PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26475702-2 2015 The aim of the current study was to examine the impact of prenatal GC exposure on the postnatal regulation of the gene encoding for phenylethanolamine N-methyltransferase (PNMT), the enzyme involved in the biosynthesis of the catecholamine, epinephrine. Catecholamines 226-239 phenylethanolamine-N-methyltransferase Rattus norvegicus 132-170 28759191-4 2017 The aims of this study are to investigate the effects of age on the biosynthetic pathway of catecholamines in adrenal medulla by determining the level of blood glucose and blood catecholamines, the gene and protein expression of biosynthetic catecholamine enzymes (TH, DBH and PNMT) as well as protein kinase substrates that involved in the phosphorylation of TH in 2DG-induced rats. Catecholamines 92-106 phenylethanolamine-N-methyltransferase Rattus norvegicus 277-281 26761434-1 2016 Phenylethanolamine N-methyltransferase (PNMT) is the terminal enzyme in the catecholamine biosynthetic pathway responsible for adrenaline biosynthesis. Catecholamines 76-89 phenylethanolamine-N-methyltransferase Rattus norvegicus 0-38 26761434-1 2016 Phenylethanolamine N-methyltransferase (PNMT) is the terminal enzyme in the catecholamine biosynthetic pathway responsible for adrenaline biosynthesis. Catecholamines 76-89 phenylethanolamine-N-methyltransferase Rattus norvegicus 40-44 28759191-4 2017 The aims of this study are to investigate the effects of age on the biosynthetic pathway of catecholamines in adrenal medulla by determining the level of blood glucose and blood catecholamines, the gene and protein expression of biosynthetic catecholamine enzymes (TH, DBH and PNMT) as well as protein kinase substrates that involved in the phosphorylation of TH in 2DG-induced rats. Catecholamines 92-105 phenylethanolamine-N-methyltransferase Rattus norvegicus 277-281 27769893-1 2016 Epinephrine is synthesised by the catecholamine biosynthetic enzyme, phenylethanolamine N-methyltransferase (PNMT), primarily in chromaffin cells of the adrenal medulla and secondarily in brainstem adrenergic neurons of the medulla oblongata. Catecholamines 34-47 phenylethanolamine-N-methyltransferase Rattus norvegicus 69-107 27769893-1 2016 Epinephrine is synthesised by the catecholamine biosynthetic enzyme, phenylethanolamine N-methyltransferase (PNMT), primarily in chromaffin cells of the adrenal medulla and secondarily in brainstem adrenergic neurons of the medulla oblongata. Catecholamines 34-47 phenylethanolamine-N-methyltransferase Rattus norvegicus 109-113 27560796-7 2016 Induction of non-sympathetical catecholamine production was observed 7 days after cold exposure by elevated TH and phenylethanolamine-N-methyltransferase (PNMT) expression, leading to an increased epinephrine levels. Catecholamines 31-44 phenylethanolamine-N-methyltransferase Rattus norvegicus 115-153 27560796-7 2016 Induction of non-sympathetical catecholamine production was observed 7 days after cold exposure by elevated TH and phenylethanolamine-N-methyltransferase (PNMT) expression, leading to an increased epinephrine levels. Catecholamines 31-44 phenylethanolamine-N-methyltransferase Rattus norvegicus 155-159 26475702-2 2015 The aim of the current study was to examine the impact of prenatal GC exposure on the postnatal regulation of the gene encoding for phenylethanolamine N-methyltransferase (PNMT), the enzyme involved in the biosynthesis of the catecholamine, epinephrine. Catecholamines 226-239 phenylethanolamine-N-methyltransferase Rattus norvegicus 172-176 21681478-3 2012 This study aimed at investigating physical exercise-related changes in gene expression of catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase in the adrenal medulla and stellate ganglia of chronically psychosocially stressed adult rats exposed daily to 20-min treadmill exercise for 12 weeks, using TaqMan RT-PCR assay. Catecholamines 90-103 phenylethanolamine-N-methyltransferase Rattus norvegicus 188-226 19112418-2 2008 The aim of this work was to investigate the changes in gene expression and protein levels of catecholamine biosynthetic enzymes: tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) in the adrenal medulla of naive control and chronically (12 weeks) socially isolated adult Wistar rat males and the response of