PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34261790-3	2021	Here, using a comprehensive set of structural, biophysical, and cell biological tools, we have uncovered a CL-binding motif (CBM) conserved between the Drp1 variable domain (VD) and the unrelated ADP/ATP carrier (AAC/ANT) that intercalates into the membrane core to effect specific CL interactions.	Adenosine Triphosphate	200-203	dynamin 1 like	Homo sapiens	152-156	
35368865-10	2022	Mechanistically, overexpressed Drp1 damaged mitochondria by overproduction of reactive oxygen species (ROS), which induced mitochondrial OXPHOS inhibition and decline of ATP production.	Adenosine Triphosphate	170-173	dynamin 1 like	Homo sapiens	31-35	
35368865-13	2022	Moreover, the decreased ATP production induced by Drp1 overexpressing activated the AMPK cellular energy stress sensor and enhanced autophagy through the AMPK-ULK1 pathway, which might play a protective role in PA growth.	Adenosine Triphosphate	24-27	dynamin 1 like	Homo sapiens	50-54	
32910998-5	2020	The results showed that blockage of dynamin-related protein-1 (Drp1) by mitochondrial division inhibitor 1 (Mdivi-1, 15 muM) apparently restored 3-MCPD-induced mitochondrial dysfunction, accompanied by prevented the collapse of mitochondrial membrane potential and ATP depletion, and suppressed the occurrence of autophagy.	Adenosine Triphosphate	265-268	dynamin 1 like	Homo sapiens	36-61	
32910998-5	2020	The results showed that blockage of dynamin-related protein-1 (Drp1) by mitochondrial division inhibitor 1 (Mdivi-1, 15 muM) apparently restored 3-MCPD-induced mitochondrial dysfunction, accompanied by prevented the collapse of mitochondrial membrane potential and ATP depletion, and suppressed the occurrence of autophagy.	Adenosine Triphosphate	265-268	dynamin 1 like	Homo sapiens	63-67	
29768044-7	2018	Mitochondrial division inhibitor-1, pharmacological inhibition of Drp1, not only inhibited mitochondrial fission but also protected against CoCl2-induced PDLSC dysfunction, as shown by increased mitochondrial membrane potential, increased ATP level, reduced reactive oxygen species (ROS) level, and decreased apoptosis.	Adenosine Triphosphate	239-242	dynamin 1 like	Homo sapiens	66-70	
29993201-7	2018	Moreover, knockdown of Drp1 markedly blocked IR-783-mediated mitochondrial fission, loss of MMP, ATP depletion, mPTP opening and apoptosis.	Adenosine Triphosphate	97-100	dynamin 1 like	Homo sapiens	23-27	
32969792-9	2020	In HaCaT cells, Drp1 transfection altered cellular ATP and proliferation, induced G2/M arrest, and affected inflammatory mediator (TNF-alpha, IL-6 and CXCL8) release.	Adenosine Triphosphate	51-54	dynamin 1 like	Homo sapiens	16-20	
29768044-8	2018	Furthermore, N-acety-l-cysteine, a pharmacological inhibitor of ROS, also abolished CoCl2-induced expression of Drp1 and protected against CoCl2-induced PDLSC dysfunction, as shown by restored mitochondrial membrane potential, ATP level, inhibited mitochondrial fission, and decreased apoptosis.	Adenosine Triphosphate	227-230	dynamin 1 like	Homo sapiens	112-116	
23772688-8	2013	Importantly, inhibition of Drp1 reversed the effects of knocking down Pink1 on neuronal death and ATP production in response to OGD.	Adenosine Triphosphate	98-101	dynamin 1 like	Homo sapiens	27-31	
24733894-6	2014	Interference of HCV-induced mitochondrial fission and mitophagy by Drp1 silencing suppressed HCV secretion, with a concomitant decrease in cellular glycolysis and ATP levels, as well as enhanced innate immune signaling.	Adenosine Triphosphate	163-166	dynamin 1 like	Homo sapiens	67-71	
29478834-4	2018	Genetic or pharmacological abrogation of DRP1 activity abolished circadian network dynamics and mitochondrial respiratory activity and eliminated circadian ATP production.	Adenosine Triphosphate	156-159	dynamin 1 like	Homo sapiens	41-45	
26514444-9	2015	These results suggest that Drp1 is required for functionally active mitochondria, and supplementing with ATP can restore the defects induced by Drp1 suppression.	Adenosine Triphosphate	105-108	dynamin 1 like	Homo sapiens	144-148	
24206264-9	2014	However, Drp1 KO MEF were slightly less sensitive to this ABT-737-induced respiratory inhibition compared with WT, and were resistant to an initial ABT-737-induced increase in ATP synthesis-independent O2 consumption.	Adenosine Triphosphate	176-179	dynamin 1 like	Homo sapiens	9-13	
21326213-4	2011	Moreover, Drp1 knockdown enhanced mitochondrial depolarization and T-cell receptor signal strength, but decreased myosin phosphorylation, ATP production and T-cell receptor assembly at the central supramolecular activation cluster (cSMAC).	Adenosine Triphosphate	138-141	dynamin 1 like	Homo sapiens	10-14	
17682056-5	2007	Once in mitochondria, Drp1 provokes an impairment of the mitochondrial electron transport chain, which results in dissipation of mitochondrial transmembrane potential, reactive oxygen species generation, and a drop in ATP levels.	Adenosine Triphosphate	218-221	dynamin 1 like	Homo sapiens	22-26