal macrophages, as judged by their ability to inhibit the intracellular proliferation of Toxoplasma gondii and their enhanced release of H2O2 and NO2-. Nitrogen Dioxide 321-324 interferon gamma Rattus norvegicus 93-102 1478682-2 1992 A single intravenous injection of 1 x 10(6) U or three injections of 2 x 10(5) U recombinant IFN-gamma (rIFN-gamma) induced optimal activation of resident and exudate peritoneal macrophages, as judged by their ability to inhibit the intracellular proliferation of Toxoplasma gondii and their enhanced release of H2O2 and NO2-. Nitrogen Dioxide 321-324 interferon gamma Rattus norvegicus 104-114 1452344-3 1992 After an intraperitoneal injection of rIFN-gamma into CBA/J mice, their peritoneal macrophages released enhanced amounts of NO2- and inhibited the intracellular proliferation of Toxoplasma gondii. Nitrogen Dioxide 124-127 interferon gamma Rattus norvegicus 38-48 1452344-4 1992 Injection of neutralizing antibodies against TNF-alpha simultaneously with the rIFN-gamma completely inhibited both the release of NO2- by macrophages and their toxoplasmastatic activity. Nitrogen Dioxide 131-134 interferon gamma Rattus norvegicus 79-89 1729374-10 1992 Macrophages incubated with rTNF-alpha in combination with a nonactivating concentration of rIFN-gamma released substantial amounts of NO2-, but rTNF-alpha and rIL-1 alpha alone, and the combination of rIL-1 alpha and a nonactivating concentration of rIFN-gamma induced only little NO2(-)-release by macrophages. Nitrogen Dioxide 134-137 interferon gamma Rattus norvegicus 91-101 1729374-10 1992 Macrophages incubated with rTNF-alpha in combination with a nonactivating concentration of rIFN-gamma released substantial amounts of NO2-, but rTNF-alpha and rIL-1 alpha alone, and the combination of rIL-1 alpha and a nonactivating concentration of rIFN-gamma induced only little NO2(-)-release by macrophages. Nitrogen Dioxide 134-137 interferon gamma Rattus norvegicus 250-260 1729374-10 1992 Macrophages incubated with rTNF-alpha in combination with a nonactivating concentration of rIFN-gamma released substantial amounts of NO2-, but rTNF-alpha and rIL-1 alpha alone, and the combination of rIL-1 alpha and a nonactivating concentration of rIFN-gamma induced only little NO2(-)-release by macrophages. Nitrogen Dioxide 281-284 interferon gamma Rattus norvegicus 91-101 1915557-1 1991 Previously, we reported that exposure of bone marrow-derived macrophages (M phi) to a phagocytic stimulus in the simultaneous presence of interferon-gamma (IFN-gamma) induced these cells to generate nitrite (NO2-). Nitrogen Dioxide 208-211 interferon gamma Rattus norvegicus 156-165 1915557-5 1991 M phi NO2- production in response to rIFN-gamma and either exogenous TNF-alpha or Leishmania was strongly enhanced by prostaglandin E2, consistent with such a mechanism. Nitrogen Dioxide 6-9 interferon gamma Rattus norvegicus 37-47 1915557-6 1991 However, addition of either Leishmania promastigotes or latex beads to M phi cultures simultaneously exposed to both IFN-gamma and exogenous murine or human rTNF-alpha further potentiated activation as measured by NO2- release. Nitrogen Dioxide 214-217 interferon gamma Rattus norvegicus 117-126 1915557-9 1991 Phagocytosis also increased M phi NO2- production elicited by IFN-gamma plus TNF-alpha in L-arginine-deficient media. Nitrogen Dioxide 34-37 interferon gamma Rattus norvegicus 62-71 2351828-3 1990 The culture supernatants of macrophage activated by IFN-gamma contain increased levels of NO2-, the production of which is inhibited by L-NMMA, but not by its D-enantiomer. Nitrogen Dioxide 90-93 interferon gamma Rattus norvegicus 52-61 3142779-2 1988 Recombinant interferon-gamma (rIFN-gamma) and recombinant tumor necrosis factor (rTNF) synergize to induce nitrite (NO2-) and nitrate (NO3-) synthesis from L-arginine as well as to cause inhibition of the iron-dependent enzyme aconitase in macrophages. Nitrogen Dioxide 116-119 interferon gamma Rattus norvegicus 30-40 25462318-6 2015 Also, NO2 inhalation induced the imbalance in the ratio of Th1/Th2 differentiation (IL-4, IFN-gamma, GATA-3 and T-bet) and the activation of following JAK-STAT pathway (JAK1, JAK3 and STAT6). Nitrogen Dioxide 6-9 interferon gamma Rattus norvegicus 90-99 8813644-2 1996 NO synthase activity (NO2- accumulation) and 130 kDa protein of inducible NO synthase were induced 24 h after treatment with interferon-gamma or lipopolysaccharide in both glial cells and RAW264.7 macrophages. Nitrogen Dioxide 22-25 interferon gamma Rattus norvegicus 125-141 7501421-4 1995 Significantly higher levels of nitrite (NO2) were detected in supernatants from macrophage cultures treated with rIFN-gamma (10 u/ml or 100 u/ml) which induced microbistatic macrophage activity as well as from macrophage cultures treated with LPS + rIFN- when compared with levels of nitrite detected in supernatants of infected macrophages treated with medium only. Nitrogen Dioxide 40-43 interferon gamma Rattus norvegicus 113-123 11927648-7 2002 Upon stimulation with antigen, IFN-gamma, or anti-CD8, nitrite production was increased significantly (8.4+/-0.6, 7.6+/-0.9, and 6.6+/-0.9 microM/2x10(5) cells/48 h NO2-, respectively; P<0.01), whereas unstimulated PMC released 2.1 +/- 0.3 microM/2 x 10(5) cells/48 h NO2-. Nitrogen Dioxide 165-168 interferon gamma Rattus norvegicus 31-40 8760140-2 1996 Stimulation of rat pleural mesothelial cells with combinations of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and LPS induced the synthesis of nitric oxide as measured by the oxidation products nitrite (NO2-) and nitrate (NO3-). Nitrogen Dioxide 262-265 interferon gamma Rattus norvegicus 139-155 8760140-2 1996 Stimulation of rat pleural mesothelial cells with combinations of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and LPS induced the synthesis of nitric oxide as measured by the oxidation products nitrite (NO2-) and nitrate (NO3-). Nitrogen Dioxide 262-265 interferon gamma Rattus norvegicus 157-166