PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12527477-1 2002 The elevated levels of circulating catecholamines (CAs) with age may be related to the increased expression of CA biosynthetic enzymes, tyrosine hydroxylase (TH) and dopamine beta hydroxylase (DbetaH) in the adrenal medulla of senescent compared with younger animals. Catecholamines 35-49 dopamine beta-hydroxylase Rattus norvegicus 166-191 12051753-1 2002 Three of the catecholamine-synthesizing enzymes, i.e., tyrosine hydroxylase (TH), aromatic l-amino acid decarboxylase, and dopamine beta-hydroxylase, were earlier shown to be up-regulated in cloned PC12D cells overexpressing V-1, a cdc10/SWI6 motif-containing protein. Catecholamines 13-26 dopamine beta-hydroxylase Rattus norvegicus 123-148 11032889-1 2000 Nicotine treatment increases intracellular free Ca(2+) concentration [Ca(2+)](i), stimulates catecholamine release, and elevates gene expression for the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH). Catecholamines 153-166 dopamine beta-hydroxylase Rattus norvegicus 218-243 11173223-2 2001 Immunoreactivity for the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), aromatic-L-amino-acid decarboxylase (AADC) and dopamine beta-hydroxylase (DBH) was present in all chromaffin cells, while phenylethanolamine N-methyltransferase (PNMT) was used to determine adrenergic chromaffin cell groups. Catecholamines 25-38 dopamine beta-hydroxylase Rattus norvegicus 134-159 11173223-2 2001 Immunoreactivity for the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), aromatic-L-amino-acid decarboxylase (AADC) and dopamine beta-hydroxylase (DBH) was present in all chromaffin cells, while phenylethanolamine N-methyltransferase (PNMT) was used to determine adrenergic chromaffin cell groups. Catecholamines 25-38 dopamine beta-hydroxylase Rattus norvegicus 161-164 11032889-1 2000 Nicotine treatment increases intracellular free Ca(2+) concentration [Ca(2+)](i), stimulates catecholamine release, and elevates gene expression for the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH). Catecholamines 153-166 dopamine beta-hydroxylase Rattus norvegicus 245-248 11028916-10 2000 Since PHM is homologous in sequence and mechanism to dopamine beta-monooxygenase (DBM; EC 1.14.17.1), the enzyme that converts dopamine to norepinephrine during catecholamine biosynthesis, these structural and mechanistic insights are extended to DBM. Catecholamines 161-174 dopamine beta-hydroxylase Rattus norvegicus 53-80 11144961-8 2000 These grafted chromaffin cells also expressed immunoreactivities for the other catecholamine-synthesizing enzymes 7 weeks after grafting, including: dopamine-beta-hydroxylase (DbetaH) and phenylethanolamine-N-methyltransferase (PNMT). Catecholamines 79-92 dopamine beta-hydroxylase Rattus norvegicus 149-174 9353359-3 1997 As a consequence of the redox chemistry of the selenium moiety, phenylaminoalkyl selenides possess the remarkable characteristic of propagating a cycle of turnover-dependent local depletion of reduced ascorbate when processed by the key enzyme of catecholamine metabolism, dopamine-beta-monooxygenase. Catecholamines 247-260 dopamine beta-hydroxylase Rattus norvegicus 273-300 10562636-5 1999 An increased catecholamine synthesis was indicated by the raised (P < 0.05) plasma dopamine beta-hydroxylase activity at 3 days, but this was decreased (P < 0. Catecholamines 13-26 dopamine beta-hydroxylase Rattus norvegicus 86-111 10336176-5 1999 We also conducted immunohistochemistry of the catecholamine synthesizing enzymes, tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH), in sections from perfusion-fixed male rats and showed that TH is present in neuronal perikarya and processes in the anteroventral periventricular region of the mPOA, while DBH was only seen in fibers and terminals. Catecholamines 46-59 dopamine beta-hydroxylase Rattus norvegicus 139-142 9765218-3 1998 Here, we provide evidence that overexpression of a novel cdc10/SWI6 motif-containing protein, V-1, elicits the coordinate up-regulation of tyrosine hydroxylase, aromatic L-amino acid decarboxylase, and dopamine beta-hydroxylase mRNAs in the neuronal cell line PC12D, and as a result, catecholamine levels are increased. Catecholamines 284-297 