PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30126430-11 2018 In THP-1 cells, RIP3 and NLRP3 interaction was enhanced by LPS/ATP stimulation resulting in IL-1beta and IL-18 production. Adenosine Triphosphate 63-66 GLI family zinc finger 2 Homo sapiens 3-8 28013001-9 2017 The basal respiration level and ATP-production decreased in the THP-1 cells exposed to the IC50 of DON with no major impact on mitochondrial function. Adenosine Triphosphate 32-35 GLI family zinc finger 2 Homo sapiens 64-69 29077063-5 2017 ATP evoked a concentration-dependent increase in intracellular calcium in both THP-1 monocyte and macrophages. Adenosine Triphosphate 0-3 GLI family zinc finger 2 Homo sapiens 79-84 26212544-3 2015 The NLRP3 inflammasome could be activated by lipopolysaccharide (LPS) plus ATP or monosodium urate (MSU) in PMA-pretreated THP-1 macrophages. Adenosine Triphosphate 75-78 GLI family zinc finger 2 Homo sapiens 123-128 27528275-3 2016 Moreover, ATP signaling is required for the ensuing recognition and phagocytosis of damaged erythrocytes by the monocytic cell line THP-1. Adenosine Triphosphate 10-13 GLI family zinc finger 2 Homo sapiens 132-137 30090452-7 2016 We also detected that THP-1 cells only partially hydrolyse extracellular adenosine triphosphate, leading to accumulation of the mono-phosphate derivative, AMP. Adenosine Triphosphate 73-95 GLI family zinc finger 2 Homo sapiens 22-27 27103438-3 2016 Here, we demonstrate for the first time that TSPO ligands, especially Ro5-4864, potently suppressed ATP-induced NLRP3 inflammasome activation in THP-1 and BMDM cells. Adenosine Triphosphate 100-103 GLI family zinc finger 2 Homo sapiens 145-150 26616294-9 2016 The aim of our study was to evaluate the effect of ANP on IL-1beta/NALP3/caspase-1 expression in LPS/ATP-stimulated human THP1 monocytes. Adenosine Triphosphate 101-104 GLI family zinc finger 2 Homo sapiens 122-126 26054298-5 2015 Notably, treatment of supernatants with Apyrase to remove ATP potently inhibited migration of THP-1 monocytes and partially blocked migration of primary human monocytes. Adenosine Triphosphate 58-61 GLI family zinc finger 2 Homo sapiens 94-99 25271060-7 2014 We demonstrate that THP-1 cells rapidly secrete ATP during signalling downstream of the CCL2-CCR2 axis and suggest this might act as a mechanism for P2Y6 receptor co-activation following CCL2 activation of the CCR2 receptor. Adenosine Triphosphate 48-51 GLI family zinc finger 2 Homo sapiens 20-25 26317859-9 2015 METHODS: THP-1 macrophages were treated with hydrogen peroxide and extracellular ATP in the presence or absence of AT-RvD1 (1000-0.1 nM). Adenosine Triphosphate 81-84 GLI family zinc finger 2 Homo sapiens 9-14 25639477-9 2015 However, co-treatment of THP-1 cells with ATP and 1,25(OH)2D3 resulted in more IL-1beta secretion than ATP or 1,25(OH)2D3 alone. Adenosine Triphosphate 42-45 GLI family zinc finger 2 Homo sapiens 25-30 25639477-9 2015 However, co-treatment of THP-1 cells with ATP and 1,25(OH)2D3 resulted in more IL-1beta secretion than ATP or 1,25(OH)2D3 alone. Adenosine Triphosphate 103-106 GLI family zinc finger 2 Homo sapiens 25-30 25192940-10 2014 Furthermore, in vitro studies on two macrophage cell lines (J774A.1 and THP-1) revealed that ATP uptake is improved consistently with the iron content of CS-Fe/ATP nanoparticles, and correlated to their lower dissociation in biological medium, allowing interesting perspectives for the intracellular delivery of ATP. Adenosine Triphosphate 93-96 GLI family zinc finger 2 Homo sapiens 72-77 25192940-10 2014 Furthermore, in vitro studies on two macrophage