these animals to additional immobilization stress (2 h). Catecholamines 93-106 phenylethanolamine-N-methyltransferase Rattus norvegicus 192-230 19893991-3 2009 In the present study, the changes in gene expression of the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) and protein levels in the right and left heart auricles of naive control and long-term (12 weeks) socially isolated rats were investigated by Taqman RT-PCR and Western blot analysis. Catecholamines 60-73 phenylethanolamine-N-methyltransferase Rattus norvegicus 158-196 19893991-3 2009 In the present study, the changes in gene expression of the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) and protein levels in the right and left heart auricles of naive control and long-term (12 weeks) socially isolated rats were investigated by Taqman RT-PCR and Western blot analysis. Catecholamines 60-73 phenylethanolamine-N-methyltransferase Rattus norvegicus 198-202 20378607-4 2010 We identified cis-acting eQTLs for Dbh, Pnmt (catecholamine biosynthesis) and Vamp1 (catecholamine secretion); enzymatic activities of Dbh and Pnmt paralleled transcripts, with pQTLs for activities mirroring eQTLs. Catecholamines 46-59 phenylethanolamine-N-methyltransferase Rattus norvegicus 40-44 20378607-4 2010 We identified cis-acting eQTLs for Dbh, Pnmt (catecholamine biosynthesis) and Vamp1 (catecholamine secretion); enzymatic activities of Dbh and Pnmt paralleled transcripts, with pQTLs for activities mirroring eQTLs. Catecholamines 46-59 phenylethanolamine-N-methyltransferase Rattus norvegicus 143-147 20378607-4 2010 We identified cis-acting eQTLs for Dbh, Pnmt (catecholamine biosynthesis) and Vamp1 (catecholamine secretion); enzymatic activities of Dbh and Pnmt paralleled transcripts, with pQTLs for activities mirroring eQTLs. Catecholamines 85-98 phenylethanolamine-N-methyltransferase Rattus norvegicus 143-147 19539715-2 2009 Phenylethanolamine N-methyltransferase (PNMT) is the terminal enzyme in the catecholamine biosynthetic pathway, responsible for epinephrine biosynthesis, and is primarily localized in the adrenal gland. Catecholamines 76-89 phenylethanolamine-N-methyltransferase Rattus norvegicus 0-38 19539715-2 2009 Phenylethanolamine N-methyltransferase (PNMT) is the terminal enzyme in the catecholamine biosynthetic pathway, responsible for epinephrine biosynthesis, and is primarily localized in the adrenal gland. Catecholamines 76-89 phenylethanolamine-N-methyltransferase Rattus norvegicus 40-44 19112418-2 2008 The aim of this work was to investigate the changes in gene expression and protein levels of catecholamine biosynthetic enzymes: tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) in the adrenal medulla of naive control and chronically (12 weeks) socially isolated adult Wistar rat males and the response of these animals to additional immobilization stress (2 h). Catecholamines 93-106 phenylethanolamine-N-methyltransferase Rattus norvegicus 232-236 18190898-1 2008 Egr1, a transcription factor rapidly induced by various stimuli including stress, can elevate transcription of genes for the catecholamine biosynthetic enzymes TH and PNMT. Catecholamines 125-138 phenylethanolamine-N-methyltransferase Rattus norvegicus 167-171 18987458-6 2008 Real-time quantitative polymerase-chain reaction was performed to quantify relative expression levels of mRNAs for catecholamine biosynthetic enzymes in the adrenals and the anterocervical ganglia: tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT). Catecholamines 115-128 phenylethanolamine-N-methyltransferase Rattus norvegicus 261-299 18987458-6 2008 Real-time quantitative polymerase-chain reaction was performed to quantify relative expression levels of mRNAs for catecholamine biosynthetic enzymes in the adrenals and the anterocervical ganglia: tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT). Catecholamines 115-128 phenylethanolamine-N-methyltransferase Rattus norvegicus 301-305 17356229-1 2006 Phenylethanolamine N-methyltransferase (PNMT) is a final enzyme in catecholamine synthesizing cascade that converts noradrenaline to adrenaline. Catecholamines 67-80 phenylethanolamine-N-methyltransferase Rattus norvegicus 0-38 17356229-1 2006 Phenylethanolamine N-methyltransferase (PNMT) is a final enzyme in catecholamine synthesizing cascade that