PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33983927-5 2021 A genome-wide RNAi screen for modifiers of this rack1 suppression phenotype revealed that knockdown of the E3 ubiquitin ligase, POE (Purity of essence), further suppressed polyQ-induced cell death, resulting in nearly wild-type looking eyes. polyglutamine 172-177 purity of essence Drosophila melanogaster 128-131 33983927-7 2021 These results suggest that RACK1 plays a key role in polyQ pathogenesis by promoting POE-dependent degradation of ERK, and implicate RACK1/POE/ERK as potent drug targets for treatment of polyQ diseases. polyglutamine 53-58 purity of essence Drosophila melanogaster 85-88 33983927-7 2021 These results suggest that RACK1 plays a key role in polyQ pathogenesis by promoting POE-dependent degradation of ERK, and implicate RACK1/POE/ERK as potent drug targets for treatment of polyQ diseases. polyglutamine 53-58 purity of essence Drosophila melanogaster 139-142