PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28746172-7 2017 After Bonferroni correction the polymorphism rs4680 (ValMet) in COMT was significantly associated with lower SBP in participants treated with CCBs (P = .009) with an especially strong impact in elderly individuals (age >= 70) alone (Delta = -14.08 mm Hg, P = .0005).These results underline the important role of estrogens and catecholamines in hypertension and the importance of genotype dependent, age-related adjustments of calcium-channel blocker treatment. Catecholamines 329-343 catechol-O-methyltransferase Homo sapiens 64-68 29677196-3 2018 Given the previously established role of catecholamines in both placebo effects and stress, we hypothesized that genetic variation in catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, would moderate responses to an intervention intended to alter participants" mindsets about stress. Catecholamines 41-55 catechol-O-methyltransferase Homo sapiens 134-162 29677196-3 2018 Given the previously established role of catecholamines in both placebo effects and stress, we hypothesized that genetic variation in catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, would moderate responses to an intervention intended to alter participants" mindsets about stress. Catecholamines 41-55 catechol-O-methyltransferase Homo sapiens 164-168 29677196-3 2018 Given the previously established role of catecholamines in both placebo effects and stress, we hypothesized that genetic variation in catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, would moderate responses to an intervention intended to alter participants" mindsets about stress. Catecholamines 198-212 catechol-O-methyltransferase Homo sapiens 134-162 29677196-3 2018 Given the previously established role of catecholamines in both placebo effects and stress, we hypothesized that genetic variation in catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, would moderate responses to an intervention intended to alter participants" mindsets about stress. Catecholamines 198-212 catechol-O-methyltransferase Homo sapiens 164-168 28968204-1 2017 Catechol-O-methyltransferase (COMT) is an abundant S-adenosylmethionine (SAM-)-dependent methyltransferase that methylates catechol compounds, including catecholamines and catecholestrogens.COMT gene located at chromosome 22q11.2 contains a functional polymorphism at codon 158(Val158Met), which has been related to psychiatric diseases and different types of cancer. Catecholamines 153-167 catechol-O-methyltransferase Homo sapiens 0-28 28968204-1 2017 Catechol-O-methyltransferase (COMT) is an abundant S-adenosylmethionine (SAM-)-dependent methyltransferase that methylates catechol compounds, including catecholamines and catecholestrogens.COMT gene located at chromosome 22q11.2 contains a functional polymorphism at codon 158(Val158Met), which has been related to psychiatric diseases and different types of cancer. Catecholamines 153-167 catechol-O-methyltransferase Homo sapiens 30-34 28968204-1 2017 Catechol-O-methyltransferase (COMT) is an abundant S-adenosylmethionine (SAM-)-dependent methyltransferase that methylates catechol compounds, including catecholamines and catecholestrogens.COMT gene located at chromosome 22q11.2 contains a functional polymorphism at codon 158(Val158Met), which has been related to psychiatric diseases and different types of cancer. Catecholamines 153-167 catechol-O-methyltransferase Homo sapiens 190-194 29426301-1 2018 BACKGROUND: The Catechol-O-methyltransferase (COMT) represents the key enzyme in catecholamine degradation. Catecholamines 81-94 catechol-O-methyltransferase Homo sapiens 16-44 29426301-1 2018 BACKGROUND: The Catechol-O-methyltransferase (COMT) represents the key enzyme in catecholamine degradation. Catecholamines 81-94 catechol-O-methyltransferase Homo sapiens 46-50 29426301-2 2018 Recent studies suggest that the COMT rs4680 polymorphism is associated with the response to endogenous and exogenous catecholamines. Catecholamines 117-131 catechol-O-methyltransferase Homo sapiens 32-36 29594134-1 2018 Background: The catechol-O-methyltransferase (COMT) Val158Met gene influences cognition and behavior in psychiatric illnesses; its low-activity allele, methionine (Met), may be associated with behavior reflecting catecholamine overactivity. Catecholamines 213-226 catechol-O-methyltransferase Homo sapiens 16-44 29594134-1 2018 Background: The catechol-O-methyltransferase (COMT) Val158Met gene influences cognition and behavior in psychiatric illnesses; its low-activity allele, methionine (Met), may be associated with behavior reflecting catecholamine overactivity. Catecholamines 213-226 catechol-O-methyltransferase Homo sapiens 46-50 29594134-8 2018 Conclusion: This preliminary study suggests that arousal and positive valence are influenced in a linear fashion by COMT, presumably due to increased catecholamine in frontal regions, but these findings require replication in a larger sample. Catecholamines 150-163 catechol-O-methyltransferase Homo sapiens 116-120 29270116-11 2017 These data provide insight into the potential influences of COMT-regulated variations in catecholamine levels on brain function, which may represent endophenotypes for disorders of impulsivity. Catecholamines 89-102 catechol-O-methyltransferase Homo sapiens 60-64 28452825-3 2017 Val-allele carriers of a common polymorphism of the COMT gene (Val158Met, rs4680) have rapid removal of catecholamines in the prefrontal cortex, limbic system, and reward centers. Catecholamines 104-118 catechol-O-methyltransferase Homo sapiens 52-56 27939670-1 2017 Catechol-O-methyltransferase (COMT) is involved in the methylation and inactivation of endogenous and xenobiotic catechol compounds, and serves as a common biochemical link in the catecholamine and catecholestrogen metabolism. Catecholamines 180-193 catechol-O-methyltransferase Homo sapiens 30-34 27780702-2 2017 Catechol-O-methyltransferase, an enzyme that metabolizes catecholamines, is a neuromodulator that is involved with perception and sensitivity to pain. Catecholamines 57-71 catechol-O-methyltransferase Homo sapiens 0-28 27780702-5 2017 OBJECTIVE: The methionine-containing catechol-O-methyltransferase protein coded by the L allele results in elevated catecholamine levels, reduced inactivation of the dopaminergic and adrenergic systems, and increased sensitivity to pain. Catecholamines 116-129 catechol-O-methyltransferase Homo sapiens 37-65 28049082-1 2017 Catechol-O-methyltransferase (COMT) inactivates catecholamines, Val/Val genotype was associated to an increased amygdala (Amy) response to negative stimuli and can influence the symptoms severity and the outcome of bipolar disorder, probably mediated by the COMT polymorphism (rs4680) interaction between cortical and subcortical dopaminergic neurotransmission. Catecholamines 48-62 catechol-O-methyltransferase Homo sapiens 0-28 28049082-1 2017 Catechol-O-methyltransferase (COMT) inactivates catecholamines, Val/Val genotype was associated to an increased amygdala (Amy) response to negative stimuli and can influence the symptoms severity and the outcome of bipolar disorder, probably mediated by the COMT polymorphism (rs4680) interaction between cortical and subcortical dopaminergic neurotransmission. Catecholamines 48-62 catechol-O-methyltransferase Homo sapiens 30-34 28049082-1 2017 Catechol-O-methyltransferase (COMT) inactivates catecholamines, Val/Val genotype was associated to an increased amygdala (Amy) response to negative stimuli and can influence the symptoms severity and the outcome of bipolar disorder, probably mediated by the COMT polymorphism (rs4680) interaction between cortical and subcortical dopaminergic neurotransmission. Catecholamines 48-62 catechol-O-methyltransferase Homo sapiens 258-262 28625321-1 2017 OBJECTIVES: Catechol-O-methyltransferase (COMT) is a key enzyme in degradation pathways of estrogens and catecholamines. Catecholamines 105-119 catechol-O-methyltransferase Homo sapiens 12-40 28625321-1 2017 OBJECTIVES: Catechol-O-methyltransferase (COMT) is a key enzyme in degradation pathways of estrogens and catecholamines. Catecholamines 105-119 catechol-O-methyltransferase Homo sapiens 42-46 28456872-1 2017 Catechol-O-methyltransferase (COMT) is an enzyme that catalyses the methylation of catechol substrates, classically in catecholamine metabolism, but also acting upon other substrates such as oestrogen and polyphenols. Catecholamines 119-132 catechol-O-methyltransferase Homo sapiens 0-28 27987399-2 2017 Since catechol-O-methyltransferase (COMT) metabolizes catecholamines and mediates adrenergic, noradrenergic, and dopaminergic signaling responses, we investigated the effects of the COMT polymorphisms rs4633 and rs4680 on cerebrospinal fluid (CSF) catecholamine concentrations in autopsies of subjects who died of drug intoxication. Catecholamines 54-68 catechol-O-methyltransferase Homo sapiens 6-34 27987399-2 2017 Since catechol-O-methyltransferase (COMT) metabolizes catecholamines and mediates adrenergic, noradrenergic, and dopaminergic signaling responses, we investigated the effects of the COMT polymorphisms rs4633 and rs4680 on cerebrospinal fluid (CSF) catecholamine concentrations in autopsies of subjects who died of drug intoxication. Catecholamines 54-68 catechol-O-methyltransferase Homo sapiens 36-40 27987399-2 2017 Since catechol-O-methyltransferase (COMT) metabolizes catecholamines and mediates adrenergic, noradrenergic, and dopaminergic signaling responses, we investigated the effects of the COMT polymorphisms rs4633 and rs4680 on cerebrospinal fluid (CSF) catecholamine concentrations in autopsies of subjects who died of drug intoxication. Catecholamines 54-67 catechol-O-methyltransferase Homo sapiens 6-34 27987399-2 2017 Since catechol-O-methyltransferase (COMT) metabolizes catecholamines and mediates adrenergic, noradrenergic, and dopaminergic signaling responses, we investigated the effects of the COMT polymorphisms rs4633 and rs4680 on cerebrospinal fluid (CSF) catecholamine concentrations in autopsies of subjects who died of drug intoxication. Catecholamines 54-67 catechol-O-methyltransferase Homo sapiens 36-40 28456872-1 2017 Catechol-O-methyltransferase (COMT) is an enzyme that catalyses the methylation of catechol substrates, classically in catecholamine metabolism, but also acting upon other substrates such as oestrogen and polyphenols. Catecholamines 119-132 catechol-O-methyltransferase Homo sapiens 30-34 27619075-4 2016 COMT is a critical enzyme in the degradation of catecholamine neurotransmitters in the brain. Catecholamines 48-61 catechol-O-methyltransferase Homo sapiens 0-4 27282867-2 2016 Genetic variation in catechol-O-methyltransferase (COMT), an enzyme that degrades catecholamines, is associated with cardiometabolic risk factors and incident cardiovascular disease (CVD). Catecholamines 82-96 catechol-O-methyltransferase Homo sapiens 21-49 27457818-2 2016 Although catechol-O-methyltransferase (COMT) metabolizes catecholamines, main effectors of sympathetic function, COMT genetic variation effects on clonidine treatment are unknown. Catecholamines 57-71 catechol-O-methyltransferase Homo sapiens 9-37 27457818-2 2016 Although catechol-O-methyltransferase (COMT) metabolizes catecholamines, main effectors of sympathetic function, COMT genetic variation effects on clonidine treatment are unknown. Catecholamines 57-71 catechol-O-methyltransferase Homo sapiens 39-43 27548835-4 2016 Among the genes in the deleted region, catechol-O-methyltransferase (COMT) has a particular relevance for psychiatric disorders: lower COMT enzymatic activity decreases the clearance of dopamine (DA), yielding higher levels of catecholamines in the central nervous system. Catecholamines 227-241 catechol-O-methyltransferase Homo sapiens 39-67 27548835-4 2016 Among the genes in the deleted region, catechol-O-methyltransferase (COMT) has a particular relevance for psychiatric disorders: lower COMT enzymatic activity decreases the clearance of dopamine (DA), yielding higher levels of catecholamines in the central nervous system. Catecholamines 227-241 catechol-O-methyltransferase Homo sapiens 69-73 27548835-4 2016 Among the genes in the deleted region, catechol-O-methyltransferase (COMT) has a particular relevance for psychiatric disorders: lower COMT enzymatic activity decreases the clearance of dopamine (DA), yielding higher levels of catecholamines in the central nervous system. Catecholamines 227-241 catechol-O-methyltransferase Homo sapiens 135-139 26954460-2 2016 COMT regulates the breakdown of catecholamines, particularly dopamine, which is thought critical in maintaining cognitive function and the aetiology of schizophrenia. Catecholamines 32-46 catechol-O-methyltransferase Homo sapiens 0-4 27564542-2 2016 Simulations and experiments have identified divergent catecholamine substrate orientations in the COMT active site: molecular dynamics simulations have favored a monodentate coordination of catecholate substrates to the active site Mg2+, and crystal structures instead preserve bidentate coordination along with short (2.65 A) methyl donor-acceptor distances. Catecholamines 54-67 catechol-O-methyltransferase Homo sapiens 98-102 27282867-2 2016 Genetic variation in catechol-O-methyltransferase (COMT), an enzyme that degrades catecholamines, is associated with cardiometabolic risk factors and incident cardiovascular disease (CVD). Catecholamines 82-96 catechol-O-methyltransferase Homo sapiens 51-55 26576546-2 2016 A single-nucleotide polymorphism in catechol-o-methyltransferase (COMT), an enzyme which degrades catecholamine neurotransmitters, may influence cognitive deficits following moderate and/or severe head trauma. Catecholamines 98-111 catechol-O-methyltransferase Homo sapiens 36-64 26950706-1 2016 BACKGROUND: Patients with chronic pain disorders exhibit increased levels of catecholamines alongside diminished activity of catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines. Catecholamines 189-203 catechol-O-methyltransferase Homo sapiens 125-153 26950706-1 2016 BACKGROUND: Patients with chronic pain disorders exhibit increased levels of catecholamines alongside diminished activity of catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines. Catecholamines 189-203 catechol-O-methyltransferase Homo sapiens 155-159 26234518-3 2016 Two key genetic variants of the catecholamine system that have been related to emotion perception and attention are the catechol-O-methyl transferase genetic variant (COMT Val158Met) and the alpha2A-receptor gene promoter polymorphism (ADRA2A C-1291G) accordingly. Catecholamines 32-45 catechol-O-methyltransferase Homo sapiens 167-171 26582803-1 2016 Catechol-O-methyltransferase (COMT) plays an important role in the deactivation of catecholamine neurotransmitters and hormones. Catecholamines 83-96 catechol-O-methyltransferase Homo sapiens 0-28 26582803-1 2016 Catechol-O-methyltransferase (COMT) plays an important role in the deactivation of catecholamine neurotransmitters and hormones. Catecholamines 83-96 catechol-O-methyltransferase Homo sapiens 30-34 26549298-1 2016 The catechol-O-methyltransferase (COMT) val158met single nucleotide polymorphism (SNP) alters metabolic activity of the COMT enzyme regulating catecholamines, with the Val (valine) allele resulting in 40% greater enzymatic activity than the Met (methionine) allele. Catecholamines 143-157 catechol-O-methyltransferase Homo sapiens 4-32 26549298-1 2016 The catechol-O-methyltransferase (COMT) val158met single nucleotide polymorphism (SNP) alters metabolic activity of the COMT enzyme regulating catecholamines, with the Val (valine) allele resulting in 40% greater enzymatic activity than the Met (methionine) allele. Catecholamines 143-157 catechol-O-methyltransferase Homo sapiens 34-38 26549298-1 2016 The catechol-O-methyltransferase (COMT) val158met single nucleotide polymorphism (SNP) alters metabolic activity of the COMT enzyme regulating catecholamines, with the Val (valine) allele resulting in 40% greater enzymatic activity than the Met (methionine) allele. Catecholamines 143-157 catechol-O-methyltransferase Homo sapiens 120-124 26576546-2 2016 A single-nucleotide polymorphism in catechol-o-methyltransferase (COMT), an enzyme which degrades catecholamine neurotransmitters, may influence cognitive deficits following moderate and/or severe head trauma. Catecholamines 98-111 catechol-O-methyltransferase Homo sapiens 66-70 25640985-1 2015 AIMS: The enzyme catechol-O-methyltransferase (COMT) plays a primary role in the metabolism of catecholamine neurotransmitters and is implicated in the modulation of cognitive and emotional responses. Catecholamines 95-108 catechol-O-methyltransferase Homo sapiens 17-45 25640985-1 2015 AIMS: The enzyme catechol-O-methyltransferase (COMT) plays a primary role in the metabolism of catecholamine neurotransmitters and is implicated in the modulation of cognitive and emotional responses. Catecholamines 95-108 catechol-O-methyltransferase Homo sapiens 47-51 26198390-11 2015 This stress