converts noradrenaline to adrenaline. Catecholamines 67-80 phenylethanolamine-N-methyltransferase Rattus norvegicus 40-44 15677399-0 2004 Stressor specificity and effect of prior experience on catecholamine biosynthetic enzyme phenylethanolamine N-methyltransferase. Catecholamines 55-68 phenylethanolamine-N-methyltransferase Rattus norvegicus 89-127 15869485-3 2005 In this study on rats, we used combined anterograde neuronal tracing of CeA projections with confocal and electron microscopic immunohistochemical detection of phenylethanolamine-N-methyltransferase, the adrenaline-synthesizing enzyme present in C1 catecholamine neurones of the RVLM, and Fos, the protein product of the c-fos proto-oncogene. Catecholamines 249-262 phenylethanolamine-N-methyltransferase Rattus norvegicus 160-198 17175506-1 2006 Phenylethanolamine N-methyltransferase (PNMT) is the final enzyme in the catecholamine synthesizing cascade that converts noradrenaline (NA) to adrenaline (Adr). Catecholamines 73-86 phenylethanolamine-N-methyltransferase Rattus norvegicus 0-38 17175506-1 2006 Phenylethanolamine N-methyltransferase (PNMT) is the final enzyme in the catecholamine synthesizing cascade that converts noradrenaline (NA) to adrenaline (Adr). Catecholamines 73-86 phenylethanolamine-N-methyltransferase Rattus norvegicus 40-44 15677399-2 2004 The aim of this work was to investigate changes in catecholamine (CA) biosynthetic enzyme phenylethanolamine N-methyltransferase (PNMT) gene expression, protein level, and activity in the adrenal medulla of rats after a single or repeated exposure to various homotypic or novel heterotypic stressors. Catecholamines 51-64 phenylethanolamine-N-methyltransferase Rattus norvegicus 90-128 15677399-2 2004 The aim of this work was to investigate changes in catecholamine (CA) biosynthetic enzyme phenylethanolamine N-methyltransferase (PNMT) gene expression, protein level, and activity in the adrenal medulla of rats after a single or repeated exposure to various homotypic or novel heterotypic stressors. Catecholamines 51-64 phenylethanolamine-N-methyltransferase Rattus norvegicus 130-134 11144961-8 2000 These grafted chromaffin cells also expressed immunoreactivities for the other catecholamine-synthesizing enzymes 7 weeks after grafting, including: dopamine-beta-hydroxylase (DbetaH) and phenylethanolamine-N-methyltransferase (PNMT). Catecholamines 79-92 phenylethanolamine-N-methyltransferase Rattus norvegicus 188-226 11173223-2 2001 Immunoreactivity for the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), aromatic-L-amino-acid decarboxylase (AADC) and dopamine beta-hydroxylase (DBH) was present in all chromaffin cells, while phenylethanolamine N-methyltransferase (PNMT) was used to determine adrenergic chromaffin cell groups. Catecholamines 25-38 phenylethanolamine-N-methyltransferase Rattus norvegicus 209-247 11173223-2 2001 Immunoreactivity for the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), aromatic-L-amino-acid decarboxylase (AADC) and dopamine beta-hydroxylase (DBH) was present in all chromaffin cells, while phenylethanolamine N-methyltransferase (PNMT) was used to determine adrenergic chromaffin cell groups. Catecholamines 25-38 phenylethanolamine-N-methyltransferase Rattus norvegicus 249-253 11144961-8 2000 These grafted chromaffin cells also expressed immunoreactivities for the other catecholamine-synthesizing enzymes 7 weeks after grafting, including: dopamine-beta-hydroxylase (DbetaH) and phenylethanolamine-N-methyltransferase (PNMT). Catecholamines 79-92 phenylethanolamine-N-methyltransferase Rattus norvegicus 228-232 10700082-13 1999 Adrenal phenylethanolamine N-methyl-transferase (PNMT) mRNA levels were increased 4 h after both the PH and laparotomy and declined within 24 h. CONCLUSIONS: The first peak of catecholamine and corticosterone levels might result from unspecific stressor associated with the surgery. Catecholamines 176-189 phenylethanolamine-N-methyltransferase Rattus norvegicus 8-47 10700082-13 1999 Adrenal phenylethanolamine N-methyl-transferase (PNMT) mRNA levels were increased 4 h after both the PH and laparotomy and declined within 24 h. CONCLUSIONS: The first peak of catecholamine and corticosterone levels might result from unspecific stressor associated with the surgery. Catecholamines 176-189 