PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31413197-5 2019 We found that only the IRE-1-XBP-1 branch of UPRER is required for the longevity effects, resulting in increased ER-associated degradation (ERAD) gene expression and degradation of ER resident proteins during DR. Further, both ER hormesis and DR protect against polyglutamine aggregation in an IRE-1-dependent manner. polyglutamine 262-275 X-box binding protein 1 Homo sapiens 29-34