PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19752021-4 2009 This embryonic lethality is not likely caused by gross energy deprivation, as Drp1-null cells showed normal intracellular adenosine triphosphate levels. Adenosine Triphosphate 122-144 dynamin 1-like Mus musculus 78-82 32521505-9 2020 In particular, the Dnm1l knockout most significantly affected mitochondrial morphology, energy metabolism, and ATP production in ESCs. Adenosine Triphosphate 111-114 dynamin 1-like Mus musculus 19-24 34310799-6 2021 In contrast, the transfection of ALR into LEPCs significantly inhibited Drp1 phosphorylation, thereby favoring the maintenance of mitochondrial integrity and the preservation of ATP contents in LEPCs. Adenosine Triphosphate 178-181 dynamin 1-like Mus musculus 72-76 29166700-5 2018 Suppression of DLP1 expression by DPL1 RNAi inhibited prion-induced mitochondrial fragmentation and dysfunction (measured by ADP/ATP ratio, mitochondrial membrane potential, and mitochondrial integrity). Adenosine Triphosphate 129-132 dynamin 1-like Mus musculus 15-19 26825530-6 2016 When isolated from diabetic mice and cultured in high glucose, Drp1-null podocytes had more elongated mitochondria and better mitochondrial fitness associated with enhanced oxygen consumption and ATP production than wild-type podocytes. Adenosine Triphosphate 196-199 dynamin 1-like Mus musculus 63-67 24284040-6 2014 Drp-1 siRNA transfection preserved the mitochondrial membrane potential (MMP), reduced cytochrome c release, enhanced ATP production, and partly prevented mitochondrial swelling. Adenosine Triphosphate 118-121 dynamin 1-like Mus musculus 0-5 29673648-6 2018 However, inhibition of Drp1 by Mdivi1 (Drp1 inhibitor) resulted in higher OxPhos ATP production and lower mitochondrial membrane potential. Adenosine Triphosphate 81-84 dynamin 1-like Mus musculus 23-27 29673648-6 2018 However, inhibition of Drp1 by Mdivi1 (Drp1 inhibitor) resulted in higher OxPhos ATP production and lower mitochondrial membrane potential. Adenosine Triphosphate 81-84 dynamin 1-like Mus musculus 39-43 28432138-4 2017 Inhibition of Drp1 alleviates mitochondrial fragmentation, loss of mitochondrial membrane potential, reactive oxygen species production, ATP reduction, and synaptic depression in Abeta-treated neurons. Adenosine Triphosphate 137-140 dynamin 1-like Mus musculus 14-18 26370078-9 2015 In conclusion, failure of Drp1 disassembly impairs mitophagy, leading to a downstream cascade of mitochondrial depolarization, aberrant calcium handling, impaired ATP synthesis, and activation of sterile myocardial inflammation, resulting in heart failure. Adenosine Triphosphate 163-166 dynamin 1-like Mus musculus 26-30 25880092-8 2015 Although Drp1KO increased the distance between axonal mitochondria, mitochondrial-derived ATP still decreased similarly in Drp1KO boutons with and without mitochondria. Adenosine Triphosphate 90-93 dynamin 1-like Mus musculus 123-129 25880092-9 2015 This indicates that mitochondrial-derived ATP is rapidly dispersed in Drp1KO axons, and that the deficits in axonal bioenergetics and function are not caused by regional energy gradients. Adenosine Triphosphate 42-45 dynamin 1-like Mus musculus 70-76