PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34288568-10 2021 Further, depression-associated catecholamine specifically bound to the beta-2 adrenergic receptor (beta2 -AR) and upregulated MACC1 expression, and thus promoting neuroendocrine phenotypic transformation through direct binding between MACC1 and synaptophysin. Catecholamines 31-44 adrenoceptor beta 2 Homo sapiens 71-97 34455221-3 2021 The beta2 adrenergic receptor (beta2AR) is a catecholamine-liganded GPCR that is involved in cancer progression and wound healing. Catecholamines 45-58 adrenoceptor beta 2 Homo sapiens 4-29 34767786-8 2021 SIGNIFICANCE The beta2-adrenergic receptor (beta2 AR), which belongs to the vast family of Guanine nucleotide-binding protein coupled receptors (GPCRs), is a transmembrane protein that is activated by the catecholamines norepinephrine (noradrenaline) and epinephrine (adrenaline). Catecholamines 205-219 adrenoceptor beta 2 Homo sapiens 17-42 2561150-1 1989 The regulation of platelet alpha 2- and lymphocyte beta 2-adrenoceptor densities by alterations in endogenous catecholamines was examined. Catecholamines 110-124 adrenoceptor beta 2 Homo sapiens 51-70 34865027-2 2022 Chronic fetal hypoxemia elevates circulating catecholamines, which reduces skeletal muscle beta2 adrenoceptor content and contributes to growth and metabolic pathologies in IUGR-born offspring. Catecholamines 45-59 adrenoceptor beta 2 Homo sapiens 91-109 2478746-5 1989 After discontinuation of allapinine, the changes in beta 2-adrenoreceptor density and affinity for catecholamines remained on days 3 and 7, respectively. Catecholamines 99-113 adrenoceptor beta 2 Homo sapiens 52-73 33168470-4 2021 It appears that TTS is induced by aberrant post-beta2-adrenoceptor signalling in the setting of "surge" release of catecholamines. Catecholamines 115-129 adrenoceptor beta 2 Homo sapiens 48-66 2846457-2 1988 For this purpose these conjugated catecholamines (CA) were synthesized and investigated with respect to their alpha 2- and beta 2-adrenoceptor affinities and their biological activity in three different human cell systems: in mononuclear leukocytes (MNL), platelets, and fat cells. Catecholamines 34-48 adrenoceptor beta 2 Homo sapiens 110-142 3006842-1 1986 Catecholamines seem to inhibit transmission through airway parasympathetic ganglia by two mechanisms: Beta-2-adrenoceptor stimulation induces a ganglionic inhibition characterised by: slow onset, effect mainly on neural signals of high frequency, localisation to the presynaptic nerve terminal in the ganglion (inhibition of transmittor release). Catecholamines 0-14 adrenoceptor beta 2 Homo sapiens 102-121 6325953-1 1984 In 10 healthy volunteers the effects of acute increases in concentrations of catecholamines in plasma induced by dynamic exercise (on a bicycle for 15 min at 80% of maximum heart rate) on lymphocyte beta 2-adrenoceptor density (determined by (+/-)-125iodocyanopindolol binding) and -responsiveness (determined by cyclic AMP responses to 10 mumol/l isoprenaline) were investigated. Catecholamines 77-91 adrenoceptor beta 2 Homo sapiens 199-218 6304039-1 1983 The adenylate cyclase-coupled beta 2-adrenergic receptor of the frog erythrocyte has served as a useful model system for elucidating the mechanisms of catecholamine-induced densensitization. Catecholamines 151-164 adrenoceptor beta 2 Homo sapiens 30-56 6304039-10 1983 The catecholamine-sensitive adenylate cyclase activity established in the vesicle-Xenopus hybrids showed the characteristic agonist potency series of the donor frog erythrocyte beta 2-adrenergic receptor. Catecholamines 4-17 adrenoceptor beta 2 Homo sapiens 177-203 6110339-2 1981 BAR may be important in the placenta for mediating a variety of metabolic and hemodynamic effects of catecholamines including placental hormone synthesis and secretion, placental glycogenolysis, and placental blood flow. Catecholamines 101-115 adrenoceptor beta 2 Homo sapiens 0-3 32655246-2 2020 Nonhealing is possibly because of chronic activation of beta-2 adrenergic receptor (B2-AR) in the keratinocytes by endogenously generated catecholamines, which inhibits keratinocyte migration. Catecholamines 138-152 adrenoceptor beta 2 Homo sapiens 56-82 32034992-1 2020 INTRODUCTION: Beta-2-adrenergic receptor (ADRB2) is present in the cells of the respiratory tract, including bronchial smooth muscle cells and bronchial epithelium, and is a target for endogenous catecholamines and drugs used to treat obstructive lung diseases. Catecholamines 196-210 adrenoceptor beta 2 Homo sapiens 14-40 32034992-1 2020 INTRODUCTION: Beta-2-adrenergic receptor (ADRB2) is present in the cells of the respiratory tract, including bronchial smooth muscle cells and bronchial epithelium, and is a target for endogenous catecholamines and drugs used to treat obstructive lung diseases. Catecholamines 196-210 adrenoceptor beta 2 Homo sapiens 42-47 32076930-2 2020 The biochemical precipitant of attacks of TS is an increase in catecholamine concentrations