dopamine beta-hydroxylase Rattus norvegicus 202-227 9641484-1 1998 Nepicastat (RS-25560-197) is a novel, selective, and potent inhibitor of dopamine beta-hydroxylase, which modulates catecholamine levels (reduces norepinephrine and elevates dopamine) in cardiovascular tissues. Catecholamines 116-129 dopamine beta-hydroxylase Rattus norvegicus 73-98 9727025-2 1998 For the catecholamine biosynthetic enzymes, dopamine beta-hydroxylase and tyrosine hydroxylase, regulation of gene expression by cyclic AMP, diacyl glycerol, and Ca2+ leads to increased neurotransmitter biosynthesis. Catecholamines 8-21 dopamine beta-hydroxylase Rattus norvegicus 44-69 8756565-5 1996 Using an indirect immunological approach (plasma membrane localization of dopamine-beta-hydroxylase), we demonstrated that stimulation of rat adrenal medulla V1b receptor leads to catecholamine secretion. Catecholamines 180-193 dopamine beta-hydroxylase Rattus norvegicus 74-99 9153661-5 1997 Therefore, we compared immunoreactivity for the catecholamine-synthesizing enzyme dopamine beta-hydroxylase, for neuropeptide Y and for substance P in the intermediate gray matter of the spinal cord in control rats and in rats seven or fourteen days after transection at the fourth thoracic cord segment. Catecholamines 48-61 dopamine beta-hydroxylase Rattus norvegicus 82-107 7584561-1 1995 Local production of catecholamines in the stomach of the rat was studied by immunohistochemical demonstration of tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT), the enzymes catalyzing the formation of dopamine, noradrenaline and adrenaline, respectively. Catecholamines 20-34 dopamine beta-hydroxylase Rattus norvegicus 140-165 7584561-1 1995 Local production of catecholamines in the stomach of the rat was studied by immunohistochemical demonstration of tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT), the enzymes catalyzing the formation of dopamine, noradrenaline and adrenaline, respectively. Catecholamines 20-34 dopamine beta-hydroxylase Rattus norvegicus 167-170 7901211-2 1993 Nicotine, a major component of tobacco smoke, stimulates catecholamine secretion and activates catecholamine biosynthetic enzymes such as tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) in adrenal medullary cells. Catecholamines 95-108 dopamine beta-hydroxylase Rattus norvegicus 195-198 8572926-7 1995 The determination of plasma DBH activity could be a marker to monitor the effect of thiram on catecholamine metabolism in occupationally exposed workers but not that of disulfiram in abstinent alcoholics. Catecholamines 94-107 dopamine beta-hydroxylase Rattus norvegicus 28-31 7515319-3 1994 Brainstem sections were then processed immunohistochemically for the identification of cell bodies containing the catecholamine biosynthetic enzymes tyrosine hydroxylase, dopamine beta-hydroxylase (DBH) or phenylethanolamine-N-methyltransferase (PNMT). Catecholamines 114-127 dopamine beta-hydroxylase Rattus norvegicus 171-196 1761139-12 1991 Immunohistochemical study of BAT showed localization of DBH in perivascular mesenchymal cells which corresponded with the morphologic distribution of catecholamine as reported by Lever. Catecholamines 150-163 dopamine beta-hydroxylase Rattus norvegicus 56-59 8103115-4 1993 Concomitantly, RA reduced the specific activities of two catecholamine synthetic enzymes, tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) and the level of norepinephrine (NE). Catecholamines 57-70 dopamine beta-hydroxylase Rattus norvegicus 120-145 8103115-4 1993 Concomitantly, RA reduced the specific activities of two catecholamine synthetic enzymes, tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) and the level of norepinephrine (NE). Catecholamines 57-70 dopamine beta-hydroxylase Rattus norvegicus 147-150 1349344-3 1992 In this study the effects of a single and repeated immobilization stress on mRNA levels of the adrenal catecholamine biosynthetic enzymes, tyrosine hydroxylase and dopamine beta-hydroxylase, were examined. Catecholamines 103-116 dopamine beta-hydroxylase Rattus norvegicus 164-189 1346629-6 1992 The results indicate that dopamine is the major catecholamine located in the laryngeal nerve paraganglia and show that ganglionic cells in the