cell lines (J774A.1 and THP-1) revealed that ATP uptake is improved consistently with the iron content of CS-Fe/ATP nanoparticles, and correlated to their lower dissociation in biological medium, allowing interesting perspectives for the intracellular delivery of ATP. Adenosine Triphosphate 160-163 GLI family zinc finger 2 Homo sapiens 72-77 25192940-10 2014 Furthermore, in vitro studies on two macrophage cell lines (J774A.1 and THP-1) revealed that ATP uptake is improved consistently with the iron content of CS-Fe/ATP nanoparticles, and correlated to their lower dissociation in biological medium, allowing interesting perspectives for the intracellular delivery of ATP. Adenosine Triphosphate 160-163 GLI family zinc finger 2 Homo sapiens 72-77 24275551-10 2014 Although leptin (and LPS) has a synergistic effect with exogenous ATP on IL-18 secretion in both THP-1 and primary monocytes, experiments involving ATP assays and pharmacological inhibition of ATP signalling failed to provide any evidence that endogenous ATP secreted by leptin-stimulated monocytes was responsible for enhancement of monocyte IL-18 secretion by leptin. Adenosine Triphosphate 66-69 GLI family zinc finger 2 Homo sapiens 97-102 20860495-11 2010 In THP-1, AMP kinase (AMPK), which is activated when ATP becomes limiting, was rapidly phosphorylated by 2-DG, and expression of Bcl-2 was augmented, which might result in resistance to 2-DG. Adenosine Triphosphate 53-56 GLI family zinc finger 2 Homo sapiens 3-8 21664691-3 2011 In this report, we demonstrate that LtxA induces very rapid (1h) apoptosis in acute monocytic leukemia THP-1 cells characterized by binding of annexin V to cells, loss of mitochondrial membrane potential, depletion of cellular ATP, and fragmentation of chromosomal DNA. Adenosine Triphosphate 227-230 GLI family zinc finger 2 Homo sapiens 103-108 23777496-4 2013 THP-1 cells were preincubated with CsA, then stimulated with lipopolysaccharide (LPS), polyinosinic:polycytidylic acid or adenosine triphosphate. Adenosine Triphosphate 122-144 GLI family zinc finger 2 Homo sapiens 0-5 15600209-3 2003 RESULTS: (1) It was found that 0.4 mmol/L ATP enhanced obviously the fluorenscence strength of THP-1, NB4 and HL-60 cells, the activity rates were 54.91%, 39.45% and 30.46%, respectively. Adenosine Triphosphate 42-45 GLI family zinc finger 2 Homo sapiens 95-100 20399260-0 2010 Fluoride as a pro-inflammatory factor and inhibitor of ATP bioavailability in differentiated human THP1 monocytic cells. Adenosine Triphosphate 55-58 GLI family zinc finger 2 Homo sapiens 99-103 18187519-4 2008 DNP treatment of the human THP-1 macrophage cell line resulted in reduced ATP synthesis, and, although hyporesponsive to LPS, the metabolically stressed macrophages produced IL-1beta, IL-6, and TNF-alpha. Adenosine Triphosphate 74-77 GLI family zinc finger 2 Homo sapiens 27-32 34387857-3 2021 We examined the intracellular localization of human Pellino-2 in THP1-derived macrophages during activation with LPS and ATP. Adenosine Triphosphate 121-124 GLI family zinc finger 2 Homo sapiens 65-69 11254628-3 2001 Exposure of monocytic (THP-1) or epithelial (ECV304) cells to 40 to 160 ng/ml alpha-toxin provoked a drop in cellular ATP level that was followed by secretion of substantial amounts of interleukin-8 (IL-8). Adenosine Triphosphate 118-121 GLI family zinc finger 2 Homo sapiens 23-28 10516107-7 1999 In both THP-1 and HEK cells, MTX- and Bz-ATP-induced pores activate with similar kinetics and exhibit similar size exclusion. Adenosine Triphosphate 41-44 GLI family zinc finger 2 Homo sapiens 8-13 35563697-8 