within the myocardium, engendering inflammatory activation via biased post-receptor signalling at myocardial beta2-adrenoceptor level. Catecholamines 63-76 adrenoceptor beta 2 Homo sapiens 201-219 32296760-6 2020 In particular, investigating the activation of the catecholamine beta2-adrenergic receptor by a pathogen revealed that traction forces directly exerted on the N-terminus of the receptor via N-glycan chains activate specific signaling pathways. Catecholamines 51-64 adrenoceptor beta 2 Homo sapiens 65-90 32655246-2 2020 Nonhealing is possibly because of chronic activation of beta-2 adrenergic receptor (B2-AR) in the keratinocytes by endogenously generated catecholamines, which inhibits keratinocyte migration. Catecholamines 138-152 adrenoceptor beta 2 Homo sapiens 84-89 31609201-5 2019 Moreover, we have engineered a mutant beta2AR that lacks the catecholamine binding pocket. Catecholamines 61-74 adrenoceptor beta 2 Homo sapiens 38-45 31604529-2 2019 Different to RKIP-mediated beta-AR activation, chronic activation of beta-AR by catecholamines was shown to be detrimental for the heart. Catecholamines 80-94 adrenoceptor beta 2 Homo sapiens 69-76 31234562-2 2019 Authors designed an immunohistochemical study on the expression of the adrenal beta2-adrenergic receptor (beta2-AR), a receptor with high-affinity for catecholamines, with the aim to show which zones it is expressed in and how its expression differs in relation to the cause of death. Catecholamines 151-165 adrenoceptor beta 2 Homo sapiens 79-104 31234562-2 2019 Authors designed an immunohistochemical study on the expression of the adrenal beta2-adrenergic receptor (beta2-AR), a receptor with high-affinity for catecholamines, with the aim to show which zones it is expressed in and how its expression differs in relation to the cause of death. Catecholamines 151-165 adrenoceptor beta 2 Homo sapiens 106-114 30538630-2 2018 Catecholamine triggered beta2-adrenergic receptor (beta2-AR) signaling is important in creating a bidirectional response in the progression of ADs due to factors including diverse expression patterns, single nucleotide polymorphisms (SNPs), biased signals, and desensitization of beta2-AR, as well as different subtypes of Galpha binding to beta2-AR. Catecholamines 0-13 adrenoceptor beta 2 Homo sapiens 24-49 30542705-1 2019 The beta2-adrenergic receptor (beta2-AR, encoded by the ADRB2 gene) is a member of the G-protein-coupled receptor superfamily that can be stimulated by catecholamines. Catecholamines 152-166 adrenoceptor beta 2 Homo sapiens 4-29 30542705-1 2019 The beta2-adrenergic receptor (beta2-AR, encoded by the ADRB2 gene) is a member of the G-protein-coupled receptor superfamily that can be stimulated by catecholamines. Catecholamines 152-166 adrenoceptor beta 2 Homo sapiens 31-39 30542705-1 2019 The beta2-adrenergic receptor (beta2-AR, encoded by the ADRB2 gene) is a member of the G-protein-coupled receptor superfamily that can be stimulated by catecholamines. Catecholamines 152-166 adrenoceptor beta 2 Homo sapiens 56-61 30538630-2 2018 Catecholamine triggered beta2-adrenergic receptor (beta2-AR) signaling is important in creating a bidirectional response in the progression of ADs due to factors including diverse expression patterns, single nucleotide polymorphisms (SNPs), biased signals, and desensitization of beta2-AR, as well as different subtypes of Galpha binding to beta2-AR. Catecholamines 0-13 adrenoceptor beta 2 Homo sapiens 51-59 30538630-2 2018 Catecholamine triggered beta2-adrenergic receptor (beta2-AR) signaling is important in creating a bidirectional response in the progression of ADs due to factors including diverse expression patterns, single nucleotide polymorphisms (SNPs), biased signals, and desensitization of beta2-AR, as well as different subtypes of Galpha binding to beta2-AR. Catecholamines 0-13 adrenoceptor beta 2 Homo sapiens 280-288 30538630-2 2018 Catecholamine triggered beta2-adrenergic receptor (beta2-AR) signaling is important in creating a bidirectional response in the progression of ADs due to factors including diverse expression patterns, single nucleotide polymorphisms (SNPs), biased signals, and desensitization of beta2-AR, as well as different subtypes of Galpha binding to beta2-AR. Catecholamines 0-13 adrenoceptor beta 2 Homo sapiens 280-288 29958804-5 2018 Granulocyte macrophage progenitors (GMPs) expressed the beta2 adrenergic receptor, a target of catecholamines. Catecholamines 95-109 adrenoceptor beta 2 Homo sapiens 56-81 30172948-8 2018 We conclude that the preferential mobilization of NK-cells, non-classical monocytes and differentiated subsets of CD8+ T-cells with exercise is largely dependent on catecholamine signaling through the beta2-AR. Catecholamines 165-178 adrenoceptor beta 2 Homo sapiens 201-209 29063982-1 2018 In the heart, catecholamine effects occur by activation of beta-adrenergic receptors (beta-ARs), mainly the beta 1 (beta1-AR) and beta 2 (beta2-AR) subtypes, both of which couple to