PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16766198-3 2006 However, the role of CBP has been controversial and the relationship between polyglutamine-induced toxicity and CBP depletion has not been examined on an individual cell basis. polyglutamine 77-90 CREB binding protein Mus musculus 112-115 12490527-0 2003 Cell death triggered by polyglutamine-expanded huntingtin in a neuronal cell line is associated with degradation of CREB-binding protein. polyglutamine 24-37 CREB binding protein Mus musculus 116-136 15003169-5 2004 We then tested the hypothesis that polyglutamine-expanded AR interferes with CREB binding protein (CBP)-mediated transcription of vascular endothelial growth factor (VEGF) and observed altered CBP-AR binding and VEGF reduction in AR100 mice. polyglutamine 35-48 CREB binding protein Mus musculus 77-97 15003169-5 2004 We then tested the hypothesis that polyglutamine-expanded AR interferes with CREB binding protein (CBP)-mediated transcription of vascular endothelial growth factor (VEGF) and observed altered CBP-AR binding and VEGF reduction in AR100 mice. polyglutamine 35-48 CREB binding protein Mus musculus 99-102 15003169-5 2004 We then tested the hypothesis that polyglutamine-expanded AR interferes with CREB binding protein (CBP)-mediated transcription of vascular endothelial growth factor (VEGF) and observed altered CBP-AR binding and VEGF reduction in AR100 mice. polyglutamine 35-48 CREB binding protein Mus musculus 193-196 12490527-4 2003 Nuclear inclusions containing polyQ-expanded htt recruit the transcriptional cofactor, CREB-binding protein (CBP). polyglutamine 30-35 CREB binding protein Mus musculus 87-107 12490527-4 2003 Nuclear inclusions containing polyQ-expanded htt recruit the transcriptional cofactor, CREB-binding protein (CBP). polyglutamine 30-35 CREB binding protein Mus musculus 109-112 12490527-7 2003 However, in addition to CBP recruitment, we show here that CBP ubiquitylation and degradation can be selectively enhanced by polyQ-expanded htt. polyglutamine 125-130 CREB binding protein Mus musculus 24-27 12490527-7 2003 However, in addition to CBP recruitment, we show here that CBP ubiquitylation and degradation can be selectively enhanced by polyQ-expanded htt. polyglutamine 125-130 CREB binding protein Mus musculus 59-62 11264541-2 2001 We found that CBP was depleted from its normal nuclear location and was present in polyglutamine aggregates in HD cell culture models, HD transgenic mice, and human HD postmortem brain. polyglutamine 83-96 CREB binding protein Mus musculus 14-17 10958659-0 2000 CREB-binding protein sequestration by expanded polyglutamine. polyglutamine 47-60 CREB binding protein Mus musculus 0-20