PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29860311-2 2018 The expanded polyglutamine in ATXN1 increases the protein"s stability and results in its accumulation and toxicity. polyglutamine 13-26 Ataxin 1 Drosophila melanogaster 30-35 23652004-2 2013 Here we show that transitional endoplasmic reticulum ATPase (TERA)/valosin-containing protein (VCP)/p97 directly binds to multiple polyglutamine disease proteins (huntingtin, ataxin-1, ataxin-7 and androgen receptor) via polyglutamine sequence. polyglutamine 131-144 Ataxin 1 Drosophila melanogaster 175-183 33772540-1 2021 Spinocerebellar Ataxia Type 1 (SCA1) is an autosomal dominant neurodegenerative disorder caused by a polyglutamine expansion in the ataxin-1 protein. polyglutamine 101-114 Ataxin 1 Drosophila melanogaster 132-140 18166084-2 2007 SCA1 and SCA2 are two ataxias caused by expansion of polyglutamine tracts in Ataxin-1 (ATXN1) and Ataxin-2 (ATXN2), respectively, two proteins that are otherwise unrelated. polyglutamine 53-66 Ataxin 1 Drosophila melanogaster 77-85 17114940-1 2006 In an earlier report two P-transposon insertion alleles of the noncoding hsromega gene, hsromega(05241) and P292 were shown to enhance neurodegeneration caused by expression of ataxin-1 protein with expanded poly-Q in a Drosophila model. polyglutamine 208-214 Ataxin 1 Drosophila melanogaster 177-185 12757707-2 2003 In SCA1, this expansion produces an abnormally long polyglutamine tract in the protein ataxin-1. polyglutamine 52-65 Ataxin 1 Drosophila melanogaster 87-95 33772540-3 2021 We demonstrate that both endogenous and transfected ataxin-1 localizes to sites of DNA damage, which is impaired by polyglutamine expansion. polyglutamine 116-129 Ataxin 1 Drosophila melanogaster 52-60 33772540-8 2021 The similarities between the ataxin-1 and the huntingtin responses to DNA damage provide further support for a shared pathogenic mechanism for polyglutamine expansion diseases. polyglutamine 143-156 Ataxin 1 Drosophila melanogaster 29-37