recurrent and superior laryngeal nerves show immunolabelling for one of the enzymes in the catecholamine synthetic pathway, dopamine-beta-hydroxylase. Catecholamines 234-247 dopamine beta-hydroxylase Rattus norvegicus 267-292 1686923-2 1991 In this study, the effect of elevated KCl, under isotonic and hypertonic conditions, on the changes in mRNA levels of the catecholamine biosynthetic enzymes, tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) was compared. Catecholamines 122-135 dopamine beta-hydroxylase Rattus norvegicus 188-213 1686923-2 1991 In this study, the effect of elevated KCl, under isotonic and hypertonic conditions, on the changes in mRNA levels of the catecholamine biosynthetic enzymes, tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) was compared. Catecholamines 122-135 dopamine beta-hydroxylase Rattus norvegicus 215-218 2204497-0 1990 Dopamine beta-hydroxylase inhibition reveals a selective influence of endotoxin on catecholamine content of rat tissues. Catecholamines 83-96 dopamine beta-hydroxylase Rattus norvegicus 0-25 1976532-1 1990 Immunohistochemical localization of the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), and phenylethanolamine N-methyltransferase (PNMT) was employed to reveal the anatomical organization of the A1 noradrenergic cell group in the caudal ventrolateral medulla oblongata of the rat. Catecholamines 40-53 dopamine beta-hydroxylase Rattus norvegicus 102-127 1976532-1 1990 Immunohistochemical localization of the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), and phenylethanolamine N-methyltransferase (PNMT) was employed to reveal the anatomical organization of the A1 noradrenergic cell group in the caudal ventrolateral medulla oblongata of the rat. Catecholamines 40-53 dopamine beta-hydroxylase Rattus norvegicus 129-132 1747753-2 1991 We used antisera against the catecholamine synthesizing enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT), and one against the transmitter serotonin (5-HT). Catecholamines 29-42 dopamine beta-hydroxylase Rattus norvegicus 91-116 1747753-2 1991 We used antisera against the catecholamine synthesizing enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT), and one against the transmitter serotonin (5-HT). Catecholamines 29-42 dopamine beta-hydroxylase Rattus norvegicus 118-121 1884235-4 1991 In addition, unilateral vsubLC lesions dramatically reduced the catecholamine innervation of the ipsilateral paraventricular nucleus (PVN), as qualitatively determined with dopamine beta-hydroxylase immunocytochemistry, suggesting that a pathway ascending with catecholaminergic fibers was disrupted. Catecholamines 64-77 dopamine beta-hydroxylase Rattus norvegicus 173-198 2622800-3 1989 Antibodies to CRF, ACTH(1-39) and the catecholamine synthesizing enzymes which are tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) were utilized. Catecholamines 38-51 dopamine beta-hydroxylase Rattus norvegicus 137-140 2622800-3 1989 Antibodies to CRF, ACTH(1-39) and the catecholamine synthesizing enzymes which are tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) were utilized. Catecholamines 38-51 dopamine beta-hydroxylase Rattus norvegicus 110-135 35409327-3 2022 Four weeks after kaolin injection into the cisterna magna, immunodetection of the catecholamine-synthetizing enzymes TH and dopamine-beta-hydroxylase (DBH) was performed in the LC and spinal cord. Catecholamines 82-95 dopamine beta-hydroxylase Rattus norvegicus 124-149 2846338-2 1988 Immunohistochemical labeling of medullary neurons containing the catecholamine biosynthetic enzymes tyrosine hydroxylase, dopamine beta-hydroxylase, and phenylethanolamine N-methyltransferase was used to reveal the anatomical location of A1 noradrenergic neurons within the ventrolateral medulla. Catecholamines 65-78 dopamine beta-hydroxylase Rattus norvegicus 122-147 2440918-4 1987 Galanin immunoreactivity was found to coexist with dopamine-beta-hydroxylase (DBH) immunoreactivity in subsets of retrogradely labeled neurons of the A1 and A6 (locus coeruleus) catecholamine cell groups; no evidence was adduced for the presence of galanin in adrenergic (i.e., phenylethanolamine-N-methyltransferase-positive) neurons that project to the PVH. Catecholamines 178-191 