phenylethanolamine-N-methyltransferase Rattus norvegicus 49-53 9590505-8 1998 Concomitantly, the expression of phenylethanolamine-N-methyl transferase (PNMT), but not of other catecholamine synthesizing enzymes, was enhanced. Catecholamines 98-111 phenylethanolamine-N-methyltransferase Rattus norvegicus 33-72 10219960-2 1999 1.1.2.8, PNMT), the final enzyme in the cascade of catecholamine synthesis, is differentially regulated in adrenergic neurons in the brain and in adrenal chromaffin cells. Catecholamines 51-64 phenylethanolamine-N-methyltransferase Rattus norvegicus 9-13 10064798-3 1999 Adrenaline levels were undetectable in the PCG but to test the hypothesis that PNMT is active in SIF cells, catecholamines were measured in ganglia of rats pretreated with pargyline, an inhibitor of the monoamine oxidase, the major enzyme involved in the catecholamine degradation. Catecholamines 108-122 phenylethanolamine-N-methyltransferase Rattus norvegicus 79-83 10064798-3 1999 Adrenaline levels were undetectable in the PCG but to test the hypothesis that PNMT is active in SIF cells, catecholamines were measured in ganglia of rats pretreated with pargyline, an inhibitor of the monoamine oxidase, the major enzyme involved in the catecholamine degradation. Catecholamines 108-121 phenylethanolamine-N-methyltransferase Rattus norvegicus 79-83 9590505-8 1998 Concomitantly, the expression of phenylethanolamine-N-methyl transferase (PNMT), but not of other catecholamine synthesizing enzymes, was enhanced. Catecholamines 98-111 phenylethanolamine-N-methyltransferase Rattus norvegicus 74-78 9380436-3 1997 The enzymes tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) catalyze the rate-limiting step in the catecholamine pathway and production of epinephrine, respectively. Catecholamines 127-140 phenylethanolamine-N-methyltransferase Rattus norvegicus 42-80 9380436-3 1997 The enzymes tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) catalyze the rate-limiting step in the catecholamine pathway and production of epinephrine, respectively. Catecholamines 127-140 phenylethanolamine-N-methyltransferase Rattus norvegicus 82-86 7715798-3 1994 Polyclonal antisera directed towards phenylethanolamine N-methyltransferase (PNMT) and tyrosine hydroxylase (TH), biosynthetic enzymes of catecholamines, were used for the simultaneous immunocytochemical detection of adrenergic fibers and TIDA neurons, respectively, in Vibratome sections of the rat hypothalamus. Catecholamines 138-152 phenylethanolamine-N-methyltransferase Rattus norvegicus 37-75 7584561-1 1995 Local production of catecholamines in the stomach of the rat was studied by immunohistochemical demonstration of tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT), the enzymes catalyzing the formation of dopamine, noradrenaline and adrenaline, respectively. Catecholamines 20-34 phenylethanolamine-N-methyltransferase Rattus norvegicus 176-214 7584561-1 1995 Local production of catecholamines in the stomach of the rat was studied by immunohistochemical demonstration of tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT), the enzymes catalyzing the formation of dopamine, noradrenaline and adrenaline, respectively. Catecholamines 20-34 phenylethanolamine-N-methyltransferase Rattus norvegicus 216-220 9315384-9 1997 Tyrosine hydroxylase was detected in the RVLM and NTS and PNMT was also detected in the RVLM, which agrees with the distribution of catecholamine neurons in the medulla. Catecholamines 132-145 phenylethanolamine-N-methyltransferase Rattus norvegicus 58-62 7958625-4 1994 By contrast, the expression, specific activity, and immunoreactivity of other catecholamine-synthesizing enzymes, e.g., phenylethanolamine-N-methyl-transferase (PNMT), were not altered. Catecholamines 78-91 phenylethanolamine-N-methyltransferase Rattus norvegicus 161-165 1685739-1 1991 We have measured levels of mRNA coding for the catecholamine synthesizing enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (D beta H), phenylethanolamine N-methyltransferase (PNMT) and for neuropeptide Y (NPY) in rat adrenal medulla by using in situ hybridization histochemistry. Catecholamines 47-60 phenylethanolamine-N-methyltransferase Rattus norvegicus 187-191 1747753-2 1991 We used antisera against the catecholamine synthesizing enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT), and