escalation was limited to incident cases with COMT diplotypes coding for low-activity COMT, signifying impaired catabolism of catecholamines. Catecholamines 138-152 catechol-O-methyltransferase Homo sapiens 58-62 26251232-1 2015 Numerous studies demonstrate that the Methionine variant of the catechol-O-methyltransferase Val158Met polymorphism, which confers less efficient catabolism of catecholamines, is associated with increased focal activation of prefrontal cortex (PFC) and higher levels of executive function abilities. Catecholamines 160-174 catechol-O-methyltransferase Homo sapiens 64-92 26251232-3 2015 Effects of early adversity on stress response physiology and the inverted U shape relating catecholamine levels to neural activity in PFC indicate the need to take into account early experience when considering relations between genes such as COMT and executive cognitive ability. Catecholamines 91-104 catechol-O-methyltransferase Homo sapiens 243-247 26251232-5 2015 Specifically, the Valine variant of the COMT Val158Met polymorphism, which confers more rather than less efficient catabolism of catecholamines is associated with higher executive function abilities at child ages 48 and 60 months and with faster growth of executive function for children experiencing early adversity, as indexed by cumulative risk factors in the home at child ages 7, 15, 24, and 36 months. Catecholamines 129-143 catechol-O-methyltransferase Homo sapiens 40-44 26528222-3 2015 Several findings suggest that catecholamine-related genes may contribute to insight problem solving, among which the catechol-O-methyltransferase (COMT) gene is the most promising candidate. Catecholamines 30-43 catechol-O-methyltransferase Homo sapiens 117-145 26528222-3 2015 Several findings suggest that catecholamine-related genes may contribute to insight problem solving, among which the catechol-O-methyltransferase (COMT) gene is the most promising candidate. Catecholamines 30-43 catechol-O-methyltransferase Homo sapiens 147-151 26198390-11 2015 This stress escalation was limited to incident cases with COMT diplotypes coding for low-activity COMT, signifying impaired catabolism of catecholamines. Catecholamines 138-152 catechol-O-methyltransferase Homo sapiens 98-102 26346727-4 2015 COMT has an important role in regulating the embryonic levels of catecholamine neurotransmitters (such as dopamine, norepinephrine, and epinephrine) and estrogens. Catecholamines 65-78 catechol-O-methyltransferase Homo sapiens 0-4 25466290-2 2015 The catechol-O-methyltransferase (COMT) gene is an interesting candidate, being one of the major mammalian enzymes involved in the catabolism of catecholamines. Catecholamines 145-159 catechol-O-methyltransferase Homo sapiens 4-32 25466290-2 2015 The catechol-O-methyltransferase (COMT) gene is an interesting candidate, being one of the major mammalian enzymes involved in the catabolism of catecholamines. Catecholamines 145-159 catechol-O-methyltransferase Homo sapiens 34-38 25466290-8 2015 Since the COMT enzyme inactivates catecholamines, it was hypothesized that the response to stimulant drugs differs between COMT genotypes. Catecholamines 34-48 catechol-O-methyltransferase Homo sapiens 10-14 25466290-8 2015 Since the COMT enzyme inactivates catecholamines, it was hypothesized that the response to stimulant drugs differs between COMT genotypes. Catecholamines 34-48 catechol-O-methyltransferase Homo sapiens 123-127 25320962-2 2015 In particular, the catechol-O-methyltransferase (COMT) gene, located on chromosome 22q11.2, regulates catecholamine signaling in the prefrontal cortex and is implicated in anxiety, pain, and stress responsivity. Catecholamines 102-115 catechol-O-methyltransferase Homo sapiens 19-47 25897233-1 2015 PURPOSE: This study investigated the relationships among the plasma levels of catecholamine metabolites, the clinical response to duloxetine treatment, and Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene. Catecholamines 78-91 catechol-O-methyltransferase Homo sapiens 186-214 25897233-14 2015 CONCLUSION: The relationship among the COMT Val158Met polymorphism, plasma levels of catecholamine metabolites, and responses to duloxetine is complex. Catecholamines 85-98 catechol-O-methyltransferase Homo sapiens 39-43 25320962-2 2015 In particular, the catechol-O-methyltransferase (COMT) gene, located on chromosome 22q11.2, regulates catecholamine signaling in the prefrontal cortex and is implicated in anxiety, pain, and stress responsivity. Catecholamines 102-115 catechol-O-methyltransferase Homo sapiens 49-53 26630958-3 2015 COMT is involved in catabolizing catecholamines such as dopamine. Catecholamines 33-47 catechol-O-methyltransferase Homo sapiens 0-4 26266996-4 2015 While many of these have focused in the past on markers related to neurotransmitter systems such as catecholamines (catechol-O-methyltransferase (COMT)) and serotonin, novel target genes have recently emerged. Catecholamines 100-114 catechol-O-methyltransferase Homo sapiens 116-144 26266996-4 2015 While many of these have focused in the past on markers related to neurotransmitter systems such as catecholamines (catechol-O-methyltransferase (COMT)) and serotonin, novel target genes have recently emerged. Catecholamines 100-114 catechol-O-methyltransferase Homo sapiens 146-150 25600541-2 2015 It has been shown that the inactivation of dopamine and other catecholamines causes a common polymorphism generating substantial variations in COMT enzyme activity. Catecholamines 62-76 catechol-O-methyltransferase Homo sapiens 143-147 25083741-10 2014 Interestingly, NE"s growth-suppressive effect is modulated by endogenously expressed catecholamine-inactivating enzymes (catechol-O-methyltransferase and l-monoamine oxidase) and is dominant over the growth-promoting effects of PDE inhibitors. Catecholamines 85-98 catechol-O-methyltransferase Homo sapiens 121-149 25108642-1 2014 Catechol-O-methyltransferase (COMT) is one of the cardinal enzymes that metabolize dopamine and other catecholamine neurotransmitters in the central and peripheral nervous system. Catecholamines 102-115 catechol-O-methyltransferase Homo sapiens 0-28 25108642-1 2014 Catechol-O-methyltransferase (COMT) is one of the cardinal enzymes that metabolize dopamine and other catecholamine neurotransmitters in the central and peripheral nervous system. Catecholamines 102-115 catechol-O-methyltransferase Homo sapiens 30-34 24460628-0 2014 Comprehensive interrogation of CpG island methylation in the gene encoding COMT, a key estrogen and catecholamine regulator. Catecholamines 100-113 catechol-O-methyltransferase Homo sapiens 75-79 24509724-9 2014 Thus, these mice (1) support the argument that human COMT Val158Met polymorphism modulates behavioral functions and most importantly (2) exhibit the expected treatment effects supporting the "inverted U shaped" dose response of catecholamine signaling on cognitive function. Catecholamines 228-241 catechol-O-methyltransferase Homo sapiens 53-57 24727346-1 2014 Decreased activity of catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, contributes to pain in humans and animals. Catecholamines 86-100 catechol-O-methyltransferase Homo sapiens 22-50 24727346-1 2014 Decreased activity of catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, contributes to pain in humans and animals. Catecholamines 86-100 catechol-O-methyltransferase Homo sapiens 52-56 23963787-1 2014 Catechol-O-methyltransferase, encoded by COMT gene, is the primary enzyme that metabolizes catecholamines. Catecholamines 91-105 catechol-O-methyltransferase Homo sapiens 0-28 23963787-1 2014 Catechol-O-methyltransferase, encoded by COMT gene, is the primary enzyme that metabolizes catecholamines. Catecholamines 91-105 catechol-O-methyltransferase Homo sapiens 41-45 24342707-2 2014 Enzymes like catechol-O-methyl-transferase (COMT) are involved in the elimination of catecholamines playing a possible role in central sensitization and pain. Catecholamines 85-99 catechol-O-methyltransferase Homo sapiens 13-42 24342707-2 2014 Enzymes like catechol-O-methyl-transferase (COMT) are involved in the elimination of catecholamines playing a possible role in central sensitization and pain. Catecholamines 85-99 catechol-O-methyltransferase Homo sapiens 44-48 24575113-2 2014 Catechol-O-methyltransferase (COMT) may have a prominent role in AD pathophysiology by affecting the metabolism of catecholamine neurotransmitters and estrogen. Catecholamines 115-128 catechol-O-methyltransferase Homo sapiens 0-28 24575113-2 2014 Catechol-O-methyltransferase (COMT) may have a prominent role in AD pathophysiology by affecting the metabolism of catecholamine neurotransmitters and estrogen. Catecholamines 115-128 catechol-O-methyltransferase Homo sapiens 30-34 25035343-1 2014 OBJECTIVE: Catechol-O-methyltransferase (COMT), a key enzyme in catecholamine metabolism, is implicated in cardiovascular, sympathetic, and endocrine pathways. Catecholamines 64-77 catechol-O-methyltransferase Homo sapiens 11-39 25035343-1 2014 OBJECTIVE: Catechol-O-methyltransferase (COMT), a key enzyme in catecholamine metabolism, is implicated in cardiovascular, sympathetic, and endocrine pathways. Catecholamines 64-77 catechol-O-methyltransferase Homo sapiens 41-45 24467942-1 2014 BACKGROUND: Catechol-O-methyltransferase (COMT) metabolizes catecholamines in the prefrontal cortex (PFC). Catecholamines 60-74 catechol-O-methyltransferase Homo sapiens 12-40 24467942-1 2014 BACKGROUND: Catechol-O-methyltransferase (COMT) metabolizes catecholamines in the prefrontal cortex (PFC). Catecholamines 60-74 catechol-O-methyltransferase Homo sapiens 42-46 24389396-1 2014 Catechol-O-methyltransferase (COMT) plays a key role in the degradation of catecholamine neurotransmitters within the brain. Catecholamines 75-88 catechol-O-methyltransferase Homo sapiens 0-28 24389396-1 2014 Catechol-O-methyltransferase (COMT) plays a key role in the degradation of catecholamine neurotransmitters within the brain. Catecholamines 75-88 catechol-O-methyltransferase Homo sapiens 30-34 24343288-1 2013 BACKGROUND: Catechol-O-methyltransferase (COMT) metabolizes catecholamines in different tissues. Catecholamines 60-74 catechol-O-methyltransferase Homo sapiens 12-40 24343288-1 2013 BACKGROUND: Catechol-O-methyltransferase (COMT) metabolizes catecholamines in different tissues. Catecholamines 60-74 catechol-O-methyltransferase Homo sapiens 42-46 23701723-1 2013 The enzyme catechol-O-methyltransferase (COMT) metabolizes catecholamine neurotransmitters involved in a number of physiological functions, including pain perception. Catecholamines 59-72 catechol-O-methyltransferase Homo sapiens 11-39 23774690-1 2013 Catechol-O-methyltransferase (COMT) inactivates the catecholamines adrenaline, noradrenaline and dopamine. Catecholamines 52-66 catechol-O-methyltransferase Homo sapiens 0-28 23774690-1 2013 Catechol-O-methyltransferase (COMT) inactivates the catecholamines adrenaline, noradrenaline and dopamine. Catecholamines 52-66 catechol-O-methyltransferase Homo sapiens 30-34 24174958-5 2013 Hg(2+) increases catecholamine levels through the inhibition of S-adenosylmethionine and subsequently catechol-O-methyltransferase (COMT), while a single nucleotide polymorphism of the COMT gene (rs769224) was recently found to be significantly associated with the development of coronary artery lesions in KS. Catecholamines 17-30 catechol-O-methyltransferase Homo sapiens 102-130 24174958-5 2013 Hg(2+) increases catecholamine levels through the inhibition of S-adenosylmethionine and subsequently catechol-O-methyltransferase (COMT), while a single nucleotide polymorphism of the COMT gene (rs769224) was recently found to be significantly associated with the development of coronary artery lesions in KS. Catecholamines 17-30 catechol-O-methyltransferase Homo sapiens 132-136 24174958-5 2013 Hg(2+) increases catecholamine levels through the inhibition of S-adenosylmethionine and subsequently catechol-O-methyltransferase (COMT), while a single nucleotide polymorphism of the COMT gene (rs769224) was recently found to be significantly associated with the development of coronary artery lesions in KS. Catecholamines 17-30 catechol-O-methyltransferase Homo sapiens 185-189 23701723-1 2013 The enzyme catechol-O-methyltransferase (COMT) metabolizes catecholamine neurotransmitters involved in a number of physiological functions, including pain perception. Catecholamines 59-72 catechol-O-methyltransferase Homo sapiens 41-45 23351565-2 2013 COMT enzyme participates in metabolic pathways involving brain catecholamines, as well as steroid hormones such as estrogens. Catecholamines 63-77 catechol-O-methyltransferase Homo sapiens 0-4 22665263-7 2013 In the main meta-analysis, OCD was associated with serotonin-related polymorphisms (5-HTTLPR and HTR2A) and, in males only, with polymorphisms involved in catecholamine modulation (COMT and MAOA). Catecholamines 155-168 catechol-O-methyltransferase Homo sapiens 181-185 23475824-1 2013 Catechol-O-Methyltransferase (COMT) is a critical regulator of catecholamine levels in the brain. Catecholamines 63-76 catechol-O-methyltransferase Homo sapiens 0-28 23475824-1 2013 Catechol-O-Methyltransferase (COMT) is a critical regulator of catecholamine levels in the brain. Catecholamines 63-76 catechol-O-methyltransferase Homo sapiens 30-34 23280413-1 2013 Catechol-O-methyltransferase (COMT) catalyzes the methylation of catecholamines, including neurotransmitters like dopamine, epinephrine and norepinephrine, leading to their degradation. Catecholamines 65-79 catechol-O-methyltransferase Homo sapiens 0-28 23280413-1 2013 Catechol-O-methyltransferase (COMT) catalyzes the methylation of catecholamines, including neurotransmitters like dopamine, epinephrine and norepinephrine, leading to their degradation. Catecholamines 65-79 catechol-O-methyltransferase Homo sapiens 30-34 23184041-1 2013 The gene coding for catecol-o-methyltransferase (COMT), participant in the metabolism of catecholamines, has long been implicated as a candidate gene for schizophrenia. Catecholamines 89-103 catechol-O-methyltransferase Homo sapiens 20-47 23184041-1 2013 The gene coding for catecol-o-methyltransferase (COMT), participant in the metabolism of catecholamines, has long been implicated as a candidate gene for schizophrenia. Catecholamines 89-103 catechol-O-methyltransferase Homo sapiens 49-53 22784685-1 2012 BACKGROUND: The Met158 allele of catechol-O-methyl transferase (COMT) gene is associated with increased levels of catecholamines in the prefrontal cortex and may increase the likelihood of aggressiveness. Catecholamines 114-128 catechol-O-methyltransferase Homo sapiens 33-62 24450388-1 2013 Catechol-O-methyltransferase (COMT) is the enzyme which catalyzes the transfer of a methyl group from S-adenosylmethionine to catechols and catecholamines, like the neurotransmitters dopamine, epinephrine and norepinephrine. Catecholamines 140-154 catechol-O-methyltransferase Homo sapiens 0-28 24450388-1 2013 Catechol-O-methyltransferase (COMT) is the enzyme which catalyzes the transfer of a methyl group from S-adenosylmethionine to catechols and catecholamines, like the neurotransmitters dopamine, epinephrine and norepinephrine. Catecholamines 140-154 catechol-O-methyltransferase Homo sapiens 30-34 22528689-2 2013 The purpose of the present study was to investigate the relationship of three common haplotypes of COMT gene affecting the metabolism of catecholamines on pain sensitivity in patients with fibromyalgia (FM). Catecholamines 137-151 catechol-O-methyltransferase Homo sapiens 99-103 24167357-4 2013 While catechol-O-methyltransferase (COMT) is involved in metabolizing catecholamines, a single-nucleotide polymorphism (SNP) in the COMT gene leads to different enzyme activities according to genotype. Catecholamines 70-84 catechol-O-methyltransferase Homo sapiens 6-34 24167357-4 2013 While catechol-O-methyltransferase (COMT) is involved in metabolizing catecholamines, a single-nucleotide polymorphism (SNP) in the COMT gene leads to different enzyme activities according to genotype. Catecholamines 70-84 catechol-O-methyltransferase Homo sapiens 36-40 24167357-4 2013 While catechol-O-methyltransferase (COMT) is involved in metabolizing catecholamines, a single-nucleotide polymorphism (SNP) in the COMT gene leads to different enzyme activities according to genotype. Catecholamines 70-84 catechol-O-methyltransferase Homo sapiens 132-136 22152146-2 2012 The enzyme catechol-O-methyltransferase (COMT) catabolizes catecholamines and the COMT Val158Met polymorphism has been linked to several neuropsychiatric variables. Catecholamines 59-73 catechol-O-methyltransferase Homo sapiens 11-39 22152146-2 2012 The enzyme catechol-O-methyltransferase (COMT) catabolizes catecholamines and the COMT Val158Met polymorphism has been linked to several neuropsychiatric variables. Catecholamines 59-73 catechol-O-methyltransferase Homo sapiens 41-45 22152146-2 2012 The enzyme catechol-O-methyltransferase (COMT) catabolizes catecholamines and the COMT Val158Met polymorphism