PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9834040-0	1998	Metabolism of ropivacaine in humans is mediated by CYP1A2 and to a minor extent by CYP3A4: an interaction study with fluvoxamine and ketoconazole as in vivo inhibitors.	Ropivacaine	14-25	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	51-57	
24671884-5	2014	The new models were validated by showing improved predictions of the systemic clearances of ropivacaine (major CYP1A2 substrate; minor CYP3A4 substrate) and alfentanil (major CYP3A4 substrate) compared with those using a previous ontogeny function based on in vitro data (alfentanil: mean squared prediction error 3.0 vs. 6.8; ropivacaine: mean squared prediction error 2.3 vs.14.2).	Ropivacaine	92-103	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	111-117	
25808509-9	2015	CONCLUSIONS: Our present data demonstrate that CYP1A2 SNPs rs11636419 and rs17861162 alter the sensitivity of epidural ropivacaine in patients undergoing breast cancer surgery.	Ropivacaine	119-130	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	47-53	
14715049-15	2004	The main CYP isoforms involved are CYP3A4 for lidocaine and bupivacaine and CYP1A2 for ropivacaine.	Ropivacaine	87-98	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	76-82	
9834040-2	1998	The metabolism of the local anesthetic ropivacaine to 3-hydroxyropivacaine and (S)-2",6"-pipecoloxylidide was shown in vitro to be dependent on CYP1A2 and 3A4, respectively.	Ropivacaine	39-50	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	144-150	
9834040-12	1998	CONCLUSIONS: CYP1A2 is the most important isozyme for the metabolism of ropivacaine.	Ropivacaine	72-83	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	13-19