PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18089306-6	2007	Our results showed a time-dependent increase in iNOS expression, which was also confirmed by increased plasma formation of NO2-/NO3-.	Nitrogen Dioxide	123-126	nitric oxide synthase 2	Rattus norvegicus	48-52	
25272454-3	2014	Similar rise of the NO2-/NO3- concentration in the rats" blood after "stress", "diabetes mellitus" and "diabetes mellitus + stress" combines with an increase of iNOS transcripts in the myocardium to 6, 5.8 and 51 times compared with control.	Nitrogen Dioxide	20-23	nitric oxide synthase 2	Rattus norvegicus	161-165	
10574472-9	1999	As a consequence of down-regulation of iNOS and GTP-CH I genes, almost 3-fold diminished generation of NO2- by rat macrophages was observed.	Nitrogen Dioxide	103-106	nitric oxide synthase 2	Rattus norvegicus	39-43	
16170330-7	2005	Analysis of mRNA expression for iNOS, COX-2 and CINC-2 in lung tissue showed an upregulation of these enzymes, which paralleled elevated levels of LTB4, PGE2, TNF-alpha, IL-6 and NO2- in BAL fluid.	Nitrogen Dioxide	179-182	nitric oxide synthase 2	Rattus norvegicus	32-36	
12132579-3	2002	NO production (NO2-), indicating iNOS activity, was much higher in the young rat hepatocytes following stimulation with LPS or IL-1beta.	Nitrogen Dioxide	15-18	nitric oxide synthase 2	Rattus norvegicus	33-37	
9729377-8	1998	Media accumulation of NO2- and PGE2 was inhibited by Tau-Cl in a concentration dependent manner and this was accompanied by decreased amounts of iNOS and COX-2 proteins in cell lysates.	Nitrogen Dioxide	22-25	nitric oxide synthase 2	Rattus norvegicus	145-149	
9488173-3	1998	In addition, 4VO produced a gradual increase in hippocampal NO2- and NO3- levels over a 24 h period after reperfusion, which was abolished by an inducible NO synthase inhibitor, aminoguanidine (10 mg/kg, intraperitoneally).	Nitrogen Dioxide	60-63	nitric oxide synthase 2	Rattus norvegicus	145-166	
8880896-6	1996	Reduced synthesis of NO2- was associated with reduced NOS-2 mRNA levels suggesting that the induction of NOS-2 was inhibited.	Nitrogen Dioxide	21-24	nitric oxide synthase 2	Rattus norvegicus	54-59	
9322519-9	1997	Treatment with the selective iNOS inhibitor, aminoguanidine, inhibited iNOS enzymatic activity and overproduction of NO2-/NO3-.	Nitrogen Dioxide	117-121	nitric oxide synthase 2	Rattus norvegicus	29-33	
8880896-6	1996	Reduced synthesis of NO2- was associated with reduced NOS-2 mRNA levels suggesting that the induction of NOS-2 was inhibited.	Nitrogen Dioxide	21-24	nitric oxide synthase 2	Rattus norvegicus	105-110	
7527875-8	1994	The induction of iNOS mRNA by LPS was markedly inhibited by actinomycin D and dexamethasone, as was the accumulation of NO2-/NO3- in the media.	Nitrogen Dioxide	120-123	nitric oxide synthase 2	Rattus norvegicus	17-21	
7536940-8	1995	Moreover, the change in iNOS mRNA in the AM obtained from rats given MTB and MAC correlated with the production of the reactive nitrogen intermediates (RNI) NO2- and NO3- in BAL fluid, lung homogenate, and the spontaneous generation of RNI by isolated AM ex vivo and occurred without measurable increases in BAL fluid tumor necrosis factor-alpha (TNF-alpha).	Nitrogen Dioxide	157-160	nitric oxide synthase 2	Rattus norvegicus	24-28	
7542281-4	1995	The time course of the induction of inducible nitric oxide synthase (iNOS) protein in the pouch tissue was found to coincide with the production of NO2-.	Nitrogen Dioxide	148-151	nitric oxide synthase 2	Rattus norvegicus	36-67	
7542281-4	1995	The time course of the induction of inducible nitric oxide synthase (iNOS) protein in the pouch tissue was found to coincide with the production of NO2-.	Nitrogen Dioxide	148-151	nitric oxide synthase 2	Rattus norvegicus	69-73	
7504482-3	1993	The addition of aminoguanidine (1 mM), a preferential inhibitor of the inducible NO-synthase, completely abolished NO2-accumulation.	Nitrogen Dioxide	115-118	nitric oxide synthase 2	Rattus norvegicus	71-92	
7509342-1	1994	By measurements of NO2-/NO3- (NOx) production and Northern blot analysis, we studied the effects of a membrane-permeable cAMP derivative, 8-bromo-cAMP, on the expression of inducible nitric oxide synthase (iNOS) gene and the synthesis of NOx in cultured rat vascular smooth muscle cells (VSMCs).	Nitrogen Dioxide	19-22	nitric oxide synthase 2	Rattus norvegicus	173-204	
7682068-3	1993	Inducible nitric oxide synthase (iNOS) activity was determined by measuring the stable nitrogen oxide end products of L-arginine oxidation: nitrite (NO2-) and nitrate (NO3-).	Nitrogen Dioxide	149-152	nitric oxide synthase 2	Rattus norvegicus	0-31	
7682068-3	1993	Inducible nitric oxide synthase (iNOS) activity was determined by measuring the stable nitrogen oxide end products of L-arginine oxidation: nitrite (NO2-) and nitrate (NO3-).	Nitrogen Dioxide	149-152	nitric oxide synthase 2	Rattus norvegicus	33-37