has been linked to several neuropsychiatric variables. Catecholamines 59-73 catechol-O-methyltransferase Homo sapiens 82-86 22784685-1 2012 BACKGROUND: The Met158 allele of catechol-O-methyl transferase (COMT) gene is associated with increased levels of catecholamines in the prefrontal cortex and may increase the likelihood of aggressiveness. Catecholamines 114-128 catechol-O-methyltransferase Homo sapiens 64-68 22483291-1 2012 One of the most important enzymes in the catecholamine cycle, catecholamine-O-methyltransferase (COMT), plays a critical role in the extracellular metabolism of dopamine and norepinephrine both in the periphery and the central nervous system. Catecholamines 41-54 catechol-O-methyltransferase Homo sapiens 62-95 22483294-2 2012 Catechol-O-mehyltransferase (COMT) is surfacing with a prominent role in AD pathophysiology by affecting the metabolism of catecholamine neurotransmitters and estrogen. Catecholamines 123-136 catechol-O-methyltransferase Homo sapiens 0-27 22483294-2 2012 Catechol-O-mehyltransferase (COMT) is surfacing with a prominent role in AD pathophysiology by affecting the metabolism of catecholamine neurotransmitters and estrogen. Catecholamines 123-136 catechol-O-methyltransferase Homo sapiens 29-33 22483298-3 2012 The present review summarises clinical, mutant, and psychopharmacological data related to catechol-O-methyltransferase (COMT), an enzyme involved in the catabolism of catecholamine neurotransmitters, with a view to establishing the antipsychotic potential of compounds targeting the action of this enzyme. Catecholamines 167-180 catechol-O-methyltransferase Homo sapiens 90-118 22483298-3 2012 The present review summarises clinical, mutant, and psychopharmacological data related to catechol-O-methyltransferase (COMT), an enzyme involved in the catabolism of catecholamine neurotransmitters, with a view to establishing the antipsychotic potential of compounds targeting the action of this enzyme. Catecholamines 167-180 catechol-O-methyltransferase Homo sapiens 120-124 22337560-1 2012 BACKGROUND: The COMT enzyme metabolizes catecholamines and thus modulates adrenergic, noradrenergic and dopaminergic signaling. Catecholamines 40-54 catechol-O-methyltransferase Homo sapiens 16-20 22569243-1 2012 CONTEXT: The high diagnostic performance of plasma-free metanephrines (metanephrine and normetanephrine) (MN) for pheochromocytoma (PHEO) results from the tumoral expression of catechol-O-methyltransferase (COMT), the enzyme involved in O-methylation of catecholamines (CAT). Catecholamines 254-268 catechol-O-methyltransferase Homo sapiens 177-205 22483291-1 2012 One of the most important enzymes in the catecholamine cycle, catecholamine-O-methyltransferase (COMT), plays a critical role in the extracellular metabolism of dopamine and norepinephrine both in the periphery and the central nervous system. Catecholamines 41-54 catechol-O-methyltransferase Homo sapiens 97-101 22371619-7 2012 The effect of the gene polymorphism of catechol-O-methyltransferase (COMT) on individual variations in switching frequency suggests that the balance of exploration and stabilization is modulated by catecholamines such as dopamine and noradrenalin. Catecholamines 198-212 catechol-O-methyltransferase Homo sapiens 39-67 22371619-7 2012 The effect of the gene polymorphism of catechol-O-methyltransferase (COMT) on individual variations in switching frequency suggests that the balance of exploration and stabilization is modulated by catecholamines such as dopamine and noradrenalin. Catecholamines 198-212 catechol-O-methyltransferase Homo sapiens 69-73 21447540-3 2011 The catechol-O-methyltransferase (COMT) gene, located within the deleted region, encodes for the enzyme COMT that is important for degradation of catecholamines, including dopamine (DA). Catecholamines 146-160 catechol-O-methyltransferase Homo sapiens 4-32 23056605-1 2012 Catechol-O-methyltransferase (COMT) degrades catecholamines, such as dopamine and epinephrine, by methylating them in the presence of a divalent metal cation (usually Mg(II)), and S-adenosyl-L-methionine. Catecholamines 45-59 catechol-O-methyltransferase Homo sapiens 0-28 23056605-1 2012 Catechol-O-methyltransferase (COMT) degrades catecholamines, such as dopamine and epinephrine, by methylating them in the presence of a divalent metal cation (usually Mg(II)), and S-adenosyl-L-methionine. Catecholamines 45-59 catechol-O-methyltransferase Homo sapiens 30-34 21601990-1 2011 Personality trait research has shown associations with many genes, prominently those of the catecholamine metabolism such as dopamine beta hydroxylase (DBH), catechol-O-methyltransferase (COMT), and monoamine oxidase A (MAOA). Catecholamines 92-105 catechol-O-methyltransferase Homo sapiens 158-186 21601990-1 2011 Personality trait research has shown associations with many genes, prominently those of the catecholamine metabolism such as dopamine beta hydroxylase (DBH), catechol-O-methyltransferase (COMT), and monoamine oxidase A (MAOA). Catecholamines 92-105 catechol-O-methyltransferase Homo sapiens 188-192 22790479-2 2012 The catechol-O-methyltransferase (COMT) gene encodes an enzyme that degrades catecholamines and estrogens to less active metabolites. Catecholamines 77-91 catechol-O-methyltransferase Homo sapiens 4-32 22790479-2 2012 The catechol-O-methyltransferase (COMT) gene encodes an enzyme that degrades catecholamines and estrogens to less active metabolites. Catecholamines 77-91 catechol-O-methyltransferase Homo sapiens 34-38 21790467-1 2012 Meditation may show differential effects on stress and plasma catecholamines based on genetic polymorphisms in brain-derived neurotrophic factor (BDNF) and catechol O-methyl transferase (COMT). Catecholamines 62-76 catechol-O-methyltransferase Homo sapiens 156-185 21790467-1 2012 Meditation may show differential effects on stress and plasma catecholamines based on genetic polymorphisms in brain-derived neurotrophic factor (BDNF) and catechol O-methyl transferase (COMT). Catecholamines 62-76 catechol-O-methyltransferase Homo sapiens 187-191 21656904-1 2011 Catechol-O-methyltransferase (genetic locus, COMT) is a major enzyme involved in catecholamine metabolism and has been associated with numerous psychiatric phenotypes. Catecholamines 81-94 catechol-O-methyltransferase Homo sapiens 0-28 21656904-1 2011 Catechol-O-methyltransferase (genetic locus, COMT) is a major enzyme involved in catecholamine metabolism and has been associated with numerous psychiatric phenotypes. Catecholamines 81-94 catechol-O-methyltransferase Homo sapiens 45-49 21486747-1 2011 Catechol-O-methyltransferase (COMT) is a major enzyme controlling catecholamine levels that plays a central role in cognition, affective mood and pain perception. Catecholamines 66-79 catechol-O-methyltransferase Homo sapiens 0-28 21486747-1 2011 Catechol-O-methyltransferase (COMT) is a major enzyme controlling catecholamine levels that plays a central role in cognition, affective mood and pain perception. Catecholamines 66-79 catechol-O-methyltransferase Homo sapiens 30-34 21486391-1 2011 One of the candidate genes for suicide is also a gene in the pathway for catecholamine degradation encoding an enzyme catechol-O-methyl-transferase (COMT). Catecholamines 73-86 catechol-O-methyltransferase Homo sapiens 118-147 21486391-1 2011 One of the candidate genes for suicide is also a gene in the pathway for catecholamine degradation encoding an enzyme catechol-O-methyl-transferase (COMT). Catecholamines 73-86 catechol-O-methyltransferase Homo sapiens 149-153 21397335-1 2011 BACKGROUND: Catechol-O-methyltransferase (COMT) inactivates catecholamines, and a G-A transition in the COMT gene (rs4680) influences the enzyme activity and the interaction between cortical and subcortical dopaminergic neurotransmission. Catecholamines 60-74 catechol-O-methyltransferase Homo sapiens 12-40 21397335-1 2011 BACKGROUND: Catechol-O-methyltransferase (COMT) inactivates catecholamines, and a G-A transition in the COMT gene (rs4680) influences the enzyme activity and the interaction between cortical and subcortical dopaminergic neurotransmission. Catecholamines 60-74 catechol-O-methyltransferase Homo sapiens 42-46 21397335-1 2011 BACKGROUND: Catechol-O-methyltransferase (COMT) inactivates catecholamines, and a G-A transition in the COMT gene (rs4680) influences the enzyme activity and the interaction between cortical and subcortical dopaminergic neurotransmission. Catecholamines 60-74 catechol-O-methyltransferase Homo sapiens 104-108 21447540-3 2011 The catechol-O-methyltransferase (COMT) gene, located within the deleted region, encodes for the enzyme COMT that is important for degradation of catecholamines, including dopamine (DA). Catecholamines 146-160 catechol-O-methyltransferase Homo sapiens 34-38 21447540-3 2011 The catechol-O-methyltransferase (COMT) gene, located within the deleted region, encodes for the enzyme COMT that is important for degradation of catecholamines, including dopamine (DA). Catecholamines 146-160 catechol-O-methyltransferase Homo sapiens 104-108 20619611-1 2010 RATIONALE: The catechol-O-methyltransferase (COMT) enzyme inactivates catecholamines, and the COMT Val(108/158)Met polymorphism (rs4680) influences the enzyme activity. Catecholamines 70-84 catechol-O-methyltransferase Homo sapiens 15-43 21437260-1 2011 BACKGROUND: The catechol-O-methyltransferase (COMT) enzyme has a key function in the degradation of catecholamines and a functional polymorphism is val158met. Catecholamines 100-114 catechol-O-methyltransferase Homo sapiens 16-44 21437260-1 2011 BACKGROUND: The catechol-O-methyltransferase (COMT) enzyme has a key function in the degradation of catecholamines and a functional polymorphism is val158met. Catecholamines 100-114 catechol-O-methyltransferase Homo sapiens 46-50 20725062-3 2011 Epigallocatechin-3-gallate (EGCG: the most bioactive catechin in green tea) inhibits catechol-O-methyltransferase, an enzyme contributing to the degradation of catecholamines. Catecholamines 160-174 catechol-O-methyltransferase Homo sapiens 85-113 21302344-3 2011 We hypothesized that 5HTTLPR genotype would show little association with prefrontal cognitive performance, but that COMT and MAOA would have interacting effects on cognition through their shared influence on prefrontal catecholamine availability. Catecholamines 219-232 catechol-O-methyltransferase Homo sapiens 116-120 21302344-6 2011 In boys but not girls, there was a modest but statistically significant interaction between MAOA and COMT genotypes such that increased prefrontal catecholamine availability was associated with better working memory. Catecholamines 147-160 catechol-O-methyltransferase Homo sapiens 101-105 21648315-2 2011 COMT is involved in the breakdown of dopamine and other catecholamines, especially in the frontal cortex; hence the carriers of Met allele, with the lower enzymatic activity, are expected to perform better on particular neuro-cognitive tests. Catecholamines 56-70 catechol-O-methyltransferase Homo sapiens 0-4 20619611-1 2010 RATIONALE: The catechol-O-methyltransferase (COMT) enzyme inactivates catecholamines, and the COMT Val(108/158)Met polymorphism (rs4680) influences the enzyme activity. Catecholamines 70-84 catechol-O-methyltransferase Homo sapiens 45-49 20619611-1 2010 RATIONALE: The catechol-O-methyltransferase (COMT) enzyme inactivates catecholamines, and the COMT Val(108/158)Met polymorphism (rs4680) influences the enzyme activity. Catecholamines 70-84 catechol-O-methyltransferase Homo sapiens 94-98 21154325-1 2010 The enzyme catechol-O-methyltransferase (COMT) transfers a methyl group from S-adenosylmethionine to the benzene ring of catecholamines including the neurotransmitters dopamine, epinephrine and norepinephrine. Catecholamines 121-135 catechol-O-methyltransferase Homo sapiens 11-39 21154325-1 2010 The enzyme catechol-O-methyltransferase (COMT) transfers a methyl group from S-adenosylmethionine to the benzene ring of catecholamines including the neurotransmitters dopamine, epinephrine and norepinephrine. Catecholamines 121-135 catechol-O-methyltransferase Homo sapiens 41-45 20974455-2 2010 COMT is one of the enzymes that metabolizes catecholamines, thereby acting as a key modulator of dopaminergic and adrenergic/noradrenergic neurotransmissions, which play a key role in pain modulation. Catecholamines 44-58 catechol-O-methyltransferase Homo sapiens 0-4 19946713-1 2010 The catechol-O-methyltransferase gene (COMT) plays a crucial role in the metabolism of catecholamines in the frontal cortex. Catecholamines 87-101 catechol-O-methyltransferase Homo sapiens 4-32 19946713-1 2010 The catechol-O-methyltransferase gene (COMT) plays a crucial role in the metabolism of catecholamines in the frontal cortex. Catecholamines 87-101 catechol-O-methyltransferase Homo sapiens 39-43 20122740-1 2010 BACKGROUND: Catechol-O-methyltransferase (COMT) inactivates catecholamines, and a G-A transition in the COMT gene (rs4680) influences the enzyme activity and the interaction between cortical and subcortical dopaminergic neurotransmission. Catecholamines 60-74 catechol-O-methyltransferase Homo sapiens 12-40 20122740-1 2010 BACKGROUND: Catechol-O-methyltransferase (COMT) inactivates catecholamines, and a G-A transition in the COMT gene (rs4680) influences the enzyme activity and the interaction between cortical and subcortical dopaminergic neurotransmission. Catecholamines 60-74 catechol-O-methyltransferase Homo sapiens 42-46 20122740-1 2010 BACKGROUND: Catechol-O-methyltransferase (COMT) inactivates catecholamines, and a G-A transition in the COMT gene (rs4680) influences the enzyme activity and the interaction between cortical and subcortical dopaminergic neurotransmission. Catecholamines 60-74 catechol-O-methyltransferase Homo sapiens 104-108 22371762-1 2010 Catecholamine signaling pathways in the peripheral and central nervous systems (PNS, CNS, respectively) utilize catechol-O-methyltransferase (COMT) as a major regulatory enzyme responsible for deactivation of dopamine (DA), norepinephrine (NE) and epinephrine (E). Catecholamines 0-13 catechol-O-methyltransferase Homo sapiens 112-140 22371762-1 2010 Catecholamine signaling pathways in the peripheral and central nervous systems (PNS, CNS, respectively) utilize catechol-O-methyltransferase (COMT) as a major regulatory enzyme responsible for deactivation of dopamine (DA), norepinephrine (NE) and epinephrine (E). Catecholamines 0-13 catechol-O-methyltransferase Homo sapiens 142-146 19912274-7 2010 Given the striking similarities between the enzymatic steps in the morphine biosynthetic pathway and those driving the evolutionary adaptation of catecholamine chemical species to accommodate an expansion of interactive but distinct signaling systems, it is our overall contention that the evolutionary emergence of catecholamine systems required conservation and selective "retrofit" of specific enzyme activities, that is, COMT, drawn from cellular morphine expression. Catecholamines 316-329 catechol-O-methyltransferase Homo sapiens 425-429 18989660-2 2009 The COMT enzyme inactivates catecholamines, and the COMT Val(108/158)Met polymorphism (rs4680) influences the enzyme activity. Catecholamines 28-42 catechol-O-methyltransferase Homo sapiens 4-8 19881467-2 2009 The catechol-O-methyltransferase (COMT) gene, which is located in the 22q11 microdeletion, has been considered as a candidate gene for schizophrenia because of its ability to degrade catecholamines, including dopamine. Catecholamines 183-197 catechol-O-methyltransferase Homo sapiens 4-32 19881467-2 2009 The catechol-O-methyltransferase (COMT) gene, which is located in the 22q11 microdeletion, has been considered as a candidate gene for schizophrenia because of its ability to degrade catecholamines, including dopamine. Catecholamines 183-197 catechol-O-methyltransferase Homo sapiens 34-38 20074440-2 2009 Catechol-O-methyltransferase (COMT) is the major catecholamine-clearing pathway and involved in the mediation of pain perception in humans, and the hypothesized role of pain perception in FM. Catecholamines 49-62 catechol-O-methyltransferase Homo sapiens 0-28 20074440-2 2009 Catechol-O-methyltransferase (COMT) is the major catecholamine-clearing pathway and involved in the mediation of pain perception in humans, and the hypothesized role of pain perception in FM. Catecholamines 49-62 catechol-O-methyltransferase Homo sapiens 30-34 19464960-3 2009 We sought to investigate the relationships between catecholamine-related polymorphisms [dopamine-D(3) receptor (DRD3) Ser9Gly and catechol-O-methyltransferase (COMT) Val158Met] and thermal pain measures in healthy subjects and FM patients. Catecholamines 51-64 catechol-O-methyltransferase Homo sapiens 130-158 19464960-3 2009 We sought to investigate the relationships between catecholamine-related polymorphisms [dopamine-D(3) receptor (DRD3) Ser9Gly and catechol-O-methyltransferase (COMT) Val158Met] and thermal pain measures in healthy subjects and FM patients. Catecholamines 51-64 catechol-O-methyltransferase Homo sapiens 