PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32240172-4 2020 RAN translation of the CAG sense and CUG anti-sense RNAs produces six distinct repeat peptides: polyalanine (polyAla, from both CAG and CUG repeats), polyserine (polySer), polyleucine (polyLeu), polycysteine (polyCys), and polyglutamine (polyGln). polyglutamine 223-236 RAN, member RAS oncogene family Homo sapiens 0-3 33157084-5 2020 Despite having distinct cellular localization, RAN polyQ and RAN polyA proteins are very often coexpressed in the same cell, impairing nuclear integrity and inducing apoptosis. polyglutamine 51-56 RAN, member RAS oncogene family Homo sapiens 47-50 32240172-4 2020 RAN translation of the CAG sense and CUG anti-sense RNAs produces six distinct repeat peptides: polyalanine (polyAla, from both CAG and CUG repeats), polyserine (polySer), polyleucine (polyLeu), polycysteine (polyCys), and polyglutamine (polyGln). polyglutamine 238-245 RAN, member RAS oncogene family Homo sapiens 0-3 21423665-5 2011 A recent advance reveals that RNA transcripts with expanded CAG repeats can be translated in the complete absence of a starting ATG, and this Repeat Associated Non-ATG translation (RAN-translation) occurs across expanded CAG repeats in all reading frames (CAG, AGC, and GCA) to produce homopolymeric proteins of long polyglutamine, polyserine, and polyalanine tracts. polyglutamine 317-330 RAN, member RAS oncogene family Homo sapiens 181-184 28819073-2 2017 Recently, the "polyglutamine disorders" caused by the coding CAG repeat expansions were also clarified that they were involved in RNA mechanism or RAN translation. polyglutamine 15-28 RAN, member RAS oncogene family Homo sapiens 147-150 26086378-8 2015 Strong RAN translation was also observed when driving the ATXN2 sequence with the CMV promoter with ATXN2 sequence downstream of the CAG repeat truncated to 18 bp in the polyglutamine frame but not in the polyserine or polyalanine frames. polyglutamine 170-183 RAN, member RAS oncogene family Homo sapiens 7-10 26590344-6 2015 This is the first demonstration that RAN proteins are expressed across an expansion located in an open reading frame and suggests RAN translation may also contribute to other polyglutamine diseases. polyglutamine 175-188 RAN, member RAS oncogene family Homo sapiens 37-40 26590344-6 2015 This is the first demonstration that RAN proteins are expressed across an expansion located in an open reading frame and suggests RAN translation may also contribute to other polyglutamine diseases. polyglutamine 175-188 RAN, member RAS oncogene family Homo sapiens 130-133 21173221-4 2011 Additionally, we show that RAN translation across human spinocerebellar ataxia type 8 (SCA8) and myotonic dystrophy type 1 (DM1) CAG expansion transcripts results in the accumulation of SCA8 polyalanine and DM1 polyglutamine expansion proteins in previously established SCA8 and DM1 mouse models and human tissue. polyglutamine 211-224 RAN, member RAS oncogene family Homo sapiens 27-30 11155740-11 2000 Our data indicate that ARA24 could also interact with AR, and that this binding is decreased by an expanding poly-glutamine (Q) length within AR. polyglutamine 109-123 RAN, member RAS oncogene family Homo sapiens 23-28 10400640-0 1999 The linkage of Kennedy"s neuron disease to ARA24, the first identified androgen receptor polyglutamine region-associated coactivator. polyglutamine 89-102 RAN, member RAS oncogene family Homo sapiens 43-48 10400640-2 1999 Here we report the identification of a nuclear G-protein, Ras-related nuclear protein/ARA24, as the first AR coactivator that can bind differentially with different lengths of poly-Q within AR. polyglutamine 176-182 RAN, member RAS oncogene family Homo sapiens 86-91 10400640-3 1999 In the yeast and mammalian reciprocal interacting assays, our data suggested the interaction of AR N-terminal domain with ARA24 diminishes as the poly-Q length increases. polyglutamine 146-152 RAN, member RAS oncogene family Homo sapiens 122-127 10400640-4 1999 The coactivation of ARA24 also diminishes with the poly-Q expansion within AR. polyglutamine 51-57 RAN, member RAS oncogene family Homo sapiens 20-25