one against the transmitter serotonin (5-HT). Catecholamines 29-42 phenylethanolamine-N-methyltransferase Rattus norvegicus 167-171 1577991-1 1992 Phenylethanolamine N-methyltransferase (PNMT), the final enzyme in the catecholamine biosynthetic pathway that converts norepinephrine to epinephrine, has been detected in the retinas of various vertebrate species. Catecholamines 71-84 phenylethanolamine-N-methyltransferase Rattus norvegicus 0-38 1577991-1 1992 Phenylethanolamine N-methyltransferase (PNMT), the final enzyme in the catecholamine biosynthetic pathway that converts norepinephrine to epinephrine, has been detected in the retinas of various vertebrate species. Catecholamines 71-84 phenylethanolamine-N-methyltransferase Rattus norvegicus 40-44 12106366-5 1992 The nature of these chromaffin cells was examined by immunocytochemistry using antibodies against the catecholamine-synthesizing enzyme phenylethanolamine N-methyltransferase (PNMT), which are capable of distinguishing between adrenergic and noradrenergic cells. Catecholamines 102-115 phenylethanolamine-N-methyltransferase Rattus norvegicus 136-174 12106366-5 1992 The nature of these chromaffin cells was examined by immunocytochemistry using antibodies against the catecholamine-synthesizing enzyme phenylethanolamine N-methyltransferase (PNMT), which are capable of distinguishing between adrenergic and noradrenergic cells. Catecholamines 102-115 phenylethanolamine-N-methyltransferase Rattus norvegicus 176-180 1895567-1 1991 Interactions between gamma-aminobutyric acid (GABA)- and catecholamine (CA)-containing cells in the rat retina was revealed by a double-labeling immunocytochemical technique using the antisera to GABA- and CA-synthesizing enzymes, such as tyrosine hydroxylase (TH) and phenylethanolamine-N-methyltransferase (PNMT). Catecholamines 57-70 phenylethanolamine-N-methyltransferase Rattus norvegicus 269-307 2006996-9 1991 This enzyme differs from adrenal PNMT in substrate and inhibitor specificity and its activity is enhanced by catecholamine depletion and by glucocorticoid treatment. Catecholamines 109-122 phenylethanolamine-N-methyltransferase Rattus norvegicus 33-37 1895567-1 1991 Interactions between gamma-aminobutyric acid (GABA)- and catecholamine (CA)-containing cells in the rat retina was revealed by a double-labeling immunocytochemical technique using the antisera to GABA- and CA-synthesizing enzymes, such as tyrosine hydroxylase (TH) and phenylethanolamine-N-methyltransferase (PNMT). Catecholamines 57-70 phenylethanolamine-N-methyltransferase Rattus norvegicus 309-313 2622800-3 1989 Antibodies to CRF, ACTH(1-39) and the catecholamine synthesizing enzymes which are tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) were utilized. Catecholamines 38-51 phenylethanolamine-N-methyltransferase Rattus norvegicus 146-184 1976532-1 1990 Immunohistochemical localization of the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), and phenylethanolamine N-methyltransferase (PNMT) was employed to reveal the anatomical organization of the A1 noradrenergic cell group in the caudal ventrolateral medulla oblongata of the rat. Catecholamines 40-53 phenylethanolamine-N-methyltransferase Rattus norvegicus 139-177 1976532-1 1990 Immunohistochemical localization of the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), and phenylethanolamine N-methyltransferase (PNMT) was employed to reveal the anatomical organization of the A1 noradrenergic cell group in the caudal ventrolateral medulla oblongata of the rat. Catecholamines 40-53 phenylethanolamine-N-methyltransferase Rattus norvegicus 179-183 2354362-7 1990 These results suggest that phenylethanolamine N-methyltransferase (PNMT)-containing terminals in the rat spinal cord can synthesize epinephrine, but that little if any epinephrine is stored in synaptic vesicles due to the rapid metabolism of cytoplasmic catecholamines by monoamine oxidase. Catecholamines 254-268 phenylethanolamine-N-methyltransferase Rattus norvegicus 27-65 2354362-7 1990 These results suggest that phenylethanolamine N-methyltransferase (PNMT)-containing terminals in the rat spinal cord can synthesize epinephrine, but that little if any epinephrine is stored in synaptic vesicles due to the rapid metabolism of cytoplasmic catecholamines by monoamine