PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33572154-6 2021 Intracellular calcium responses to ATP indicated differentiation of the functional astrocyte population with constitutive monocyte chemoattractant protein-1 (MCP-1/CCL2) and tissue inhibitor of metalloproteinases-2 (TIMP-2) expression. Adenosine Triphosphate 35-38 C-C motif chemokine ligand 2 Homo sapiens 122-156 33572154-6 2021 Intracellular calcium responses to ATP indicated differentiation of the functional astrocyte population with constitutive monocyte chemoattractant protein-1 (MCP-1/CCL2) and tissue inhibitor of metalloproteinases-2 (TIMP-2) expression. Adenosine Triphosphate 35-38 C-C motif chemokine ligand 2 Homo sapiens 158-163 33572154-6 2021 Intracellular calcium responses to ATP indicated differentiation of the functional astrocyte population with constitutive monocyte chemoattractant protein-1 (MCP-1/CCL2) and tissue inhibitor of metalloproteinases-2 (TIMP-2) expression. Adenosine Triphosphate 35-38 C-C motif chemokine ligand 2 Homo sapiens 164-168 30643045-5 2018 ATP at low concentration (5 mumol/L) significantly inhibited LPS-induced mRNA expression of IL-1beta, MCP-1 and ICAM-1(P<0.05), downregulated the LPS-induced protein expression of TLR4, MyD88 and CD14 in EPCs (P<0.05), and suppressed LPS-induced activation of NF-kappaB signaling pathway (P<0.05). Adenosine Triphosphate 0-3 C-C motif chemokine ligand 2 Homo sapiens 102-107 32686520-5 2020 Furthermore, extracellular ATP aggravates PA-induced monocyte chemoattractant protein-1 secretion and monocyte infiltration of tubular cells, enlarging the inflammatory response in both macrophages and HK-2 cells via the purinergic P2X7 receptor-mammalian target of rapamycin-forkhead box O1-thioredoxin-interacting protein/NOD-like receptor protein 3 inflammasome pathway. Adenosine Triphosphate 27-30 C-C motif chemokine ligand 2 Homo sapiens 53-87 22897577-6 2012 We have previously shown that the sympathetic nerve cotransmitter adenosine-5"-triphosphate (ATP) and adenosine-5"-O-(3-thio) triphosphate (ATPgammaS), an ATP analogue that is resistant to hydrolysis, increase secretion of the chemokines CXCL8 (interleukin-8), CCL2 (monocyte chemotactic protein-1) and CXCL1 (growth-regulated oncogene alpha) by dermal microvascular ECs. Adenosine Triphosphate 93-96 C-C motif chemokine ligand 2 Homo sapiens 261-265 25272052-7 2015 P2X7R antagonists, such as the oxidized ATP, A438079, brilliant blue G, and broad spectrum P2 receptor antagonist suramin, attenuated Tat-induced CCL2 release in a calcium- and extracellular signal-regulated kinase (ERK)1/2-dependent manner. Adenosine Triphosphate 40-43 C-C motif chemokine ligand 2 Homo sapiens 146-150 25276053-2 2014 The extracellular nucleotide signalling molecules UTP and ATP acting via the P2Y2 receptor are known to induce CCL2 secretion in macrophages. Adenosine Triphosphate 58-61 C-C motif chemokine ligand 2 Homo sapiens 111-115 25271060-7 2014 We demonstrate that THP-1 cells rapidly secrete ATP during signalling downstream of the CCL2-CCR2 axis and suggest this might act as a mechanism for P2Y6 receptor co-activation following CCL2 activation of the CCR2 receptor. Adenosine Triphosphate 48-51 C-C motif chemokine ligand 2 Homo sapiens 88-92 25271060-7 2014 We demonstrate that THP-1 cells rapidly secrete ATP during signalling downstream of the CCL2-CCR2 axis and suggest this might act as a mechanism for P2Y6 receptor co-activation following CCL2 activation of the CCR2 receptor. Adenosine Triphosphate 48-51 C-C motif chemokine ligand 2 Homo sapiens 187-191 23948942-8 2014 Astroglial activation and CCL2 release was induced by ATP released by damaged