PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18164682-4 2008 ATP inhibited radiation-induced TNF-alpha release and increased IL-10 release. Adenosine Triphosphate 0-3 interleukin 10 Homo sapiens 64-69 32804985-7 2020 In addition to the effects of KW3110 on J774A.1 cells, KW3110 treatment induced IL-10 production in the supernatants of human monocytes, and KW3110 or IL-10 treatment suppressed caspase-1 activation and IL-1beta production in the supernatants of LPS/ATP-stimulated cells. Adenosine Triphosphate 250-253 interleukin 10 Homo sapiens 151-156 12626548-6 2003 TNF-alpha, IL-10, and IL-5 production showed intermediate sensitivity to these ATP analogs. Adenosine Triphosphate 79-82 interleukin 10 Homo sapiens 11-16 11160202-5 2001 On the other hand, ATP markedly and dose-dependently inhibited LPS- and soluble CD40 ligand-dependent production of IL-1alpha, IL-1beta, TNF-alpha, IL-6, and IL-12, whereas IL-1 receptor antagonist and IL-10 production was not affected. Adenosine Triphosphate 19-22 interleukin 10 Homo sapiens 202-207 11160202-6 2001 As a result, T cell lines generated from allogeneic naive CD45RA(+) T cells primed with DCs matured in the presence of ATP produced lower amounts of IFN-gamma and higher levels of IL-4, IL-5, and IL-10 compared with T cell lines obtained with LPS-stimulated DCs. Adenosine Triphosphate 119-122 interleukin 10 Homo sapiens 196-201 34175493-7 2022 However, ATP may also undergo catalysis by ectonucleotidases present in the parasite membrane, generating adenosine, which activates P1 receptors and induces the production of anti-inflammatory molecules such as prostaglandin E2 and IL-10. Adenosine Triphosphate 9-12 interleukin 10 Homo sapiens 233-238 18472047-7 2008 Results showed that ATP decreased the rise in concentrations of TNF-alpha, interferon-gamma (IFN-gamma) and IL-1beta, but increased concentrations of IL-8 and IL-10. Adenosine Triphosphate 20-23 interleukin 10 Homo sapiens 159-164 17705579-10 2007 Our results suggest an association between low ATP and IL-10 concentrations and the presence of infection. Adenosine Triphosphate 47-50 interleukin 10 Homo sapiens 55-60 16298759-4 2006 In the presence of H(2)O(2), ATP at concentrations of 100 and 300 microM inhibited Tumour Necrosis factor-alpha (TNF-alpha) release and stimulated IL-10 release in LPS-PHA stimulated whole blood. Adenosine Triphosphate 29-32 interleukin 10 Homo sapiens 147-152 15719372-3 2005 The purpose of the present study was to determine the effects of ATP on TNF-alpha, IL-6 and IL-10 release in stimulated whole blood. Adenosine Triphosphate 65-68 interleukin 10 Homo sapiens 92-97 15719372-5 2005 Furthermore, these ATP concentrations induced an increase in IL-10 secretion by 48+/-5% and 62+/-7% in whole blood. Adenosine Triphosphate 19-22 interleukin 10 Homo sapiens 61-66 15719372-6 2005 The ATP analogue adenosine 5"-O-(3-thiotriphosphate) (ATP-gamma-S) and adenosine 5"-diphosphate (ADP) also inhibited TNF-alpha release, but only ADP showed a stimulatory effect on IL-10. Adenosine Triphosphate 4-7 interleukin 10 Homo sapiens 180-185 15719372-8 2005 These results show, for the first time, that ATP inhibits the inflammatory response in stimulated whole blood as indicated by inhibition of TNF-alpha and stimulation of IL-10 release and that this effect is predominantly mediated by ATP and not by adenosine. Adenosine Triphosphate 45-48 interleukin 10 Homo sapiens 169-174 34202215-10 2021 Our results suggest that ATP and TNF-alpha dominantly induce the physiological activities of 3 dpi neurons and microglia, and IL-10 effectively suppresses such changes of both activated cells in K+ channel- and P2 receptor-dependent manner, while IL-4 suppresses neurons preferentially. Adenosine Triphosphate 25-28 interleukin 10 Homo sapiens 126-131 32118580-7 2020 In (LPS/ATP-stimulated) PBMCs, IL-18/TNF/caspase-1 were all significantly decreased and IL-10 was increased with both combinations. Adenosine Triphosphate 8-11 interleukin 10 Homo sapiens 88-93 26435068-5 2017 In THP-1 cells, CORM-2 treatment dose-dependently reduced the activation of caspase-1 and the secretion of IL-1beta, and increased the levels of IL-10, in response to LPS and adenosine 5"-triphosphate (ATP), an NLRP3 inflammasome activation model. Adenosine Triphosphate 175-200 interleukin 10 Homo sapiens 145-150 31911118-5 2020 The processes include the generation of "Find-Me" signals (such as adenosine triphosphate/uridine triphosphate, fractalkine, lysophosphatidylcholine, and sphingosine-1-phosphate) for the recruitment of viable macrophages, generation of the "Eat-Me" signals (for example, phosphatidylserine) for the engulfment process, and, finally, release of anti-inflammatory mediators (including transforming factor beta and interleukin-10) as a tolerance-enhancing and an anti-inflammatory response, and for the motile behavior of the apoptotic cell. Adenosine Triphosphate 67-89 interleukin 10 Homo sapiens 412-426 29031722-6 2017 IL10/TGFbeta-activated MPhis displayed high CD163 and low CD40 expression and secreted factors that decreased UQCRC2 gene/protein expression and ATP-linked respiration in human white adipocytes. Adenosine Triphosphate 145-148 interleukin 10 Homo sapiens 0-4 25458313-6 2015 Th cells cultured in the presence of supernatant derived from LPS/ATP inflammasome activated PBMC showed increased Th17 and GM-CSF+ Th17 cell frequencies in HC and MS patients and decreased anti-inflammatory IL-10+Th cell frequency in HC compared to Th cells cultured in the presence of control supernatant. Adenosine Triphosphate 66-69 interleukin 10 Homo sapiens 208-213 26990545-7 2016 Production of IL-10 and expression of CD39 by CD8(+) T cells was independently regulated, being respectively blocked by extracellular ATP and enhanced by an A2A adenosine receptor agonist. Adenosine Triphosphate 134-137 interleukin 10 Homo sapiens 14-19 19748989-4 2009 Here, we show that extracellular ATP impairs in an IL-10-dependent fashion the expression of the tolerogenic soluble and membrane-bound HLA-G Ag in human monocytes. Adenosine Triphosphate 33-36 interleukin 10 Homo sapiens 51-56 21145936-11 2011 Moreover, ATP increased the production of the proinflammatory cytokines interleukin-2, interferon-gamma, and interleukin-12p70, while decreasing the anti-inflammatory cytokine interleukin-10, and this finding was associated with the reduced ability of MSCs to inhibit T-cell proliferation. Adenosine Triphosphate 10-13 interleukin 10 Homo sapiens 176-190 19748989-7 2009 Inhibition by ATP was reverted by supplementation of culture medium with exogenous IL-10. Adenosine Triphosphate 14-17 interleukin 10 Homo sapiens 83-88 19748989-8 2009 Due to the well-known immunosuppressive activity of IL-10 and soluble HLA-G, this novel effect of ATP might be relevant for the pathophysiology and therapy of inflammatory disorders. Adenosine Triphosphate 98-101 interleukin 10 Homo sapiens 52-57