dopamine beta-hydroxylase Rattus norvegicus 51-76 2883207-9 1987 The analysis of immunoreactivity to the catecholamine-synthesizing enzymes showed that there was a cell population with intense reactivity to both tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH). Catecholamines 40-53 dopamine beta-hydroxylase Rattus norvegicus 177-202 2883207-9 1987 The analysis of immunoreactivity to the catecholamine-synthesizing enzymes showed that there was a cell population with intense reactivity to both tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH). Catecholamines 40-53 dopamine beta-hydroxylase Rattus norvegicus 204-207 6572968-0 1983 Genes for catecholamine biosynthesis: cloning by expression and identification of the cDNA for rat dopamine beta-hydroxylase. Catecholamines 10-23 dopamine beta-hydroxylase Rattus norvegicus 99-124 3980483-7 1985 We propose that in addition to the dopamine beta-hydroxylase which is found in catecholamine storage vesicles and released during stimulus-coupled exocytosis, PC12 cells also have a constitutive secretory pathway for dopamine beta-hydroxylase and that the enzyme released by this second pathway is sulfated. Catecholamines 79-92 dopamine beta-hydroxylase Rattus norvegicus 35-60 2858497-6 1985 In this study the location of catecholamine-synthesizing enzymes was examined in the serial sections of the caudal medulla oblongata of the rat: tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), and phenylethanolamine N-methyl transferase (PNMT). Catecholamines 30-43 dopamine beta-hydroxylase Rattus norvegicus 199-202 6715801-5 1984 These results suggest that an age-related increase in adrenal DBH activity may, at least in part, contribute to increased levels of circulating catecholamines. Catecholamines 144-158 dopamine beta-hydroxylase Rattus norvegicus 62-65 6305955-11 1983 These experiments suggest that the proportions of the subunit forms of dopamine beta-hydroxylase can be regulated in cells by external signals and this may reflect alterations in post-translational processing enzymes and may serve as a potential mechanism to regulate catecholamine metabolism. Catecholamines 268-281 dopamine beta-hydroxylase Rattus norvegicus 71-96 6611632-2 1983 The authors determined the dissociation constant, the constant of copper complex formation, the inhibitory action on the catecholamine biosynthesis enzyme dopamine beta-hydroxylase (DBH; copper glycoprotein), as well as the antihypertensive effect on spontaneously hypertensive rats of a series of substituted picolinic or fusaric acids (FA; 5-n-butylpicolinic acids). Catecholamines 121-134 dopamine beta-hydroxylase Rattus norvegicus 155-180 6358942-3 1983 alpha-Methyl-p-tyrosine, diethyldithiocarbamate and SKF 64139 inhibit catecholamine synthesis at the level of tyrosine hydroxylase, dopamine beta-hydroxylase and phenylethanolamine N-methyltransferase, respectively. Catecholamines 70-83 dopamine beta-hydroxylase Rattus norvegicus 132-157 6183680-1 1982 Resulting from literature data concerning interactions between catecholamines and Substance P (SP) the influence of SP on the activity of dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) was studied in rat adrenals. Catecholamines 63-77 dopamine beta-hydroxylase Rattus norvegicus 138-163 6339120-5 1983 Administration of fusaric acid, a dopamine-beta-hydroxylase inhibitor markedly decreased urinary excretion of catecholamine and prostaglandin E in both SHR and Wistar rat and abolished the development of hypertension in SHR. Catecholamines 110-123 dopamine beta-hydroxylase Rattus norvegicus 34-59 6183680-1 1982 Resulting from literature data concerning interactions between catecholamines and Substance P (SP) the influence of SP on the activity of dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) was studied in rat adrenals. Catecholamines 63-77 dopamine beta-hydroxylase Rattus norvegicus 165-168 7092762-1 1982 Dopamine-beta-hydroxylase (DBH) is unique among the catecholamine biosynthetic enzymes in that release from sympathoadrenal cells during neurotransmission is an integral part of the enzyme"s physiology. Catecholamines 52-65 dopamine beta-hydroxylase Rattus norvegicus 0-25 7098414-1 1982 In the myocardium of the weightless and centrifuged