neurons through interaction with P2X7 receptors present on astrocyte surface. Adenosine Triphosphate 54-57 C-C motif chemokine ligand 2 Homo sapiens 26-30 22897577-6 2012 We have previously shown that the sympathetic nerve cotransmitter adenosine-5"-triphosphate (ATP) and adenosine-5"-O-(3-thio) triphosphate (ATPgammaS), an ATP analogue that is resistant to hydrolysis, increase secretion of the chemokines CXCL8 (interleukin-8), CCL2 (monocyte chemotactic protein-1) and CXCL1 (growth-regulated oncogene alpha) by dermal microvascular ECs. Adenosine Triphosphate 66-91 C-C motif chemokine ligand 2 Homo sapiens 261-265 22897577-6 2012 We have previously shown that the sympathetic nerve cotransmitter adenosine-5"-triphosphate (ATP) and adenosine-5"-O-(3-thio) triphosphate (ATPgammaS), an ATP analogue that is resistant to hydrolysis, increase secretion of the chemokines CXCL8 (interleukin-8), CCL2 (monocyte chemotactic protein-1) and CXCL1 (growth-regulated oncogene alpha) by dermal microvascular ECs. Adenosine Triphosphate 66-91 C-C motif chemokine ligand 2 Homo sapiens 267-297 22897577-6 2012 We have previously shown that the sympathetic nerve cotransmitter adenosine-5"-triphosphate (ATP) and adenosine-5"-O-(3-thio) triphosphate (ATPgammaS), an ATP analogue that is resistant to hydrolysis, increase secretion of the chemokines CXCL8 (interleukin-8), CCL2 (monocyte chemotactic protein-1) and CXCL1 (growth-regulated oncogene alpha) by dermal microvascular ECs. Adenosine Triphosphate 93-96 C-C motif chemokine ligand 2 Homo sapiens 267-297 22897577-6 2012 We have previously shown that the sympathetic nerve cotransmitter adenosine-5"-triphosphate (ATP) and adenosine-5"-O-(3-thio) triphosphate (ATPgammaS), an ATP analogue that is resistant to hydrolysis, increase secretion of the chemokines CXCL8 (interleukin-8), CCL2 (monocyte chemotactic protein-1) and CXCL1 (growth-regulated oncogene alpha) by dermal microvascular ECs. Adenosine Triphosphate 140-143 C-C motif chemokine ligand 2 Homo sapiens 261-265 22897577-6 2012 We have previously shown that the sympathetic nerve cotransmitter adenosine-5"-triphosphate (ATP) and adenosine-5"-O-(3-thio) triphosphate (ATPgammaS), an ATP analogue that is resistant to hydrolysis, increase secretion of the chemokines CXCL8 (interleukin-8), CCL2 (monocyte chemotactic protein-1) and CXCL1 (growth-regulated oncogene alpha) by dermal microvascular ECs. Adenosine Triphosphate 140-143 C-C motif chemokine ligand 2 Homo sapiens 267-297 22897577-8 2012 We have now demonstrated that AFC dose-dependently inhibits ATP-, ATPgammaS- and TNFalpha-induced production of CXCL1, CXCL8 and CCL2 by a human dermal microvascular EC line (HMEC-1) in vitro under conditions that do not affect cell viability. Adenosine Triphosphate 60-63 C-C motif chemokine ligand 2 Homo sapiens 129-133 22299633-6 2012 When human EPCs were stimulated with LPS and nucleotides, ATP or UTP inhibited the expression of pro-inflammatory cytokines including MCP-1 (monocyte chemoattractant protein-1), IFNalpha (interferon alpha), TNFalpha (tumour necrosis factor alpha) and adhesion molecule VCAM-1 (vascular cell adhesion molecule 1) induced by LPS. Adenosine Triphosphate 58-61 C-C motif chemokine ligand 2 Homo sapiens 134-139 22299633-6 2012 When human EPCs were stimulated with LPS and nucleotides, ATP or UTP inhibited the expression of pro-inflammatory cytokines including MCP-1 (monocyte chemoattractant protein-1), IFNalpha (interferon alpha), TNFalpha (tumour necrosis factor alpha) and adhesion molecule VCAM-1 (vascular cell adhesion molecule 1) induced by LPS. Adenosine Triphosphate 58-61 C-C motif chemokine ligand 2 Homo sapiens 141-175 22330806-1 