PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29911570-6 2018 Instead, chronic T cells appeared to rely on oxidative phosphorylation (OXPHOS) and fatty acid oxidation (FAO) to produce ATP for IFNgamma synthesis. Adenosine Triphosphate 122-125 interferon gamma Homo sapiens 130-138 26823467-3 2016 Exposure of primary human airway epithelial cell cultures to IFN-gamma for 48 h did not alter Panx1 protein expression but significantly decreased ATP release in response to hypotonic stress. Adenosine Triphosphate 147-150 interferon gamma Homo sapiens 61-70 27598576-3 2016 Here, we demonstrate that priming of microglia with interferon-gamma (IFN gamma) substantially enhanced production of reactive oxygen species (ROS) following stimulation of microglia with ATP. Adenosine Triphosphate 188-191 interferon gamma Homo sapiens 52-68 27598576-3 2016 Here, we demonstrate that priming of microglia with interferon-gamma (IFN gamma) substantially enhanced production of reactive oxygen species (ROS) following stimulation of microglia with ATP. Adenosine Triphosphate 188-191 interferon gamma Homo sapiens 70-79 26823467-5 2016 Duox2 suppression by siRNA led to an increase in ATP release in control cells and restoration of ATP release in cells treated with IFN-gamma. Adenosine Triphosphate 97-100 interferon gamma Homo sapiens 131-140 26823467-11 2016 This led to a 2-fold increase in ATP release in cells treated with IFN-gamma that was also inhibited by probenecid. Adenosine Triphosphate 33-36 interferon gamma Homo sapiens 67-76 26823467-14 2016 Therefore, airway epithelial cells release less ATP in response to hypotonic stress in an inflammatory environment (IFN-gamma exposure). Adenosine Triphosphate 48-51 interferon gamma Homo sapiens 116-125 29463472-5 2018 Adenosine triphosphate (ATP) distributed by aerobic glycolysis is critical for sustaining IFN-gamma triggered JAK (Janus tyrosine kinase)-STAT-1 (Signal Transducer and Activator of Transcription 1) signaling with phosphorylation of the transcription factor STAT-1 as its signature trait. Adenosine Triphosphate 0-22 interferon gamma Homo sapiens 90-99 29463472-5 2018 Adenosine triphosphate (ATP) distributed by aerobic glycolysis is critical for sustaining IFN-gamma triggered JAK (Janus tyrosine kinase)-STAT-1 (Signal Transducer and Activator of Transcription 1) signaling with phosphorylation of the transcription factor STAT-1 as its signature trait. Adenosine Triphosphate 24-27 interferon gamma Homo sapiens 90-99 29031722-7 2017 In contrast, LPS/IFNgamma-activated MPhis showed high CD40 and low CD163 expression and secreted factors that enhanced adipocyte mitochondrial activity resulting in a total difference of 37% in ATP-linked respiration of white adipocytes (p = 0.0024) when comparing the effect of LPS/IFNgamma- vs IL10/TGFbeta-activated MPhis. Adenosine Triphosphate 194-197 interferon gamma Homo sapiens 17-25 24978193-6 2014 However, the stable ATP analogue ATPgammaS increased the release of IL-1beta and IFNgamma, and the effect was greatly increased in lungs from smokers. Adenosine Triphosphate 20-23 interferon gamma Homo sapiens 81-89 23382974-7 2013 ATP plus atypical lipopolysaccharide from P. gingivalis (signaling through TLR2) was slightly superior to E. coli-derived LPS (TLR4 ligand) for inducing the high IL-23-secreting DC-like phenotype, but greatly inferior for inducing IL-12 p70 production when paired with IFN-gamma, a distinction reflected in activated DCs" ability to deviate lymphocytes toward Th1. Adenosine Triphosphate 0-3 interferon gamma Homo sapiens 269-278 23461851-5 2013 It was further confirmed that ATP was released from HaCaT cells stimulated with IFN-gamma. Adenosine Triphosphate 30-33 interferon gamma Homo sapiens 80-89 24414257-3 2014 Here we show that IFN-gamma decreases ATP-mediated apical BK activation in normal human airway epithelial cells cultured at the air-liquid interface. Adenosine Triphosphate 