rats flown for 18.5 days onboard the biosatellite Cosmos-936 the catecholamine concentration and activity of enzymes involved in their synthesis and degradation--dopamine-beta-hydroxylase, monoamine oxidase and catechol-O-methyl transferase--were measured. Catecholamines 117-130 dopamine beta-hydroxylase Rattus norvegicus 214-239 7092762-1 1982 Dopamine-beta-hydroxylase (DBH) is unique among the catecholamine biosynthetic enzymes in that release from sympathoadrenal cells during neurotransmission is an integral part of the enzyme"s physiology. Catecholamines 52-65 dopamine beta-hydroxylase Rattus norvegicus 27-30 6163796-2 1981 The catecholamine synthesizing enzymes TH and DBH, found jointly only in noradrenergic and adrenergic neurons, were localized in cells having a similar morphology and topographical distribution. Catecholamines 4-17 dopamine beta-hydroxylase Rattus norvegicus 46-49 458440-1 1979 Knowledge of the vesicular origin of circulating dopamine beta-hydroxylase (DbetaH) is indispensable for any attempts to explain the parallelism or lack of it between circulating enzyme and catecholamines as they may relate to physiological stress, forms of hypertension, neurological disorders, and the response to pharmacological agents. Catecholamines 190-204 dopamine beta-hydroxylase Rattus norvegicus 49-74 7289544-1 1981 The concentration of catecholamines and activity of enzymes involved in their synthesis and degradation, i. e. dopamine-beta-hydroxylase, monoamine oxidase and catechol-O-methyl transferase, were measured in the myocardium of rats flown for 19.5 days aboard Cosmos-782 and used in the synchronous and vivarium experiments. Catecholamines 21-35 dopamine beta-hydroxylase Rattus norvegicus 111-136 530533-2 1979 The catecholamine (CA) levels were measured after inhibition of dopamine-beta-hydroxylase (DBH) or phenylethanolamine-N-methyltransferase (PNMT). Catecholamines 4-17 dopamine beta-hydroxylase Rattus norvegicus 64-89 530533-2 1979 The catecholamine (CA) levels were measured after inhibition of dopamine-beta-hydroxylase (DBH) or phenylethanolamine-N-methyltransferase (PNMT). Catecholamines 4-17 dopamine beta-hydroxylase Rattus norvegicus 91-94 458440-1 1979 Knowledge of the vesicular origin of circulating dopamine beta-hydroxylase (DbetaH) is indispensable for any attempts to explain the parallelism or lack of it between circulating enzyme and catecholamines as they may relate to physiological stress, forms of hypertension, neurological disorders, and the response to pharmacological agents. Catecholamines 190-204 dopamine beta-hydroxylase Rattus norvegicus 76-82 201940-4 1977 Finally, in Experiment 3, the three DBH inhibitors reduced self-stimulation (a behavior dependent upon catecholamines) in a dose-related manner and intraventricular injections of 1-norepinephrine reinstated normal rates of self-stimulation. Catecholamines 103-117 dopamine beta-hydroxylase Rattus norvegicus 36-39 23469-5 1978 The activity of adrenal catecholamine-synthesizing enzymes also increased with age: tyrosine hydroxylase gradually increased until the 360th day, dopamine-beta-hydroxylase and phenylethanolamine-N-methyl transferase until the 200th day. Catecholamines 24-37 dopamine beta-hydroxylase Rattus norvegicus 146-171 1153081-0 1975 Effect of a dopamine beta-hydroxylase inhibitor on tissue catecholamine levels in spontaneously hypertensive rats subjected to immobilization-cold stress. Catecholamines 58-71 dopamine beta-hydroxylase Rattus norvegicus 12-37 932994-9 1976 Catecholamine release induced by 56 mM K+ appears to be by exocytosis, since this release is dependent upon extracellular Ca++, and is accompanied by the release of dopamine beta-monooxygenase, but not of lactate dehydrogenase, from the cells. Catecholamines 0-13 dopamine beta-hydroxylase Rattus norvegicus 165-192 11494-0 1976 Depletion and recovery of catecholamines in the rat adrenal medulla and its relationship with dopamine beta-hydroxylase. Catecholamines 26-40 dopamine beta-hydroxylase Rattus norvegicus 94-119 958503-1 1976 Cold exposure of rats for 4 h and simultaneous inhibition of dopamine beta-hydroxylase by FLA-63 (25mg/kg) led to a reduction of the catecholamine content of the adrenal medulla by 46% and of the