2022 Our results revealed that CBD and, for the first time, THC significantly inhibited NLRP3 inflammasome activation following LPS + ATP stimulation, leading to a reduction in the levels of IL-1beta in THP-1 macrophages and HBECs. Adenosine Triphosphate 129-132 GLI family zinc finger 2 Homo sapiens 198-203 34217685-2 2021 In this study, the effect of luteolin on pyroptosis and the underlying mechanism were investigated using the canonical NLRP3 inflammasome in THP-1 macrophages induced by LPS/ATP. Adenosine Triphosphate 174-177 GLI family zinc finger 2 Homo sapiens 141-146 32538272-0 2020 Multi-walled carbon nanotubes induce IL-1beta secretion by activating hemichannels-mediated ATP release in THP-1 macrophages. Adenosine Triphosphate 92-95 GLI family zinc finger 2 Homo sapiens 107-112 33524445-2 2021 Niclosamide, CCCP and BAM15 inhibited LPS plus ATP-induced increases of NLRP3 protein and IL-1beta mRNA levels in RAW264.7 macrophages and THP-1 derived macrophages. Adenosine Triphosphate 47-50 GLI family zinc finger 2 Homo sapiens 139-144 32866784-8 2020 Additionally, IL-1beta/IL-18 secretion from ATP + LPS stimulated THP-1-derived macrophages was RalA-dependently suppressed by levornidazole, suggesting that RalA might have an inhibitory effect on NLRP3 inflammasome activation. Adenosine Triphosphate 44-47 GLI family zinc finger 2 Homo sapiens 65-70 32627113-0 2020 Transient receptor potential ankyrin 1 contributes to the ATP-elicited oxidative stress and inflammation in THP-1-derived macrophage. Adenosine Triphosphate 58-61 GLI family zinc finger 2 Homo sapiens 108-113 32627113-4 2020 In this study, we suggested that transient receptor potential ankyrin 1 (TRPA1), a member of TRP superfamily, participates in ATP-induced oxidative stress and inflammation in human acute monocytic leukemia cell line (THP-1)-derived macrophage. Adenosine Triphosphate 126-129 GLI family zinc finger 2 Homo sapiens 217-222 32538272-4 2020 Our results showed that the unmodified and COOH MWCNTs could induce ATP release and ATP-P2X7R axis-dependent IL-1beta secretion from THP-1 macrophages. Adenosine Triphosphate 68-71 GLI family zinc finger 2 Homo sapiens 133-138 30735689-3 2019 Undifferentiated THP1 cells constitutively express NLRP3, and NLRP3 inflammasome activation occurred in response to canonical NLRP3 activation stimuli including nigericin, ATP, and urea crystals, culminating in pro-IL-1beta cleavage, extracellular release of mature IL-1beta, and pyroptosis. Adenosine Triphosphate 172-175 GLI family zinc finger 2 Homo sapiens 17-21 30081297-1 2018 Previously, we reported pivotal role of P2RX7 in augmenting autophagy in THP-1 cells upon Calcimycin treatment by modulating intracellular Calcium regulated ATP production but the role of immune modulators in Calcimycin induced autophagy is not known. Adenosine Triphosphate 157-160 GLI family zinc finger 2 Homo sapiens 73-78 32022249-4 2020 HepG2 cells were incubated in conditioned medium from LPS/ATP-activated THP-1 human macrophages with silenced or overexpressed P2X7R. Adenosine Triphosphate 58-61 GLI family zinc finger 2 Homo sapiens 72-77 32022249-6 2020 HepG2 cells were cultured with the conditioned medium from the LPS/ATP-activated THP-1 macrophages. Adenosine Triphosphate 67-70 GLI family zinc finger 2 Homo sapiens 81-86 32022249-12 2020 SIRT1-LKB1-AMPK-SREBP1 axis-mediated lipid accumulation in HepG2 cells was reduced, when HepG2 cells were cultured with conditioned medium from LPS/ATP-activated THP-1 macrophages pretreated with 2354glu. Adenosine Triphosphate 148-151 GLI family zinc finger 2 Homo sapiens 162-167