PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21892924-0 2012 Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans. polyglutamine 14-27 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 106-112 32453327-9 2020 The mechanism proposed is the activation of DAF-16, HSP-16.2 and SOD-3 in whole body tissues to increase the antioxidant capacity and regulation of proteostasis, decreasing PolyQ aggregation and toxicity and reducing ROS levels, leading to an increase in lifespan, and healthspan. polyglutamine 173-178 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 44-50 22956852-2 2012 In Caenorhabditis elegans, sir-2.1/SIRT1 overexpression protects neurons from the early phases of expanded polyglutamine (polyQ) toxicity, and this protection requires the longevity-promoting factor daf-16/FOXO. polyglutamine 107-120 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 199-205 22956852-2 2012 In Caenorhabditis elegans, sir-2.1/SIRT1 overexpression protects neurons from the early phases of expanded polyglutamine (polyQ) toxicity, and this protection requires the longevity-promoting factor daf-16/FOXO. polyglutamine 122-127 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 199-205