PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21317158-1 2011 Spinal and bulbar muscular atrophy (SBMA), or Kennedy"s disease, is a late-onset motor neuron disease (MND) caused by an abnormal expansion of the CAG repeat in the androgen receptor (AR) gene on the X-chromosome, encoding a polyglutamine (poly-Q) sequence in the protein product. polyglutamine 225-238 androgen receptor Mus musculus 165-182 21317158-1 2011 Spinal and bulbar muscular atrophy (SBMA), or Kennedy"s disease, is a late-onset motor neuron disease (MND) caused by an abnormal expansion of the CAG repeat in the androgen receptor (AR) gene on the X-chromosome, encoding a polyglutamine (poly-Q) sequence in the protein product. polyglutamine 225-238 androgen receptor Mus musculus 184-186 21317158-1 2011 Spinal and bulbar muscular atrophy (SBMA), or Kennedy"s disease, is a late-onset motor neuron disease (MND) caused by an abnormal expansion of the CAG repeat in the androgen receptor (AR) gene on the X-chromosome, encoding a polyglutamine (poly-Q) sequence in the protein product. polyglutamine 240-246 androgen receptor Mus musculus 165-182 21317158-1 2011 Spinal and bulbar muscular atrophy (SBMA), or Kennedy"s disease, is a late-onset motor neuron disease (MND) caused by an abnormal expansion of the CAG repeat in the androgen receptor (AR) gene on the X-chromosome, encoding a polyglutamine (poly-Q) sequence in the protein product. polyglutamine 240-246 androgen receptor Mus musculus 184-186 21317158-2 2011 Mutant poly-Q-expanded AR protein is widely expressed but leads to selective lower motoneuron death. polyglutamine 7-13 androgen receptor Mus musculus 23-25 21921465-2 2010 The cause of SBMA is the expansion of a trinucleotide CAG repeat, which encodes the polyglutamine tract, within the first exon of the androgen receptor (AR) gene. polyglutamine 84-97 androgen receptor Mus musculus 134-151 21921465-2 2010 The cause of SBMA is the expansion of a trinucleotide CAG repeat, which encodes the polyglutamine tract, within the first exon of the androgen receptor (AR) gene. polyglutamine 84-97 androgen receptor Mus musculus 153-155 19228953-0 2009 Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk. polyglutamine 0-13 androgen receptor Mus musculus 23-40 19228953-1 2009 Spinal and bulbar muscular atrophy (SBMA) is an inherited neuromuscular disorder caused by a polyglutamine (polyQ) repeat expansion in the androgen receptor (AR). polyglutamine 93-106 androgen receptor Mus musculus 139-156 19228953-1 2009 Spinal and bulbar muscular atrophy (SBMA) is an inherited neuromuscular disorder caused by a polyglutamine (polyQ) repeat expansion in the androgen receptor (AR). polyglutamine 93-106 androgen receptor Mus musculus 158-160 19228953-1 2009 Spinal and bulbar muscular atrophy (SBMA) is an inherited neuromuscular disorder caused by a polyglutamine (polyQ) repeat expansion in the androgen receptor (AR). polyglutamine 108-113 androgen receptor Mus musculus 139-156 19228953-1 2009 Spinal and bulbar muscular atrophy (SBMA) is an inherited neuromuscular disorder caused by a polyglutamine (polyQ) repeat expansion in the androgen receptor (AR). polyglutamine 108-113 androgen receptor Mus musculus 158-160 19228953-5 2009 Using primary neurons from mice transgenic or deficient for apoptosis-related genes, we determined that polyQ-AR apoptotic activation is fully dependent on Bax. polyglutamine 104-109 androgen receptor Mus musculus 110-112 19228953-9 2009 As apoptotic mediators are candidates for toxic fragment generation and other cellular processes linked to neuron dysfunction, delineation of the apoptotic activation pathway induced by polyQ-expanded AR may shed light on the pathogenic cascade in SBMA and other motor neuron diseases. polyglutamine 186-191 androgen receptor Mus musculus 201-203 19279159-0 2009 Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy. polyglutamine 25-38 androgen receptor Mus musculus 48-65 19279159-3 2009 To clarify the importance of the nucleus in SBMA, we genetically manipulated the nuclear localization signal of the polyglutamine-expanded AR. polyglutamine 116-129 androgen receptor Mus musculus 139-141 19279159-5 2009 While we found that nuclear localization of polyglutamine-expanded AR is required for SBMA, we also discovered, using cell models of SBMA, that it is insufficient for both aggregation and toxicity and requires androgens for these disease features. polyglutamine 44-57 androgen receptor Mus musculus 67-69 19279159-8 2009 Thus, our studies firmly establish that polyglutamine-expanded AR must reside within nuclei in the presence of its ligand to cause SBMA. polyglutamine 40-53 androgen receptor Mus musculus 63-65 18210842-1 2007 SBMA is a hereditary neurodegenerative disease caused by expansion of a trinucleotide CAG repeat, which encodes the polyglutamine tract, in the first exon of the androgen receptor (AR) gene. polyglutamine 116-129 androgen receptor Mus musculus 162-179 18321505-3 2008 This surprising result challenges the orthodox view that KD/SBMA requires expression of polyglutamine expanded androgen receptor within motoneurons. polyglutamine 88-101 androgen receptor Mus musculus 111-128 18210842-1 2007 SBMA is a hereditary neurodegenerative disease caused by expansion of a trinucleotide CAG repeat, which encodes the polyglutamine tract, in the first exon of the androgen receptor (AR) gene. polyglutamine 116-129 androgen receptor Mus musculus 181-183 17494697-1 2007 Spinal and bulbar muscular atrophy (SBMA) is an inherited motor neuron disease caused by the expansion of a