38-41 interferon gamma Homo sapiens 18-27 22753954-8 2012 We found that pharmacological inhibition of P2X4 receptors with TNP-ATP inhibited transcriptional up-regulation of TNF-alpha and IFN-gamma in gammadelta T cells stimulated with anti-CD3/CD28-coated beads or IPP. Adenosine Triphosphate 68-71 interferon gamma Homo sapiens 129-138 22951220-10 2012 The explants exhibited a significant increase of caspase-3 activity when the colonic epithelial cells were incubated with IFN-gamma followed by ATP as compared to control cells. Adenosine Triphosphate 144-147 interferon gamma Homo sapiens 122-131 21102458-4 2010 Stimulation of antigen-presenting cells (APCs) with ATP led to increased expression of CD80 and CD86 in vitro and in vivo and actuated a cascade of proinflammatory events, including signal transducer and activator of transcription-1 (STAT1) phosphorylation, interferon-gamma (IFN-gamma) production and donor T cell expansion, whereas regulatory T cell numbers were reduced. Adenosine Triphosphate 52-55 interferon gamma Homo sapiens 258-274 21145936-11 2011 Moreover, ATP increased the production of the proinflammatory cytokines interleukin-2, interferon-gamma, and interleukin-12p70, while decreasing the anti-inflammatory cytokine interleukin-10, and this finding was associated with the reduced ability of MSCs to inhibit T-cell proliferation. Adenosine Triphosphate 10-13 interferon gamma Homo sapiens 87-103 20722064-9 2011 Addition of ATP to flagellin caused greater weight loss and increased antiflagellin antibody titers, as well as decreased colonic interferon gamma (IFN-gamma) and higher antiflagellin IgG1/IgG2 ratios, which indicate decreased Th1 polarization. Adenosine Triphosphate 12-15 interferon gamma Homo sapiens 130-157 21102458-4 2010 Stimulation of antigen-presenting cells (APCs) with ATP led to increased expression of CD80 and CD86 in vitro and in vivo and actuated a cascade of proinflammatory events, including signal transducer and activator of transcription-1 (STAT1) phosphorylation, interferon-gamma (IFN-gamma) production and donor T cell expansion, whereas regulatory T cell numbers were reduced. Adenosine Triphosphate 52-55 interferon gamma Homo sapiens 276-285 20670615-1 2010 The P2X7 receptor is an extracellular ATP-gated cation channel critical in inflammation and immunity, and can be up-regulated by IFN-gamma and LPS. Adenosine Triphosphate 38-41 interferon gamma Homo sapiens 129-138 20670615-8 2010 Co-incubation of cells with TGF-beta1 plus IFN-gamma and LPS prevented the up-regulation of P2X7 expression and ATP-induced ethidium(+) uptake in a concentration-dependent fashion with a maximum effect at 5ng/ml and with an IC(50) of ~0.4ng/ml. Adenosine Triphosphate 112-115 interferon gamma Homo sapiens 43-52 18521569-12 2008 CONCLUSIONS: ATP and ADP at high-micromolar concentrations reduce secretion of the main Th1 cytokines TNFalpha, IL-12(p70) and IFNgamma in LPS stimulated human blood. Adenosine Triphosphate 13-16 interferon gamma Homo sapiens 127-135 18805021-2 2008 In this study, supernatants from LPS/ATP-stimulated human monocytes were analyzed for their ability to induce IFNgamma production by KG-1 cells. Adenosine Triphosphate 37-40 interferon gamma Homo sapiens 110-118 18521569-0 2008 "Host tissue damage" signal ATP impairs IL-12 and IFNgamma secretion in LPS stimulated whole human blood. Adenosine Triphosphate 28-31 interferon gamma Homo sapiens 50-58 18521569-9 2008 ADP, ATPgammaS, BzATP, and CV1808, but not UTP displayed IL-12(p70) and IFNgamma reducing effect similar to ATP. Adenosine Triphosphate 5-8 interferon gamma Homo sapiens 72-80 20339378-1 2010 We have previously analysed the bioenergetic consequences of activating J774.A1 macrophages (MPhi) with interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS) and found that there is a nitric oxide (NO)-dependent mitochondrial impairment and stabilization of hypoxia-inducible factor (HIF)-1alpha, which synergize to activate glycolysis and generate large quantities of ATP. Adenosine Triphosphate 373-376 interferon gamma Homo sapiens 122-131 19306841-6 2009 Stimulation of HeLa cells with IFNgamma upregulates expression of P2X(7) mRNA and full-length protein, modifies ATP-dependent calcium fluxes, and renders the cells sensitive to ATP-induced apoptosis, which can be blocked by a P2X(7) antagonist. Adenosine Triphosphate 112-115 interferon gamma Homo sapiens 31-39 19306841-6 2009 Stimulation of HeLa cells with IFNgamma upregulates expression of P2X(7) mRNA and full-length protein, modifies ATP-dependent calcium fluxes, and renders the cells sensitive to ATP-induced apoptosis, which can be blocked by a P2X(7) antagonist. Adenosine Triphosphate 177-180 interferon gamma Homo sapiens 31-39 19306841-7 2009 IFNgamma treatment also increased dramatically the sensitivity of the intestinal epithelial cell line, HCT8, to ATP-induced apoptosis. Adenosine Triphosphate 112-115 interferon gamma Homo sapiens 0-8 17039239-3 2007 Notably, extracellular ATP displayed a complex regulation of IFN-gamma-stimulated chemokine expression, with upregulation of CC chemokine ligand 2 (CCL2), CCL5 and CXC chemokine ligand 8 (CXCL8), and suppression of the receptor CXC chemokine receptor 3 (CXCR3), CXCL9, CXCL10, and CXCL11. Adenosine Triphosphate 23-26 interferon gamma Homo sapiens 61-70 18678988-3 2008 We investigated effects of interferon-gamma (INF-gamma) on ATP-induced responses in vascular endothelial cells. Adenosine Triphosphate 59-62 interferon gamma Homo sapiens 27-43 18678988-3 2008 We investigated effects of interferon-gamma (INF-gamma) on ATP-induced responses in vascular endothelial cells. Adenosine Triphosphate 59-62 interferon gamma Homo sapiens 45-54 18678988-4 2008 Treatment of human umbilical vein endothelial cells (HUVECs) with IFN-gamma for 24 h resulted in an enhancement of the ATP-induced increase in intracellular Ca2+ concentration ([Ca2+]i) without affecting the UTP-induced one. Adenosine Triphosphate 119-122 interferon gamma Homo sapiens 66-75 18678988-5 2008 The increased Ca2+ response to ATP in IFN-gamma-treated cells was dependent on the extracellular Ca2+, and was not inhibited by the phospholipase C inhibitor U73122. Adenosine Triphosphate 31-34 interferon gamma Homo sapiens 38-47 18678988-7 2008 IFN-gamma increased P2X4-receptor mRNA and protein, accompanied by an increase in ATP-triggered membrane current. Adenosine Triphosphate 82-85 interferon gamma Homo sapiens 0-9 18472047-7 2008 Results showed that ATP decreased the rise in concentrations of TNF-alpha, interferon-gamma (IFN-gamma) and IL-1beta, but increased concentrations of IL-8 and IL-10. Adenosine Triphosphate 20-23 interferon gamma Homo sapiens 75-91 18472047-7 2008 Results showed that ATP decreased the rise in concentrations of TNF-alpha, interferon-gamma (IFN-gamma) and IL-1beta, but increased concentrations of IL-8 and IL-10. Adenosine Triphosphate 20-23 interferon gamma Homo sapiens 93-102 16474838-0 2006 The mutation in the ATP-binding region of JAK1, identified in human uterine leiomyosarcomas, results in defective interferon-gamma inducibility of TAP1 and LMP2. Adenosine Triphosphate 20-23 interferon gamma Homo sapiens 114-130 17015954-2 2006 In this study, we investigated the change in Ca2+-ATPase activities and ATP levels in the human lens epithelial cell line SRA 01/04 (HLE cells) with the stimulation of interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS). Adenosine Triphosphate 50-53 interferon gamma Homo sapiens 168-184 17015954-2 2006 In this study, we investigated the change in Ca2+-ATPase activities and ATP levels in the human lens epithelial cell line SRA 01/04 (HLE cells) with the stimulation of interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS). Adenosine Triphosphate 50-53 interferon gamma Homo sapiens 186-195 17015954-5 2006 Ca2+-ATPase activities