PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8878434-2 1996 We wondered if insulin or IGF-I induced expression of alpha1 adrenergic receptors in vascular smooth muscle cells (VSMCs) which could enhance smooth muscle contraction and cell growth activated by catecholamines. Catecholamines 197-211 insulin-like growth factor 1 Rattus norvegicus 26-31 8878434-8 1996 These results suggest that insulin/IGF-I regulate expression of alpha1 receptors in VSMCs and potentially enhance the effects of catecholamines in settings of hyperinsulinemia. Catecholamines 129-143 insulin-like growth factor 1 Rattus norvegicus 35-40 26399932-14 2016 CONCLUSION: IGF-1 treatment attenuates diastolic and systolic dysfunction associated with chronic catecholamine-induced cardiomyopathy while preserving adrenergic sensitivity and promoting BH4 production. Catecholamines 98-111 insulin-like growth factor 1 Rattus norvegicus 12-17