PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
171710-3	1975	These findings are suggestive of a second messenger role of cyclic AMP in the beta-adrenoreceptor-mediated actions of catecholamines on myocardial contractile force and relaxation, in which Ca2+ would serve as a third messenger and be subject, respectively, to more effective removal from its binding sites on troponin.	Catecholamines	118-132	adenine phosphoribosyltransferase	Homo sapiens	67-70	
171710-4	1975	An alternative interpretation regards Ca2+ and cyclic AMP as interdependent twin second messengers in the catecholamine-induced inotropism.	Catecholamines	106-119	adenine phosphoribosyltransferase	Homo sapiens	54-57	
171710-5	1975	Since the physiological meaning of the reported effects of cyclic AMP on isolated myocardial membrane preparations is far from established an instances of a dissociation between the effects of catecholamines on myocardial contractile force and cyclic AMP levels have been observed, there is still room for hypotheses that relegate cyclic AMP to a nonobligatory, at most, supportive role in the action of the catecholamines on cardiac contraction.	Catecholamines	408-422	adenine phosphoribosyltransferase	Homo sapiens	251-254	
171710-5	1975	Since the physiological meaning of the reported effects of cyclic AMP on isolated myocardial membrane preparations is far from established an instances of a dissociation between the effects of catecholamines on myocardial contractile force and cyclic AMP levels have been observed, there is still room for hypotheses that relegate cyclic AMP to a nonobligatory, at most, supportive role in the action of the catecholamines on cardiac contraction.	Catecholamines	408-422	adenine phosphoribosyltransferase	Homo sapiens	251-254	
72410-4	1977	In guinea-pig and human lung fragments, catecholamines and PGs increase cyclic AMP levels and inhibit the release of histamine, SRS-A and ECF-A following antigen challenge.	Catecholamines	40-54	adenine phosphoribosyltransferase	Homo sapiens	79-82