the Gs protein that activates the adenylyl cyclase signaling pathway. Catecholamines 14-27 adrenoceptor beta 2 Homo sapiens 138-146 28498637-6 2017 In addition, we demonstrated that catecholamines induced resistance of cervical cancer cells to chemotherapeutics both in vitro and in vivo and that beta2-AR was overexpressed in cervical cancer tissues. Catecholamines 34-48 adrenoceptor beta 2 Homo sapiens 149-157 28710773-4 2017 We demonstrated that a proportion of human Th17 cells express beta 2-adrenergic receptor (beta2AR), a G protein-coupled receptor that responds to catecholamines. Catecholamines 146-160 adrenoceptor beta 2 Homo sapiens 62-88 28710773-4 2017 We demonstrated that a proportion of human Th17 cells express beta 2-adrenergic receptor (beta2AR), a G protein-coupled receptor that responds to catecholamines. Catecholamines 146-160 adrenoceptor beta 2 Homo sapiens 90-97 28512254-0 2017 Catecholamines facilitate VEGF-dependent angiogenesis via beta2-adrenoceptor-induced Epac1 and PKA activation. Catecholamines 0-14 adrenoceptor beta 2 Homo sapiens 58-76 28498637-1 2017 It has been suggested that beta2-adrenergic receptor (beta2-AR)-mediated signaling induced by catecholamines regulates the degradation of p53. Catecholamines 94-108 adrenoceptor beta 2 Homo sapiens 27-52 28498637-1 2017 It has been suggested that beta2-adrenergic receptor (beta2-AR)-mediated signaling induced by catecholamines regulates the degradation of p53. Catecholamines 94-108 adrenoceptor beta 2 Homo sapiens 54-62 28498637-3 2017 In the present study, we demonstrated that catecholamines upregulated the expression of silent information regulator 1 (Sirt1) through activating beta2-AR-mediated signaling pathway, since selective beta2-AR antagonist ICI 118, 551 and non-selective beta-blocker proprenolol effectively repressed isoproterenol (ISO)-induced Sirt1 expression. Catecholamines 43-57 adrenoceptor beta 2 Homo sapiens 146-154 28498637-3 2017 In the present study, we demonstrated that catecholamines upregulated the expression of silent information regulator 1 (Sirt1) through activating beta2-AR-mediated signaling pathway, since selective beta2-AR antagonist ICI 118, 551 and non-selective beta-blocker proprenolol effectively repressed isoproterenol (ISO)-induced Sirt1 expression. Catecholamines 43-57 adrenoceptor beta 2 Homo sapiens 199-207 28512254-10 2017 In accordance, beta2AR- and AC-activation, but not Epac1 stimulation increased VEGF secretion in HUVEC.Our data indicate that high levels of catecholamines, which occur during chronic stress, prime the endothelium for angiogenesis through a beta2AR-mediated increase in endothelial VEGFR-2 expression and VEGF secretion. Catecholamines 141-155 adrenoceptor beta 2 Homo sapiens 15-22 28512254-10 2017 In accordance, beta2AR- and AC-activation, but not Epac1 stimulation increased VEGF secretion in HUVEC.Our data indicate that high levels of catecholamines, which occur during chronic stress, prime the endothelium for angiogenesis through a beta2AR-mediated increase in endothelial VEGFR-2 expression and VEGF secretion. Catecholamines 141-155 adrenoceptor beta 2 Homo sapiens 241-248 28498637-7 2017 Our data suggest that the p53-dependent, chemotherapeutics-induced cytotoxicity in cervical cancer cells may be compromised by catecholamines-induced upregulation of the Sirt1 expression through activating the beta2-AR signaling. Catecholamines 127-141 adrenoceptor beta 2 Homo sapiens 210-218 28074314-2 2017 beta-adrenergic receptors (beta-AR) are targets of endogenous catecholamines such as epinephrine that have gained importance in the context of cancer biology. Catecholamines 62-76 adrenoceptor beta 2 Homo sapiens 27-34 28489379-1 2017 By means of a formal structural hybridization of the antipsychotic drug aripiprazole and the heterocyclic catecholamine surrogates present in the beta2-adrenoceptor agonists procaterol and BI-167107 (4), we designed and synthesized a collection of novel hydroxy-substituted heteroarylpiperazines and heteroarylhomopiperazines with high dopamine D2 receptor (D2R) affinity. Catecholamines 106-119 adrenoceptor beta 2 Homo sapiens 146-164 28074314-12 2017 This study highlights that catecholamines, through beta-AR activation, seem to be involved in mammary gland development, inducing mature duct formation. Catecholamines 27-41 adrenoceptor beta 2 Homo sapiens 51-58 25798840-4 2016 In this study, we show that the expression of beta2-AR, which mediates most catecholamine-induced effects, negatively correlates with trastuzumab response in the patients with Her2-overexpressing breast cancer. Catecholamines 76-89 adrenoceptor beta 2 Homo sapiens 46-54 27379911-1 2016 BACKGROUND: Catecholamine infusion elicits an increase in clotting factors and this increase has been attributed to stimulation of beta2-adrenorecptors (beta2AR). Catecholamines 12-25 adrenoceptor beta 2 Homo sapiens 131-151 27379911-1 2016 BACKGROUND: Catecholamine infusion elicits an increase in clotting factors and this