brain by 68%. Catecholamines 133-146 dopamine beta-hydroxylase Rattus norvegicus 61-86 1254939-6 1976 Dopamine-beta-hydroxylase inhibition produced by FLA-63, fusaric acid or diethyldithiocarbamate resulted in all cases in a 50-70% reduction of the catecholamine fluorescence in the subependymal layer, whereas only minute effects were observed in the lateral palisade zone. Catecholamines 147-160 dopamine beta-hydroxylase Rattus norvegicus 0-25 30651588-4 2019 In the adrenal glands of prehypertensive SHR, the expression of catecholamine biosynthetic enzymes Ddc, Dbh and Pnmt was lower than in aged-matched Wistar-Kyoto rats. Catecholamines 64-77 dopamine beta-hydroxylase Rattus norvegicus 104-107 31306490-12 2019 Taken together, our results point to a novel mechanism by which Ang II participates in the regulation of axonal synthesis of NE by modulating the local trafficking and expression of TH and DBH, two key enzymes involved in the catecholamine biosynthetic pathway. Catecholamines 226-239 dopamine beta-hydroxylase Rattus norvegicus 189-192 5572168-1 1971 Dopamine-beta- hydroxylase is an enzyme that is localized to catecholamine-containing vesicles in sympathetic nerves and the adrenal medulla, and is also found in the serum. Catecholamines 61-74 dopamine beta-hydroxylase Rattus norvegicus 0-26 30651588-6 2019 In the adrenal glands of adult SHR, the expression of catecholamine biosynthetic enzymes Th, Ddc, Dbh and Pnmt was decreased along the amounts of dopamine and noradrenaline (50% and 38%, respectively, p < 0.001). Catecholamines 54-67 dopamine beta-hydroxylase Rattus norvegicus 98-101 27618227-9 2017 The catecholamine biosynthetic enzyme dopamine-beta-hydroxylase (DbetaH) was increased in FD/O but not FD/E A2 cells. Catecholamines 4-17 dopamine beta-hydroxylase Rattus norvegicus 38-63 28737969-6 2017 Moreover, immobilization stress elevated the mRNA levels of tyrosine hydroxylase (Th), dopamine beta-hydroxylase (Dbh), and cytochrome P450 side-chain cleavage (P450scc), which are related to catecholamine and corticosterone synthesis in the adrenal gland. Catecholamines 192-205 dopamine beta-hydroxylase Rattus norvegicus 87-112 24259582-1 2013 We have shown that an antibody to dopamine-beta-hydroxylase conjugated with saporin (anti-DBH-SAP) damages catecholamine neurons in the nucleus tractus solitarii (NTS) of rat, attenuates arterial baroreflexes, and leads to lability of arterial blood pressure, damage to cardiac myocytes, and, in some animals, sudden death. Catecholamines 107-120 dopamine beta-hydroxylase Rattus norvegicus 34-59 28759191-4 2017 The aims of this study are to investigate the effects of age on the biosynthetic pathway of catecholamines in adrenal medulla by determining the level of blood glucose and blood catecholamines, the gene and protein expression of biosynthetic catecholamine enzymes (TH, DBH and PNMT) as well as protein kinase substrates that involved in the phosphorylation of TH in 2DG-induced rats. Catecholamines 92-106 dopamine beta-hydroxylase Rattus norvegicus 269-272 25978516-8 2015 Both responses were eliminated by a lesion of catecholamine neurons innervating orexin neurons using the retrogradely transported immunotoxin, anti-dopamine-beta-hydroxylase saporin, which is specifically internalized by dopamine-beta-hydroxylase-expressing catecholamine neurons. Catecholamines 46-59 dopamine beta-hydroxylase Rattus norvegicus 148-173 25978516-8 2015 Both responses were eliminated by a lesion of catecholamine neurons innervating orexin neurons using the retrogradely transported immunotoxin, anti-dopamine-beta-hydroxylase saporin, which is specifically internalized by dopamine-beta-hydroxylase-expressing catecholamine neurons. Catecholamines 46-59 dopamine beta-hydroxylase Rattus norvegicus 221-246 25978516-8 2015 Both responses were eliminated by a lesion of catecholamine neurons innervating orexin neurons using the retrogradely transported immunotoxin, anti-dopamine-beta-hydroxylase saporin, which is specifically internalized by dopamine-beta-hydroxylase-expressing catecholamine neurons. Catecholamines 258-271 dopamine beta-hydroxylase Rattus norvegicus 148-173 25978516-8 2015 Both responses were eliminated by a lesion of catecholamine neurons innervating orexin