PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10208851-7	1999	This is the first direct evidence that the expression of extended polyQ activates caspases and together with the previous findings that some of the products of genes responsible for CAG repeat diseases are substrates of caspase-3 indicates an important role of caspases in the pathogenesis of these diseases.	polyglutamine	66-71	caspase 3	Homo sapiens	220-229	
9813160-0	1998	Caspase-3 cleaves the expanded androgen receptor protein of spinal and bulbar muscular atrophy in a polyglutamine repeat length-dependent manner.	polyglutamine	100-113	caspase 3	Homo sapiens	0-9	
9813160-4	1998	We now report that in vitro translated full-length AR proteins containing different sized polyglutamine repeats (24, 65 and 97 repeats, respectively) are specifically cleaved by recombinant caspase-3, liberating a polyglutamine containing fragment, and that the susceptibility to cleavage is polyglutamine repeat length-dependent.	polyglutamine	90-103	caspase 3	Homo sapiens	190-199	
9813160-4	1998	We now report that in vitro translated full-length AR proteins containing different sized polyglutamine repeats (24, 65 and 97 repeats, respectively) are specifically cleaved by recombinant caspase-3, liberating a polyglutamine containing fragment, and that the susceptibility to cleavage is polyglutamine repeat length-dependent.	polyglutamine	214-227	caspase 3	Homo sapiens	190-199	
9813160-4	1998	We now report that in vitro translated full-length AR proteins containing different sized polyglutamine repeats (24, 65 and 97 repeats, respectively) are specifically cleaved by recombinant caspase-3, liberating a polyglutamine containing fragment, and that the susceptibility to cleavage is polyglutamine repeat length-dependent.	polyglutamine	214-227	caspase 3	Homo sapiens	190-199	
22764223-0	2012	ALS-associated ataxin 2 polyQ expansions enhance stress-induced caspase 3 activation and increase TDP-43 pathological modifications.	polyglutamine	24-29	caspase 3	Homo sapiens	64-73	
9705838-5	1998	In contrast, an N-terminal-deleted fragment containing polyQ produced by the proteolytic cleavage with caspase-3 is found both in the nucleus and the cytoplasm.	polyglutamine	55-60	caspase 3	Homo sapiens	103-112	
8696339-0	1996	Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract.	polyglutamine	89-102	caspase 3	Homo sapiens	26-33	
22764223-5	2012	We also connect intermediate-length ataxin 2 polyQ expansions to the stress-dependent activation of multiple caspases, including caspase 3.	polyglutamine	45-50	caspase 3	Homo sapiens	129-138	
11809726-6	2002	In mammalian cells we tested sequence-specific small dsRNAs of 22 nt; these rescued the toxicity and caspase-3 activation induced by plasmids expressing a transcript encoding an expanded polyglutamine tract.	polyglutamine	187-200	caspase 3	Homo sapiens	101-110	
22684686-6	2012	Recent findings show that the brain is commonly seriously affected in the polyglutamine SCAs (i.e. SCA1, SCA2, SCA3, SCA6, SCA7, and SCA17) and that the patterns of brain damage in these diseases overlap considerably in patients suffering from advanced disease stages.	polyglutamine	74-87	caspase 3	Homo sapiens	99-103	
14709594-5	2004	Drugs that inhibit polyglutamine-dependent activation of caspase-3 were subjected to follow-up screens to identify compounds that reproducibly prevent polyglutamine-induced cytotoxicity.	polyglutamine	19-32	caspase 3	Homo sapiens	57-66	
12824190-1	2003	Phosphorylation of the polyglutamine-expanded form of androgen receptor regulates its cleavage by caspase-3 and enhances cell death.	polyglutamine	23-36	caspase 3	Homo sapiens	98-107	
12824190-11	2003	We propose a mechanism by which phosphorylation at serine 514 of AR enhances the ability of caspase-3 to cleave AR and generate cytotoxic polyQ fragments.	polyglutamine	138-143	caspase 3	Homo sapiens	92-101