increase has been attributed to stimulation of beta2-adrenorecptors (beta2AR). Catecholamines 12-25 adrenoceptor beta 2 Homo sapiens 153-160 27385593-2 2016 Beta-2 adrenoreceptor (ADRB2) is a functional G-coupled protein expressed in the vascular endothelium of lungs, alveolar walls, and the ganglions of cholinergic nerves which induces bronchodilation in response to catecholamines. Catecholamines 213-227 adrenoceptor beta 2 Homo sapiens 0-21 27385593-2 2016 Beta-2 adrenoreceptor (ADRB2) is a functional G-coupled protein expressed in the vascular endothelium of lungs, alveolar walls, and the ganglions of cholinergic nerves which induces bronchodilation in response to catecholamines. Catecholamines 213-227 adrenoceptor beta 2 Homo sapiens 23-28 25798840-8 2016 Thus, trastuzumab resistance-dependent PI3K/Akt/mTOR pathway is controlled by catecholamine-induced beta2-AR activation. Catecholamines 78-91 adrenoceptor beta 2 Homo sapiens 100-108 25591042-2 2015 The release of endogenous catecholamines associated with shock or the administration of beta2-adrenergic receptor (beta2AR) agonists enhances AFC via a 3"-5"-cyclic adenosine monophosphate-dependent mechanism. Catecholamines 26-40 adrenoceptor beta 2 Homo sapiens 88-113 26221068-1 2015 The beta-2 adrenergic receptor (beta-2 AR) modulates metabolic processes in skeletal muscle, liver, and adipose tissue in response to catecholamine stimulation. Catecholamines 134-147 adrenoceptor beta 2 Homo sapiens 4-30 26221068-1 2015 The beta-2 adrenergic receptor (beta-2 AR) modulates metabolic processes in skeletal muscle, liver, and adipose tissue in response to catecholamine stimulation. Catecholamines 134-147 adrenoceptor beta 2 Homo sapiens 32-41 25591042-2 2015 The release of endogenous catecholamines associated with shock or the administration of beta2-adrenergic receptor (beta2AR) agonists enhances AFC via a 3"-5"-cyclic adenosine monophosphate-dependent mechanism. Catecholamines 26-40 adrenoceptor beta 2 Homo sapiens 115-122 24056936-6 2013 Here we present structures of the active-state human beta2AR bound to three chemically distinct agonists: the ultrahigh-affinity agonist BI167107, the high-affinity catecholamine agonist hydroxybenzyl isoproterenol, and the low-affinity endogenous agonist adrenaline. Catecholamines 165-178 adrenoceptor beta 2 Homo sapiens 53-60 24929186-4 2014 In this study, we investigated the effects of quercetin-3-O-glucuronide (Q3G), a circulating metabolite of quercetin, which is a type of natural flavonoid, on the catecholamine-induced beta2-adrenergic receptor (beta2-AR)-mediated response in MDA-MB-231 human breast cancer cells expressing beta2-AR. Catecholamines 163-176 adrenoceptor beta 2 Homo sapiens 185-210 24929186-4 2014 In this study, we investigated the effects of quercetin-3-O-glucuronide (Q3G), a circulating metabolite of quercetin, which is a type of natural flavonoid, on the catecholamine-induced beta2-adrenergic receptor (beta2-AR)-mediated response in MDA-MB-231 human breast cancer cells expressing beta2-AR. Catecholamines 163-176 adrenoceptor beta 2 Homo sapiens 212-220 24929186-4 2014 In this study, we investigated the effects of quercetin-3-O-glucuronide (Q3G), a circulating metabolite of quercetin, which is a type of natural flavonoid, on the catecholamine-induced beta2-adrenergic receptor (beta2-AR)-mediated response in MDA-MB-231 human breast cancer cells expressing beta2-AR. Catecholamines 163-176 adrenoceptor beta 2 Homo sapiens 291-299 23630346-11 2013 Our data indicated a novel trastuzumab resistance mechanism, by which catecholamine-induced beta2-AR activation mediates desensitization of gastric cancer cells to trastuzumab through upregulating the MUC4 expression. Catecholamines 70-83 adrenoceptor beta 2 Homo sapiens 92-100 23630346-0 2013 Catecholamine-Induced beta2-adrenergic receptor activation mediates desensitization of gastric cancer cells to trastuzumab by upregulating MUC4 expression. Catecholamines 0-13 adrenoceptor beta 2 Homo sapiens 22-47 23630346-4 2013 Our in vitro data show that activation of beta2-adrenergic receptor (beta2-AR) triggered by catecholamine caused "targeting failure" of trastuzumab in gastric cancer cells. Catecholamines 92-105 adrenoceptor beta 2 Homo sapiens 42-67 23630346-4 2013 Our in vitro data show that activation of beta2-adrenergic receptor (beta2-AR) triggered by catecholamine caused "targeting failure" of trastuzumab in gastric cancer cells. Catecholamines 92-105 adrenoceptor beta 2 Homo sapiens 69-77 23630346-7 2013 The effects of catecholamine could be effectively blocked by beta2-AR antagonist ICI-118,551, indicating that beta2-AR-mediated signaling pathway plays a key role in upregulation of MUC4, which was previously demonstrated to interfere with the recognition and physical binding of trastuzumab to Her2 molecules. Catecholamines 15-28 adrenoceptor beta 2 Homo sapiens 61-69 23630346-7 2013 The effects of catecholamine could be effectively blocked by beta2-AR antagonist ICI-118,551, indicating