160-164 19406978-1 2009 Enzymatic pathways involving catechol-O-methyltransferase (COMT) catabolize circulating catecholamines. Catecholamines 88-102 catechol-O-methyltransferase Homo sapiens 29-57 19406978-1 2009 Enzymatic pathways involving catechol-O-methyltransferase (COMT) catabolize circulating catecholamines. Catecholamines 88-102 catechol-O-methyltransferase Homo sapiens 59-63 19406978-3 2009 We enrolled 260 patients postbypass surgery to test the hypothesis that COMT gene variants impair circulating catecholamine metabolism, predisposing to shock and acute kidney injury (AKI) after cardiac surgery. Catecholamines 110-123 catechol-O-methyltransferase Homo sapiens 72-76 19268435-1 2009 Catechol-O-methyltransferase (COMT) plays an important role in brain catecholamine metabolism. Catecholamines 69-82 catechol-O-methyltransferase Homo sapiens 0-28 19268435-1 2009 Catechol-O-methyltransferase (COMT) plays an important role in brain catecholamine metabolism. Catecholamines 69-82 catechol-O-methyltransferase Homo sapiens 30-34 18802928-2 2009 The enzyme catechol O-methyltransferase (COMT), which degrades dopamine and other catecholamines, is important for monoamine signaling in this brain-region, but genetic studies of the functional Val158Met (rs4680) polymorphism in ADHD have been inconsistent. Catecholamines 82-96 catechol-O-methyltransferase Homo sapiens 11-39 18802928-2 2009 The enzyme catechol O-methyltransferase (COMT), which degrades dopamine and other catecholamines, is important for monoamine signaling in this brain-region, but genetic studies of the functional Val158Met (rs4680) polymorphism in ADHD have been inconsistent. Catecholamines 82-96 catechol-O-methyltransferase Homo sapiens 41-45 19462939-2 2009 As the elimination of the catecholamine metabolites could also be enantioselective, the aim of the present study was to investigate the O-methylation to the corresponding methoxy derivatives catalyzed by the soluble or membrane-bound form of the catechol-O-methyltransferase (COMT). Catecholamines 26-39 catechol-O-methyltransferase Homo sapiens 246-274 19462939-2 2009 As the elimination of the catecholamine metabolites could also be enantioselective, the aim of the present study was to investigate the O-methylation to the corresponding methoxy derivatives catalyzed by the soluble or membrane-bound form of the catechol-O-methyltransferase (COMT). Catecholamines 26-39 catechol-O-methyltransferase Homo sapiens 276-280 19462939-8 2009 Our data showed that the S-enantiomers of all studied catecholamines were preferably O-methylated by both types of COMT. Catecholamines 54-68 catechol-O-methyltransferase Homo sapiens 115-119 19291302-1 2009 BACKGROUND: Catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, has recently been implicated in the modulation of pain. Catecholamines 76-90 catechol-O-methyltransferase Homo sapiens 12-40 19291302-1 2009 BACKGROUND: Catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, has recently been implicated in the modulation of pain. Catecholamines 76-90 catechol-O-methyltransferase Homo sapiens 42-46 18989660-2 2009 The COMT enzyme inactivates catecholamines, and the COMT Val(108/158)Met polymorphism (rs4680) influences the enzyme activity. Catecholamines 28-42 catechol-O-methyltransferase Homo sapiens 52-56 19023276-2 2009 Catechol- O-methyltransferase (COMT) inactivates catecholamines, and a G to A substitution in codon 108 in the soluble COMT mRNA (or codon 158 in the membrane-bound form) substitutes methionine for valine and alters enzyme activity. Catecholamines 49-63 catechol-O-methyltransferase Homo sapiens 0-29 18297236-8 2009 The results demonstrate increased catecholamine metabolism via elevated catechol-O-methyl transferase activity during intermittent sprinting. Catecholamines 34-47 catechol-O-methyltransferase Homo sapiens 72-101 19023276-2 2009 Catechol- O-methyltransferase (COMT) inactivates catecholamines, and a G to A substitution in codon 108 in the soluble COMT mRNA (or codon 158 in the membrane-bound form) substitutes methionine for valine and alters enzyme activity. Catecholamines 49-63 catechol-O-methyltransferase Homo sapiens 31-35 19296409-1 2009 Associations were evaluated between a functional single nucleotide polymorphism (Val158Met) in the gene encoding the catecholamine catabolic enzyme catechol O-methyltransferase (COMT), dental mercury exposure, and self-reported symptoms and mood among 183 male dentists and 213 female dental assistants. Catecholamines 117-130 catechol-O-methyltransferase Homo sapiens 148-176 21637643-3 2009 Immunocytes can degrade and inactivate catecholamines via monamine oxidase (MAO) and COMT in the cells. Catecholamines 39-53 catechol-O-methyltransferase Homo sapiens 85-89 19296409-1 2009 Associations were evaluated between a functional single nucleotide polymorphism (Val158Met) in the gene encoding the catecholamine catabolic enzyme catechol O-methyltransferase (COMT), dental mercury exposure, and self-reported symptoms and mood among 183 male dentists and 213 female dental assistants. Catecholamines 117-130 catechol-O-methyltransferase Homo sapiens 178-182 18703939-2 2008 The catechol-O-methyltransferase (COMT) enzyme degrades synaptic catecholamines and plays a specific role in the catabolism of prefrontal cortex dopamine. Catecholamines 65-79 catechol-O-methyltransferase Homo sapiens 4-32 19094200-2 2008 Catecholamines are involved in the modulation of pain and are partly metabolized by the catechol-O-methyltransferase (COMT) enzyme. Catecholamines 0-14 catechol-O-methyltransferase Homo sapiens 88-116 19094200-2 2008 Catecholamines are involved in the modulation of pain and are partly metabolized by the catechol-O-methyltransferase (COMT) enzyme. Catecholamines 0-14 catechol-O-methyltransferase Homo sapiens 118-122 18801628-2 2008 Polymorphic variants of genes encoding key enzymes of folate and methionine metabolism may have an impact on catecholamine catabolism conducted by catechol-O-methyltransferase. Catecholamines 109-122 catechol-O-methyltransferase Homo sapiens 147-175 18704099-2 2008 The catechol-O-methyltransferase (COMT) is involved in the degradation of catecholamines and a functional polymorphism (Val158Met) has been suggested to influence enzyme activity. Catecholamines 74-88 catechol-O-methyltransferase Homo sapiens 4-32 18704099-2 2008 The catechol-O-methyltransferase (COMT) is involved in the degradation of catecholamines and a functional polymorphism (Val158Met) has been suggested to influence enzyme activity. Catecholamines 74-88 catechol-O-methyltransferase Homo sapiens 34-38 18275991-6 2008 For example dysregulation of the catecholamine system could alter catechol-O-methyltransferase-catalyzed methylation, preventing removal of redox cycling catecholestrogens from the system enhancing pro-oxidant effects of estradiol. Catecholamines 33-46 catechol-O-methyltransferase Homo sapiens 66-94 18703939-2 2008 The catechol-O-methyltransferase (COMT) enzyme degrades synaptic catecholamines and plays a specific role in the catabolism of prefrontal cortex dopamine. Catecholamines 65-79 catechol-O-methyltransferase Homo sapiens 34-38 18486144-1 2008 Catechol O-methyltransferase (COMT) plays important roles in the metabolism of catecholamine neurotransmitters and catechol estrogens. Catecholamines 79-92 catechol-O-methyltransferase Homo sapiens 0-28 18486144-1 2008 Catechol O-methyltransferase (COMT) plays important roles in the metabolism of catecholamine neurotransmitters and catechol estrogens. Catecholamines 79-92 catechol-O-methyltransferase Homo sapiens 30-34 17084978-1 2007 Catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, has recently been implicated in the modulation of pain. Catecholamines 64-78 catechol-O-methyltransferase Homo sapiens 0-28 19300629-1 2007 A functional polymorphism of the gene coding for Catechol-O-methyltrasferase (COMT), an enzyme responsible for the degradation of the catecholamine dopamine (DA), epinephrine, and norepinephrine, is associated with cognitive deficits. Catecholamines 134-147 catechol-O-methyltransferase Homo sapiens 49-76 19300629-1 2007 A functional polymorphism of the gene coding for Catechol-O-methyltrasferase (COMT), an enzyme responsible for the degradation of the catecholamine dopamine (DA), epinephrine, and norepinephrine, is associated with cognitive deficits. Catecholamines 134-147 catechol-O-methyltransferase Homo sapiens 78-82 18064318-2 2007 Catechol-O-methyltransferase (COMT) is involved in the S-adenosylmethionine-dependent methylation of catecholamines and catecholestrogens and in this way contributes to homocysteine synthesis. Catecholamines 101-115 catechol-O-methyltransferase Homo sapiens 0-28 18064318-2 2007 Catechol-O-methyltransferase (COMT) is involved in the S-adenosylmethionine-dependent methylation of catecholamines and catecholestrogens and in this way contributes to homocysteine synthesis. Catecholamines 101-115 catechol-O-methyltransferase Homo sapiens 30-34 17850222-1 2007 OBJECTIVE: To test whether variation in the gene encoding the enzyme catechol-O-methyltransferase (COMT), which catalyzes the breakdown of dopamine and other catecholamine neurotransmitters, is associated with the risk for alcohol dependence and habitual smoking. Catecholamines 158-171 catechol-O-methyltransferase Homo sapiens 69-97 17850222-1 2007 OBJECTIVE: To test whether variation in the gene encoding the enzyme catechol-O-methyltransferase (COMT), which catalyzes the breakdown of dopamine and other catecholamine neurotransmitters, is associated with the risk for alcohol dependence and habitual smoking. Catecholamines 158-171 catechol-O-methyltransferase Homo sapiens 99-103 17880176-2 2007 In the present study, we have cloned and expressed the human soluble and membrane-bound COMTs (S-COMT and MB-COMT, respectively) in Escherichia coli and have studied their biochemical characteristics for the O-methylation of representative classes of endogenous catechol substrates (catecholamines and catechol estrogens) as well as exogenous catechol substrates (bioflavonoids and tea catechins). Catecholamines 283-297 catechol-O-methyltransferase Homo sapiens 88-92 17761405-1 2007 Catechol-O-methyltransferase (COMT) is one of the major enzymes for the degradation of catecholamines. Catecholamines 87-101 catechol-O-methyltransferase Homo sapiens 0-28 17761405-1 2007 Catechol-O-methyltransferase (COMT) is one of the major enzymes for the degradation of catecholamines. Catecholamines 87-101 catechol-O-methyltransferase Homo sapiens 30-34 18442637-1 2008 Catechol O-methyltransferase (COMT) degrades catecholamines and estrogens, both of which are of known importance for cardiovascular risk factors such as obesity and hypertension. Catecholamines 45-59 catechol-O-methyltransferase Homo sapiens 0-28 18442637-1 2008 Catechol O-methyltransferase (COMT) degrades catecholamines and estrogens, both of which are of known importance for cardiovascular risk factors such as obesity and hypertension. Catecholamines 45-59 catechol-O-methyltransferase Homo sapiens 30-34 17510945-3 2007 A functional polymorphism on the human catechol-O-methyltransferase (COMT) gene, which codes for the catecholamines inactivating enzyme COMT, has been shown to influence aggressive and anger-related traits in various clinical populations. Catecholamines 101-115 catechol-O-methyltransferase Homo sapiens 39-67 17510945-3 2007 A functional polymorphism on the human catechol-O-methyltransferase (COMT) gene, which codes for the catecholamines inactivating enzyme COMT, has been shown to influence aggressive and anger-related traits in various clinical populations. Catecholamines 101-115 catechol-O-methyltransferase Homo sapiens 69-73 17510945-3 2007 A functional polymorphism on the human catechol-O-methyltransferase (COMT) gene, which codes for the catecholamines inactivating enzyme COMT, has been shown to influence aggressive and anger-related traits in various clinical populations. Catecholamines 101-115 catechol-O-methyltransferase Homo sapiens 136-140 17525973-2 2007 Two genes that have been highlighted in the literature as being involved are HTR1B, which codes for the serotonin 1B receptor, and COMT, which is related to the inactivation of catecholamines. Catecholamines 177-191 catechol-O-methyltransferase Homo sapiens 131-135 17982691-5 2007 Given the striking similarities between the enzymatic steps in the morphine biosynthetic pathway and those driving the evolutionary adaptation of catecholamine chemical species to accommodate an expansion of interactive but distinct signaling systems, we surmise that the evolutionary emergence of catecholamine systems required conservation and selective "retrofit" of specific enzyme activities, i.e. catechol O-methyl transferase and phenylethanol-amine N-methyl transferase, drawn from cellular morphine expression. Catecholamines 298-311 catechol-O-methyltransferase Homo sapiens 403-432 17924258-4 2007 An amino acid polymorphism (Val158Met) in the COMT gene affects the activity level of COMT, which affects the levels of available catecholamines in the brain. Catecholamines 130-144 catechol-O-methyltransferase Homo sapiens 46-50 17924258-4 2007 An amino acid polymorphism (Val158Met) in the COMT gene affects the activity level of COMT, which affects the levels of available catecholamines in the brain. Catecholamines 130-144 catechol-O-methyltransferase Homo sapiens 86-90 17419009-1 2007 The Val158Met polymorphism of the COMT gene is functional, easily detectable, and significantly related to metabolism of catecholamines, which underlie pathogenesis of a significant number of mental disorders. Catecholamines 121-135 catechol-O-methyltransferase Homo sapiens 34-38 17482701-1 2007 Catechol-O-methyltransferase (COMT) is one of the enzymes that degrade catecholamine neurotransmitters including dopamine. Catecholamines 71-84 catechol-O-methyltransferase Homo sapiens 0-28 17482701-1 2007 Catechol-O-methyltransferase (COMT) is one of the enzymes that degrade catecholamine neurotransmitters including dopamine. Catecholamines 71-84 catechol-O-methyltransferase Homo sapiens 30-34 17084978-1 2007 Catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, has recently been implicated in the modulation of pain. Catecholamines 64-78 catechol-O-methyltransferase Homo sapiens 30-34 17961261-4 2007 Catechol-O-methyltransferase (COMT), an enzyme, is the major catecholamine-clearing pathway. Catecholamines 61-74 catechol-O-methyltransferase Homo sapiens 0-28 17240060-4 2007 Of particular interest was catechol-O-methyl transferase (COMT), an enzyme involved in metabolizing catecholamines released following neuronal activity. Catecholamines 100-114 catechol-O-methyltransferase Homo sapiens 27-56 17240060-4 2007 Of particular interest was catechol-O-methyl transferase (COMT), an enzyme involved in metabolizing catecholamines released following neuronal activity. Catecholamines 100-114 catechol-O-methyltransferase Homo sapiens 58-62 17240060-8 2007 Since dopamine transporter expression has been reported to be down-regulated after brain injury, COMT-mediated catecholamine metabolism may play a more prominent role in terminating catecholamine signaling in injured areas. Catecholamines 111-124 catechol-O-methyltransferase Homo sapiens 97-101 17240060-8 2007 Since dopamine transporter expression has been reported to be down-regulated after brain injury, COMT-mediated catecholamine metabolism may play a more prominent role in terminating catecholamine signaling in injured areas. Catecholamines 182-195 catechol-O-methyltransferase Homo sapiens 97-101 17961261-4 2007 Catechol-O-methyltransferase (COMT), an enzyme, is the major catecholamine-clearing pathway. Catecholamines 61-74 catechol-O-methyltransferase Homo sapiens 30-34 17961261-5 2007 There are several single-nucleotide polymorphisms (SNPs) in the COMT gene associated with the different catecholamine-clearing abilities of the COMT enzyme. Catecholamines 104-117 catechol-O-methyltransferase Homo sapiens 64-68 17961261-5 2007 There are several single-nucleotide polymorphisms (SNPs) in the COMT gene associated with the different catecholamine-clearing abilities of the COMT enzyme. Catecholamines 104-117 catechol-O-methyltransferase Homo sapiens 144-148 16848906-3 2006 RESULTS: Variations in the catecholamine metabolizing enzyme genes (MAOA and COMT) showed significant associations with the maximum post-operative pain rating while the serotonin transporter gene (SLC6A4) showed association with the onset time of post-operative pain. Catecholamines 27-40 catechol-O-methyltransferase Homo sapiens 77-81 18466599-1 2007 The COMT and DBH genes are physically located at chromosomes 22q11 and 9q34, respectively, and both COMT and DBH are involved in catecholamine metabolism and are strong candidates for certain psychiatric and neurological disorders. Catecholamines 129-142 catechol-O-methyltransferase Homo sapiens 4-8 18466599-1 2007 The COMT and DBH genes are physically located at chromosomes 22q11 and 9q34, respectively, and both COMT and DBH are involved in catecholamine