oxidase. Catecholamines 254-268 phenylethanolamine-N-methyltransferase Rattus norvegicus 67-71 2575695-3 1989 To further investigate the effects of stress on the expression of the catecholamine biosynthetic enzymes, we have isolated a rat cDNA clone encoding the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase (PNMT). Catecholamines 70-83 phenylethanolamine-N-methyltransferase Rattus norvegicus 185-223 2575695-3 1989 To further investigate the effects of stress on the expression of the catecholamine biosynthetic enzymes, we have isolated a rat cDNA clone encoding the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase (PNMT). Catecholamines 70-83 phenylethanolamine-N-methyltransferase Rattus norvegicus 225-229 2622800-3 1989 Antibodies to CRF, ACTH(1-39) and the catecholamine synthesizing enzymes which are tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) were utilized. Catecholamines 38-51 phenylethanolamine-N-methyltransferase Rattus norvegicus 186-190 2566714-2 1989 The two catecholamine enzyme immunoreactivities (phenylethanolamine-N-methyltransferase, and tyrosine-hydroxylase) were not found in the same cells, while gamma-aminobutyric acid (GABA) immunoreactivity was observed in large tyrosine-hydroxylase immunoreactive cells, but not in phenylethanolamine-N-methyltransferase immunoreactive cells. Catecholamines 8-21 phenylethanolamine-N-methyltransferase Rattus norvegicus 49-87 2566714-2 1989 The two catecholamine enzyme immunoreactivities (phenylethanolamine-N-methyltransferase, and tyrosine-hydroxylase) were not found in the same cells, while gamma-aminobutyric acid (GABA) immunoreactivity was observed in large tyrosine-hydroxylase immunoreactive cells, but not in phenylethanolamine-N-methyltransferase immunoreactive cells. Catecholamines 8-21 phenylethanolamine-N-methyltransferase Rattus norvegicus 279-317 2903502-4 1988 After administration of the catecholamine-depleting drug reserpine to rats, a brief increase, followed by a dramatic decrease, in the level of PNMTase mRNA was observed in the adrenal medulla. Catecholamines 28-41 phenylethanolamine-N-methyltransferase Rattus norvegicus 143-150 2566632-2 1989 The coexistence of GAD with the catecholamine-synthesizing enzymes tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) was analyzed in consecutive sections or by staining one section consecutively with different antisera. Catecholamines 32-45 phenylethanolamine-N-methyltransferase Rattus norvegicus 137-141 6132028-6 1983 In the present study, the catecholamine-synthesizing enzyme, phenylethanolamine-N-methyltransferase (PNMT), and the neuropeptide, somatostatin, have been used as examples from the central nervous system of the rat, but the procedure is applicable to other antigens as well as other cell types and tissues. Catecholamines 26-39 phenylethanolamine-N-methyltransferase Rattus norvegicus 61-99 2897090-4 1988 Furthermore these catecholamine neurons exhibited immunoreactivity for an adrenaline-synthesizing enzyme, phenylethanolamine N-methyltransferase. Catecholamines 18-31 phenylethanolamine-N-methyltransferase Rattus norvegicus 106-144 3440206-5 1987 In E13 explants, immunoreactivity to both PNMT and tyrosine hydroxylase, the rate limiting enzyme in catecholamine synthesis, was observed. Catecholamines 101-114 phenylethanolamine-N-methyltransferase Rattus norvegicus 42-46 2946301-12 1986 We conclude that the induction of PNMT by reserpine involves depletion of catecholamines and serotonin, the depletion of serotonin having the more powerful effect. Catecholamines 74-88 phenylethanolamine-N-methyltransferase Rattus norvegicus 34-38 2878821-7 1986 The absence of TH enzyme in the PNMT-positive cells raises the question of the enzymatic activity of PNMT, which appears to be different from the classical pathway of catecholamine biosynthesis in the retina. Catecholamines 167-180 phenylethanolamine-N-methyltransferase Rattus norvegicus 101-105 2874553-5 1986 Comparison of the deduced amino acid sequence of bovine PNMTase to rat tyrosine hydroxylase reveals that PNMTase shares significant homology with tyrosine hydroxylase and supports previous protein and immunological data suggesting that the catecholamine biosynthetic enzymes are structurally related. Catecholamines 240-253 phenylethanolamine-N-methyltransferase