increased and ATP levels decreased in HLE cells stimulated with the combination of IFN-gamma and LPS. Adenosine Triphosphate 5-8 interferon gamma Homo sapiens 106-115 16474838-7 2006 We now identify the G871E mutation in the ATP-binding region of Janus kinases 1, suggesting that the loss of TAP1 and LMP2 induction is a defect in the earliest steps of the IFN-gamma-signal pathway, resulting in the inability of SKN cells to upregulate the antigen-processing pathway. Adenosine Triphosphate 42-45 interferon gamma Homo sapiens 174-183 14607949-4 2003 IFN-gamma-primed, mycobacteria-infected macrophages from wild-type individuals were incubated with ATP and this induced apoptosis and reduced mycobacterial viability by 90%. Adenosine Triphosphate 99-102 interferon gamma Homo sapiens 0-9 16574426-3 2006 ATP-depletion or inhibition of N-glycosylation was found to cause IFN-gamma to accumulate into detergent-insoluble aggregates in the ER. Adenosine Triphosphate 0-3 interferon gamma Homo sapiens 66-75 16574426-5 2006 Interaction of the five first chaperones with IFN-gamma was regulated co-ordinately by ATP. Adenosine Triphosphate 87-90 interferon gamma Homo sapiens 46-55 16118322-6 2005 We demonstrate also that ATP significantly potentiates the up-regulation of IDO--a negative regulator of T lymphocyte proliferation--and kynurenine production initiated by interferon-gamma (IFN-gamma) in human DCs. Adenosine Triphosphate 25-28 interferon gamma Homo sapiens 172-188 16118322-6 2005 We demonstrate also that ATP significantly potentiates the up-regulation of IDO--a negative regulator of T lymphocyte proliferation--and kynurenine production initiated by interferon-gamma (IFN-gamma) in human DCs. Adenosine Triphosphate 25-28 interferon gamma Homo sapiens 190-199 15721216-3 2005 Immunostimulation with LPS+IFN-gamma induced the sustained activation of ERK1/2 for up to 48 h. Glucose deprivation caused the loss of ATP and consequently cell death in immunostimulated astroglia, which was significantly blocked by the treatment with the ERK kinase (MEK1) inhibitor, PD98059 (10-40 microM), to inhibit the ERK1/2 pathways. Adenosine Triphosphate 135-138 interferon gamma Homo sapiens 27-36 15734263-12 2005 In parallel with the increase in endogenous NO, administration of LPS and IFN-gamma suppressed cell viability, mitochondrial membrane potential, and ATP synthesis. Adenosine Triphosphate 149-152 interferon gamma Homo sapiens 74-83 15130941-6 2004 Amphoterin was secreted from phorbol ester and interferon-gamma (IFN-gamma)-activated macrophages, and the secretion was inhibited by blocking the adenosine 5"-triphosphate (ATP)-binding cassette transporter-1, a member of the multidrug resistance protein family. Adenosine Triphosphate 147-172 interferon gamma Homo sapiens 65-74 15130941-6 2004 Amphoterin was secreted from phorbol ester and interferon-gamma (IFN-gamma)-activated macrophages, and the secretion was inhibited by blocking the adenosine 5"-triphosphate (ATP)-binding cassette transporter-1, a member of the multidrug resistance protein family. Adenosine Triphosphate 174-177 interferon gamma Homo sapiens 65-74 15942904-10 2005 CONCLUSIONS: Various polymorphisms in P2X7 abrogate IFN- gamma /ATP-induced killing of mycobacteria by human macrophages and, thus, may contribute to variability in susceptibility to mycobacterial infections. Adenosine Triphosphate 64-67 interferon gamma Homo sapiens 52-62 14746803-3 2003 Using DD-PCR analysis, adenine nucleotide translocase (ANT) 3, an enzyme which exchanges ATP and ADP through mitochondrial membrane, has been identified as a novel target counter-regulated by IL-4 and IFN-gamma. Adenosine Triphosphate 89-92 interferon gamma Homo sapiens 201-210 11160202-6 2001 As a result, T cell lines generated from allogeneic naive CD45RA(+) T cells primed with DCs matured in the presence of ATP produced lower amounts of IFN-gamma and higher levels of IL-4, IL-5, and IL-10 