metabolism and are strong candidates for certain psychiatric and neurological disorders. Catecholamines 129-142 catechol-O-methyltransferase Homo sapiens 100-104 16476412-2 2006 We begin by considering the COMT gene, its transcripts and proteins, and its relevance for central catecholamine function. Catecholamines 99-112 catechol-O-methyltransferase Homo sapiens 28-32 17205121-2 2006 We examined whether the relationship between coffee intake and incidence of CHD events is dependent on the metabolism of circulating catecholamines, as determined by functional polymorphism of the catechol-O-methyltransferase (COMT) gene. Catecholamines 133-147 catechol-O-methyltransferase Homo sapiens 197-225 17205121-2 2006 We examined whether the relationship between coffee intake and incidence of CHD events is dependent on the metabolism of circulating catecholamines, as determined by functional polymorphism of the catechol-O-methyltransferase (COMT) gene. Catecholamines 133-147 catechol-O-methyltransferase Homo sapiens 227-231 16470514-1 2006 The enzyme catechol-O-methyltransferase (COMT) plays an important role in the metabolism of catechol estrogens and degradation of the catecholamine neurotransmitters, such as epinephrine. Catecholamines 134-147 catechol-O-methyltransferase Homo sapiens 11-39 16470514-1 2006 The enzyme catechol-O-methyltransferase (COMT) plays an important role in the metabolism of catechol estrogens and degradation of the catecholamine neurotransmitters, such as epinephrine. Catecholamines 134-147 catechol-O-methyltransferase Homo sapiens 41-45 16906330-5 2006 A classical metabolic pathway of CAs shared by the nervous and endocrine systems is present in the immune cells, i.e., the immunocytes have the enzymes for synthesis of CAs [e.g. tyrosine hydroxylase (TH)] and the enzymes for degradation of CAs [e.g. monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT)]. Catecholamines 33-36 catechol-O-methyltransferase Homo sapiens 279-308 16906330-5 2006 A classical metabolic pathway of CAs shared by the nervous and endocrine systems is present in the immune cells, i.e., the immunocytes have the enzymes for synthesis of CAs [e.g. tyrosine hydroxylase (TH)] and the enzymes for degradation of CAs [e.g. monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT)]. Catecholamines 33-36 catechol-O-methyltransferase Homo sapiens 310-314 16906330-5 2006 A classical metabolic pathway of CAs shared by the nervous and endocrine systems is present in the immune cells, i.e., the immunocytes have the enzymes for synthesis of CAs [e.g. tyrosine hydroxylase (TH)] and the enzymes for degradation of CAs [e.g. monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT)]. Catecholamines 169-172 catechol-O-methyltransferase Homo sapiens 279-308 16906330-5 2006 A classical metabolic pathway of CAs shared by the nervous and endocrine systems is present in the immune cells, i.e., the immunocytes have the enzymes for synthesis of CAs [e.g. tyrosine hydroxylase (TH)] and the enzymes for degradation of CAs [e.g. monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT)]. Catecholamines 169-172 catechol-O-methyltransferase Homo sapiens 310-314 16906330-5 2006 A classical metabolic pathway of CAs shared by the nervous and endocrine systems is present in the immune cells, i.e., the immunocytes have the enzymes for synthesis of CAs [e.g. tyrosine hydroxylase (TH)] and the enzymes for degradation of CAs [e.g. monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT)]. Catecholamines 169-172 catechol-O-methyltransferase Homo sapiens 279-308 16906330-5 2006 A classical metabolic pathway of CAs shared by the nervous and endocrine systems is present in the immune cells, i.e., the immunocytes have the enzymes for synthesis of CAs [e.g. tyrosine hydroxylase (TH)] and the enzymes for degradation of CAs [e.g. monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT)]. Catecholamines 169-172 catechol-O-methyltransferase Homo sapiens 310-314 16406650-5 2006 COMT metabolizes catechols and catecholamines, a pathway relevant to neurodegeneration. Catecholamines 31-45 catechol-O-methyltransferase Homo sapiens 0-4 16542735-0 2006 Influence of the catechol-O-methyltransferase Val108/158Met polymorphism on the plasma concentration of catecholamine metabolites and on clinical features in type I bipolar disorder--a preliminary report. Catecholamines 104-117 catechol-O-methyltransferase Homo sapiens 17-45 16564429-6 2006 The COMT G158A substitution results in a three- to four-fold decreased activity of the COMT enzyme, which may influence CNS synaptic catecholamine breakdown and could also play a role in MS inflammation. Catecholamines 133-146 catechol-O-methyltransferase Homo sapiens 4-8 16564429-6 2006 The COMT G158A substitution results in a three- to four-fold decreased activity of the COMT enzyme, which may influence CNS synaptic catecholamine breakdown and could also play a role in MS inflammation. Catecholamines 133-146 catechol-O-methyltransferase Homo sapiens 87-91 16266697-2 2006 In addition, CAs are known to be metabolized by catechol-O-methyltransferase (COMT) to produce their 3-O-methyl metabolites. Catecholamines 13-16 catechol-O-methyltransferase Homo sapiens 48-76 16266697-2 2006 In addition, CAs are known to be metabolized by catechol-O-methyltransferase (COMT) to produce their 3-O-methyl metabolites. Catecholamines 13-16 catechol-O-methyltransferase Homo sapiens 78-82 15935994-10 2005 The COMT Val(108/158)Met polymorphism modifies the severity of endophenotypes for schizophrenia, indicating that impaired catecholamine regulation contributes to neuropsychiatric risk in 22q11DS. Catecholamines 122-135 catechol-O-methyltransferase Homo sapiens 4-8 16892369-1 2006 Inhibition of the enzyme catechol O-methyltransferase offers a therapeutic handle to regulate the catabolism of catecholamine neurotransmitters, providing valuable assistance in the treatment of CNS disorders such as Parkinson"s disease. Catecholamines 112-125 catechol-O-methyltransferase Homo sapiens 25-53 16965190-5 2006 Frontal lobe dysfunction and mutations in the catechol O-methyltransferase (COMT) gene involved in dopamine metabolism and catecholamine inactivation have been linked to agitation in patients with schizophrenia and bipolar disorder. Catecholamines 123-136 catechol-O-methyltransferase Homo sapiens 46-74 16965190-5 2006 Frontal lobe dysfunction and mutations in the catechol O-methyltransferase (COMT) gene involved in dopamine metabolism and catecholamine inactivation have been linked to agitation in patients with schizophrenia and bipolar disorder. Catecholamines 123-136 catechol-O-methyltransferase Homo sapiens 76-80 17028449-10 2006 CONCLUSIONS: These findings seem to suggest that a turnover of catecholamines, connected with polymorphism determining high activity of COMT enzyme, is connected with the risk of ED occurrence, particularly anorexia nervosa. Catecholamines 63-77 catechol-O-methyltransferase Homo sapiens 136-140 16878403-1 2006 Catechol-O-methyltransferase (COMT) degrades the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. Catecholamines 49-62 catechol-O-methyltransferase Homo sapiens 0-28 16878403-1 2006 Catechol-O-methyltransferase (COMT) degrades the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. Catecholamines 49-62 catechol-O-methyltransferase Homo sapiens 30-34 16253764-3 2005 This polymorphism has been the subject of intense molecular epidemiological studies because of the important role of COMT in the metabolism of catecholamines and catechol estrogens. Catecholamines 143-157 catechol-O-methyltransferase Homo sapiens 117-121 16360899-4 2006 In the present study, we investigated the association between personality traits and systematic combination of functional polymorphisms in three genes that regulate the metabolism of catecholamines, namely, tyrosine hydroxylase (TH), monoamine oxidase A (MAOA), and catechol-O-methyltransferase (COMT). Catecholamines 183-197 catechol-O-methyltransferase Homo sapiens 266-294 16360899-4 2006 In the present study, we investigated the association between personality traits and systematic combination of functional polymorphisms in three genes that regulate the metabolism of catecholamines, namely, tyrosine hydroxylase (TH), monoamine oxidase A (MAOA), and catechol-O-methyltransferase (COMT). Catecholamines 183-197 catechol-O-methyltransferase Homo sapiens 296-300 18543469-3 2006 Among his early pioneering research achievements in applying chemical and biochemical approaches to neuroscience were the discoveries of the painkiller acetaminophen (Tylenol, Paracetamol) and the liver microsomal drug-metabolizing enzymes, and the establishment of catechol-O-methyltransferase as an important enzyme in catecholamine metabolism. Catecholamines 321-334 catechol-O-methyltransferase Homo sapiens 266-294 16215614-4 2005 Furthermore, variability in an enzyme-degrading catecholamines (COMT gene) may also alter the efficacy of morphine, which shows that genetic variability in non-opioid systems may indirectly influence the clinical opioid efficacy. Catecholamines 48-62 catechol-O-methyltransferase Homo sapiens 64-68 16045647-4 2005 Furthermore, variability in an enzyme degrading catecholamines (COMT gene) alters the efficacy of morphine demonstrating that genetic variability in non-opioid systems may indirectly influence the clinical efficacy from morphine. Catecholamines 48-62 catechol-O-methyltransferase Homo sapiens 64-68 15862471-2 2005 Catechol-O-methyltransferase (COMT) is one of the enzymes that metabolize catecholamine neurotransmitters. Catecholamines 74-87 catechol-O-methyltransferase Homo sapiens 0-28 16223057-7 2005 RESULTS: COMT Vall58Met is a common (minor allele frequency 0.42), functional, catecholamine-metabolizing enzyme polymorphism with threefold relevance. Catecholamines 79-92 catechol-O-methyltransferase Homo sapiens 9-13 15862471-2 2005 Catechol-O-methyltransferase (COMT) is one of the enzymes that metabolize catecholamine neurotransmitters. Catecholamines 74-87 catechol-O-methyltransferase Homo sapiens 30-34 15817751-0 2004 Catecholamines and aggression: the role of COMT and MAO polymorphisms. Catecholamines 0-14 catechol-O-methyltransferase Homo sapiens 43-47 15583702-1 2005 The available data from preclinical and pharmacological studies on the role of the C-O-methyl transferase (COMT) support the hypothesis that abnormal catecholamine transmission has been implicated in the pathogenesis of mood disorders (MD). Catecholamines 150-163 catechol-O-methyltransferase Homo sapiens 83-105 15583702-1 2005 The available data from preclinical and pharmacological studies on the role of the C-O-methyl transferase (COMT) support the hypothesis that abnormal catecholamine transmission has been implicated in the pathogenesis of mood disorders (MD). Catecholamines 150-163 catechol-O-methyltransferase Homo sapiens 107-111 15645182-1 2005 Catechol-O-methyltransferase (COMT) inactivates circulating catechol hormones, catechol neurotransmitters, and xenobiotic catecholamines by methylating their catechol moieties. Catecholamines 122-136 catechol-O-methyltransferase Homo sapiens 0-28 15645182-1 2005 Catechol-O-methyltransferase (COMT) inactivates circulating catechol hormones, catechol neurotransmitters, and xenobiotic catecholamines by methylating their catechol moieties. Catecholamines 122-136 catechol-O-methyltransferase Homo sapiens 30-34 15673663-1 2005 Catechol-O-methyltransferase (COMT) degrades the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. Catecholamines 49-62 catechol-O-methyltransferase Homo sapiens 0-28 15673663-1 2005 Catechol-O-methyltransferase (COMT) degrades the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. Catecholamines 49-62 catechol-O-methyltransferase Homo sapiens 30-34 15690966-9 2004 COMT is one of the two enzymes degrading catecholamines such as dopamine. Catecholamines 41-55 catechol-O-methyltransferase Homo sapiens 0-4 15613245-1 2004 BACKGROUND: An association has been observed between the catechol-O-methyltransferase (COMT) gene, the predominant means of catecholamine catabolism within the prefrontal cortex (PFC), and neuropsychological task performance in healthy and schizophrenic adults. Catecholamines 124-137 catechol-O-methyltransferase Homo sapiens 57-85 15613245-1 2004 BACKGROUND: An association has been observed between the catechol-O-methyltransferase (COMT) gene, the predominant means of catecholamine catabolism within the prefrontal cortex (PFC), and neuropsychological task performance in healthy and schizophrenic adults. Catecholamines 124-137 catechol-O-methyltransferase Homo sapiens 87-91 15817751-3 2004 Two major enzymes are responsible for catecholamine catabolism in the brain: catechol-O-methyltransferase (COMT) and monoamine oxidase A (MAOA). Catecholamines 38-51 catechol-O-methyltransferase Homo sapiens 77-105 15817751-3 2004 Two major enzymes are responsible for catecholamine catabolism in the brain: catechol-O-methyltransferase (COMT) and monoamine oxidase A (MAOA). Catecholamines 38-51 catechol-O-methyltransferase Homo sapiens 107-111 15817751-5 2004 If aggressive behavior is enhanced by catecholaminergic activity, then the lower activity of COMT and MAOA (resulting in a slower inactivation of catecholamines) should indirectly enhance aggression. Catecholamines 146-160 catechol-O-methyltransferase Homo sapiens 93-97 15556832-9 2004 These COMT metabolites may also help in elucidation of still undiscovered genetic and acquired disorders of catecholamine metabolism. Catecholamines 108-121 catechol-O-methyltransferase Homo sapiens 6-10 14767563-6 2004 Catechol-O-methyltransferase (COMT)-mediated methylation metabolism of catecholamine neurotransmitters is a crucial first-line detoxification pathway, and its role in the causation and prevention of PD is also discussed. Catecholamines 71-84 catechol-O-methyltransferase Homo sapiens 0-28 15211623-6 2004 These results fail to support the theory that functional polymorphisms within the MAOA, MAOB, or COMT genes, as determinants of catecholamine enzymatic activity, are risk factors for aggressive behavior. Catecholamines 128-141 catechol-O-methyltransferase Homo sapiens 97-101 15211633-2 2004 The variety of psychiatric manifestations in patients with the 22q11 microdeletion and the role of COMT in the degradation of catecholamine neurotransmitters may thus suggest a general involvement of the COMT gene in psychiatric diseases. Catecholamines 126-139 catechol-O-methyltransferase Homo sapiens 99-103 15211633-2 2004 The variety of psychiatric manifestations in patients with the 22q11 microdeletion and the role of COMT in the degradation of catecholamine neurotransmitters may thus suggest a general involvement of the COMT gene in psychiatric diseases. Catecholamines 126-139 catechol-O-methyltransferase Homo sapiens 204-208 15309045-4 2004 The first gene codes for catechol-O-methyltransferase, an enzyme involved in catecholamine degradation, and the second gene codes for brain-derived neurotrophic factor, a growth factor implicated in cell survival, synaptogenesis and the development of cortical pyramidal neurons. Catecholamines 77-90 catechol-O-methyltransferase Homo sapiens 25-53 15124004-1 2004 The enzyme catechol-o-methyltransferase (COMT) transfers a methyl group from adenosylmethionine to catecholamines including the neurotransmitters dopamine, epinephrine and norepinephrine. Catecholamines 99-113 catechol-O-methyltransferase Homo sapiens 11-39 15124004-1 2004 The enzyme catechol-o-methyltransferase (COMT) transfers a methyl group from adenosylmethionine to catecholamines including the neurotransmitters dopamine, epinephrine and norepinephrine. Catecholamines 99-113 catechol-O-methyltransferase Homo sapiens 41-45 15292328-2 2004 Because catecholamines are also substrates for COMT, we hypothesize that catecholamines may abrogate the vasoprotective effects of estradiol by competing for COMT and inhibiting methoxyestradiol formation. Catecholamines 8-22 catechol-O-methyltransferase Homo sapiens 47-51 15292328-2 2004 Because catecholamines are also substrates for COMT, we hypothesize that catecholamines may abrogate the vasoprotective effects of estradiol by competing for COMT and inhibiting methoxyestradiol formation. Catecholamines 73-87 catechol-O-methyltransferase Homo sapiens 47-51 15292328-2 2004 Because catecholamines are also substrates for COMT, we hypothesize that catecholamines may abrogate the vasoprotective effects of estradiol by competing for COMT and inhibiting methoxyestradiol formation. Catecholamines 73-87 catechol-O-methyltransferase Homo sapiens 158-162 15127078-3 2004 Z26491) is a polymorphism of the gene encoding COMT, a major enzyme in catecholamine inactivation. Catecholamines 71-84 catechol-O-methyltransferase Homo sapiens 47-51 15261699-7 2004 As both COMT and MAO genes are involved in degrading catecholamines, we also sought evidence for additive and epistatic effects, but none was observed. Catecholamines 53-67 catechol-O-methyltransferase Homo sapiens 8-12 14966473-1 2004 Catechol O-methyltransferase (COMT) plays an important role in the metabolism of catecholamines, catecholestrogens and catechol drugs. Catecholamines 81-95 catechol-O-methyltransferase Homo sapiens 0-28 14966473-1 2004 Catechol O-methyltransferase (COMT) plays an important role in the metabolism of catecholamines, catecholestrogens and catechol drugs. Catecholamines 81-95 catechol-O-methyltransferase Homo sapiens 30-34 15118357-1 2004 The gene coding for catechol-O-methyltransferase (COMT), which is involved in the metabolism of catecholamines, has long been implicated as a candidate gene for schizophrenia. Catecholamines 96-110 catechol-O-methyltransferase Homo sapiens 20-48 15118357-1 2004 The gene coding for catechol-O-methyltransferase (COMT), which is involved in the metabolism of catecholamines, has long been implicated as a candidate gene for schizophrenia. Catecholamines 96-110 catechol-O-methyltransferase Homo sapiens 50-54 14767563-6 2004 Catechol-O-methyltransferase (COMT)-mediated methylation metabolism of catecholamine neurotransmitters is a crucial first-line detoxification pathway, and its role in the causation and prevention of PD is also discussed. Catecholamines 71-84 catechol-O-methyltransferase Homo sapiens 30-34 14767563-7 2004 On the basis of the modulation of COMT-mediated methylation of catecholamines, it is mechanistically explained that hyperhomocysteinemia would be a pathogenic factor in PD whereas vitamins B6, B12, and folate would be a protective factor. Catecholamines 63-77 catechol-O-methyltransferase Homo sapiens 34-38 12913061-2 2003 Catecholamines are also substrates for catechol-O-methyltransferase and therefore, might abrogate the renoprotective effects of estradiol by inhibiting formation of methoxyestradiols. Catecholamines 0-14 catechol-O-methyltransferase Homo sapiens 39-67 12535946-1 2003 Catechol O-methyltransferase (COMT) is involved in the inactivation of catecholamines, including the neurotransmitter dopamine. Catecholamines 71-85 catechol-O-methyltransferase Homo sapiens 0-28 12842306-2 2003 Catechol-O-methyltransferase (COMT) is an enzyme involved in catecholamine inactivation. Catecholamines 61-74 catechol-O-methyltransferase Homo sapiens 0-28 12842306-2 2003 Catechol-O-methyltransferase (COMT) is an enzyme involved in catecholamine inactivation. Catecholamines 61-74 catechol-O-methyltransferase Homo sapiens 30-34 12739038-2 2003 Catechol-O-methyltransferase (COMT) enzyme inactivates catecholamines and catecholamine-containing drugs. Catecholamines 55-69 catechol-O-methyltransferase Homo sapiens 0-28 12739038-2 2003 Catechol-O-methyltransferase (COMT) enzyme inactivates catecholamines and catecholamine-containing drugs. Catecholamines 55-69 catechol-O-methyltransferase Homo sapiens 30-34 12739038-2 2003 Catechol-O-methyltransferase (COMT) enzyme inactivates catecholamines and catecholamine-containing drugs. Catecholamines 55-68 catechol-O-methyltransferase Homo sapiens 0-28 12739038-2 2003 Catechol-O-methyltransferase (COMT) enzyme inactivates catecholamines and catecholamine-containing drugs. Catecholamines 55-68 catechol-O-methyltransferase Homo sapiens 30-34 14673217-1 2003 Catechol-O-methyltransferase (COMT) is an enzyme that inactivates catecholamines, including levodopa. Catecholamines 66-80 catechol-O-methyltransferase Homo sapiens 0-28 14673217-1 2003 Catechol-O-methyltransferase (COMT) is an enzyme that inactivates catecholamines, including levodopa. Catecholamines 66-80 catechol-O-methyltransferase Homo sapiens 30-34 12535946-1 2003 Catechol O-methyltransferase (COMT) is involved in the inactivation of catecholamines, including the neurotransmitter dopamine. Catecholamines 71-85 catechol-O-methyltransferase Homo sapiens 30-34 12402217-2 2002 One of these is its biochemical function in metabolism of catecholamine neurotransmitters; another is the microdeletion, on chromosome 22q11, that includes the COMT gene and causes velocardiofacial syndrome, a syndrome associated with a high rate of psychosis, particularly schizophrenia. Catecholamines 58-71 catechol-O-methyltransferase Homo sapiens 160-164 12438556-1 2002 Two different uptake processes terminate the synaptic action of released catecholamines in brain: the high-affinity uptake to presynaptic nerve terminals (uptake(1), followed by oxidation by monoamine oxidase, MAO) or glial cells uptake (uptake(2), followed by O-methylation by catechol-O-methyltransferase, COMT, and/or oxidation by MAO). Catecholamines 73-87 catechol-O-methyltransferase Homo sapiens 278-306 12436243-1 2002 Catechol-O-methyl transferase (COMT) catalyzes the first step in one of the major pathways in the degradation of catecholamines. Catecholamines 113-127 catechol-O-methyltransferase Homo sapiens 0-29 12436243-1 2002 Catechol-O-methyl transferase (COMT) catalyzes the first step in one of the major pathways in the degradation of catecholamines. Catecholamines 113-127 catechol-O-methyltransferase Homo sapiens 31-35 12438556-1 2002 Two different uptake processes terminate the synaptic action of released catecholamines in brain: the high-affinity uptake to presynaptic nerve terminals (uptake(1), followed by oxidation by monoamine oxidase, MAO) or glial cells uptake (uptake(2), followed by O-methylation by catechol-O-methyltransferase, COMT, and/or oxidation by MAO). Catecholamines 73-87 catechol-O-methyltransferase Homo sapiens 308-312 12564841-1 2002 BACKGROUND: Catechol-O-methyltransferase (COMT) catalyses the inactivation of catecholamines. Catecholamines 78-92 catechol-O-methyltransferase Homo sapiens 12-40 12564841-1 2002 BACKGROUND: Catechol-O-methyltransferase (COMT) catalyses the inactivation of catecholamines. Catecholamines 78-92 catechol-O-methyltransferase Homo sapiens 42-46 12564841-9 2002 CONCLUSION: The established assay method used to assess S- and MB-COMT activities in human erythrocytes could be useful to elucidate catecholamine metabolism in the normal physiological state as well as in the pathology of certain diseases. Catecholamines 133-146 catechol-O-methyltransferase Homo sapiens 66-70 12083324-1 2002 The metabolic O-methylation of endogenous catecholamines and other catechols catalyzed by catechol-O-methyltransferase (COMT; EC 2.1.1.6) was first described by Dr. Julix Axelrod and his colleagues almost half a century ago. Catecholamines 42-56 catechol-O-methyltransferase Homo sapiens 90-118 12371153-2 2002 In this paper, a unifying hypothesis is proposed which suggests that hyperhomocysteinemia may exert its pathogenic effects largely through metabolic accumulation of S-adenosyl-L-homocysteine, a strong noncompetitive inhibitor of the catechol-O-methyltransferase (COMT)-mediated methylation metabolism of various catechol substrates (such as catecholamines and catechol estrogens). Catecholamines 341-355 catechol-O-methyltransferase Homo sapiens 233-261 12126868-1 2002 Genetic polymorphism of catechol-O-methyltransferase (COMT), involved in the degradation of catecholamine neurotransmitters, has been investigated as a candidate for modifier of susceptibility to development of schizophrenia. Catecholamines 92-105 catechol-O-methyltransferase Homo sapiens 24-52 12126868-1 2002 Genetic polymorphism of catechol-O-methyltransferase (COMT), involved in the degradation of catecholamine neurotransmitters, has been investigated as a candidate for modifier of susceptibility to development of schizophrenia. Catecholamines 92-105 catechol-O-methyltransferase Homo sapiens 54-58 15177064-1 2002 The inhibition of catechol-O-methyltransferase (COMT) may impair catecholamine clearance resulting in unwanted cardiac and hemodynamic events. Catecholamines 65-78 catechol-O-methyltransferase Homo sapiens 18-46 15177064-1 2002 The inhibition of catechol-O-methyltransferase (COMT) may impair catecholamine clearance resulting in unwanted cardiac and hemodynamic events. Catecholamines 65-78 catechol-O-methyltransferase Homo sapiens 48-52 12053603-3 2002 In the search of factors that can precipitate degeneration of dopaminergic neurons the role of enzymes catabolising xenobiotics (CYP2D6, NAT2) and enzymes metabolising catecholamines (COMT, MAO B) has been postulated. Catecholamines 168-182 catechol-O-methyltransferase Homo sapiens 184-188 11803531-2 2001 Molecular genetic and pharmacological studies suggest the involvement of dopaminergic and noradrenergic neurotransmitter systems in ADHD, e.g., several reports have found association between ADHD and the dopamine receptor gene DRD-4, the dopamine transporter gene DAT1, and the catecholamine clearance enzyme catechol-O-methyltransferase. Catecholamines 278-291 catechol-O-methyltransferase Homo sapiens 309-337 10898900-2 2000 The enzyme catechol-O-methyltransferase (COMT) plays a key role in the degradation of catecholamines such as dopamine, L-DOPA, adrenaline, and noradrenaline and therefore could be considered as a candidate locus for ADHD susceptibility. Catecholamines 86-100 catechol-O-methyltransferase Homo sapiens 11-39 11701460-2 2001 Catecholamines are also substrates for COMT, and increased levels of catecholamines are associated with vasoocclusive disorders. Catecholamines 0-14 catechol-O-methyltransferase Homo sapiens 39-43 11701460-3 2001 We hypothesize that catecholamines may abrogate the vasoprotective effects of 2-hydroxyestradiol by competing for COMT and inhibiting 2-methoxyestradiol formation. Catecholamines 20-34 catechol-O-methyltransferase Homo sapiens 114-118 11735324-0 2001 Catecholamine metabolism in the brain by membrane-bound and soluble catechol-o-methyltransferase (COMT) estimated by enzyme kinetic values. Catecholamines 0-13 catechol-O-methyltransferase Homo sapiens 68-96 11735324-0 2001 Catecholamine metabolism in the brain by membrane-bound and soluble catechol-o-methyltransferase (COMT) estimated by enzyme kinetic values. Catecholamines 0-13 catechol-O-methyltransferase Homo sapiens 98-102 11502905-0 2001 Catecholamines in patients with 22q11.2 deletion syndrome and the low-activity COMT polymorphism. Catecholamines 0-14 catechol-O-methyltransferase Homo sapiens 79-83 11502905-3 2001 One etiologic hypothesis for this condition is that deletion of the COMT gene from one chromosome 22 results in increased catecholamine neurotransmission, particularly if the undeleted chromosome 22 encodes a variant of COMT with low activity. Catecholamines 122-135 catechol-O-methyltransferase Homo sapiens 68-72 11502905-3 2001 One etiologic hypothesis for this condition is that deletion of the COMT gene from one chromosome 22 results in increased catecholamine neurotransmission, particularly if the undeleted chromosome 22 encodes a variant of COMT with low activity. Catecholamines 122-135 catechol-O-methyltransferase Homo sapiens 220-224 11735087-5 2001 The results indicate that this compound undergoes the action of catechol-O-methyl transferase (COMT), enzymes involved in the catecholamine catabolism, resulting in an enhanced excretion of HVA1c. Catecholamines 126-139 catechol-O-methyltransferase Homo sapiens 64-93 11735087-5 2001 The results indicate that this compound undergoes the action of catechol-O-methyl transferase (COMT), enzymes involved in the catecholamine catabolism, resulting in an enhanced excretion of HVA1c. Catecholamines 126-139 catechol-O-methyltransferase Homo sapiens 95-99 11597779-9 2001 Although altered catecholamine activity due to polymorphism of COMT gene may be one of the mechanisms involved in the pathogenesis of migraine, these mechanisms are not related to presence or absence of aura. Catecholamines 17-30 catechol-O-methyltransferase Homo sapiens 63-67 11440283-2 2001 Much of this degradation is produced by catechol-O-methyltransferase (COMT), an enzyme involved in the metabolism of catecholamines and catechol compounds. Catecholamines 117-131 catechol-O-methyltransferase Homo sapiens 40-68 11440283-2 2001 Much of this degradation is produced by catechol-O-methyltransferase (COMT), an enzyme involved in the metabolism of catecholamines and catechol compounds. Catecholamines 117-131 catechol-O-methyltransferase Homo sapiens 70-74 10898900-2 2000 The enzyme catechol-O-methyltransferase (COMT) plays a key role in the degradation of catecholamines such as dopamine, L-DOPA, adrenaline, and noradrenaline and therefore could be considered as a candidate locus for ADHD susceptibility. Catecholamines 86-100 catechol-O-methyltransferase Homo sapiens 41-45 10834300-3 2000 Chronic L-dopa induces catechol-O-methyltransferase (COMT) and methionine adenosyl transferase (MAT), enzymes involved in the methylation of catecholamines (CA). Catecholamines 141-155 catechol-O-methyltransferase Homo sapiens 23-51 10834300-3 2000 Chronic L-dopa induces catechol-O-methyltransferase (COMT) and methionine adenosyl transferase (MAT), enzymes involved in the methylation of catecholamines (CA). Catecholamines 141-155 catechol-O-methyltransferase Homo sapiens 53-57 9707588-1 1998 Catechol-O-methyltransferase (COMT) is one of the major mammalian enzymes involved in the metabolic degradation of catecholamines and is considered a candidate for several psychiatric disorders and symptoms, including the psychopathology associated with the 22q11 microdeletion syndrome. Catecholamines 115-129 catechol-O-methyltransferase Homo sapiens 0-28 10450274-1 1999 OBJECTIVE: Catechol O-methyltransferase (COMT) is involved in the degradation of catecholamine neurotransmitters. Catecholamines 81-94 catechol-O-methyltransferase Homo sapiens 11-39 10450274-1 1999 OBJECTIVE: Catechol O-methyltransferase (COMT) is involved in the degradation of catecholamine neurotransmitters. Catecholamines 81-94 catechol-O-methyltransferase Homo sapiens 41-45 10385681-1 1999 Catechol-O-methyltransferase (COMT, EC 2.1.1.6) is a ubiquitous enzyme that is crucial to the metabolism of carcinogenic catechols and catecholamines. Catecholamines 135-149 catechol-O-methyltransferase Homo sapiens 0-28 10385681-1 1999 Catechol-O-methyltransferase (COMT, EC 2.1.1.6) is a ubiquitous enzyme that is crucial to the metabolism of carcinogenic catechols and catecholamines. Catecholamines 135-149 catechol-O-methyltransferase Homo sapiens 30-34 10490696-1 1999 Catechol-O-methyltransferase (COMT) catalyzes the degradation of catecholamines and could therefore play a role in the etiology of schizophrenia. Catecholamines 65-79 catechol-O-methyltransferase Homo sapiens 0-28 10490696-1 1999 Catechol-O-methyltransferase (COMT) catalyzes the degradation of catecholamines and could therefore play a role in the etiology of schizophrenia. Catecholamines 65-79 catechol-O-methyltransferase Homo sapiens 30-34 10516661-2 1999 We examined the existence of catecholamine metabolizing enzymes (catechol-O-methyltransferase, COMT, and monoamine oxidase, MAO) in CHO cells transfected with norepinephrine (NE) transporter (NET) cDNA. Catecholamines 29-42 catechol-O-methyltransferase Homo sapiens 65-93 10516661-2 1999 We examined the existence of catecholamine metabolizing enzymes (catechol-O-methyltransferase, COMT, and monoamine oxidase, MAO) in CHO cells transfected with norepinephrine (NE) transporter (NET) cDNA. Catecholamines 29-42 catechol-O-methyltransferase Homo sapiens 95-99 9707588-1 1998 Catechol-O-methyltransferase (COMT) is one of the major mammalian enzymes involved in the metabolic degradation of catecholamines and is considered a candidate for several psychiatric disorders and symptoms, including the psychopathology associated with the 22q11 microdeletion syndrome. Catecholamines 115-129 catechol-O-methyltransferase Homo sapiens 30-34 9702744-1 1998 Catechol-O-methyltransferase (COMT) plays a major role in the breakdown of catecholamines. Catecholamines 75-89 catechol-O-methyltransferase Homo sapiens 0-28 9702744-1 1998 Catechol-O-methyltransferase (COMT) plays a major role in the breakdown of catecholamines. Catecholamines 75-89 catechol-O-methyltransferase Homo sapiens 30-34 9702745-10 1998 Individuals with COMT LL would be expected to have higher levels of transynaptic catecholamines due to a reduced COMT degradation of norepinephrine and dopamine. Catecholamines 81-95 catechol-O-methyltransferase Homo sapiens 17-21 9702745-10 1998 Individuals with COMT LL would be expected to have higher levels of transynaptic catecholamines due to a reduced COMT degradation of norepinephrine and dopamine. Catecholamines 81-95 catechol-O-methyltransferase Homo sapiens 113-117 9754371-19 1998 Inactivation of catecholamines is mediated by catechol-O-methyltransferase and by the monoamine oxidases A and B. Catecholamines 16-30 catechol-O-methyltransferase Homo sapiens 46-74 9626157-2 1998 Presence in pheochromocytomas of catechol-O-methyltransferase (COMT), the enzyme responsible for conversion of catecholamines to metanephrines, was confirmed by Western blot analysis, enzyme assay, and immunohistochemistry. Catecholamines 111-125 catechol-O-methyltransferase Homo sapiens 33-61 9626157-2 1998 Presence in pheochromocytomas of catechol-O-methyltransferase (COMT), the enzyme responsible for conversion of catecholamines to metanephrines, was confirmed by Western blot analysis, enzyme assay, and