PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12524342-2 2002 The normal cellular function of ataxin-2 and the mechanism by which polyglutamine expansion of ataxin-2 causes neurodegeneration remain unknown. polyglutamine 68-81 Ataxin-2 Drosophila melanogaster 95-103 18166084-2 2007 SCA1 and SCA2 are two ataxias caused by expansion of polyglutamine tracts in Ataxin-1 (ATXN1) and Ataxin-2 (ATXN2), respectively, two proteins that are otherwise unrelated. polyglutamine 53-66 Ataxin-2 Drosophila melanogaster 9-13 18166084-2 2007 SCA1 and SCA2 are two ataxias caused by expansion of polyglutamine tracts in Ataxin-1 (ATXN1) and Ataxin-2 (ATXN2), respectively, two proteins that are otherwise unrelated. polyglutamine 53-66 Ataxin-2 Drosophila melanogaster 98-106 16835262-1 2006 Mutations resulting in the expansion of a polyglutamine tract in the protein ataxin-2 give rise to the neurodegenerative disorders spinocerebellar ataxia type 2 and Parkinson"s disease. polyglutamine 42-55 Ataxin-2 Drosophila melanogaster 77-85 16835262-2 2006 The normal cellular function of ataxin-2 and the mechanism by which polyglutamine expansion of ataxin-2 causes neurodegeneration are unknown. polyglutamine 68-81 Ataxin-2 Drosophila melanogaster 95-103 16835262-8 2006 Our results raise the possibility that polyglutamine expansions within ataxin-2 cause neurodegeneration by interfering with the translational regulation of particular mRNAs. polyglutamine 39-52 Ataxin-2 Drosophila melanogaster 71-79 34077532-3 2021 The sequence encoding the polyQ repeat also varies with disease presentation: a pure CAG repeat is associated with SCA2, whereas the CAG repeat in ALS and parkinsonism is typically interrupted with the glutamine encoding CAA codon. polyglutamine 26-31 Ataxin-2 Drosophila melanogaster 115-119 34977501-2 2022 Atx2 undergoes polyglutamine expansion leading to amyotrophic lateral sclerosis (ALS) or spinocerebellar ataxia type 2 (SCA2). polyglutamine 15-28 Ataxin-2 Drosophila melanogaster 0-4 34077532-8 2021 These data indicate that ataxin-2 encoded by a pure CAG vs interrupted CAA/G polyQ repeat domain is associated with differential toxicity, indicating that mechanisms associated with the purity of the sequence of the polyQ domain contribute to disease. polyglutamine 77-82 Ataxin-2 Drosophila melanogaster 25-33 34077532-8 2021 These data indicate that ataxin-2 encoded by a pure CAG vs interrupted CAA/G polyQ repeat domain is associated with differential toxicity, indicating that mechanisms associated with the purity of the sequence of the polyQ domain contribute to disease. polyglutamine 216-221 Ataxin-2 Drosophila melanogaster 25-33