polyglutamine tract within the androgen receptor (AR). polyglutamine 108-121 androgen receptor Mus musculus 139-156 17494697-1 2007 Spinal and bulbar muscular atrophy (SBMA) is an inherited motor neuron disease caused by the expansion of a polyglutamine tract within the androgen receptor (AR). polyglutamine 108-121 androgen receptor Mus musculus 158-160 15102712-1 2004 Spinal and bulbar muscular atrophy (SBMA) is an inherited motor neuron disease caused by the expansion of a polyglutamine (polyQ) tract within the androgen receptor. polyglutamine 108-121 androgen receptor Mus musculus 147-164 17359355-5 2007 The histopathologic hallmarks of SBMA are diffuse nuclear accumulation and nuclear inclusions of the mutant AR with expanded polyQ in residual motor neurones in the brainstem and spinal cord as well as in some other visceral organs. polyglutamine 125-130 androgen receptor Mus musculus 108-110 16155577-3 2005 We examined the therapeutic effects of 17-allylamino-17-demethoxygeldanamycin (17-AAG), a potent Hsp90 inhibitor, and its ability to degrade polyglutamine-expanded mutant AR. polyglutamine 141-154 androgen receptor Mus musculus 171-173 17359355-3 2007 SBMA is caused by expansion of a polyglutamine (polyQ)-encoding CAG trinucleotide repeat in the androgen receptor (AR) gene. polyglutamine 33-46 androgen receptor Mus musculus 96-113 17359355-3 2007 SBMA is caused by expansion of a polyglutamine (polyQ)-encoding CAG trinucleotide repeat in the androgen receptor (AR) gene. polyglutamine 33-46 androgen receptor Mus musculus 115-117 17359355-3 2007 SBMA is caused by expansion of a polyglutamine (polyQ)-encoding CAG trinucleotide repeat in the androgen receptor (AR) gene. polyglutamine 48-53 androgen receptor Mus musculus 96-113 17359355-3 2007 SBMA is caused by expansion of a polyglutamine (polyQ)-encoding CAG trinucleotide repeat in the androgen receptor (AR) gene. polyglutamine 48-53 androgen receptor Mus musculus 115-117 17334372-1 2007 Motor neuron degeneration resulting from the aggregation of the androgen receptor with an expanded polyglutamine tract (AR-polyQ) has been linked to the development of spinal and bulbar muscular atrophy (SBMA or Kennedy disease). polyglutamine 99-112 androgen receptor Mus musculus 64-81 16741751-8 2006 The administration of 17-AAG significantly ameliorated polyQ-mediated motor neuron degeneration by reducing the total amount of mutant AR. polyglutamine 55-60 androgen receptor Mus musculus 135-137 16772330-8 2006 Promoter-reporter assays confirmed that AR transactivation competence diminishes in a polyQ length-dependent fashion. polyglutamine 86-91 androgen receptor Mus musculus 40-42 16260738-1 2005 Spinal and bulbar muscular atrophy (SBMA) is an adult-onset motor neuron disease caused by the expansion of a trinucleotide CAG repeat encoding the polyglutamine tract in the first exon of the androgen receptor gene (AR). polyglutamine 148-161 androgen receptor Mus musculus 193-210 15102712-1 2004 Spinal and bulbar muscular atrophy (SBMA) is an inherited motor neuron disease caused by the expansion of a polyglutamine (polyQ) tract within the androgen receptor. polyglutamine 123-128 androgen receptor Mus musculus 147-164 15003169-2 2004 SBMA is caused by polyglutamine repeat expansions in the androgen receptor (AR). polyglutamine 18-31 androgen receptor Mus musculus 57-74 15152038-2 2004 We have developed a transgenic model of the polyglutamine disease spinal and bulbar muscular atrophy (SBMA), an adult-onset, slowly progressive motor neuron disease caused by polyglutamine expansion in the androgen receptor (AR). polyglutamine 44-57 androgen receptor Mus musculus 206-223 15152038-2 2004 We have developed a transgenic model of the polyglutamine disease spinal and bulbar muscular atrophy (SBMA), an adult-onset, slowly progressive motor neuron disease caused by polyglutamine expansion in the androgen receptor (AR). polyglutamine 44-57 androgen receptor Mus musculus 225-227 15133611-3 2004 The molecular basis of SBMA is the expansion of a trinucleotide CAG repeat, which encodes the polyglutamine (polyQ) tract in the first exon of the androgen receptor (AR) gene. polyglutamine 94-107 androgen receptor Mus musculus 147-164 15133611-3 2004 The molecular basis of SBMA is the expansion of a trinucleotide CAG repeat, which encodes the polyglutamine (polyQ) tract in the first exon of the androgen receptor (AR) gene. polyglutamine 94-107 androgen receptor Mus musculus 166-168 15133611-3 2004 The molecular basis of SBMA is the expansion of a trinucleotide CAG repeat, which encodes the polyglutamine (polyQ) tract in the first exon of the androgen receptor (AR) gene. polyglutamine 109-114 androgen receptor Mus musculus 147-164 15133611-3 2004 The molecular basis of SBMA is the expansion of a trinucleotide CAG repeat, which encodes the polyglutamine (polyQ) tract in the first exon of the androgen receptor (AR) gene. polyglutamine 109-114 androgen receptor Mus musculus 166-168 15003169-2 2004 SBMA is caused by polyglutamine repeat expansions in the androgen receptor (AR). polyglutamine 18-31 androgen receptor Mus musculus 76-78 15003169-5 2004 We then tested the hypothesis that polyglutamine-expanded AR interferes with CREB binding protein (CBP)-mediated transcription of vascular endothelial growth factor (VEGF) and observed altered CBP-AR binding and VEGF reduction in AR100 mice. polyglutamine 35-48 androgen receptor Mus musculus 58-60 12812978-0 2003 Transglutaminase potentiates ligand-dependent proteasome dysfunction induced by polyglutamine-expanded androgen receptor. polyglutamine 