compared with T cell lines obtained with LPS-stimulated DCs. Adenosine Triphosphate 119-122 interferon gamma Homo sapiens 149-158 12626548-7 2003 Depletion of extracellular ATP also inhibited secretion of IFN-gamma, but not IL-4, supporting the interpretation that extracellular ATP is required for secretion of some, but not all, cytokines. Adenosine Triphosphate 27-30 interferon gamma Homo sapiens 59-68 12626548-7 2003 Depletion of extracellular ATP also inhibited secretion of IFN-gamma, but not IL-4, supporting the interpretation that extracellular ATP is required for secretion of some, but not all, cytokines. Adenosine Triphosphate 133-136 interferon gamma Homo sapiens 59-68 12090349-3 2001 We hypothesized that treatments with liposome encapsulated ATP or NAD+ would protect human endothelial cells exposed to endotoxin (LPS) and interferon-gamma (IFN-gamma) from energy failure. Adenosine Triphosphate 59-62 interferon gamma Homo sapiens 140-156 12090349-3 2001 We hypothesized that treatments with liposome encapsulated ATP or NAD+ would protect human endothelial cells exposed to endotoxin (LPS) and interferon-gamma (IFN-gamma) from energy failure. Adenosine Triphosphate 59-62 interferon gamma Homo sapiens 158-167 11342663-0 2001 ATP mediates calcium signaling between astrocytes and microglial cells: modulation by IFN-gamma. Adenosine Triphosphate 0-3 interferon gamma Homo sapiens 86-95 11342663-6 2001 IFN-gamma increased ATP release and potentiated the P2X(7)-mediated cytolytic effect. Adenosine Triphosphate 20-23 interferon gamma Homo sapiens 0-9 12626548-0 2003 Secretion of IL-2 and IFN-gamma, but not IL-4, by antigen-specific T cells requires extracellular ATP. Adenosine Triphosphate 98-101 interferon gamma Homo sapiens 22-31 9867857-4 1999 Similar to other nuclear import signals, we show that a peptide representing amino acids 95-132 of IFN-gamma (IFN-gamma(95-132)) containing the polybasic sequence 126RKRKRSR132 was capable of specifying nuclear uptake of the autofluorescent protein, APC, in an energy-dependent fashion that required both ATP and GTP. Adenosine Triphosphate 305-308 interferon gamma Homo sapiens 99-108 10470745-14 1999 CONCLUSION: Mild acidosis augments IFN-gamma-induced intestinal epithelial hyperpermeability and ATP depletion, possibly by fostering the formation of peroxynitrous acid and/or hydroxyl radical. Adenosine Triphosphate 97-100 interferon gamma Homo sapiens 35-44 10470745-12 1999 However, when the cells were incubated for 72 hrs with the same concentration of IFN-gamma under mildly acidic conditions (i.e., pHo 7.0 or 6.6), ATP levels were significantly decreased. Adenosine Triphosphate 146-149 interferon gamma Homo sapiens 81-90 9867857-4 1999 Similar to other nuclear import signals, we show that a peptide representing amino acids 95-132 of IFN-gamma (IFN-gamma(95-132)) containing the polybasic sequence 126RKRKRSR132 was capable of specifying nuclear uptake of the autofluorescent protein, APC, in an energy-dependent fashion that required both ATP and GTP. Adenosine Triphosphate 305-308 interferon gamma Homo sapiens 110-119 8955215-8 1996 Finally, IFN-gamma and LPS synergistically up-regulated mRNA encoding the P2X7 receptor, a recently cloned ATP-gated channel that exhibits a P2zR phenotype. Adenosine Triphosphate 107-110 interferon gamma Homo sapiens 9-18 7544574-5 1995 In the presence of limiting concentrations (micromolar) of ATP, activation was also dependent upon stimulation with IFN-gamma, whereas at millimolar concentrations of ATP, gamma RF-1 was activated by either sodium orthovanadate or pervanadate in the absence of ligand. Adenosine Triphosphate 59-62 interferon gamma Homo sapiens 116-125 8847103-4 1995 On the contrary, ATP and glutamate treatment of astrocytes prior to a combination of interleukin-1 beta and interferon-gamma markedly reduced (30-50%) subsequent NOS mRNA expression. Adenosine Triphosphate 17-20 interferon gamma Homo