PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33813098-4	2021	We hypothesised that both ATP- and flow-induced eNOS activation are regulated by SOCE derived from Orai1 channels and members of the transient receptor potential canonical (TRPC) channel family.	Adenosine Triphosphate	26-29	nitric oxide synthase 3	Bos taurus	48-52	
33813098-6	2021	The peak and sustained ATP-induced calcium signal and the resulting eNOS activation were attenuated by inhibition of TRPC3, which we found to be store operated.	Adenosine Triphosphate	23-26	nitric oxide synthase 3	Bos taurus	68-72	
33813098-10	2021	Our results suggest that TRPC3 is a store-operated channel in BAECs and is the key regulator of ATP-induced eNOS activation, whereas flow stimulation also recruits TRPC4 into the pathway for the synthesis of NO.	Adenosine Triphosphate	96-99	nitric oxide synthase 3	Bos taurus	108-112	
10899167-7	2000	Evidence for the direct phosphorylation of eNOS by MAP kinase in BAEC came from "back-phosphorylation" experiments using [gamma-(32)P]ATP and ERK in vitro to phosphorylate eNOS isolated from cells previously treated with bradykinin or the MAP kinase inhibitor PD98059.	Adenosine Triphosphate	134-137	nitric oxide synthase 3	Bos taurus	43-47	
21454579-10	2011	Mutating the Ser-635 to nonphosphorylatable alanine prevented ATP from activating eNOS in cells.	Adenosine Triphosphate	62-65	nitric oxide synthase 3	Bos taurus	82-86	
34474112-4	2021	As such, this study sought to characterise the contribution of PKCeta and PKCbeta in regulating calcium signaling and endothelial nitric oxide synthase (eNOS) activation after exposure of endothelial cells to ATP or shear stress.	Adenosine Triphosphate	209-212	nitric oxide synthase 3	Bos taurus	153-157	
34474112-6	2021	The participation of PKC isozymes in calcium flux, eNOS phosphorylation and NO production was assessed following stimulation with ATP or shear stress.	Adenosine Triphosphate	130-133	nitric oxide synthase 3	Bos taurus	51-55	
9223444-4	1997	Exposure of BAEC to the eNOS-activating agonists, BK, histamine, or ATP produces transient increases in the amounts of detergent-insoluble caveolin-1.	Adenosine Triphosphate	68-71	nitric oxide synthase 3	Bos taurus	24-28