PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33860865-2 2021 TSC mutation leads to continuous activation of the mTOR pathway that requires adaptation to increased ATP requirement. Adenosine Triphosphate 102-105 TSC complex subunit 1 Homo sapiens 0-3 23142078-2 2013 We show that glucose and glutamine, by supplying carbons to the TCA cycle to produce ATP, positively feed back to mTORC1 through an AMPK-, TSC1/2-, and Rag-independent mechanism by regulating mTORC1 assembly and its lysosomal localization. Adenosine Triphosphate 85-88 TSC complex subunit 1 Homo sapiens 139-143 20444419-3 2010 It is thought that agents that increase the cellular AMP/ATP ratio, such as the antidiabetic biguanides metformin and phenformin, inhibit mTORC1 through AMPK activation of TSC1/2-dependent or -independent mechanisms. Adenosine Triphosphate 57-60 TSC complex subunit 1 Homo sapiens 172-176