Rattus norvegicus 105-112 2871139-5 1986 The results show that there are two types of PNMT-containing cells: those containing PNMT exclusively and those containing PNMT with two other catecholamine-synthesizing enzymes, tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC), but not dopamine beta-hydroxylase (DBH). Catecholamines 143-156 phenylethanolamine-N-methyltransferase Rattus norvegicus 45-49 2858497-6 1985 In this study the location of catecholamine-synthesizing enzymes was examined in the serial sections of the caudal medulla oblongata of the rat: tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), and phenylethanolamine N-methyl transferase (PNMT). Catecholamines 30-43 phenylethanolamine-N-methyltransferase Rattus norvegicus 209-248 2858497-6 1985 In this study the location of catecholamine-synthesizing enzymes was examined in the serial sections of the caudal medulla oblongata of the rat: tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), and phenylethanolamine N-methyl transferase (PNMT). Catecholamines 30-43 phenylethanolamine-N-methyltransferase Rattus norvegicus 250-254 6515125-0 1984 Inhibitors of phenylethanolamine-N-methyltransferase: effects on brain catecholamine content and blood pressure in DOCA-salt hypertensive rats. Catecholamines 71-84 phenylethanolamine-N-methyltransferase Rattus norvegicus 14-52 3319049-5 1987 The majority of PNMT containing cells in the brainstem/medulla appear to also contain other catecholamine biosynthetic enzymes. Catecholamines 92-105 phenylethanolamine-N-methyltransferase Rattus norvegicus 16-20 3555831-1 1987 The distribution of catecholamine synthesizing enzymes within the paraventricular nucleus of the rat hypothalamus is elucidated immunocytochemically by use of antibodies to tyrosine hydroxylase, dopamine beta-hydroxylase, and phenylethanolamine-N-methyltransferase. Catecholamines 20-33 phenylethanolamine-N-methyltransferase Rattus norvegicus 226-264 6498634-6 1984 Activities of the catecholamine-degrading enzyme monoamine oxidase (MAO) and the adrenaline-synthesizing enzyme phenylethanolamine-N-methyltransferase (PNMT) served to monitor chronic alterations of catecholamine turnover in myocardium. Catecholamines 199-212 phenylethanolamine-N-methyltransferase Rattus norvegicus 112-150 6498634-6 1984 Activities of the catecholamine-degrading enzyme monoamine oxidase (MAO) and the adrenaline-synthesizing enzyme phenylethanolamine-N-methyltransferase (PNMT) served to monitor chronic alterations of catecholamine turnover in myocardium. Catecholamines 199-212 phenylethanolamine-N-methyltransferase Rattus norvegicus 152-156 6358942-3 1983 alpha-Methyl-p-tyrosine, diethyldithiocarbamate and SKF 64139 inhibit catecholamine synthesis at the level of tyrosine hydroxylase, dopamine beta-hydroxylase and phenylethanolamine N-methyltransferase, respectively. Catecholamines 70-83 phenylethanolamine-N-methyltransferase Rattus norvegicus 162-200 6132028-6 1983 In the present study, the catecholamine-synthesizing enzyme, phenylethanolamine-N-methyltransferase (PNMT), and the neuropeptide, somatostatin, have been used as examples from the central nervous system of the rat, but the procedure is applicable to other antigens as well as other cell types and tissues. Catecholamines 26-39 phenylethanolamine-N-methyltransferase Rattus norvegicus 101-105 7150354-7 1982 The increase in PNMT activity appears to be a compensatory response to depletion of medullary catecholamines by DNLCA or alpha-methyltyrosine. Catecholamines 94-108 phenylethanolamine-N-methyltransferase Rattus norvegicus 16-20 6183680-1 1982 Resulting from literature data concerning interactions between catecholamines and Substance P (SP) the influence of SP on the activity of dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) was studied in rat adrenals. Catecholamines 63-77 phenylethanolamine-N-methyltransferase Rattus norvegicus 214-218 7178654-0 1982 Effects of phenylethanolamine N-methyltransferase inhibitors on rat brain catecholamine levels and body temperature. Catecholamines 74-87 phenylethanolamine-N-methyltransferase Rattus norvegicus 11-49 7052550-0 1980 Changes in rat hypothalamic and brain stem catecholamine concentrations following acute administration of phenylethanolamine-N-methyltransferase inhibitors. Catecholamines 43-56 