80-93 androgen receptor Mus musculus 103-120 12962912-0 2003 Protective effects of estrogens on polyglutamine-expanded androgen receptor aggregation in mice. polyglutamine 35-48 androgen receptor Mus musculus 58-75 12962912-1 2003 Spinal and bulbar muscular atrophy is a motor neuronopathy caused by a polyglutamine expansion in the androgen receptor (AR). polyglutamine 71-84 androgen receptor Mus musculus 102-119 12962912-1 2003 Spinal and bulbar muscular atrophy is a motor neuronopathy caused by a polyglutamine expansion in the androgen receptor (AR). polyglutamine 71-84 androgen receptor Mus musculus 121-123 12962912-7 2003 We conclude that estrogens protect polyglutamine-expanded AR from aggregation through a non-genomic mechanism possibly involving estrogen binding to the AR. polyglutamine 35-48 androgen receptor Mus musculus 58-60 12962912-7 2003 We conclude that estrogens protect polyglutamine-expanded AR from aggregation through a non-genomic mechanism possibly involving estrogen binding to the AR. polyglutamine 35-48 androgen receptor Mus musculus 153-155 12812978-7 2003 Furthermore, HEK GFP(u)-1 cells expressing polyglutamine-expanded androgen receptor and transglutaminase exhibit ligand-dependent proteasome dysfunction; this effect was not observed in the presence of cystamine, a transglutaminase inhibitor. polyglutamine 43-56 androgen receptor Mus musculus 66-83 12657679-1 2003 Spinal and bulbar muscular atrophy (SBMA) is an inherited motor neuron disease caused by the expansion of the polyglutamine (polyQ) tract within the androgen receptor (AR). polyglutamine 110-123 androgen receptor Mus musculus 149-166 12783846-3 2003 Expression of the polyglutamine-expanded truncated AR protein, but not the full-length expanded protein, resulted in the formation of cytoplasmic and nuclear aggregates and eventual cell death. polyglutamine 18-31 androgen receptor Mus musculus 51-53 12657679-1 2003 Spinal and bulbar muscular atrophy (SBMA) is an inherited motor neuron disease caused by the expansion of the polyglutamine (polyQ) tract within the androgen receptor (AR). polyglutamine 110-123 androgen receptor Mus musculus 168-170 12657679-1 2003 Spinal and bulbar muscular atrophy (SBMA) is an inherited motor neuron disease caused by the expansion of the polyglutamine (polyQ) tract within the androgen receptor (AR). polyglutamine 125-130 androgen receptor Mus musculus 149-166 12657679-1 2003 Spinal and bulbar muscular atrophy (SBMA) is an inherited motor neuron disease caused by the expansion of the polyglutamine (polyQ) tract within the androgen receptor (AR). polyglutamine 125-130 androgen receptor Mus musculus 168-170 12205033-0 2002 Androgen receptor with elongated polyglutamine tract forms aggregates that alter axonal trafficking and mitochondrial distribution in motor neuronal processes. polyglutamine 33-46 androgen receptor Mus musculus 0-17 12189162-7 2002 Motor dysfunction was observed in both male and female animals, showing that in SBMA the polyglutamine repeat expansion causes a dominant gain-of-function mutation in the AR. polyglutamine 89-102 androgen receptor Mus musculus 171-173 14526186-4 2003 The molecular basis of SBMA is the expansion of a trinucleotide CAG repeat, which encodes the polyglutamine (polyQ) tract, in the first exon of the androgen receptor (AR) gene. polyglutamine 94-107 androgen receptor Mus musculus 148-165 14526186-4 2003 The molecular basis of SBMA is the expansion of a trinucleotide CAG repeat, which encodes the polyglutamine (polyQ) tract, in the first exon of the androgen receptor (AR) gene. polyglutamine 94-107 androgen receptor Mus musculus 167-169 14526186-4 2003 The molecular basis of SBMA is the expansion of a trinucleotide CAG repeat, which encodes the polyglutamine (polyQ) tract, in the first exon of the androgen receptor (AR) gene. polyglutamine 109-114 androgen receptor Mus musculus 148-165 14526186-4 2003 The molecular basis of SBMA is the expansion of a trinucleotide CAG repeat, which encodes the polyglutamine (polyQ) tract, in the first exon of the androgen receptor (AR) gene. polyglutamine 109-114 androgen receptor Mus musculus 167-169 14526186-5 2003 The pathologic hallmark is nuclear inclusions (NIs) containing the mutant and truncated AR with expanded polyQ in the residual motor neurons in the brainstem and spinal cord as well as in some other visceral organs. polyglutamine 105-110 androgen receptor Mus musculus 88-90 12438937-0 2002 Ligand-dependent aggregation of polyglutamine-expanded androgen receptor in neuronal cells. polyglutamine 32-45 androgen receptor Mus musculus 55-72 12438937-1 2002 Spinal and bulbar muscular atrophy (SBMA) is a motor neuronopathy caused by a polyglutamine expansion in the androgen receptor that forms characteristic inclusions in affected neurons. polyglutamine 78-91 androgen receptor Mus musculus 109-126 12438937-6 2002 Differential modulation of polyglutamine-expanded androgen receptor aggregation by ligands in neuronal cells may partly explain the absence of an overt disease phenotype in female carriers of the SBMA mutation and define conditions to explore further the role of androgen receptor aggregation in the pathogenesis of SBMA. polyglutamine 27-40 androgen receptor Mus musculus 50-67 12438937-6 2002 Differential modulation of polyglutamine-expanded androgen receptor aggregation by ligands in neuronal cells may partly explain the absence of an overt disease phenotype in female carriers of the SBMA mutation and define conditions to explore further the role of androgen receptor aggregation in the