immunohistochemistry. Catecholamines 111-125 catechol-O-methyltransferase Homo sapiens 63-67 9626157-4 1998 Immunohistochemistry revealed colocalization of COMT in the same chromaffin cells where catecholamines are translocated into storage vesicles by the vesicular monoamine transporter. Catecholamines 88-102 catechol-O-methyltransferase Homo sapiens 48-52 9532347-3 1998 Distally, it includes the gene for catechol-O-methyl-transferase (COMT), an enzyme that catalyzes the O-methylation of catecholamine neurotransmitters, including dopamine, and which therefore is considered a candidate gene for schizophrenia. Catecholamines 119-132 catechol-O-methyltransferase Homo sapiens 35-64 9532347-3 1998 Distally, it includes the gene for catechol-O-methyl-transferase (COMT), an enzyme that catalyzes the O-methylation of catecholamine neurotransmitters, including dopamine, and which therefore is considered a candidate gene for schizophrenia. Catecholamines 119-132 catechol-O-methyltransferase Homo sapiens 66-70 9535125-1 1998 Catechol-O-methyltransferase (COMT) is an enzyme which inactivates catecholamine neurotransmitters by methylation, and is considered a candidate for involvement in schizophrenia. Catecholamines 67-80 catechol-O-methyltransferase Homo sapiens 0-28 9535125-1 1998 Catechol-O-methyltransferase (COMT) is an enzyme which inactivates catecholamine neurotransmitters by methylation, and is considered a candidate for involvement in schizophrenia. Catecholamines 67-80 catechol-O-methyltransferase Homo sapiens 30-34 9467687-10 1998 A catechol-O-methyltransferase (COMT) inhibitor combined with an MAO inhibitor might synergistically maximise the levels of catecholamines in the CNS. Catecholamines 124-138 catechol-O-methyltransferase Homo sapiens 2-30 9467687-10 1998 A catechol-O-methyltransferase (COMT) inhibitor combined with an MAO inhibitor might synergistically maximise the levels of catecholamines in the CNS. Catecholamines 124-138 catechol-O-methyltransferase Homo sapiens 32-36 9326274-0 1997 Metabolism of catecholamines by catechol-O-methyltransferase in cells expressing recombinant catecholamine transporters. Catecholamines 14-28 catechol-O-methyltransferase Homo sapiens 32-60 9861640-1 1998 Catechol-O-methyltransferase (COMT) catalyses the methylation, and hence the inactivation, of catecholamines including the neurotransmitters dopamine and noradrenaline. Catecholamines 94-108 catechol-O-methyltransferase Homo sapiens 0-28 9861640-1 1998 Catechol-O-methyltransferase (COMT) catalyses the methylation, and hence the inactivation, of catecholamines including the neurotransmitters dopamine and noradrenaline. Catecholamines 94-108 catechol-O-methyltransferase Homo sapiens 30-34 9432090-2 1997 COMT inactivates catecholamines and converts primary catecholestrogens (CE) into their O-methylated form yielding the 2- (2-MeOE) and 4-methoxyestrogens (4-MeOE). Catecholamines 17-31 catechol-O-methyltransferase Homo sapiens 0-4 9326274-1 1997 To determine if catechol-O-methyltransferase (COMT) metabolizes catecholamines within cell lines used for heterologous expression of plasmalemmal transporters and alters the measured characteristics of 3H-substrate transport, the uptake of monoamine transporter substrates was assessed in three cell lines (C6 glioma, L-M fibroblast, and HEK293 cells) that had been transfected with the recombinant human transporters. Catecholamines 64-78 catechol-O-methyltransferase Homo sapiens 16-44 9326274-1 1997 To determine if catechol-O-methyltransferase (COMT) metabolizes catecholamines within cell lines used for heterologous expression of plasmalemmal transporters and alters the measured characteristics of 3H-substrate transport, the uptake of monoamine transporter substrates was assessed in three cell lines (C6 glioma, L-M fibroblast, and HEK293 cells) that had been transfected with the recombinant human transporters. Catecholamines 64-78 catechol-O-methyltransferase Homo sapiens 46-50 9121699-1 1997 Catechol-O-methyltransferase (COMT) is an enzyme that inactivates catecholamines such as adrenaline, noradrenaline, dopamine, and levodopa. Catecholamines 66-80 catechol-O-methyltransferase Homo sapiens 0-28 9330018-4 1997 The enzyme catechol-O-methyltransferase (COMT) plays a key role in the degradation of catecholamine neurotransmitters and is a candidate for involvement in bipolar disorder. Catecholamines 86-99 catechol-O-methyltransferase Homo sapiens 11-39 9330018-4 1997 The enzyme catechol-O-methyltransferase (COMT) plays a key role in the degradation of catecholamine neurotransmitters and is a candidate for involvement in bipolar disorder. Catecholamines 86-99 catechol-O-methyltransferase Homo sapiens 41-45 9091339-2 1997 The 4-hydroxyestrogens are known to have both a strong estrogenic potency and affinity for catechol-O-methyltransferase (COMT), the enzyme that deactivates catecholamines. Catecholamines 156-170 catechol-O-methyltransferase Homo sapiens 91-119 9091339-2 1997 The 4-hydroxyestrogens are known to have both a strong estrogenic potency and affinity for catechol-O-methyltransferase (COMT), the enzyme that deactivates catecholamines. Catecholamines 156-170 catechol-O-methyltransferase Homo sapiens 121-125 9121699-1 1997 Catechol-O-methyltransferase (COMT) is an enzyme that inactivates catecholamines such as adrenaline, noradrenaline, dopamine, and levodopa. Catecholamines 66-80 catechol-O-methyltransferase Homo sapiens 30-34 8988970-1 1997 OBJECTIVE: Catechol O-methyltransferase (COMT) is an enzyme that inactivates catecholamines. Catecholamines 77-91 catechol-O-methyltransferase Homo sapiens 11-39 8988970-1 1997 OBJECTIVE: Catechol O-methyltransferase (COMT) is an enzyme that inactivates catecholamines. Catecholamines 77-91 catechol-O-methyltransferase Homo sapiens 41-45 9029240-3 1997 In addition, the strong affinity of CE for the catecholamine-deactivating enzyme catechol-O-methyltransferase (COMT) has led to speculations about their possible role in safeguarding norepinephrine from premature decomposition during exercise. Catecholamines 47-60 catechol-O-methyltransferase Homo sapiens 81-109 9029240-3 1997 In addition, the strong affinity of CE for the catecholamine-deactivating enzyme catechol-O-methyltransferase (COMT) has led to speculations about their possible role in safeguarding norepinephrine from premature decomposition during exercise. Catecholamines 47-60 catechol-O-methyltransferase Homo sapiens 111-115 8902889-1 1996 Catechol-O-methyl transferase (COMT) metabolizes a variety of catecholamines such as dopamine, adrenaline and noradrenaline. Catecholamines 62-76 catechol-O-methyltransferase Homo sapiens 0-29 8950414-2 1996 Catechol-O-methyl-transferase (COMT), which is involved in the metabolism of catecholamines, was mapped to 22q11 and is considered a possible candidate gene for schizophrenia. Catecholamines 77-91 catechol-O-methyltransferase Homo sapiens 0-29 8950414-2 1996 Catechol-O-methyl-transferase (COMT), which is involved in the metabolism of catecholamines, was mapped to 22q11 and is considered a possible candidate gene for schizophrenia. Catecholamines 77-91 catechol-O-methyltransferase Homo sapiens 31-35 8902889-1 1996 Catechol-O-methyl transferase (COMT) metabolizes a variety of catecholamines such as dopamine, adrenaline and noradrenaline. Catecholamines 62-76 catechol-O-methyltransferase Homo sapiens 31-35 7703232-6 1995 S-COMT showed about 15 times higher Km values for catecholamines than MB-COMT. Catecholamines 50-64 catechol-O-methyltransferase Homo sapiens 2-6 8807664-1 1996 Catechol-O-methyltransferase (COMT) inactivates catecholamines and catechol drugs such as L-DOPA. Catecholamines 48-62 catechol-O-methyltransferase Homo sapiens 0-28 8807664-1 1996 Catechol-O-methyltransferase (COMT) inactivates catecholamines and catechol drugs such as L-DOPA. Catecholamines 48-62 catechol-O-methyltransferase Homo sapiens 30-34 8807664-5 1996 The identification of a gentic marker associated with significant alterations in enzyme activity will facilitate the analysis of a possible role for the COMT gene in neuropsychiatric conditions in which abnormalities in catecholamine neurotransmission are believed to occur, including mood disorders, schizophrenia, obsessive compulsive disorder, alcohol and substance abuse, and attention deficit hyperactivity disorder. Catecholamines 220-233 catechol-O-methyltransferase Homo sapiens 153-157 8561211-1 1996 OBJECTIVE: Catechol O-methyltransferase (COMT) inactivates catecholamines by methylating their m-hydroxy group. Catecholamines 59-73 catechol-O-methyltransferase Homo sapiens 11-39 8612391-0 1996 Simultaneous inhibition of catechol-O-methyltransferase and monoamine oxidase A: effects on hemodynamics and catecholamine metabolism in healthy volunteers. Catecholamines 109-122 catechol-O-methyltransferase Homo sapiens 27-55 8612391-1 1996 OBJECTIVE: To evaluate the effects of simultaneous pharmacologic inhibition of catechol-O-methyltransferase (COMT) and monoamine oxidase type A (MAO-A) on hemodynamics and catecholamine metabolism in healthy volunteers at rest and during exercise. Catecholamines 172-185 catechol-O-methyltransferase Homo sapiens 79-107 8612391-16 1996 The changes in the catecholamine metabolite concentrations provide evidence of effective COMT and MAO inhibition. Catecholamines 19-32 catechol-O-methyltransferase Homo sapiens 89-93 8561211-1 1996 OBJECTIVE: Catechol O-methyltransferase (COMT) inactivates catecholamines by methylating their m-hydroxy group. Catecholamines 59-73 catechol-O-methyltransferase Homo sapiens 41-45 7648772-2 1995 Entacapone could potentiate the hemodynamic effects of exogenously administered catecholamines, which are substrates of the COMT enzyme. Catecholamines 80-94 catechol-O-methyltransferase Homo sapiens 124-128 8127373-1 1994 Catechol O-methyltransferase (COMT, EC 2.1.1.6) is important in the central nervous system because it metabolizes catecholamine neurotransmitters such as dopamine. Catecholamines 114-127 catechol-O-methyltransferase Homo sapiens 0-28 7874370-0 1994 COMT inhibition by high-dose entacapone does not affect hemodynamics but changes catecholamine metabolism in healthy volunteers at rest and during exercise. Catecholamines 81-94 catechol-O-methyltransferase Homo sapiens 0-4 8035323-1 1994 Catechol-O-methyltransferase (COMT) catalyzes the O-methylation of catecholamine and catechol drugs such as levodopa and methyldopa. Catecholamines 67-80 catechol-O-methyltransferase Homo sapiens 0-28 8035323-1 1994 Catechol-O-methyltransferase (COMT) catalyzes the O-methylation of catecholamine and catechol drugs such as levodopa and methyldopa. Catecholamines 67-80 catechol-O-methyltransferase Homo sapiens 30-34 8127373-1 1994 Catechol O-methyltransferase (COMT, EC 2.1.1.6) is important in the central nervous system because it metabolizes catecholamine neurotransmitters such as dopamine. Catecholamines 114-127 catechol-O-methyltransferase Homo sapiens 30-34 8156092-5 1994 In which catecholamine levels from the cord blood were low despite simultaneous elevated maternal values (1.93 and 29.46 nmol/l norepinephrine, respectively), possibly owing to the high activity of the catecholamine degradative enzymes monoamine oxidase and COMT at the placental level. Catecholamines 202-215 catechol-O-methyltransferase Homo sapiens 258-262 12959293-2 1993 Catechol-O-methyltransferase (COMT) inhibition might be assumed to potentiate the effects of circulating catecholamines, particularly under conditions of enhanced catecholamine release. Catecholamines 105-119 catechol-O-methyltransferase Homo sapiens 0-28 12959293-2 1993 Catechol-O-methyltransferase (COMT) inhibition might be assumed to potentiate the effects of circulating catecholamines, particularly under conditions of enhanced catecholamine release. Catecholamines 105-119 catechol-O-methyltransferase Homo sapiens 30-34 12959293-2 1993 Catechol-O-methyltransferase (COMT) inhibition might be assumed to potentiate the effects of circulating catecholamines, particularly under conditions of enhanced catecholamine release. Catecholamines 105-118 catechol-O-methyltransferase Homo sapiens 0-28 12959293-2 1993 Catechol-O-methyltransferase (COMT) inhibition might be assumed to potentiate the effects of circulating catecholamines, particularly under conditions of enhanced catecholamine release. Catecholamines 105-118 catechol-O-methyltransferase Homo sapiens 30-34 12959293-4 1993 The purpose of the present study was to establish whether the novel COMT inhibitor, entacapone, changes haemodynamic responses and catecholamine metabolism during exercise. Catecholamines 131-144 catechol-O-methyltransferase Homo sapiens 68-72 12959293-12 1993 However, it altered the metabolic profile of catecholamines, which was shown by increases in the plasma concentrations of the monoamine oxidase-dependent metabolites DHPG (by up to 100%) and DOPAC (by up to 53%), and by a decrease of the COMT-dependent metabolite MHPG (by up to 29%). Catecholamines 45-59 catechol-O-methyltransferase Homo sapiens 238-242 8369108-3 1993 Therefore inhibition of enzymes, like the extraneuronal and neuronal located MAO or the predominantly glial situated COMT, which both metabolize catecholamines, may induce an increased biosynthesis of neurotrophic factors. Catecholamines 145-159 catechol-O-methyltransferase Homo sapiens 117-121 8482451-1 1993 BACKGROUND: Catechol-O-methyltransferase (COMT) inhibition prevents tissue degradation of catecholamines including dopamine. Catecholamines 90-104 catechol-O-methyltransferase Homo sapiens 12-40 8482451-1 1993 BACKGROUND: Catechol-O-methyltransferase (COMT) inhibition prevents tissue degradation of catecholamines including dopamine. Catecholamines 90-104 catechol-O-methyltransferase Homo sapiens 42-46 8369108-6 1993 But on the other hand in vivo and in vitro studies show, that COMT-inhibitors may intensify the metabolisation of catecholamines in neurones by MAO, what may cause an enhanced generation of free radicals. Catecholamines 114-128 catechol-O-methyltransferase Homo sapiens 62-66 2239489-0 1990 Catechol-O-methyltransferase and its role in catecholamine metabolism. Catecholamines 45-58 catechol-O-methyltransferase Homo sapiens 0-28 1927294-1 1991 Catecholamines that are released in excess during human labor are inactivated mainly by catechol-O-methyltransferase (COMT). Catecholamines 0-14 catechol-O-methyltransferase Homo sapiens 88-116 1927294-1 1991 Catecholamines that are released in excess during human labor are inactivated mainly by catechol-O-methyltransferase (COMT). Catecholamines 0-14 catechol-O-methyltransferase Homo sapiens 118-122 2175152-6 1990 The metabolism of catecholestrogens may be divided into reversible and irreversible reactions, of which the reaction with the catechol-O-methyltransferase, and thereby the interaction with catecholamines, the conjugation, and the thioether formation are the most prominent. Catecholamines 189-203 catechol-O-methyltransferase Homo sapiens 126-154 1572656-1 1992 Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is a physiologically important enzyme in the metabolism of catecholamine neurotransmitters and catechol drugs. Catecholamines 107-120 catechol-O-methyltransferase Homo sapiens 0-28 1572656-1 1992 Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is a physiologically important enzyme in the metabolism of catecholamine neurotransmitters and catechol drugs. Catecholamines 107-120 catechol-O-methyltransferase Homo sapiens 30-34 1992709-4 1991 The other enzyme of catecholamine metabolism, catechol-O-methyltransferase, did not show any difference in activity between the two layers. Catecholamines 20-33 catechol-O-methyltransferase Homo sapiens 46-74 2089098-1 1990 The life span of extracellular catecholamines is limited by the combination of uptake and subsequent intracellular metabolism by either monoamine oxidase (MAO) and/or catechol-O-methyl transferase (COMT). Catecholamines 31-45 catechol-O-methyltransferase Homo sapiens 167-196 2089098-1 1990 The life span of extracellular catecholamines is limited by the combination of uptake and subsequent intracellular metabolism by either monoamine oxidase (MAO) and/or catechol-O-methyl transferase (COMT). Catecholamines 31-45 catechol-O-methyltransferase Homo sapiens 198-202 8082488-5 1994 COMT inhibitors decrease tissue degradation of catecholamines, including dopamine. Catecholamines 47-61 catechol-O-methyltransferase Homo sapiens 0-4 35226170-2 2022 This study was done to evaluate the levels of catecholamines in skin and plasma samples of active vitiligo patients" and gene expression changes in catecholamines" metabolism regulatory genes (COMT and GTPCH1), immunoregulatory genes (CTLA4 and PTPN22), and Catalase in active vitiligo patients. Catecholamines 148-162 catechol-O-methyltransferase Homo sapiens 193-197 34439627-4 2021 Childhood trauma and functional genetic polymorphisms in catecholamines converting enzymes, such as mono-amino-oxidase A (MAO-A) and catechol-o-methyltransferase (COMT) have been suggested to augment an aggressive behavioral