neurons using the retrogradely transported immunotoxin, anti-dopamine-beta-hydroxylase saporin, which is specifically internalized by dopamine-beta-hydroxylase-expressing catecholamine neurons. Catecholamines 258-271 dopamine beta-hydroxylase Rattus norvegicus 221-246 24631866-10 2014 Western blotting of laser-microdissected A2 neurons revealed glucoprivic stimulation of Fos, but inhibition of the catecholamine synthetic enzyme, dopamine-beta-hydroxylase; 5TG also diminished A2 estrogen receptor (ER)-alpha and progesterone receptor profiles, but augmented ER-beta protein. Catecholamines 115-128 dopamine beta-hydroxylase Rattus norvegicus 147-172 28759191-4 2017 The aims of this study are to investigate the effects of age on the biosynthetic pathway of catecholamines in adrenal medulla by determining the level of blood glucose and blood catecholamines, the gene and protein expression of biosynthetic catecholamine enzymes (TH, DBH and PNMT) as well as protein kinase substrates that involved in the phosphorylation of TH in 2DG-induced rats. Catecholamines 92-105 dopamine beta-hydroxylase Rattus norvegicus 269-272 26062632-6 2015 Then, with the use of the retrogradely transported immunotoxin, anti-DBH conjugated to saporin (DSAP), which targets and destroys DBH-expressing catecholamine neurons, we examined the hypothesis that catecholamine neurons are required for orexin-induced feeding. Catecholamines 200-213 dopamine beta-hydroxylase Rattus norvegicus 69-72 26062632-6 2015 Then, with the use of the retrogradely transported immunotoxin, anti-DBH conjugated to saporin (DSAP), which targets and destroys DBH-expressing catecholamine neurons, we examined the hypothesis that catecholamine neurons are required for orexin-induced feeding. Catecholamines 200-213 dopamine beta-hydroxylase Rattus norvegicus 130-133 23675273-1 2012 Dopoamine-beta-hydroxylase (DBH) is a catecholamine-synthesizing enzyme which catalyzes the formation of norepinephrine from dopamine. Catecholamines 38-51 dopamine beta-hydroxylase Rattus norvegicus 0-26 23675273-1 2012 Dopoamine-beta-hydroxylase (DBH) is a catecholamine-synthesizing enzyme which catalyzes the formation of norepinephrine from dopamine. Catecholamines 38-51 dopamine beta-hydroxylase Rattus norvegicus 28-31 20736996-3 2010 We hypothesized that disulfiram"s inhibition of dopamine beta-hydroxylase (DBH), the catecholamine biosynthetic enzyme that converts dopamine (DA) to norepinephrine (NE) in noradrenergic neurons, underlies the drug"s ability to treat cocaine dependence. Catecholamines 85-98 dopamine beta-hydroxylase Rattus norvegicus 48-73 21681478-3 2012 This study aimed at investigating physical exercise-related changes in gene expression of catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase in the adrenal medulla and stellate ganglia of chronically psychosocially stressed adult rats exposed daily to 20-min treadmill exercise for 12 weeks, using TaqMan RT-PCR assay. Catecholamines 90-103 dopamine beta-hydroxylase Rattus norvegicus 152-177 21681478-3 2012 This study aimed at investigating physical exercise-related changes in gene expression of catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase in the adrenal medulla and stellate ganglia of chronically psychosocially stressed adult rats exposed daily to 20-min treadmill exercise for 12 weeks, using TaqMan RT-PCR assay. Catecholamines 90-103 dopamine beta-hydroxylase Rattus norvegicus 179-182 21777029-3 2011 Here we investigated the expression of mRNAs for catecholamine biosynthetic enzymes tyrosine-hydroxylase, dopamine-beta-hydroxylase and phenylethanolamine N-methyl-transferase, and for beta(1)- and beta(2)-adrenoceptors in the right and left ventricles of rats exposed to chronic unpredictable mild stress. Catecholamines 49-62 dopamine beta-hydroxylase Rattus norvegicus 106-131 20736996-3 2010 We hypothesized that disulfiram"s inhibition of dopamine beta-hydroxylase (DBH), the catecholamine biosynthetic enzyme that converts dopamine (DA) to norepinephrine (NE) in noradrenergic neurons, underlies the drug"s ability to treat cocaine dependence. Catecholamines 85-98 dopamine beta-hydroxylase Rattus norvegicus 75-78 20827341-2 2010 It is well established that long-term stress leads to the