pathogenesis of SBMA. polyglutamine 27-40 androgen receptor Mus musculus 263-280 11152658-1 2001 Spinal and bulbar muscular atrophy (SBMA) is a motor neuron disease caused by the expansion of a polyglutamine tract within the androgen receptor. polyglutamine 97-110 androgen receptor Mus musculus 128-145 11751688-1 2001 Spinobulbar muscular atrophy is a progressive motor neuron disease caused by abnormal polyglutamine tract expansion in the androgen receptor (AR) gene, and is part of a family of central nervous system (CNS) neurodegenerative diseases, including Huntington"s disease (HD). polyglutamine 86-99 androgen receptor Mus musculus 123-140 11751688-1 2001 Spinobulbar muscular atrophy is a progressive motor neuron disease caused by abnormal polyglutamine tract expansion in the androgen receptor (AR) gene, and is part of a family of central nervous system (CNS) neurodegenerative diseases, including Huntington"s disease (HD). polyglutamine 86-99 androgen receptor Mus musculus 142-144 11751688-4 2001 A previous study reported that activation of the wild-type glucocorticoid receptor (wtGR) suppressed the aggregation of expanded polyglutamine proteins derived from AR and huntingtin, whereas a mutant receptor containing an internal deletion, GRDelta108-317, increased polyglutamine protein aggregation, in this case primarily within the nucleus. polyglutamine 129-142 androgen receptor Mus musculus 165-167 32019272-0 2020 Polyglutamine-Expanded Androgen Receptor Alteration of Skeletal Muscle Homeostasis and Myonuclear Aggregation Are Affected by Sex, Age and Muscle Metabolism. polyglutamine 0-13 androgen receptor Mus musculus 23-40 9384612-0 1998 Truncated forms of the androgen receptor are associated with polyglutamine expansion in X-linked spinal and bulbar muscular atrophy. polyglutamine 61-74 androgen receptor Mus musculus 23-40 9384612-4 1998 In addition, the presence of an expanded polyglutamine tract in the SBMA androgen receptor appears to enhance the production of C-terminally truncated fragments of the protein. polyglutamine 41-54 androgen receptor Mus musculus 73-90 9111734-1 1997 Expansion of the polyglutamine tracts in the androgen receptor (AR) has been recognized as a cause of X-linked spinal and bulbar muscular atrophy (SBMA). polyglutamine 17-30 androgen receptor Mus musculus 45-62 9111734-1 1997 Expansion of the polyglutamine tracts in the androgen receptor (AR) has been recognized as a cause of X-linked spinal and bulbar muscular atrophy (SBMA). polyglutamine 17-30 androgen receptor Mus musculus 64-66 9111734-5 1997 Our results demonstrate that expansion of polyglutamine tracts in the AR may affect the proliferation and differentiation of nerve cells. polyglutamine 42-55 androgen receptor Mus musculus 70-72 34417184-1 2021 Spinal and bulbar muscular atrophy (SBMA) is an X-linked, adult-onset neuromuscular condition caused by an abnormal polyglutamine (polyQ) tract expansion in androgen receptor (AR) protein. polyglutamine 116-129 androgen receptor Mus musculus 157-174 34417184-1 2021 Spinal and bulbar muscular atrophy (SBMA) is an X-linked, adult-onset neuromuscular condition caused by an abnormal polyglutamine (polyQ) tract expansion in androgen receptor (AR) protein. polyglutamine 116-129 androgen receptor Mus musculus 176-178 34417184-1 2021 Spinal and bulbar muscular atrophy (SBMA) is an X-linked, adult-onset neuromuscular condition caused by an abnormal polyglutamine (polyQ) tract expansion in androgen receptor (AR) protein. polyglutamine 131-136 androgen receptor Mus musculus 157-174 34417184-1 2021 Spinal and bulbar muscular atrophy (SBMA) is an X-linked, adult-onset neuromuscular condition caused by an abnormal polyglutamine (polyQ) tract expansion in androgen receptor (AR) protein. polyglutamine 131-136 androgen receptor Mus musculus 176-178 34417184-5 2021 Here, we characterized the role of AR isoform 2, a naturally occurring variant encoding a truncated AR lacking the polyQ-harboring domain, as a regulatory switch of AR genomic functions in androgen-responsive tissues. polyglutamine 115-120 androgen receptor Mus musculus 100-102 34417184-5 2021 Here, we characterized the role of AR isoform 2, a naturally occurring variant encoding a truncated AR lacking the polyQ-harboring domain, as a regulatory switch of AR genomic functions in androgen-responsive tissues. polyglutamine 115-120 androgen receptor Mus musculus 165-167 35522298-6 2022 This adult-onset neuromuscular disease is caused by a polyglutamine expansion (polyQ) in AR and is characterized by progressive muscle weakness and atrophy secondary to a combination of lower motor neuron degeneration and primary muscle atrophy. polyglutamine 54-67 androgen receptor Mus musculus 89-91 35522298-6 2022 This adult-onset neuromuscular disease is caused by a polyglutamine expansion (polyQ) in AR and is characterized by progressive muscle weakness and atrophy secondary to a combination of lower motor neuron degeneration and primary muscle atrophy. polyglutamine 79-84 androgen receptor Mus musculus 89-91 35522298-7 2022 Here we found that the presence of an elongated polyQ tract impairs AR cooperativity with SMAD4, leading to an inability to mount an effective anti-atrophy gene expression programme in skeletal muscle in response to denervation. polyglutamine 48-53 androgen receptor Mus musculus 68-70 32856205-1 2021 Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by expansions of a polyglutamine (polyQ) tract in the androgen receptor (AR) gene. polyglutamine 95-108 androgen receptor Mus musculus 130-147 32856205-1 2021 Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by expansions of a polyglutamine (polyQ) tract in the androgen receptor (AR) gene. polyglutamine 95-108 androgen receptor Mus musculus 149-151 32856205-1 2021 Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by expansions of a polyglutamine (polyQ) tract in the androgen receptor (AR) gene. polyglutamine 110-115 androgen receptor Mus musculus 130-147 32856205-1 2021 Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by expansions of a polyglutamine (polyQ) tract in the androgen receptor (AR) gene. polyglutamine 110-115 androgen receptor Mus musculus 149-151 33738134-6 2021 In this study, we demonstrate that an unlocked nucleic acid (UNA)-modified CAG-siRNA shows high selectivity for polyQ-expanded androgen receptor (AR) inhibition in in vitro cell models and that lipid nanoparticle (LNP)-mediated delivery of the CAG-siRNA selectively suppresses mutant AR in the central nervous system of an SBMA mouse model. polyglutamine 112-117 androgen receptor Mus musculus 127-144 33738134-6 2021 In this study, we demonstrate that an unlocked nucleic acid (UNA)-modified CAG-siRNA shows high selectivity for polyQ-expanded androgen receptor (AR) inhibition in in vitro cell models and that lipid nanoparticle (LNP)-mediated delivery of the CAG-siRNA selectively suppresses mutant AR in the central nervous system of an SBMA mouse model. polyglutamine 112-117 androgen receptor Mus musculus 146-148 33170804-2 2021 In spinal and bulbar muscular atrophy (SBMA), polyQ expansion within the androgen receptor (AR) causes progressive neuromuscular toxicity, the molecular basis of which is unclear. polyglutamine 46-51 androgen receptor Mus musculus 73-90 33170804-2 2021 In spinal and bulbar muscular atrophy (SBMA), polyQ expansion within the androgen receptor (AR) causes progressive neuromuscular toxicity, the molecular basis of which is unclear. polyglutamine 46-51 androgen receptor Mus musculus 92-94 33170804-3 2021 Using quantitative proteomics, we identified changes in the AR interactome caused by polyQ expansion. polyglutamine 85-90 androgen receptor Mus musculus 60-62 33170804-4 2021 We found that the deubiquitinase USP7 preferentially interacts with polyQ-expanded AR, and that lowering USP7 levels reduced mutant AR aggregation and cytotoxicity in cell models of SBMA. polyglutamine 68-73 androgen receptor Mus musculus 83-85 32019272-1 2020 Polyglutamine (polyQ) expansions in the androgen receptor (AR) gene cause spinal and bulbar muscular atrophy (SBMA), a neuromuscular disease characterized by lower motor neuron (MN) loss and skeletal muscle atrophy, with an unknown mechanism. polyglutamine 0-13 androgen receptor Mus musculus 40-57 32019272-1 2020 Polyglutamine (polyQ) expansions in the androgen receptor (AR) gene cause spinal and bulbar muscular atrophy (SBMA), a neuromuscular disease characterized by lower motor neuron (MN) loss and skeletal muscle atrophy, with an unknown mechanism. polyglutamine 0-13 androgen receptor Mus musculus 59-61 32019272-1 2020 Polyglutamine (polyQ) expansions in the androgen receptor (AR) gene cause spinal and bulbar muscular atrophy (SBMA), a neuromuscular disease characterized by lower motor neuron (MN) loss and skeletal muscle atrophy, with an unknown mechanism. polyglutamine 15-20 androgen receptor Mus musculus 40-57 32019272-1 2020 Polyglutamine (polyQ) expansions in the androgen receptor (AR) gene cause spinal and bulbar muscular atrophy (SBMA), a neuromuscular disease characterized by lower motor neuron (MN) loss and skeletal muscle atrophy, with an unknown mechanism. polyglutamine 15-20 androgen receptor Mus musculus 59-61 32019272-3 2020 We show that polyQ-expanded AR causes motor dysfunction, premature death, IIb-to-IIa/IIx fiber-type change, glycolytic-to-oxidative fiber-type switching, upregulation of atrogenes and autophagy genes and mitochondrial dysfunction in skeletal muscle, together with signs of muscle denervation at late stage of disease. polyglutamine 13-18 androgen receptor Mus musculus 28-30 32019272-4 2020 PolyQ expansions in the AR resulted in nuclear enrichment. polyglutamine 0-5 androgen receptor Mus musculus 24-26 32019272-6 2020 Finally, we found that two-week induction of expression of polyQ-expanded AR in adult mice was sufficient to cause premature death, body weight loss and muscle atrophy, but not aggregation, metabolic alterations, motor coordination and fiber-type switch, indicating that expression of the disease protein in the adulthood is sufficient to recapitulate several, but not all SBMA manifestations in mice. polyglutamine 59-64 androgen receptor Mus musculus 74-76 29809168-0 2018 Androgen receptor polyglutamine expansion drives age-dependent quality control defects and muscle dysfunction. polyglutamine 18-31 androgen receptor Mus musculus 0-17 30148479-4 2018 Here we used a transgenic mouse model for spinal and bulbar muscular atrophy (SBMA), a neuromuscular disease caused by polyglutamine expansion in the androgen receptor (AR), to test gene silencing by a newly identified AR-targeting miRNA, miR-298. polyglutamine 119-132 androgen receptor Mus musculus 150-167 30940675-1 2019 Spinal and bulbar muscular atrophy (SBMA) is a polyglutamine-mediated neuromuscular disease caused by a CAG repeat expansion in the androgen receptor (AR) gene. polyglutamine 47-60 androgen receptor Mus musculus 132-149 30940675-1 2019 Spinal and bulbar muscular atrophy (SBMA) is a polyglutamine-mediated neuromuscular disease caused by a CAG repeat expansion in the androgen receptor (AR) gene. polyglutamine 