PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
6870900-0	1983	Inhibition of human brain dihydropteridine reductase [E.C.1.6.99.10] by the oxidation products of catecholamines, the aminochromes.	Catecholamines	98-112	quinoid dihydropteridine reductase	Homo sapiens	26-52	
6824696-0	1983	Inhibition of dihydropteridine reductase by catecholamines and related compounds.	Catecholamines	44-58	quinoid dihydropteridine reductase	Homo sapiens	14-40	
1956581-5	1991	Since BH4, NADH and DHPR are ubiquitous in mammalian tissues, this system may play an important role in the reduction of the oxidation products of catecholamines.	Catecholamines	147-161	quinoid dihydropteridine reductase	Homo sapiens	20-24	
6315964-4	1983	These results support the hypothesis that catechol estrogens may interfere with catecholamine metabolism by acting as inhibitors of enzymes involved in catecholamine metabolism, such as dihydropteridine reductase.	Catecholamines	80-93	quinoid dihydropteridine reductase	Homo sapiens	186-212	
6315964-4	1983	These results support the hypothesis that catechol estrogens may interfere with catecholamine metabolism by acting as inhibitors of enzymes involved in catecholamine metabolism, such as dihydropteridine reductase.	Catecholamines	152-165	quinoid dihydropteridine reductase	Homo sapiens	186-212	
5289368-0	1971	Dihydropteridine reductase: implication on the regulation of catecholamine biosynthesis.	Catecholamines	61-74	quinoid dihydropteridine reductase	Homo sapiens	0-26	
5289368-1	1971	The low tissue concentrations of tetrahydrobiopterin, as well as the antagonism between the catecholamine feedback inhibition of tyrosine hydroxylase and the reduced cofactor concentrations, suggest that dihydropteridine reductase may play an important role in the regulation of catecholamine biosynthesis.	Catecholamines	92-105	quinoid dihydropteridine reductase	Homo sapiens	204-230	
5289368-1	1971	The low tissue concentrations of tetrahydrobiopterin, as well as the antagonism between the catecholamine feedback inhibition of tyrosine hydroxylase and the reduced cofactor concentrations, suggest that dihydropteridine reductase may play an important role in the regulation of catecholamine biosynthesis.	Catecholamines	279-292	quinoid dihydropteridine reductase	Homo sapiens	204-230	
5289368-3	1971	This system has several important characteristics: (a) the rate of dihydroxyphenylalanine formation can be controlled by the concentration of dihydropteridine reductase; (b) low concentrations of catecholamines (2 x 10(-5) M) can produce a marked inhibition of tyrosine hydroxylase activity; and (c) the catecholamine feedback-inhibition of tyrosine hydroxylase can be antagonized by increasing concentrations of dihydropteridine reductase.	Catecholamines	196-210	quinoid dihydropteridine reductase	Homo sapiens	142-168	
5289368-3	1971	This system has several important characteristics: (a) the rate of dihydroxyphenylalanine formation can be controlled by the concentration of dihydropteridine reductase; (b) low concentrations of catecholamines (2 x 10(-5) M) can produce a marked inhibition of tyrosine hydroxylase activity; and (c) the catecholamine feedback-inhibition of tyrosine hydroxylase can be antagonized by increasing concentrations of dihydropteridine reductase.	Catecholamines	196-210	quinoid dihydropteridine reductase	Homo sapiens	413-439	
5289368-3	1971	This system has several important characteristics: (a) the rate of dihydroxyphenylalanine formation can be controlled by the concentration of dihydropteridine reductase; (b) low concentrations of catecholamines (2 x 10(-5) M) can produce a marked inhibition of tyrosine hydroxylase activity; and (c) the catecholamine feedback-inhibition of tyrosine hydroxylase can be antagonized by increasing concentrations of dihydropteridine reductase.	Catecholamines	196-209	quinoid dihydropteridine reductase	Homo sapiens	413-439	
5289368-4	1971	The properties of the in vitro tyrosine hydroxylase-dihydropteridine reductase system suggest that dihydropteridine reductase may have an important role in vivo in the determination of the rates of dihydroxyphenylalanine formation and on the effectiveness of the catecholamine feedback-inhibition of tyrosine hydroxylase activity.	Catecholamines	263-276	quinoid dihydropteridine reductase	Homo sapiens	52-78	
5289368-4	1971	The properties of the in vitro tyrosine hydroxylase-dihydropteridine reductase system suggest that dihydropteridine reductase may have an important role in vivo in the determination of the rates of dihydroxyphenylalanine formation and on the effectiveness of the catecholamine feedback-inhibition of tyrosine hydroxylase activity.	Catecholamines	263-276	quinoid dihydropteridine reductase	Homo sapiens	99-125