that beta2-AR-mediated signaling pathway plays a key role in upregulation of MUC4, which was previously demonstrated to interfere with the recognition and physical binding of trastuzumab to Her2 molecules. Catecholamines 15-28 adrenoceptor beta 2 Homo sapiens 110-118 22466342-1 2012 CONTEXT: The beta(2)-adrenergic receptor (ADRB2) influences regulation of energy balance by stimulating catecholamine-induced lipolysis in adipose tissue. Catecholamines 104-117 adrenoceptor beta 2 Homo sapiens 42-47 22261351-7 2012 We observed that the beta-adrenoceptor agonist (isoproterenol) and beta(2)-adrenoceptor agonist (salbutamol) stimulated catecholamine (NE and EP) release from human adrenal chromaffin cells. Catecholamines 120-133 adrenoceptor beta 2 Homo sapiens 67-87 22261351-8 2012 Furthermore, the beta(2)-adrenoceptor antagonist (ICI 118,551; 100 nM) and beta(3)-adrenoceptor antagonist (SR 59230A; 100 nM) inhibited the catecholamine release stimulated by isoproterenol and nicotine in chromaffin cells. Catecholamines 141-154 adrenoceptor beta 2 Homo sapiens 17-37 18772317-1 2008 Fluorescence studies with purified human beta(2)-adrenoceptor (beta(2)AR) revealed that the endogenous catecholamines, (-)-epinephrine (EPI), (-)-norepinephrine (NE), and dopamine (DOP), stabilize distinct active receptor conformations. Catecholamines 103-117 adrenoceptor beta 2 Homo sapiens 41-61 20739277-1 2010 beta(2)-adrenergic receptors (beta(2)-AR) are low abundance, integral membrane proteins that mediate the effects of catecholamines at the cell surface. Catecholamines 116-130 adrenoceptor beta 2 Homo sapiens 0-28 20739277-1 2010 beta(2)-adrenergic receptors (beta(2)-AR) are low abundance, integral membrane proteins that mediate the effects of catecholamines at the cell surface. Catecholamines 116-130 adrenoceptor beta 2 Homo sapiens 30-40 18772317-13 2008 In conclusion, our data with betaAR-G(s)alpha fusion proteins show that endogenous catecholamines and ISO stabilize distinct conformations in the beta(1)AR and beta(2)AR. Catecholamines 83-97 adrenoceptor beta 2 Homo sapiens 160-169 22094268-14 2012 beta2AR but not GR was significantly increased after an acute stressor, which supports the hypothesis that catecholamine-mediated signal pathways in communication with the central nervous and immune systems play a fundamental role in acute stress-mediated immune alterations. Catecholamines 107-120 adrenoceptor beta 2 Homo sapiens 0-7 23056231-1 2012 A highly crystallizable T4 lysozyme (T4L) was fused to the N-terminus of the beta(2) adrenergic receptor (beta(2)AR), a G-protein coupled receptor (GPCR) for catecholamines. Catecholamines 158-172 adrenoceptor beta 2 Homo sapiens 77-104 23056231-1 2012 A highly crystallizable T4 lysozyme (T4L) was fused to the N-terminus of the beta(2) adrenergic receptor (beta(2)AR), a G-protein coupled receptor (GPCR) for catecholamines. Catecholamines 158-172 adrenoceptor beta 2 Homo sapiens 106-115 22013013-13 2011 CONCLUSIONS: Local catecholamine release into the VMH enhances counterregulatory responses to hypoglycemia via stimulation of B2AR. Catecholamines 19-32 adrenoceptor beta 2 Homo sapiens 126-130 21617201-4 2011 These exogenous catecholamines engage membrane-bound beta(2)-adrenergic receptors (beta(2)AR) on airway epithelial and smooth muscle cells to cause airway dilation. Catecholamines 16-30 adrenoceptor beta 2 Homo sapiens 83-92 20135061-3 2010 Catecholamines, released during ACS, contribute to platelet aggregation through platelet alpha2A-(alpha2A-AR) and beta2-adrenergic receptor (beta2-AR) stimulation. Catecholamines 0-14 adrenoceptor beta 2 Homo sapiens 114-139 20135061-3 2010 Catecholamines, released during ACS, contribute to platelet aggregation through platelet alpha2A-(alpha2A-AR) and beta2-adrenergic receptor (beta2-AR) stimulation. Catecholamines 0-14 adrenoceptor beta 2 Homo sapiens 141-149 19857486-6 2010 The action of these catecholamines was antagonized by beta(2)-adrenoceptor antagonist, but not by alpha(1)-, alpha(2)- and beta(1)-adrenoceptor antagonist. Catecholamines 20-34 adrenoceptor beta 2 Homo sapiens 54-74 19857969-0 2009 Structural basis of the selectivity of the beta(2)-adrenergic receptor for fluorinated catecholamines. Catecholamines 87-101 adrenoceptor beta 2 Homo sapiens 43-70 19857969-4 2009 Here, through a combination of molecular modeling and site-directed mutagenesis, we have identified N293 in the beta(2)-adrenergic receptor as a crucial residue for the selectivity of the receptor for catecholamines fluorinated at different positions. Catecholamines 201-215 adrenoceptor beta 2 Homo sapiens 112-139 19576569-1 2009 In humans, three genes--ADRB1, ADRB2 and ADRB3--encode beta-adrenoreceptors (ADRB); these molecules mediate the action of catecholamines in multiple tissues and play pivotal roles in cardiovascular, respiratory, metabolic, and immunological functions. Catecholamines 122-136 adrenoceptor beta 2 Homo sapiens 31-36 18772317-1 2008 Fluorescence studies with purified human