47-60 androgen receptor Mus musculus 151-153 29809168-1 2018 Skeletal muscle has emerged as a critical, disease-relevant target tissue in spinal and bulbar muscular atrophy, a degenerative disorder of the neuromuscular system caused by a CAG/polyglutamine (polyQ) expansion in the androgen receptor (AR) gene. polyglutamine 181-194 androgen receptor Mus musculus 220-237 29809168-1 2018 Skeletal muscle has emerged as a critical, disease-relevant target tissue in spinal and bulbar muscular atrophy, a degenerative disorder of the neuromuscular system caused by a CAG/polyglutamine (polyQ) expansion in the androgen receptor (AR) gene. polyglutamine 196-201 androgen receptor Mus musculus 220-237 29809168-1 2018 Skeletal muscle has emerged as a critical, disease-relevant target tissue in spinal and bulbar muscular atrophy, a degenerative disorder of the neuromuscular system caused by a CAG/polyglutamine (polyQ) expansion in the androgen receptor (AR) gene. polyglutamine 196-201 androgen receptor Mus musculus 239-241 28117338-3 2017 Expression of polyglutamine-expanded AR causes damage to motor neurons and skeletal muscle cells. polyglutamine 14-27 androgen receptor Mus musculus 37-39 29897452-2 2018 This disease, which impairs neuromuscular function, is linked to a polyglutamine expansion mutation in the androgen receptor (AR). polyglutamine 67-80 androgen receptor Mus musculus 107-124 29897452-2 2018 This disease, which impairs neuromuscular function, is linked to a polyglutamine expansion mutation in the androgen receptor (AR). polyglutamine 67-80 androgen receptor Mus musculus 126-128 28117338-5 2017 We show that treatment of myotubes expressing polyglutamine-expanded AR with the beta-agonist clenbuterol increases their size. polyglutamine 46-59 androgen receptor Mus musculus 69-71 28117338-6 2017 Clenbuterol activated the phosphatidylinositol-3-kinase (PI3K)/Akt/mechanistic target of rapamycin (mTOR) pathway and decreased the accumulation of polyglutamine-expanded AR. polyglutamine 148-161 androgen receptor Mus musculus 171-173 26551462-1 2015 Spinal and bulbar muscular atrophy (SBMA) is an inherited motor neuron disease caused by the expansion of a polyglutamine (polyQ)-encoding tract within the androgen receptor (AR) gene. polyglutamine 108-121 androgen receptor Mus musculus 156-173 28003546-1 2016 Spinobulbar muscular atrophy (SBMA) is an X-linked neuromuscular disease caused by polyglutamine (polyQ) expansion in the androgen receptor (AR) gene. polyglutamine 83-96 androgen receptor Mus musculus 122-139 28003546-1 2016 Spinobulbar muscular atrophy (SBMA) is an X-linked neuromuscular disease caused by polyglutamine (polyQ) expansion in the androgen receptor (AR) gene. polyglutamine 83-96 androgen receptor Mus musculus 141-143 28003546-1 2016 Spinobulbar muscular atrophy (SBMA) is an X-linked neuromuscular disease caused by polyglutamine (polyQ) expansion in the androgen receptor (AR) gene. polyglutamine 98-103 androgen receptor Mus musculus 122-139 28003546-1 2016 Spinobulbar muscular atrophy (SBMA) is an X-linked neuromuscular disease caused by polyglutamine (polyQ) expansion in the androgen receptor (AR) gene. polyglutamine 98-103 androgen receptor Mus musculus 141-143 27517091-2 2016 In spinal bulbar muscular atrophy (SBMA), a disorder linked to a CAG/polyglutamine repeat expansion in the androgen receptor (AR) gene, the disease-causing AR disrupts axonal transport by acting in both a cell-autonomous fashion in the motoneurons themselves, and in a non-cell-autonomous fashion in muscle. polyglutamine 69-82 androgen receptor Mus musculus 107-124 27517091-2 2016 In spinal bulbar muscular atrophy (SBMA), a disorder linked to a CAG/polyglutamine repeat expansion in the androgen receptor (AR) gene, the disease-causing AR disrupts axonal transport by acting in both a cell-autonomous fashion in the motoneurons themselves, and in a non-cell-autonomous fashion in muscle. polyglutamine 69-82 androgen receptor Mus musculus 126-128 27517091-2 2016 In spinal bulbar muscular atrophy (SBMA), a disorder linked to a CAG/polyglutamine repeat expansion in the androgen receptor (AR) gene, the disease-causing AR disrupts axonal transport by acting in both a cell-autonomous fashion in the motoneurons themselves, and in a non-cell-autonomous fashion in muscle. polyglutamine 69-82 androgen receptor Mus musculus 156-158 26551462-1 2015 Spinal and bulbar muscular atrophy (SBMA) is an inherited motor neuron disease caused by the expansion of a polyglutamine (polyQ)-encoding tract within the androgen receptor (AR) gene. polyglutamine 108-121 androgen receptor Mus musculus 175-177 26551462-1 2015 Spinal and bulbar muscular atrophy (SBMA) is an inherited motor neuron disease caused by the expansion of a polyglutamine (polyQ)-encoding tract within the androgen receptor (AR) gene. polyglutamine 123-128 androgen receptor Mus musculus 156-173 26551462-1 2015 Spinal and bulbar muscular atrophy (SBMA) is an inherited motor neuron disease caused by the expansion of a polyglutamine (polyQ)-encoding tract within the androgen receptor (AR) gene. polyglutamine 123-128 androgen receptor Mus musculus 175-177 25607836-2 2015 It is caused by a polyglutamine (polyQ) expansion in the androgen receptor (AR), a transcription factor that is activated upon hormone binding. polyglutamine 18-31 androgen receptor Mus musculus 57-74 26673324-1 2015 Spinal and bulbar muscular atrophy (SBMA) is a neurodegenerative disease caused by a polyglutamine expansion in the androgen receptor (AR) and is associated with misfolding and aggregation of the mutant