PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35209223-6 2022 Bioinformatics analysis revealed these proteins are mainly ATP-binding and/or ATPase activity proteins, such as CKB, HSP86, HSP70-1, HSP90, ATPSF1beta and ACTG1, and highly associated with the regulation of the role of PKR in interferon induction and the antiviral response signaling pathway (P = 10-6), PI3K/AKT signaling pathway (P = 10-5) and eNOS signaling pathway (P = 10-4). Adenosine Triphosphate 59-62 nitric oxide synthase 3 Homo sapiens 346-350 10510297-1 1999 The endothelial nitric oxide synthase (eNOS) is activated in response to stimulation of endothelial cells by a number of vasoactive substances including, bradykinin (BK), angiotensin II (Ang II), endothelin-1 (ET-1) and ATP. Adenosine Triphosphate 220-223 nitric oxide synthase 3 Homo sapiens 4-37 9277445-1 1997 In a previous study, we reported that nitric oxide (.NO) affects surfactant synthesis and ATP levels in alveolar type II cells and suggested that there is constitutive nitric oxide synthase (cNOS) activity in the cells. Adenosine Triphosphate 90-93 nitric oxide synthase 3 Homo sapiens 191-195 35209223-7 2022 The results show that baicalin exerts multiply pharmacological functions, such as antiviral, anti-inflammatory, antitumor, and antioxidant functions, through regulating the PKR and PI3K/AKT/eNOS signaling pathways by targeting ATP-binding and ATPase activity proteins. Adenosine Triphosphate 227-230 nitric oxide synthase 3 Homo sapiens 190-194 28138348-7 2017 Our results show that cholesterol enrichment abolished ATP-induced eNOS phosphorylation and attenuated the calcium response by the preferential inhibition of CCE. Adenosine Triphosphate 55-58 nitric oxide synthase 3 Homo sapiens 67-71 31281593-4 2019 The reduction in NOS3 was accompanied by decreased migratory capacity, which depends on intact mitochondria and ATP formation. Adenosine Triphosphate 112-115 nitric oxide synthase 3 Homo sapiens 17-21 20042732-0 2010 Shear stress-induced ATP-mediated endothelial constitutive nitric oxide synthase expression in human lymphatic endothelial cells. Adenosine Triphosphate 21-24 nitric oxide synthase 3 Homo sapiens 34-80 24300283-0 2014 Interactive effects of in vitro binge-like alcohol and ATP on umbilical endothelial nitric oxide synthase post-translational modifications and redox modulation. Adenosine Triphosphate 55-58 nitric oxide synthase 3 Homo sapiens 72-105 21145922-2 2011 Previously, we have shown that under culture conditions that allow reduction of ATP-levels after stimulation, activation of AMPK contributes to eNOS phosphorylation and activation in endothelial cells after treatment with thrombin. Adenosine Triphosphate 80-83 nitric oxide synthase 3 Homo sapiens 144-148 21145922-12 2011 Under conditions where intracellular ATP is lowered by histamine, AMPK is activated by both LKB1 and CaMKK and, in turn, mediates eNOS phosphorylation in an LKB1 dependent manner. Adenosine Triphosphate 37-40 nitric oxide synthase 3 Homo sapiens 130-134 27572151-2 2016 In uterine artery endothelial cells (UAECs), ATP activates endothelial nitric oxide synthase in a pregnancy (P)-specific manner that is dependent on Cx43 function. Adenosine Triphosphate 45-48 nitric oxide synthase 3 Homo sapiens 59-92 27572151-3 2016 Caveolar subcellular domain partitioning plays key roles in ATP-induced endothelial nitric oxide synthase activation and nitric oxide production. Adenosine Triphosphate 60-63 nitric oxide synthase 3 Homo sapiens 72-105 27572151-12 2016 These data demonstrate rapid ATP-stimulated repartitioning of Cx43 to the caveolae, where endothelial nitric oxide synthase resides and plays an important role in nitric oxide-mediated increasing uterine blood flow during pregnancy. Adenosine Triphosphate 29-32 nitric oxide synthase 3 Homo sapiens 90-123 20042732-4 2010 Exogenous ATP ranging in concentration from 10(-9) to 10(-6) M produced a significant increase in ecNOS immunohistochemical expression in a dose-dependent manner. Adenosine Triphosphate 10-13 nitric oxide synthase 3 Homo sapiens 98-103 20042732-5 2010 The increase in ecNOS expression mediated by 10(-6)M ATP was significantly reduced by 10(-5) M