PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31300048-7 2019 The results also indicated that ropivacaine was able to interact with caspase-3, promote cytoplasmic caspase-3 migration into the nucleus, stimulate cleavage of caspase-3 and PARP-1, caspase-9 proteins, inhibit the expression of Bcl-2, promote expression of Apaf-1 and mitochondria release cytochrome C, and activate the activity of caspase-3. Ropivacaine 32-43 caspase 9 Homo sapiens 183-192 32314406-12 2020 Furthermore, apoptosis was promoted, coupled with a decrease of Bcl-2 expression and increases of Bax, cleaved caspase-3 and cleaved caspase-9 expression, in Ropivacaine-treated TPC-1 cells, which was restored following ITGA2 overexpression. Ropivacaine 158-169 caspase 9 Homo sapiens 133-142