PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8674031-3 1996 Recombinant CDK4-cyclin D1 was inhibited potently by Flavopiridol (Kiapp, 65 nM), competitive with respect to ATP. Adenosine Triphosphate 110-113 cyclin D1 Homo sapiens 17-26 23742826-6 2013 In addition, ATP increased the expression of the cyclins D1 and D3 and down-regulated the cell cycle inhibitory proteins p21Cip1 and p27Kip1. Adenosine Triphosphate 13-16 cyclin D1 Homo sapiens 49-66 28474758-5 2017 ATP could promote the in vitro invasion of breast cancer cells and enhance the expression of beta-catenin as well as its downstream target genes CD44, c-Myc and cyclin D1, while P2Y2 knockdown attenuated above ATP-driven events in vitro and in vivo. Adenosine Triphosphate 0-3 cyclin D1 Homo sapiens 161-170 23318226-0 2013 ATP stimulates PGE(2)/cyclin D1-dependent VSMCs proliferation via STAT3 activation: role of PKCs-dependent NADPH oxidase/ROS generation. Adenosine Triphosphate 0-3 cyclin D1 Homo sapiens 22-31 20926450-5 2011 On the one hand, PTEN ATP-binding mutants lose their phosphatase activity and the effect of downregulation of cyclin D1. Adenosine Triphosphate 22-25 cyclin D1 Homo sapiens 110-119 22224416-9 2012 In addition, ATP enhanced the progression of cells from the G0/G1 phase to the S phase by increasing the expression of proteins for cyclin D1 and cyclin E. Silencing the P2X(4/7) and P2Y(2) receptors with siRNA targeting the corresponding receptor diminished ATP-stimulated proliferation and migration of the cardiac fibroblasts. Adenosine Triphosphate 13-16 cyclin D1 Homo sapiens 132-141 22224416-9 2012 In addition, ATP enhanced the progression of cells from the G0/G1 phase to the S phase by increasing the expression of proteins for cyclin D1 and cyclin E. Silencing the P2X(4/7) and P2Y(2) receptors with siRNA targeting the corresponding receptor diminished ATP-stimulated proliferation and migration of the cardiac fibroblasts. Adenosine Triphosphate 261-264 cyclin D1 Homo sapiens 132-141 21343394-5 2011 The bound cyclin D1 decreases the supply of ADP, ATP, and metabolites, thereby reducing energy production. Adenosine Triphosphate 49-52 cyclin D1 Homo sapiens 10-19 14767992-8 2004 Extracellular ATP as low as 10 nM was sufficient to potentiate EGF-induced cyclin D1 expression. Adenosine Triphosphate 14-17 cyclin D1 Homo sapiens 75-84 15123247-5 2004 This knowledge was applied to the design of compounds in the otherwise CDK2-selective 2-anilino-4-(thiazol-5-yl)pyrimidine pharmacophore that are potent and highly selective ATP antagonists of CDK4/cyclin D1. Adenosine Triphosphate 174-177 cyclin D1 Homo sapiens 198-207 16741950-4 2006 Here, we demonstrate that extracellular ATP has a mitogenic effect on ARO cells, increasing ERK phosphorylation, AP1 activation, and cyclin D1 expression. Adenosine Triphosphate 40-43 cyclin D1 Homo sapiens 133-142 15277517-6 2004 We demonstrate that antizyme is capable of specific, noncovalent association with cyclin D1 and that this interaction accelerates cyclin D1 degradation in vitro in the presence of only antizyme, cyclin D1, purified 26 S proteasomes, and ATP. Adenosine Triphosphate 237-240 cyclin D1 Homo sapiens 82-91 15277517-6 2004 We demonstrate that antizyme is capable of specific, noncovalent association with cyclin D1 and that this interaction accelerates cyclin D1 degradation in vitro in the presence of only antizyme, cyclin D1, purified 26 S proteasomes, and ATP. Adenosine Triphosphate 237-240 cyclin D1 Homo sapiens 130-139 15277517-6 2004 We demonstrate that antizyme is capable of specific, noncovalent association with cyclin D1 and that this interaction accelerates cyclin D1 degradation in vitro in the presence of only antizyme, cyclin D1, purified 26 S proteasomes, and ATP. Adenosine Triphosphate 237-240 cyclin D1 Homo sapiens 130-139 12154027-11 2002 DNA microarray analysis of livers from ET-743-treated animals showed a dramatic increase in the expression of ATP binding cassette transport genes Abcb1a and Abcb1b, which impart resistance to anticancer drugs, and of Cdc2a and Ccnd1, the rodent homologues of human cell cycle genes CDC2 and cyclin D1, respectively. Adenosine Triphosphate 110-113 cyclin D1 Homo sapiens 228-233 12154027-11 2002 DNA microarray analysis of livers from ET-743-treated animals showed a dramatic increase in the expression of ATP binding cassette transport genes Abcb1a and Abcb1b, which impart resistance to anticancer drugs, and of Cdc2a and Ccnd1, the rodent homologues of human cell cycle genes CDC2 and cyclin D1, respectively. Adenosine Triphosphate 110-113 cyclin D1 Homo sapiens 292-301 14646596-4 2003 Association constant, Km for ATP in CDK4/cyclin D1 was found as 418 microM, a value unusually high whereas CDK2/cyclin A was 23 microM, a value close to most of other regulatory protein kinases. Adenosine Triphosphate 29-32 cyclin D1 Homo sapiens 41-50 14646596-8 2003 These data suggest cellular CDK4/cyclin D1 activity is tightly associated with cellular ATP concentration. Adenosine Triphosphate 88-91 cyclin D1 Homo sapiens 33-42 14550307-5 2003 In contrast, the compound exhibited non-competitive inhibition with respect to ATP toward cdk4/cyclin D1, with a 45-fold reduced potency. Adenosine Triphosphate 79-82 cyclin D1 Homo sapiens 95-104