beta(2)-adrenoceptor (beta(2)AR) revealed that the endogenous catecholamines, (-)-epinephrine (EPI), (-)-norepinephrine (NE), and dopamine (DOP), stabilize distinct active receptor conformations. Catecholamines 103-117 adrenoceptor beta 2 Homo sapiens 63-72 17962519-3 2007 Analysis of adrenergic receptor ligand-binding mutants within the context of the reported high-resolution structure of beta2AR-T4L provides insights into inverse-agonist binding and the structural changes required to accommodate catecholamine agonists. Catecholamines 229-242 adrenoceptor beta 2 Homo sapiens 119-126 19091080-2 2008 In septic shock, endogenous catecholamines induce beta2-AR downregulation, leading to an increased TNF-alpha release. Catecholamines 28-42 adrenoceptor beta 2 Homo sapiens 50-58 17199132-1 2007 The beta2-adrenergic receptor is part of the catecholamine system, and variants at two polymorphic sites in the gene coding for the receptor (ADRB2) confer increased activity. Catecholamines 45-58 adrenoceptor beta 2 Homo sapiens 4-29 17713401-2 2007 Catecholamines, however, also have marked metabolic effects, particularly on glucose metabolism, and the degree of this metabolic response is directly related to the beta2-adrenoceptor activity of the individual compound used. Catecholamines 0-14 adrenoceptor beta 2 Homo sapiens 166-184 17226783-8 2007 We propose that the mechanism for the pro-motogenic effect of the beta-adrenergic antagonist is blockade of the beta2-adrenergic receptor preventing autocrine catecholamine binding. Catecholamines 159-172 adrenoceptor beta 2 Homo sapiens 112-137 17199132-1 2007 The beta2-adrenergic receptor is part of the catecholamine system, and variants at two polymorphic sites in the gene coding for the receptor (ADRB2) confer increased activity. Catecholamines 45-58 adrenoceptor beta 2 Homo sapiens 142-147 16402117-4 2006 beta(2)-Adrenoceptor agonists are the most effective bronchodilators and evolved from catecholamines from the adrenal medulla, whereas corticosteroids, from the adrenal cortex, are by far the most effective controllers of the underlying inflammatory process in the airways. Catecholamines 86-100 adrenoceptor beta 2 Homo sapiens 0-20 16443756-2 2006 Although fibroblasts express beta2-adrenergic receptors (beta2-AR) and cutaneous keratinocytes can synthesize beta-AR agonists (catecholamines), the functional significance of this hormonal mediator network in the skin has not been addressed. Catecholamines 128-142 adrenoceptor beta 2 Homo sapiens 110-117 17211240-12 2007 Plasma CRP concentration in twins was predicted by polymorphisms at three loci in physiological series within the catecholamine biosynthetic/beta-adrenergic pathway: TH (tyrosine hydroxylase), ADRB1 (beta1-adrenergic receptor) and ADRB2 (beta2-adrenergic receptor). Catecholamines 114-127 adrenoceptor beta 2 Homo sapiens 231-236 17211240-12 2007 Plasma CRP concentration in twins was predicted by polymorphisms at three loci in physiological series within the catecholamine biosynthetic/beta-adrenergic pathway: TH (tyrosine hydroxylase), ADRB1 (beta1-adrenergic receptor) and ADRB2 (beta2-adrenergic receptor). Catecholamines 114-127 adrenoceptor beta 2 Homo sapiens 238-263 16339181-8 2006 These data suggest that subjects homozygous for Arg at codon 16 of the beta2AR have reduced and MAP at rest that persist during exercise with no evidence for differential changes over the course of exercise despite large changes in catecholamines. Catecholamines 232-246 adrenoceptor beta 2 Homo sapiens 71-78 16142389-1 2005 The human beta-2 adrenergic receptor (beta2AR) is responsible for the binding of endogenous catecholamines and their exogenously administered agonists and antagonists. Catecholamines 92-106 adrenoceptor beta 2 Homo sapiens 10-36 16142389-1 2005 The human beta-2 adrenergic receptor (beta2AR) is responsible for the binding of endogenous catecholamines and their exogenously administered agonists and antagonists. Catecholamines 92-106 adrenoceptor beta 2 Homo sapiens 38-45 14559905-2 2004 The beta2 adrenoreceptor (beta2AR) is a prototypical G protein-coupled receptor (GPCR) activated by catecholamines. Catecholamines 100-114 adrenoceptor beta 2 Homo sapiens 4-24 16286511-1 2005 The beta2-adrenoceptor gene may be of particular importance for human obesity because catecholamines have a central role in energy expenditure both as neurotransmitters and hormones. Catecholamines 86-100 adrenoceptor beta 2 Homo sapiens 4-22 15817484-3 2005 In the present study, we use catechol (1,2-benzenediol, a structural component of catecholamine agonists) as a molecular probe to identify mechanistic differences between beta(2)AR activation by catecholamine agonists, such as isoproterenol, and by the structurally related non-catechol partial agonist salbutamol. Catecholamines 195-208 adrenoceptor beta 2 Homo sapiens 171-180 15226157-9 2004 We conclude that 1) catecholamines stimulate cAMP-dependent anion and fluid secretion by IMCDi cells primarily through