PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26497390-4 2015 In the present study, constructs expressing wild-type and poly-Q reduction mutants of FOXP2 were generated by polymerase chain reaction (PCR) using lentiviral vectors and transfected into the SH-SY5Y neuronal cell line. polyglutamine 58-64 forkhead box P2 Homo sapiens 86-91 29212017-5 2017 We note that Foxp2 encodes the longest polyglutamine repeat protein in the human reference genome, and we show that it can be sequestered into aggregates with polyglutamine-expanded mutant Huntingtin protein (mHTT). polyglutamine 39-52 forkhead box P2 Homo sapiens 13-18 27933109-6 2016 Finally, we analysed the functional significance of the polyglutamine tracts in FOXP2, since tract length variations have been reported in cases of neurodevelopmental disorder. polyglutamine 56-69 forkhead box P2 Homo sapiens 80-85 27933109-13 2016 Finally, we found that FOXP2 variants with reduced polyglutamine tracts did not exhibit altered behaviour in cellular assays, indicating that such tracts are non-essential for core aspects of FOXP2 function, and that tract variation is unlikely to be a highly penetrant cause of speech/language disorder. polyglutamine 51-64 forkhead box P2 Homo sapiens 23-28 26497390-6 2015 Using this cell model, the impact of FOXP2 on the expression of contactin-associated protein-like 2 (CNTNAP2) were investigated, and CNTNAP2 mRNA expression levels were observed to be significantly higher in cells expressing poly-Q-reduced FOXP2. polyglutamine 225-231 forkhead box P2 Homo sapiens 37-42 26497390-6 2015 Using this cell model, the impact of FOXP2 on the expression of contactin-associated protein-like 2 (CNTNAP2) were investigated, and CNTNAP2 mRNA expression levels were observed to be significantly higher in cells expressing poly-Q-reduced FOXP2. polyglutamine 225-231 forkhead box P2 Homo sapiens 240-245 15108192-2 2004 FOXP2, located on 7q31, is a putative transcription factor containing a polyglutamine tract and a forkhead DNA binding domain. polyglutamine 72-85 forkhead box P2 Homo sapiens 0-5 15737702-1 2005 We analyzed the FOXP2 gene, which encodes a putative transcription factor containing a polyglutamine tract and a forkhead DNA-binding domain, for a possible causative mutation in autism. polyglutamine 87-100 forkhead box P2 Homo sapiens 16-21 11894222-1 2002 The FOXP2 gene, located on human 7q31 (at the SPCH1 locus), encodes a transcription factor containing a polyglutamine tract and a forkhead domain. polyglutamine 104-117 forkhead box P2 Homo sapiens 4-9 11894222-1 2002 The FOXP2 gene, located on human 7q31 (at the SPCH1 locus), encodes a transcription factor containing a polyglutamine tract and a forkhead domain. polyglutamine 104-117 forkhead box P2 Homo sapiens 46-51 10880297-9 2000 This clone contains the CAGH44 gene, which encodes a brain-expressed protein containing a large polyglutamine stretch. polyglutamine 96-109 forkhead box P2 Homo sapiens 24-30