PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12045204-0	2002	Polyglutamine aggregates stimulate ER stress signals and caspase-12 activation.	polyglutamine	0-13	caspase 12	Mus musculus	57-67	
12045204-4	2002	We prepared antiserum against the cleavage site of mouse caspase-12 at D(318) (anti-m12D318), and showed that poly(Q)(72) with perinuclear aggregates, cytoplasmic inclusions and nuclear inclusions stimulated JNK activation and anti-m12D318 immunoreactivity, but poly(Q)(72) with dispersed aggregates and small nuclear aggregates showed a significantly less effect.	polyglutamine	110-117	caspase 12	Mus musculus	57-67	
12045204-10	2002	Thus, caspase-12 was activated by poly(Q)(72) aggregates via a pathway independent of caspase-8 and caspase-3 activation, and caspase-12 activation was closely associated with poly(Q) aggregate-mediated cell death.	polyglutamine	34-41	caspase 12	Mus musculus	6-16	
12045204-10	2002	Thus, caspase-12 was activated by poly(Q)(72) aggregates via a pathway independent of caspase-8 and caspase-3 activation, and caspase-12 activation was closely associated with poly(Q) aggregate-mediated cell death.	polyglutamine	176-183	caspase 12	Mus musculus	126-136