phenylethanolamine-N-methyltransferase Rattus norvegicus 106-144 7227455-1 1981 SKF 64139, a potent inhibitor of adrenal and brain phenylethanolamine-N-methyltransferase (PNMT), was found to have effects on catecholamines, serotonin and their metabolites in rat brain which suggest it may act as a potent inhibitor of monoamine oxidase (MAO) "in vivo" after acute administration. Catecholamines 127-141 phenylethanolamine-N-methyltransferase Rattus norvegicus 91-95 7052550-1 1980 The effect of acute phenylethanolamine-N-methyltransferase (PNMT) inhibition on rat brain catecholamine concentrations was studied. Catecholamines 90-103 phenylethanolamine-N-methyltransferase Rattus norvegicus 60-64 876399-0 1977 The effects of an inhibitor of phenylethanolamine N-methyltransferase upon stimulated adrenal catecholamine release and excretion in the rat. Catecholamines 94-107 phenylethanolamine-N-methyltransferase Rattus norvegicus 31-69 6101988-0 1980 Catecholamine-stimulated cyclic AMP formation in phenylethanolamine N-methyltransferase containing brain stem nuclei of normal rats and of rats with spontaneous genetic hypertension. Catecholamines 0-13 phenylethanolamine-N-methyltransferase Rattus norvegicus 49-87 530533-2 1979 The catecholamine (CA) levels were measured after inhibition of dopamine-beta-hydroxylase (DBH) or phenylethanolamine-N-methyltransferase (PNMT). Catecholamines 4-17 phenylethanolamine-N-methyltransferase Rattus norvegicus 99-137 530533-2 1979 The catecholamine (CA) levels were measured after inhibition of dopamine-beta-hydroxylase (DBH) or phenylethanolamine-N-methyltransferase (PNMT). Catecholamines 4-17 phenylethanolamine-N-methyltransferase Rattus norvegicus 139-143 1004027-1 1976 The effects of the catecholamine neurotoxin 6-hydroxydopamine on phenylethanolamine-N-methyl transferase (PNMT) in rat brain has been investigated by biochemical and immunohistochemical analysis. Catecholamines 19-32 phenylethanolamine-N-methyltransferase Rattus norvegicus 65-104 1004027-1 1976 The effects of the catecholamine neurotoxin 6-hydroxydopamine on phenylethanolamine-N-methyl transferase (PNMT) in rat brain has been investigated by biochemical and immunohistochemical analysis. Catecholamines 19-32 phenylethanolamine-N-methyltransferase Rattus norvegicus 106-110 1004027-6 1976 The present results show that the PNMT neurons are resistant to the neurotoxic action of 6-hydroxydopamine, possibly due to lack of catecholamine uptake mechanism or due to these neurons having an uptake mechanism with a low affinity for 6-OH-DA. Catecholamines 132-145 phenylethanolamine-N-methyltransferase Rattus norvegicus 34-38 4402984-5 1971 The increase in PNMT activity may be a response to increased utilization of catecholamines.3. Catecholamines 76-90 phenylethanolamine-N-methyltransferase Rattus norvegicus 16-20 182323-8 1976 Similar results were obtained when the effect of these manipulations were studied on phenylethanolamine N-methyltransferase, another enzyme in the catecholamine biosynthetic pathway. Catecholamines 147-160 phenylethanolamine-N-methyltransferase Rattus norvegicus 85-123 30651588-4 2019 In the adrenal glands of prehypertensive SHR, the expression of catecholamine biosynthetic enzymes Ddc, Dbh and Pnmt was lower than in aged-matched Wistar-Kyoto rats. Catecholamines 64-77 phenylethanolamine-N-methyltransferase Rattus norvegicus 112-116 30651588-6 2019 In the adrenal glands of adult SHR, the expression of catecholamine biosynthetic enzymes Th, Ddc, Dbh and Pnmt was decreased along the amounts of dopamine and noradrenaline (50% and 38%, respectively, p < 0.001). Catecholamines 54-67 phenylethanolamine-N-methyltransferase Rattus norvegicus 106-110 28801784-7 2018 Induction of non-sympathetic catecholamine production demonstrated by elevated TH and PNMT (phenylethanolamine N-methyltransferase) mRNAs was observed after 7-day cold; however, prior IMO attenuated this response. Catecholamines 29-42 phenylethanolamine-N-methyltransferase Rattus norvegicus 86-90 28801784-7 2018 Induction of non-sympathetic catecholamine production demonstrated by elevated TH and PNMT (phenylethanolamine N-methyltransferase) mRNAs was observed after 7-day cold; however, prior IMO attenuated this response. Catecholamines 29-42 phenylethanolamine-N-methyltransferase Rattus norvegicus 92-130