AR. polyglutamine 85-98 androgen receptor Mus musculus 116-133 26673324-1 2015 Spinal and bulbar muscular atrophy (SBMA) is a neurodegenerative disease caused by a polyglutamine expansion in the androgen receptor (AR) and is associated with misfolding and aggregation of the mutant AR. polyglutamine 85-98 androgen receptor Mus musculus 135-137 26673324-3 2015 Male transgenic mice expressing polyQ-expanded AR with a mutation in the FxxLF motif (F23A) to prevent the N/C interaction displayed substantially improved motor function compared with N/C-intact AR-expressing mice and showed reduced pathological features of SBMA. polyglutamine 32-37 androgen receptor Mus musculus 47-49 26673324-3 2015 Male transgenic mice expressing polyQ-expanded AR with a mutation in the FxxLF motif (F23A) to prevent the N/C interaction displayed substantially improved motor function compared with N/C-intact AR-expressing mice and showed reduced pathological features of SBMA. polyglutamine 32-37 androgen receptor Mus musculus 196-198 25904795-1 2015 Polyglutamine (polyQ) expansion of the androgen receptor (AR) causes Kennedy"s disease/spinobulbar muscular atrophy (KD/SBMA) through poorly defined cellular mechanisms. polyglutamine 0-13 androgen receptor Mus musculus 39-56 25904795-1 2015 Polyglutamine (polyQ) expansion of the androgen receptor (AR) causes Kennedy"s disease/spinobulbar muscular atrophy (KD/SBMA) through poorly defined cellular mechanisms. polyglutamine 0-13 androgen receptor Mus musculus 58-60 25904795-1 2015 Polyglutamine (polyQ) expansion of the androgen receptor (AR) causes Kennedy"s disease/spinobulbar muscular atrophy (KD/SBMA) through poorly defined cellular mechanisms. polyglutamine 15-20 androgen receptor Mus musculus 39-56 25904795-1 2015 Polyglutamine (polyQ) expansion of the androgen receptor (AR) causes Kennedy"s disease/spinobulbar muscular atrophy (KD/SBMA) through poorly defined cellular mechanisms. polyglutamine 15-20 androgen receptor Mus musculus 58-60 26308581-1 2015 Spinal and bulbar muscular atrophy (SBMA) is a progressive neuromuscular disease caused by polyglutamine expansion in the androgen receptor (AR) protein. polyglutamine 91-104 androgen receptor Mus musculus 122-139 26308581-1 2015 Spinal and bulbar muscular atrophy (SBMA) is a progressive neuromuscular disease caused by polyglutamine expansion in the androgen receptor (AR) protein. polyglutamine 91-104 androgen receptor Mus musculus 141-143 26308581-6 2015 Specifically, we have found that NLK can phosphorylate the mutant polyglutamine-expanded AR, enhance its aggregation, and promote AR-dependent gene transcription by regulating AR-cofactor interactions. polyglutamine 66-79 androgen receptor Mus musculus 89-91 26308581-6 2015 Specifically, we have found that NLK can phosphorylate the mutant polyglutamine-expanded AR, enhance its aggregation, and promote AR-dependent gene transcription by regulating AR-cofactor interactions. polyglutamine 66-79 androgen receptor Mus musculus 130-132 25719894-2 2015 This disease is caused by polyglutamine expansion mutations of the androgen receptor (AR) gene. polyglutamine 26-39 androgen receptor Mus musculus 67-84 25719894-2 2015 This disease is caused by polyglutamine expansion mutations of the androgen receptor (AR) gene. polyglutamine 26-39 androgen receptor Mus musculus 86-88 25607844-1 2015 Expansion of the polyglutamine (polyQ) tract within the androgen receptor (AR) causes neuromuscular degeneration in individuals with spinobulbar muscular atrophy (SBMA). polyglutamine 17-30 androgen receptor Mus musculus 56-73 25607844-1 2015 Expansion of the polyglutamine (polyQ) tract within the androgen receptor (AR) causes neuromuscular degeneration in individuals with spinobulbar muscular atrophy (SBMA). polyglutamine 17-30 androgen receptor Mus musculus 75-77 25607844-1 2015 Expansion of the polyglutamine (polyQ) tract within the androgen receptor (AR) causes neuromuscular degeneration in individuals with spinobulbar muscular atrophy (SBMA). polyglutamine 32-37 androgen receptor Mus musculus 56-73 25607844-1 2015 Expansion of the polyglutamine (polyQ) tract within the androgen receptor (AR) causes neuromuscular degeneration in individuals with spinobulbar muscular atrophy (SBMA). polyglutamine 32-37 androgen receptor Mus musculus 75-77 25607844-3 2015 Here, we sought to dissociate effects of diminished AR function from polyQ-mediated proteotoxicity by enhancing the transcriptional activity of polyQ AR. polyglutamine 69-74 androgen receptor Mus musculus 150-152 25607836-2 2015 It is caused by a polyglutamine (polyQ) expansion in the androgen receptor (AR), a transcription factor that is activated upon hormone binding. polyglutamine 18-31 androgen receptor Mus musculus 76-78 25607836-2 2015 It is caused by a polyglutamine (polyQ) expansion in the androgen receptor (AR), a transcription factor that is activated upon hormone binding. polyglutamine 33-38 androgen receptor Mus musculus 57-74 25607836-2 2015 It is caused by a polyglutamine (polyQ) expansion in the androgen receptor (AR), a transcription factor that is activated upon hormone binding. polyglutamine 33-38 androgen receptor Mus musculus 76-78 25607836-3 2015 The polyQ expansion in AR causes it to form intracellular aggregates and impairs transcriptional activity. polyglutamine 4-9 androgen receptor Mus musculus 23-25 24742193-1 2014 Spinal and bulbar muscular atrophy (SBMA) is a late-onset, progressive neurodegenerative disease linked to a polyglutamine (polyQ) expansion in the androgen receptor (AR). polyglutamine 109-122 androgen