induction of catecholamine biosynthetic enzymes such as tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) in adrenal medulla. Catecholamines 71-84 dopamine beta-hydroxylase Rattus norvegicus 144-169 20827341-2 2010 It is well established that long-term stress leads to the induction of catecholamine biosynthetic enzymes such as tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) in adrenal medulla. Catecholamines 71-84 dopamine beta-hydroxylase Rattus norvegicus 171-174 20378607-4 2010 We identified cis-acting eQTLs for Dbh, Pnmt (catecholamine biosynthesis) and Vamp1 (catecholamine secretion); enzymatic activities of Dbh and Pnmt paralleled transcripts, with pQTLs for activities mirroring eQTLs. Catecholamines 85-98 dopamine beta-hydroxylase Rattus norvegicus 135-138 20437524-10 2010 Considered with data demonstrating that Phox2a is part of the transcriptional complex that drives expression of dopamine-beta-hydroxylase and can also up-regulate expression of other genes, the data support the conclusion that Phox2a plays an important role in brainstem catecholamine neurotransmission and in the regulation of adaptive homeostatic functions in the adult nervous system. Catecholamines 271-284 dopamine beta-hydroxylase Rattus norvegicus 112-137 19112418-2 2008 The aim of this work was to investigate the changes in gene expression and protein levels of catecholamine biosynthetic enzymes: tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) in the adrenal medulla of naive control and chronically (12 weeks) socially isolated adult Wistar rat males and the response of these animals to additional immobilization stress (2 h). Catecholamines 93-106 dopamine beta-hydroxylase Rattus norvegicus 156-181 19893991-3 2009 In the present study, the changes in gene expression of the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) and protein levels in the right and left heart auricles of naive control and long-term (12 weeks) socially isolated rats were investigated by Taqman RT-PCR and Western blot analysis. Catecholamines 60-73 dopamine beta-hydroxylase Rattus norvegicus 122-147 19893991-3 2009 In the present study, the changes in gene expression of the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) and protein levels in the right and left heart auricles of naive control and long-term (12 weeks) socially isolated rats were investigated by Taqman RT-PCR and Western blot analysis. Catecholamines 60-73 dopamine beta-hydroxylase Rattus norvegicus 149-152 19212441-3 2009 Phagocytes isolated from adrenalectomized rats displayed enhanced expression of tyrosine-hydroxylase and dopamine-beta-hydroxylase, two key enzymes for catecholamine production and exhibited higher baseline secretion of norepinephrine and epinephrine. Catecholamines 152-165 dopamine beta-hydroxylase Rattus norvegicus 105-130 19112418-2 2008 The aim of this work was to investigate the changes in gene expression and protein levels of catecholamine biosynthetic enzymes: tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) in the adrenal medulla of naive control and chronically (12 weeks) socially isolated adult Wistar rat males and the response of these animals to additional immobilization stress (2 h). Catecholamines 93-106 dopamine beta-hydroxylase Rattus norvegicus 183-186 18987458-6 2008 Real-time quantitative polymerase-chain reaction was performed to quantify relative expression levels of mRNAs for catecholamine biosynthetic enzymes in the adrenals and the anterocervical ganglia: tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT). Catecholamines 115-128 dopamine beta-hydroxylase Rattus norvegicus 225-250 18987458-6 2008 Real-time quantitative polymerase-chain reaction was performed to quantify relative expression levels of mRNAs for catecholamine biosynthetic enzymes in the adrenals and the anterocervical ganglia: tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT). Catecholamines 115-128 dopamine beta-hydroxylase Rattus norvegicus 252-255 18783367-4 2008 mRNA for enzymes in dorsal root ganglia involved in catecholamine uptake and metabolism, dopamine beta-hydroxylase and MAO-A, were decreased by neonatal administration of capsaicin. Catecholamines 52-65 dopamine beta-hydroxylase Rattus norvegicus 89-114