2012 Although white adipocytes contain a larger number of mitochondria per cytoplasmic volume, adipocyte mitochondrial uncoupling to reduce the efficiency of ATP production on cellular function including secretory regulation of bioactive molecules such as VEGF and MCP-1 remains to be elucidated. Adenosine Triphosphate 153-156 C-C motif chemokine ligand 2 Homo sapiens 260-265 22415310-6 2012 ATP stimulation of P2Y(2) receptors increased alpha-smooth muscle actin (alpha-SMA) production, and in an ERK-dependent manner, ATP increased collagen accumulation by 60% and mRNA expression of profibrotic markers: plasminogen activator inhibitor-1 and monocyte chemotactic protein-1 by 4.5- and 4.0-fold, respectively. Adenosine Triphosphate 0-3 C-C motif chemokine ligand 2 Homo sapiens 253-283 22415310-6 2012 ATP stimulation of P2Y(2) receptors increased alpha-smooth muscle actin (alpha-SMA) production, and in an ERK-dependent manner, ATP increased collagen accumulation by 60% and mRNA expression of profibrotic markers: plasminogen activator inhibitor-1 and monocyte chemotactic protein-1 by 4.5- and 4.0-fold, respectively. Adenosine Triphosphate 128-131 C-C motif chemokine ligand 2 Homo sapiens 253-283 22222817-10 2012 Moreover, CCL2-stimulated microglia enhanced Akt phosphorylation by ATP applied extracellularly, a P2X4R-mediated response. Adenosine Triphosphate 68-71 C-C motif chemokine ligand 2 Homo sapiens 10-14 11549724-8 2001 Blocking either the ERK1/ERK2 or the p38 pathway (with PD98059 or SB203580, respectively) significantly inhibited Bz-ATP-induced MCP-1 expression. Adenosine Triphosphate 117-120 C-C motif chemokine ligand 2 Homo sapiens 129-134 19129402-7 2009 MCP-1 significantly reduced lactate dehydrogenase release from neurons after oxygen-glucose deprivation (OGD) and prevented the loss of ATP levels that occurred after OGD or treatment with glutamate. Adenosine Triphosphate 136-139 C-C motif chemokine ligand 2 Homo sapiens 0-5 17039239-3 2007 Notably, extracellular ATP displayed a complex regulation of IFN-gamma-stimulated chemokine expression, with upregulation of CC chemokine ligand 2 (CCL2), CCL5 and CXC chemokine ligand 8 (CXCL8), and suppression of the receptor CXC chemokine receptor 3 (CXCR3), CXCL9, CXCL10, and CXCL11. Adenosine Triphosphate 23-26 C-C motif chemokine ligand 2 Homo sapiens 125-146 17039239-3 2007 Notably, extracellular ATP displayed a complex regulation of IFN-gamma-stimulated chemokine expression, with upregulation of CC chemokine ligand 2 (CCL2), CCL5 and CXC chemokine ligand 8 (CXCL8), and suppression of the receptor CXC chemokine receptor 3 (CXCR3), CXCL9, CXCL10, and CXCL11. Adenosine Triphosphate 23-26 C-C motif chemokine ligand 2 Homo sapiens 148-152 19556365-8 2009 Knockdown of BRG1 by small interfering RNA blocked an ATP depletion-induced increase in TNF-alpha and MCP-1 transcription in a human proximal tubule cell line; this effect was associated with decreased recruitment of BRG1 and Pol II to these genes. Adenosine Triphosphate 54-57 C-C motif chemokine ligand 2 Homo sapiens 102-107 11549724-14 2001 The regulation of MCP-1 in astrocytes by ATP may be important in mediating communication with hematopoietic inflammatory cells. Adenosine Triphosphate 41-44 C-C motif chemokine ligand 2 Homo sapiens 18-23 8557776-7 1996 Since some ATP- or UTP-induced genes code for chemotactic proteins (monocyte chemoattractant protein-1 and osteopontin), this study suggests that these nucleotides may contribute to vascular or blood cell migration and proliferation and consequently to the genesis of arterial diseases. Adenosine Triphosphate 11-14 C-C motif chemokine ligand 2 Homo sapiens 68-102