beta2-AR activation and 2) alpha2-AR activation attenuates cAMP-dependent anion secretion. Catecholamines 20-34 adrenoceptor beta 2 Homo sapiens 119-127 15105445-12 2004 These data provide evidence for constant bidirectional sarcollemal-vesicular betaAR trafficking in the in vivo heart and show that Rab4-mediated recycling of internalized betaAR is necessary for normal cardiac catecholamine responsiveness and resensitization after agonist exposure. Catecholamines 210-223 adrenoceptor beta 2 Homo sapiens 171-177 15458278-6 2004 This study clearly demonstrated that endogenous catecholamines elicited immunosuppressive effects through beta2-AR stimulation, possibly due to down-regulation of the expression of ICAM-1, CD40 and CD14 on monocytes. Catecholamines 48-62 adrenoceptor beta 2 Homo sapiens 106-114 15266027-0 2004 "Induced-fit" mechanism for catecholamine binding to the beta2-adrenergic receptor. Catecholamines 28-41 adrenoceptor beta 2 Homo sapiens 57-82 14610528-10 2004 CONCLUSION: Multiple SNPs in the beta(2)-adrenoceptor gene form several haplotypes that markedly influence beta(2)-receptor function- and catecholamine-induced lipolysis in fat cells. Catecholamines 138-151 adrenoceptor beta 2 Homo sapiens 33-53 14559905-4 2004 We used fluorescence spectroscopy to monitor catecholamine-induced conformational changes in purified beta2AR. Catecholamines 45-58 adrenoceptor beta 2 Homo sapiens 102-109 14559905-2 2004 The beta2 adrenoreceptor (beta2AR) is a prototypical G protein-coupled receptor (GPCR) activated by catecholamines. Catecholamines 100-114 adrenoceptor beta 2 Homo sapiens 26-33 14678347-11 2004 The attenuated beta2-adrenoceptor response in the Gly16-Glu27 haplotype would be in keeping with increased susceptibility to prior down-regulation by endogenous catecholamines. Catecholamines 161-175 adrenoceptor beta 2 Homo sapiens 15-33 12538816-4 2003 The modulatory effect of these catecholamines on ICAM-1 expression was antagonized by beta 2-AR antagonist, but not by alpha 1-, alpha 2-, or beta 1-AR antagonist. Catecholamines 31-45 adrenoceptor beta 2 Homo sapiens 86-95 12732361-8 2003 These results suggest that the beta(2)-AR is the major subtype mediating catecholamine-induced cAMP changes in LNCaP cells. Catecholamines 73-86 adrenoceptor beta 2 Homo sapiens 31-41 15536395-7 2004 Efforts directed towards improving the pharmacodynamic and pharmacokinetic properties, including the long-acting and selective beta2-adrenoceptor agonists, included two major pathways of modifying the basic structure of the catecholamines, which are described in this paper. Catecholamines 224-238 adrenoceptor beta 2 Homo sapiens 127-145 14561173-9 2003 These catecholamine effects are mediated largely via beta(2)-AR activation. Catecholamines 6-19 adrenoceptor beta 2 Homo sapiens 53-63 11311236-6 2001 These results suggested that catecholamines up-regulate UCP2 and UCP3 expression through direct action on the beta2-AR in skeletal muscle. Catecholamines 29-43 adrenoceptor beta 2 Homo sapiens 110-118 12399592-1 2002 Catecholamines signal through the beta2-adrenergic receptor by promoting production of the second messenger adenosine 3",5"-monophosphate (cAMP). Catecholamines 0-14 adrenoceptor beta 2 Homo sapiens 34-59 11429395-12 2001 This suggests that genetic variance in the beta(2)-adrenoceptor gene might be important for catecholamine function in humans, at least as far as adipocyte lipolysis is concerned. Catecholamines 92-105 adrenoceptor beta 2 Homo sapiens 43-63 11739457-1 2001 The lipolytic effects of catecholamines are mediated through members of the beta(2)-adrenergic receptor (BAR-2) family. Catecholamines 25-39 adrenoceptor beta 2 Homo sapiens 76-103 11358931-2 2001 Several possibilities have been proposed, including heart rate reduction, beta2-adrenoceptor-mediated modulation of catecholamine release, antagonism of the receptor-mediated toxic actions of norepinephrine on the myocardium, and favorable effects on myocardial energetics. Catecholamines 116-129 adrenoceptor beta 2 Homo sapiens 74-92 10940302-2 2000 The counterregulatory actions of insulin on catecholamine action are well known and include phosphorylation of the beta(2)-adrenergic receptor on Tyr(350), Tyr(354), and Tyr(364) in the C-terminal cytoplasmic domain, as well as enhanced sequestration of the beta(2)-adrenergic receptor. Catecholamines 44-57 adrenoceptor beta 2 Homo sapiens 115-142 10940302-2 2000 The counterregulatory actions of insulin on catecholamine action are well known and include phosphorylation of the beta(2)-adrenergic receptor on Tyr(350), Tyr(354), and Tyr(364) in the C-terminal cytoplasmic domain, as well as enhanced sequestration of the beta(2)-adrenergic receptor. Catecholamines 44-57 adrenoceptor beta 2 Homo sapiens 258-285 10689270-7 2000 CONCLUSIONS: We conclude that the Gly16 beta(2)AR polymorphism imparts attenuated vasodilatory responses to catecholamines in normal human beings and is an important genetic component in the regulation of peripheral