suramin. Adenosine Triphosphate 53-56 nitric oxide synthase 3 Homo sapiens 16-21 20042732-10 2010 These findings suggest that shear stress produces a significant release of ATP from LEC, which activates the purinergic P2X/2Y receptor, thereby facilitating ecNOS mRNA and protein expression through inositol 1,4,5-trisphosphate-mediated release of intracellular Ca(2+) ions and the activation of Ca(2+)-activated K(+) channels in LEC. Adenosine Triphosphate 75-78 nitric oxide synthase 3 Homo sapiens 158-163 18385287-7 2008 Finally, we found that the decrease in ATP resulted in a reduction in the chaperone activity of HSP90 resulting in a decrease in its interaction with eNOS. Adenosine Triphosphate 39-42 nitric oxide synthase 3 Homo sapiens 150-154 19741206-2 2010 Uterine artery endothelial cells from nonpregnant (NP-UAECs) or pregnant (P-UAECs) ewes maintained in culture still show a pregnancy-enhanced difference in ATP-stimulated endothelial NO synthase (eNOS; official symbol NOS3) activation, even though NOS3 protein, purinergic receptors, and associated cell signaling proteins are expressed at equal levels. Adenosine Triphosphate 156-159 nitric oxide synthase 3 Homo sapiens 218-222 19741206-2 2010 Uterine artery endothelial cells from nonpregnant (NP-UAECs) or pregnant (P-UAECs) ewes maintained in culture still show a pregnancy-enhanced difference in ATP-stimulated endothelial NO synthase (eNOS; official symbol NOS3) activation, even though NOS3 protein, purinergic receptors, and associated cell signaling proteins are expressed at equal levels. Adenosine Triphosphate 156-159 nitric oxide synthase 3 Homo sapiens 248-252 19741206-7 2010 The relationship between Ca(2+) bursts and NOS3 activation is further established by the finding that (43,37)GAP27 inhibits ATP-stimulated NOS3 activation but has no effect on cell mitogenesis. Adenosine Triphosphate 124-127 nitric oxide synthase 3 Homo sapiens 43-47 19741206-7 2010 The relationship between Ca(2+) bursts and NOS3 activation is further established by the finding that (43,37)GAP27 inhibits ATP-stimulated NOS3 activation but has no effect on cell mitogenesis. Adenosine Triphosphate 124-127 nitric oxide synthase 3 Homo sapiens 139-143 18687367-0 2008 Mechanism of thrombin mediated eNOS phosphorylation in endothelial cells is dependent on ATP levels after stimulation. Adenosine Triphosphate 89-92 nitric oxide synthase 3 Homo sapiens 31-35 18687367-7 2008 Thus, conditions subjecting endothelial cells to a fall in ATP after thrombin stimulation facilitate activation of pathways partly dependent on AMPK causing downstream phosphorylation of eNOS. Adenosine Triphosphate 59-62 nitric oxide synthase 3 Homo sapiens 187-191 16716148-5 2006 U0126 pretreatment of HUVEC-CS potentiated ATP-stimulated eNOS activity, independent of changes in intracellular Ca2+ concentration ([Ca2+]i). Adenosine Triphosphate 43-46 nitric oxide synthase 3 Homo sapiens 58-62 18160488-2 2008 Our purpose was to evaluate the effects of spatial colocalization of endothelial nitric oxide synthase (eNOS) and capacitative calcium entry (CCE) channels in caveolae on eNOS activation in response to ATP. Adenosine Triphosphate 202-205 nitric oxide synthase 3 Homo sapiens 69-102 18160488-2 2008 Our purpose was to evaluate the effects of spatial colocalization of endothelial nitric oxide synthase (eNOS) and capacitative calcium entry (CCE) channels in caveolae on eNOS activation in response to ATP. Adenosine Triphosphate 202-205 nitric oxide synthase 3 Homo sapiens 104-108 18160488-2 2008 Our purpose was to evaluate the effects of spatial colocalization of endothelial nitric oxide synthase (eNOS) and capacitative calcium entry (CCE) channels in caveolae on eNOS activation in response to ATP. Adenosine Triphosphate 202-205 nitric oxide synthase 3 Homo sapiens 171-175 16716148-10 2006 T97A-eNOS was the only construct significantly different from wild-type after U0126 pretreatment and ATP stimulation of eNOS activation. Adenosine Triphosphate 101-104 nitric oxide synthase 3 Homo sapiens 5-9 16716148-10 2006 T97A-eNOS was the only construct significantly different from wild-type after U0126 pretreatment and ATP stimulation of eNOS activation. Adenosine