sapiens 108-124 1918978-0 1991 IFN-gamma enhances sensitivity of human macrophages to extracellular ATP-mediated lysis. Adenosine Triphosphate 69-72 interferon gamma Homo sapiens 0-9 7538819-4 1995 We have also shown that ATP caused the lysis of human macrophages, and that treatment of cells with interferon gamma (IFN gamma) rendered macrophages significantly more sensitive to ATP than untreated cells. Adenosine Triphosphate 24-27 interferon gamma Homo sapiens 100-116 7538819-4 1995 We have also shown that ATP caused the lysis of human macrophages, and that treatment of cells with interferon gamma (IFN gamma) rendered macrophages significantly more sensitive to ATP than untreated cells. Adenosine Triphosphate 182-185 interferon gamma Homo sapiens 100-116 7538819-4 1995 We have also shown that ATP caused the lysis of human macrophages, and that treatment of cells with interferon gamma (IFN gamma) rendered macrophages significantly more sensitive to ATP than untreated cells. Adenosine Triphosphate 182-185 interferon gamma Homo sapiens 118-127 7768980-4 1995 Of the compounds tested, three antagonists of calmodulin-linked pathways (trifluoperazine, KN-62, and calmidazolium) blocked the ATP-mediated lysis of both interferon-gamma-treated and colony-stimulating factor-treated macrophages in a dose-dependent manner. Adenosine Triphosphate 129-132 interferon gamma Homo sapiens 156-172 8206875-4 1994 Interestingly, IFN-gamma dramatically stimulated the trypsin-like and chymotrypsin-like activities of the multifunctional proteasome and depressed the peptidylglutamyl-peptide-hydrolyzing activity, without affecting the activity for ATP-, ubiquitin-dependent proteolysis. Adenosine Triphosphate 233-236 interferon gamma Homo sapiens 15-24 8321205-2 1993 In a membrane-enriched fraction prepared from human peripheral blood monocytes, IFN-gamma activation of FcRF gamma occurred within 1 min and was ATP dependent. Adenosine Triphosphate 145-148 interferon gamma Homo sapiens 80-89 34636650-14 2021 This work suggests a novel mechanistic basis for pathologic T-lymphocyte-endothelial interactions in atherosclerosis mediated by IFN-gamma, linking endothelial glucose, tryptophan, and fatty acid metabolism with NAD(H) and ATP generation, and their adverse endothelial functional consequences. Adenosine Triphosphate 223-226 interferon gamma Homo sapiens 129-138 35433496-2 2022 Both ATP-dependent chromatin remodeling complex and histone modifications has been shown to be involved in the activation of IFNgamma responsive genes. Adenosine Triphosphate 5-8 interferon gamma Homo sapiens 125-133 30092288-11 2019 JH2 ATP site targeting has the potential for reduced side effects by retaining erythropoietin and IFN-gamma functions. Adenosine Triphosphate 4-7 interferon gamma Homo sapiens 98-107 3010991-1 1986 Recombinant human interferon-gamma was phosphorylated with ATP and c-AMP-dependent protein kinase. Adenosine Triphosphate 59-62 interferon gamma Homo sapiens 18-34 32302669-3 2020 In this study, by using live cell imaging and biochemical approaches, we demonstrate that IFN-gamma plus high glucose augment endothelial connexin43 hemichannel activity, resulting in the increase of ATP release, ATP-mediated Ca2+ dynamics and production of nitric oxide and superoxide anion, as well as impaired insulin-mediated uptake and intercellular diffusion of glucose and cell survival. Adenosine Triphosphate 200-203 interferon gamma Homo sapiens 90-99 32302669-3 2020 In this study, by using live cell imaging and biochemical approaches, we demonstrate that IFN-gamma plus high glucose augment endothelial connexin43 hemichannel activity, resulting in the increase of ATP release, ATP-mediated Ca2+ dynamics and production of nitric oxide and superoxide anion, as well as impaired insulin-mediated uptake and intercellular diffusion of glucose and cell survival. Adenosine Triphosphate 213-216 interferon gamma Homo sapiens 90-99