receptor Mus musculus 148-165 24898351-1 2014 Spinal and bulbar muscular atrophy is an X-linked degenerative motor neuron disease caused by an abnormal expansion in the polyglutamine encoding CAG repeat of the androgen receptor gene. polyglutamine 123-136 androgen receptor Mus musculus 164-181 24742193-1 2014 Spinal and bulbar muscular atrophy (SBMA) is a late-onset, progressive neurodegenerative disease linked to a polyglutamine (polyQ) expansion in the androgen receptor (AR). polyglutamine 109-122 androgen receptor Mus musculus 167-169 24742193-1 2014 Spinal and bulbar muscular atrophy (SBMA) is a late-onset, progressive neurodegenerative disease linked to a polyglutamine (polyQ) expansion in the androgen receptor (AR). polyglutamine 124-129 androgen receptor Mus musculus 148-165 24742193-1 2014 Spinal and bulbar muscular atrophy (SBMA) is a late-onset, progressive neurodegenerative disease linked to a polyglutamine (polyQ) expansion in the androgen receptor (AR). polyglutamine 124-129 androgen receptor Mus musculus 167-169 22952056-1 2012 Spinal and bulbar muscular atrophy is an X-linked motor neuron disease caused by polyglutamine expansion in the androgen receptor. polyglutamine 81-94 androgen receptor Mus musculus 112-129 24150846-1 2014 Spinobulbar muscular atrophy (SBMA) is an inherited neuromuscular disorder caused by the expansion of a CAG repeat encoding a polyglutamine tract in exon 1 of the androgen receptor (AR) gene. polyglutamine 126-139 androgen receptor Mus musculus 182-184 23720649-0 2013 Mechanisms mediating spinal and bulbar muscular atrophy: investigations into polyglutamine-expanded androgen receptor function and dysfunction. polyglutamine 77-90 androgen receptor Mus musculus 100-117 23720649-6 2013 Both the structure of the polyglutamine-expanded AR (polyQ AR) and its interactions with other proteins are altered relative to the normal AR. polyglutamine 26-39 androgen receptor Mus musculus 49-51 23720649-6 2013 Both the structure of the polyglutamine-expanded AR (polyQ AR) and its interactions with other proteins are altered relative to the normal AR. polyglutamine 26-39 androgen receptor Mus musculus 59-61 23720649-6 2013 Both the structure of the polyglutamine-expanded AR (polyQ AR) and its interactions with other proteins are altered relative to the normal AR. polyglutamine 26-39 androgen receptor Mus musculus 59-61 23720649-9 2013 Other data suggests soluble polyQ AR oligomers can be harmful. polyglutamine 28-33 androgen receptor Mus musculus 34-36 23360996-3 2013 Here we show that heat shock factor-1 expression levels are associated with the accumulation of pathogenic androgen receptor in spinal and bulbar muscular atrophy, a polyglutamine-induced neurodegenerative disease. polyglutamine 166-179 androgen receptor Mus musculus 107-124 24291840-3 2013 Our study demonstrated that the expression levels of miR-196a is increased in a mouse model of spinal and bulbar muscular atrophy (SBMA), a neurodegenerative disease caused by the expansion of polyglutamine in androgen receptor (AR). polyglutamine 193-206 androgen receptor Mus musculus 210-227 24291840-3 2013 Our study demonstrated that the expression levels of miR-196a is increased in a mouse model of spinal and bulbar muscular atrophy (SBMA), a neurodegenerative disease caused by the expansion of polyglutamine in androgen receptor (AR). polyglutamine 193-206 androgen receptor Mus musculus 229-231 24742458-2 2014 SBMA is caused by CAG-polyglutamine (polyQ) repeat expansions in the androgen receptor (AR) gene. polyglutamine 22-35 androgen receptor Mus musculus 69-86 24742458-2 2014 SBMA is caused by CAG-polyglutamine (polyQ) repeat expansions in the androgen receptor (AR) gene. polyglutamine 22-35 androgen receptor Mus musculus 88-90 24742458-2 2014 SBMA is caused by CAG-polyglutamine (polyQ) repeat expansions in the androgen receptor (AR) gene. polyglutamine 37-42 androgen receptor Mus musculus 69-86 24742458-2 2014 SBMA is caused by CAG-polyglutamine (polyQ) repeat expansions in the androgen receptor (AR) gene. polyglutamine 37-42 androgen receptor Mus musculus 88-90 24150846-1 2014 Spinobulbar muscular atrophy (SBMA) is an inherited neuromuscular disorder caused by the expansion of a CAG repeat encoding a polyglutamine tract in exon 1 of the androgen receptor (AR) gene. polyglutamine 126-139 androgen receptor Mus musculus 163-180 23363377-1 2013 Spinal and bulbar muscular atrophy (SBMA) is an inherited motor neuron disease caused by the expansion of a polyglutamine (polyQ) tract within the androgen receptor (AR) gene. polyglutamine 108-121 androgen receptor Mus musculus 147-164 23363377-1 2013 Spinal and bulbar muscular atrophy (SBMA) is an inherited motor neuron disease caused by the expansion of a polyglutamine (polyQ) tract within the androgen receptor (AR) gene. polyglutamine 123-128 androgen receptor Mus musculus 147-164 23393146-1 2013 Spinal and bulbar muscular atrophy, also known as Kennedy"s disease, is an adult-onset hereditary neurodegenerative disorder caused by an expansion of the polyglutamine repeat in the first exon in the androgen receptor gene. polyglutamine 155-168 androgen receptor Mus musculus 201-218 21828246-14 2011 We conclude that AR polyglutamine repeat length is directly associated with transcriptional activity and alters the growth and development of C2C12 cells. polyglutamine 20-33 androgen receptor Mus musculus 17-19 22736030-5 2012 However, the expression of poly-Q AR sequesters PTIP away from radiation-induced nuclear foci. polyglutamine 27-33 androgen receptor Mus musculus 34-36