Triphosphate 101-104 nitric oxide synthase 3 Homo sapiens 120-124 12049652-3 2002 To investigate the molecular mechanisms underlying the rapid deactivation of eNOS after stimulation with receptor agonists, we measured the time courses of eNOS activation and intracellular free Ca2+ concentration ([Ca2+]i) in response to bradykinin (BK) and ATP. Adenosine Triphosphate 259-262 nitric oxide synthase 3 Homo sapiens 77-81 16455784-7 2006 Expression of constitutively active Akt (ca-Akt) in UAEC resulted in slight elevation of basal eNOS activity, but relative ATP-stimulated eNOS activation was not altered by ca-Akt. Adenosine Triphosphate 123-126 nitric oxide synthase 3 Homo sapiens 138-142 16455784-8 2006 Wortmannin continued to inhibit eNOS activation by ATP in the presence of ca-Akt; LY294002 still had no inhibitory effect. Adenosine Triphosphate 51-54 nitric oxide synthase 3 Homo sapiens 32-36 15784500-8 2005 The physiologic relevance of this was further underscored by the finding that ATP dose-dependently increased peak [Ca(2+)](i) and eNOS activity in COS-7/oeNOS, but also increased eNOS p-S1179 and decreased p-T497. Adenosine Triphosphate 78-81 nitric oxide synthase 3 Homo sapiens 130-134 15784500-8 2005 The physiologic relevance of this was further underscored by the finding that ATP dose-dependently increased peak [Ca(2+)](i) and eNOS activity in COS-7/oeNOS, but also increased eNOS p-S1179 and decreased p-T497. Adenosine Triphosphate 78-81 nitric oxide synthase 3 Homo sapiens 154-158 15784500-9 2005 This finding was similar to those in ovine P-UAEC treated with the Ca(2+)-mobilizing agonist ATP, wherein activation of eNOS was again concomitant with a rise p-S1179 as well as a slight decrease in p-T497. Adenosine Triphosphate 93-96 nitric oxide synthase 3 Homo sapiens 120-124 12049652-9 2002 However, when ATP was added to BK-pretreated cells or, conversely, BK to ATP-pretreated cells, activation of eNOS was comparable with that of untreated cells, suggesting that BK and ATP affect different pools of eNOS. Adenosine Triphosphate 14-17 nitric oxide synthase 3 Homo sapiens 109-113 12049652-9 2002 However, when ATP was added to BK-pretreated cells or, conversely, BK to ATP-pretreated cells, activation of eNOS was comparable with that of untreated cells, suggesting that BK and ATP affect different pools of eNOS. Adenosine Triphosphate 14-17 nitric oxide synthase 3 Homo sapiens 212-216 12049652-9 2002 However, when ATP was added to BK-pretreated cells or, conversely, BK to ATP-pretreated cells, activation of eNOS was comparable with that of untreated cells, suggesting that BK and ATP affect different pools of eNOS. Adenosine Triphosphate 73-76 nitric oxide synthase 3 Homo sapiens 109-113 12049652-9 2002 However, when ATP was added to BK-pretreated cells or, conversely, BK to ATP-pretreated cells, activation of eNOS was comparable with that of untreated cells, suggesting that BK and ATP affect different pools of eNOS. Adenosine Triphosphate 73-76 nitric oxide synthase 3 Homo sapiens 212-216 12049652-9 2002 However, when ATP was added to BK-pretreated cells or, conversely, BK to ATP-pretreated cells, activation of eNOS was comparable with that of untreated cells, suggesting that BK and ATP affect different pools of eNOS. Adenosine Triphosphate 73-76 nitric oxide synthase 3 Homo sapiens 109-113 12049652-9 2002 However, when ATP was added to BK-pretreated cells or, conversely, BK to ATP-pretreated cells, activation of eNOS was comparable with that of untreated cells, suggesting that BK and ATP affect different pools of eNOS. Adenosine Triphosphate 73-76 nitric oxide synthase 3 Homo sapiens 212-216 12049652-10 2002 The desensitization of eNOS was reversible, since removal of ATP or BK from the incubation buffer restored the response to the respective agonist within 20 min. Adenosine Triphosphate 61-64 nitric oxide synthase 3 Homo sapiens 23-27 11562476-6 2001 Nitric oxide also found to have a profound effect in cell metabolism, because ECV304+eNOS cells had lower steady state levels of ATP and higher utilization of glucose via the glycolytic pathway than ECV304 cells. Adenosine Triphosphate 129-132 nitric oxide synthase 3 Homo sapiens 85-89