blood flow and systemic arterial pressure. Catecholamines 108-122 adrenoceptor beta 2 Homo sapiens 40-49 7908406-4 1994 The increase and its reversal both were independent of the possible presence of contaminating catecholamines in the culture medium and thus appear to reflect spontaneous beta 2AR activity and direct antagonist-receptor interactions, respectively. Catecholamines 94-108 adrenoceptor beta 2 Homo sapiens 170-178 9435537-0 1997 Catecholamines increase monocyte TNF receptors and inhibit TNF through beta 2-adrenoreceptor activation. Catecholamines 0-14 adrenoceptor beta 2 Homo sapiens 71-92 9309797-1 1997 Molecular modeling studies have predicted that the beta-hydroxyl group of the catecholamines interacts with the beta 2-adrenoceptor at the serine residue at position 165 (Ser165) located on transmembrane helix IV; however, this has not been confirmed by site-directed mutagenesis. Catecholamines 78-92 adrenoceptor beta 2 Homo sapiens 112-131 9175046-14 1997 In hypotensive patients, plasma adrenaline levels were even higher; the increased plasma catecholamine levels induced an alpha 2- and beta 2-adrenoceptor downregulation. Catecholamines 89-102 adrenoceptor beta 2 Homo sapiens 121-153 8049696-4 1994 All these mechanisms are involved in homologous and heterologous regulation of beta 2-AR, which accounts for the modulation of beta 2-AR synthesis and responsiveness mediated by catecholamines, steroid hormones, inflammatory mediators and other agents. Catecholamines 178-192 adrenoceptor beta 2 Homo sapiens 79-88 8049696-4 1994 All these mechanisms are involved in homologous and heterologous regulation of beta 2-AR, which accounts for the modulation of beta 2-AR synthesis and responsiveness mediated by catecholamines, steroid hormones, inflammatory mediators and other agents. Catecholamines 178-192 adrenoceptor beta 2 Homo sapiens 127-136 10719595-11 2000 Dopexamine, a synthetic catecholamine, induces vasodilation via beta 2-adrenoceptor stimulation and potentially increases splanchnic blood flow by additional effects on dopaminergic receptors. Catecholamines 24-37 adrenoceptor beta 2 Homo sapiens 64-83 9176257-0 1997 Chronic effects of catecholamines on the beta 2-adrenoreceptor system in cultured human airway epithelial cells. Catecholamines 19-33 adrenoceptor beta 2 Homo sapiens 41-62 9100587-7 1997 The results indicate the existence of a marked impairment of catecholamine-induced lipolysis in nonobese PCOS women displaying early features of the insulin resistance syndrome due to multiple lipolysis defects as a lower beta 2-adrenoceptor density and reduced function of the protein kinase, hormone-sensitive lipase complex. Catecholamines 61-74 adrenoceptor beta 2 Homo sapiens 222-241 7613527-1 1995 To study the effect of chronic exposure to elevated plasma catecholamines on surface beta 2-adrenoceptor density, we measured these receptors in the lymphocytes of 9 patients with pheochromocytoma as well as in 27 healthy control subjects. Catecholamines 59-73 adrenoceptor beta 2 Homo sapiens 85-104 7613527-6 1995 We conclude that chronic catecholamine excess induces a decrease of lymphocyte beta 2-adrenoceptor surface number and response that is reversible upon normalization of plasma catecholamine levels. Catecholamines 25-38 adrenoceptor beta 2 Homo sapiens 79-98 7613527-6 1995 We conclude that chronic catecholamine excess induces a decrease of lymphocyte beta 2-adrenoceptor surface number and response that is reversible upon normalization of plasma catecholamine levels. Catecholamines 175-188 adrenoceptor beta 2 Homo sapiens 79-98 1334970-0 1992 Lipolytic catecholamine resistance due to decreased beta 2-adrenoceptor expression in fat cells. Catecholamines 10-23 adrenoceptor beta 2 Homo sapiens 52-71 1336061-10 1992 It is suggested that this up-regulation of the beta 2-adrenoceptor subtype could be owing to an increased importance of circulating catecholamines in modulating positive chronotropic and inotropic effects. Catecholamines 132-146 adrenoceptor beta 2 Homo sapiens 47-66 1351969-2 1992 The physiological effects of endogenous circulating catecholamines and exogenous adrenergic agonists in the lung are mediated by the beta 2-adrenergic receptor, which is present on a variety of cell types. Catecholamines 52-66 adrenoceptor beta 2 Homo sapiens 133-159 1685558-4 1991 The beta 2AR-mediated responses to the catecholamines, disclosed by CGP 20,712 A, were verified by blockade with the beta 2AR-selective ICI 118,551. Catecholamines 39-53 adrenoceptor beta 2 Homo sapiens 4-12 1685558-4 1991 The beta 2AR-mediated responses to the catecholamines, disclosed by CGP 20,712 A, were verified by blockade with the beta 2AR-selective ICI 118,551. Catecholamines 39-53 adrenoceptor beta 2 Homo sapiens 117-125 1652275-7 1991 In human heart, catecholamine-induced activation of one beta 2AR causes the production of at least four times more cyclic AMP than activation of one beta 1AR. Catecholamines 16-29 adrenoceptor beta 2 Homo sapiens 56-64