response in adulthood. Catecholamines 57-71 catechol-O-methyltransferase Homo sapiens 133-161 34439627-4 2021 Childhood trauma and functional genetic polymorphisms in catecholamines converting enzymes, such as mono-amino-oxidase A (MAO-A) and catechol-o-methyltransferase (COMT) have been suggested to augment an aggressive behavioral response in adulthood. Catecholamines 57-71 catechol-O-methyltransferase Homo sapiens 163-167 34679357-3 2021 The catechol O-methyltransferase (COMT) gene is located within the 22q11.2 region, and its product is an enzyme involved in transferring a methyl group from S-adenosylmethionine to catecholamines, including dopamine. Catecholamines 181-195 catechol-O-methyltransferase Homo sapiens 4-32 34679357-3 2021 The catechol O-methyltransferase (COMT) gene is located within the 22q11.2 region, and its product is an enzyme involved in transferring a methyl group from S-adenosylmethionine to catecholamines, including dopamine. Catecholamines 181-195 catechol-O-methyltransferase Homo sapiens 34-38 2704029-3 1989 The new compounds were also highly selective COMT inhibitors with no activity against other essential enzymes involved in the synthesis and metabolism of catecholamines. Catecholamines 154-168 catechol-O-methyltransferase Homo sapiens 45-49 2835907-4 1988 In view of the present data and the importance of catechol estrogens in prostaglandin synthesis and in potentiating the activity of catecholamines through competitive inhibition of catechol-O-methyltransferase, it is suggested that catechol estrogens may play a role in triggering the events involved in the onset of labor and delivery in humans. Catecholamines 132-146 catechol-O-methyltransferase Homo sapiens 181-209 2715273-4 1989 These HPLC assays are sufficiently sensitive and rapid to replace the use of [3H]amines and column chromatographic separation of the metabolites for most in vitro studies on the uptake and subsequent metabolism of catecholamines by monoamine oxidase and/or catechol-O-methyltransferase in tissues. Catecholamines 214-228 catechol-O-methyltransferase Homo sapiens 257-285 6956674-2 1982 PST and membrane-bound COMT were found to have the lowest Km values for both catecholamines. Catecholamines 77-91 catechol-O-methyltransferase Homo sapiens 23-27 3465676-1 1986 Catechol-O-methyltransferase (COMT) plays an important role in the inactivation of catecholamines. Catecholamines 83-97 catechol-O-methyltransferase Homo sapiens 0-28 3465676-1 1986 Catechol-O-methyltransferase (COMT) plays an important role in the inactivation of catecholamines. Catecholamines 83-97 catechol-O-methyltransferase Homo sapiens 30-34 3758430-3 1986 The elute was then desalinated and deproteinized by the ethanol-treated precipitation procedure and dried in a vacuum oven at 25 degrees C. A fraction of catecholamines was assayed with the modified procedures of the COMT-mediated radio-enzymatic method. Catecholamines 154-168 catechol-O-methyltransferase Homo sapiens 217-221 3342507-1 1988 Catechol-borate complexation and ion-pair formation combined with organic solvent extraction as preliminaries to radioenzymatic assay (REA) with catechol-O-methyltransferase-catalyzed methylation allows the quantification of catecholamines in plasma samples of any volume. Catecholamines 225-239 catechol-O-methyltransferase Homo sapiens 145-173 3973595-5 1985 These observations strongly suggest that the soluble form of COMT from human brain catalyzes the O-methylation of catecholamines via an ordered reaction mechanism in which SAM is the leading substrate. Catecholamines 114-128 catechol-O-methyltransferase Homo sapiens 61-65 3973595-6 1985 Since the membrane-bound form of COMT catalyzes the O-methylation of catecholamines through an identical reaction mechanism, these data provide further evidence that two forms of COMT, while being localized in distinct subcellular compartments, are quite similar in their molecular structure. Catecholamines 69-83 catechol-O-methyltransferase Homo sapiens 33-37 3973595-6 1985 Since the membrane-bound form of COMT catalyzes the O-methylation of catecholamines through an identical reaction mechanism, these data provide further evidence that two forms of COMT, while being localized in distinct subcellular compartments, are quite similar in their molecular structure. Catecholamines 69-83 catechol-O-methyltransferase Homo sapiens 179-183 6319050-1 1984 In the radioenzymatic assay of catecholamines, using catechol-O-methyltransferase, the yield of labelled product is frequently less than the expected value. Catecholamines 31-45 catechol-O-methyltransferase Homo sapiens 53-81 7155787-1 1982 The reactivity of a number of catechols and catecholamines with regard to the enzymatic O-methylation by catechol-O-methyltransferase (COMT) was studied. Catecholamines 44-58 catechol-O-methyltransferase Homo sapiens 105-133 7155787-1 1982 The reactivity of a number of catechols and catecholamines with regard to the enzymatic O-methylation by catechol-O-methyltransferase (COMT) was studied. Catecholamines 44-58 catechol-O-methyltransferase Homo sapiens 135-139 6956674-5 1982 At concentrations less than 100 microM, soluble COMT contributes less than 5% to the total catabolism of either catecholamine. Catecholamines 112-125 catechol-O-methyltransferase Homo sapiens 48-52 7392663-2 1980 Catecholamines in sera or tissue homogenates were enzymatically O-methylated in the presence of partially purified catechol-O-methyltransferase with S-[methyl-3H] adenosyl methionine serving as the methyl donor. Catecholamines 0-14 catechol-O-methyltransferase Homo sapiens 115-143 6939005-3 1981 It is suggested that a genetically determined deficiency of catecholamine degradative enzymes in the central nervous system or, alternatively, influences of nongenetic hormonal factors could be implicated in the findings of altered erythrocyte COMT activity reported. Catecholamines 60-73 catechol-O-methyltransferase Homo sapiens 244-248 7404186-2 1980 It depends upon the enzymatic conversion of the catecholamines to their ring o-methylated analogues in the presence of s-adenosyl-L-methionine-methyl-14C and catechol-o-methyltransferase. Catecholamines 48-62 catechol-O-methyltransferase Homo sapiens 158-186 7133376-0 1982 Assay of human erythrocyte catechol-o-methyltransferase activity with naturally occurring catecholamines as substrates. Catecholamines 90-104 catechol-O-methyltransferase Homo sapiens 27-55 7296879-0 1981 Determination of free and conjugated catecholamines and L-3,4-dihydroxyphenylalanine in plasma and urine: evidence for a catechol-O-methyltransferase inhibitor in uraemia. Catecholamines 37-51 catechol-O-methyltransferase Homo sapiens 121-149 7471434-1 1981 We investigated factors affecting sensitivity and reproducibility of radioenzymic (catechol-O-methyltransferase) measurement of plasma catecholamines. Catecholamines 135-149 catechol-O-methyltransferase Homo sapiens 83-111 546488-2 1979 The Km values, which reflect the affinity of substrate and enzyme, show that RL COMT has the highest affinity toward the catecholamine substrates followed by HP COMT and then HL COMT. Catecholamines 121-134 catechol-O-methyltransferase Homo sapiens 80-84 546488-2 1979 The Km values, which reflect the affinity of substrate and enzyme, show that RL COMT has the highest affinity toward the catecholamine substrates followed by HP COMT and then HL COMT. Catecholamines 121-134 catechol-O-methyltransferase Homo sapiens 161-165 546488-2 1979 The Km values, which reflect the affinity of substrate and enzyme, show that RL COMT has the highest affinity toward the catecholamine substrates followed by HP COMT and then HL COMT. Catecholamines 121-134 catechol-O-methyltransferase Homo sapiens 161-165 546488-3 1979 Both HP and RL COMT preparations O-methylate the catecholamines primarily in the meta position. Catecholamines 49-63 catechol-O-methyltransferase Homo sapiens 15-19 677197-1 1978 Catechol-O-methyltransferase (COMT) is the enzyme that converts catechols, e.g., catecholamines and catechol estrogens, to their methyl ethers. Catecholamines 81-95 catechol-O-methyltransferase Homo sapiens 0-28 677197-1 1978 Catechol-O-methyltransferase (COMT) is the enzyme that converts catechols, e.g., catecholamines and catechol estrogens, to their methyl ethers. Catecholamines 81-95 catechol-O-methyltransferase Homo sapiens 30-34 32953411-1 2020 Catechol-O-methyl transferase (COMT) enzyme has a role in the inactivation of catecholamine neurotransmitters. Catecholamines 78-91 catechol-O-methyltransferase Homo sapiens 0-29 96471-0 1978 A twin study on three enzymes (DBH, COMT, MAO) of catecholamine metabolism. Catecholamines 50-63 catechol-O-methyltransferase Homo sapiens 36-40 285022-2 1978 DBH is a catecholamine biosynthetic enzyme and COMT is catecholamine metabolic enzyme. Catecholamines 55-68 catechol-O-methyltransferase Homo sapiens 47-51 884603-6 1977 272, 265-276), we have measured the activity of catechol O-methyltransferase (COMT) (EC 2.1.1.6) in red blood cells (RBC) of patients with hyperthyroidism and hypothyroidism to establish whether thyroid dysfunction is associated with alterations in catecholamine catabolism. Catecholamines 249-262 catechol-O-methyltransferase Homo sapiens 48-76 884603-6 1977 272, 265-276), we have measured the activity of catechol O-methyltransferase (COMT) (EC 2.1.1.6) in red blood cells (RBC) of patients with hyperthyroidism and hypothyroidism to establish whether thyroid dysfunction is associated with alterations in catecholamine catabolism. Catecholamines 249-262 catechol-O-methyltransferase Homo sapiens 78-82 1155601-3 1975 In addition, the effect on the norepinephrine dose-response curve of the combination of a methyixanthine and U-0521,the latter a potent inhibitor of catechol O-methyltransferase, the major enzyme of catecholamine inactivation in vascular tissue, did not differ from that of U-0521 alone. Catecholamines 199-212 catechol-O-methyltransferase Homo sapiens 149-177 4256397-0 1971 The influence of block and catechol-O-methyl transferase on the sensitivity of isolated organs to catecholamines. Catecholamines 98-112 catechol-O-methyltransferase Homo sapiens 27-56 4952963-4 1965 The biochemical effects of these drugs will involve several substrates of MAO, e.g. dopamine, tyramine, serotonin and, to a lesser extent, noradrenaline and adrenaline.MAO probably regulates the metabolism of catecholamines and serotonin in tissues, while catechol-O-methyltransferase is responsible for the metabolism of circulating noradrenaline and adrenaline.Certain pharmacological effects of MAOI are related to the accumulation of monoamines in various tissues that follows the decrease of intraneuronal deamination. Catecholamines 209-223 catechol-O-methyltransferase Homo sapiens 256-284 32866920-2 2020 COMT expression is directedly associated with various mental diseases and cancers due to its essential role in catalyzing metabolic inactivation of endogenous catecholamines and catechol estrogens. Catecholamines 159-173 catechol-O-methyltransferase Homo sapiens 0-4 623944-5 1978 Further data correlating COMT assays with catecholamine metabolites in depressed patients may reveal homogeneous biochemical subgroups which could serve as a guide to rational therapy. Catecholamines 42-55 catechol-O-methyltransferase Homo sapiens 25-29 945099-1 1976 Significant sibling-sibling and within-family correlations of human red blood cell catechol-o-methyl transferase activity have suggested a high degree of genetic control over levels of activity of this catecholamine-related enzyme. Catecholamines 202-215 catechol-O-methyltransferase Homo sapiens 83-112 169167-0 1975 Supersensitivity to catecholamines after impairment of extraneuronal uptake or catechol-O-methyl transferase. Catecholamines 20-34 catechol-O-methyltransferase Homo sapiens 79-108 169167-1 1975 In cat papillary muscle and nictitating membrane block of extraneuronal catechol-O-methyl transferase (COMT) by 3",4"-dihydroxy-alpha-methyl propiophenone (U-0521) or of extraneuronal uptake by hydrocortisone causes supersensitivity to catecholamines whenever the experimental conditions result in a high sensitivity of the organ to catecholamines. Catecholamines 236-250 catechol-O-methyltransferase Homo sapiens 103-107 169167-1 1975 In cat papillary muscle and nictitating membrane block of extraneuronal catechol-O-methyl transferase (COMT) by 3",4"-dihydroxy-alpha-methyl propiophenone (U-0521) or of extraneuronal uptake by hydrocortisone causes supersensitivity to catecholamines whenever the experimental conditions result in a high sensitivity of the organ to catecholamines. Catecholamines 333-347 catechol-O-methyltransferase Homo sapiens 103-107 33108341-2 2021 In the present study we focus on three genetic variants important for modulating experimental pain related to serotonin (SLC6A4 5-HTTLPR/rs25531 A>G), catecholamine (COMT rs4680 Val158Met) and opioid (OPRM1 rs1799971 A118G) signaling. Catecholamines 151-164 catechol-O-methyltransferase Homo sapiens 166-170 32976278-2 2022 COMT modulates catecholamine metabolism, and polymorphisms within the rs4680 allele result in variable enzyme activity. Catecholamines 15-28 catechol-O-methyltransferase Homo sapiens 0-4 32953411-1 2020 Catechol-O-methyl transferase (COMT) enzyme has a role in the inactivation of catecholamine neurotransmitters. Catecholamines 78-91 catechol-O-methyltransferase Homo sapiens 31-35 30790653-1 2019 The COMT gene encodes for catechol-O-methyl-transferase, an enzyme playing a major role in regulation of synaptic catecholamine neurotransmitters. Catecholamines 114-127 catechol-O-methyltransferase Homo sapiens 4-8 32162598-8 2020 Together with our previous findings in catechol-o-methyltransferase, polymorphisms in catecholamine metabolizing enzymes appear to primarily influence acute pain in SCD. Catecholamines 86-99 catechol-O-methyltransferase Homo sapiens 39-67 32071497-1 2020 Catechol-O-methyletransferase (COMT) enzyme is involved in the inactivation of catecholamine and catechol estrogens. Catecholamines 79-92 catechol-O-methyltransferase Homo sapiens 0-29 32071497-1 2020 Catechol-O-methyletransferase (COMT) enzyme is involved in the inactivation of catecholamine and catechol estrogens. Catecholamines 79-92 catechol-O-methyltransferase Homo sapiens 31-35 31239688-2 2019 Catechol-O-methyltransferase (COMT) is a methylation enzyme that catalyzes endogenous catecholamines. Catecholamines 86-100 catechol-O-methyltransferase Homo sapiens 0-28 31239688-2 2019 Catechol-O-methyltransferase (COMT) is a methylation enzyme that catalyzes endogenous catecholamines. Catecholamines 86-100 catechol-O-methyltransferase Homo sapiens 30-34 31744341-3 2020 COMT inhibition can block metabolism of catecholamines including DA. Catecholamines 40-54 catechol-O-methyltransferase Homo sapiens 0-4 31838976-1 2019 Background Genetic variation in catechol-O-methyltransferase (COMT), a key enzyme in estrogen and catecholamine metabolism, has plausible physiological links to cardiovascular disease (CVD) and its risk factors. Catecholamines 98-111 catechol-O-methyltransferase Homo sapiens 32-60 31838976-1 2019 Background Genetic variation in catechol-O-methyltransferase (COMT), a key enzyme in estrogen and catecholamine metabolism, has plausible physiological links to cardiovascular disease (CVD) and its risk factors. Catecholamines 98-111 catechol-O-methyltransferase Homo sapiens 62-66 31112503-6 2019 The activity of catechol-O-methyltransferase (COMT), a key catecholamine-inactivating enzyme that has been scantly investigated thus far owing to the lack of commercially available kits, will be also determined by a newly developed high performance liquid chromatography method, which is herein described. Catecholamines 59-72 catechol-O-methyltransferase Homo sapiens 16-44 31112503-6 2019 The activity of catechol-O-methyltransferase (COMT), a key catecholamine-inactivating enzyme that has been scantly investigated thus far owing to the lack of commercially available kits, will be also determined by a newly developed high performance liquid chromatography method, which is herein described. Catecholamines 59-72 catechol-O-methyltransferase Homo sapiens 46-50 31164811-2 2019 Heritable variation in catecholamine signaling is produced by a common functional polymorphism in the catechol-O-methyltransferase (COMT), with Val carriers exhibiting greater degradation of catecholamines than Met carriers. Catecholamines 23-36 catechol-O-methyltransferase Homo sapiens 102-130 31164811-2 2019 Heritable variation in catecholamine signaling is produced by a common functional polymorphism in the catechol-O-methyltransferase (COMT), with Val carriers exhibiting greater degradation of catecholamines than Met carriers. Catecholamines 23-36 catechol-O-methyltransferase Homo sapiens 132-136 31164811-2 2019 Heritable variation in catecholamine signaling is produced by a common functional polymorphism in the catechol-O-methyltransferase (COMT), with Val carriers exhibiting greater degradation of catecholamines than Met carriers. Catecholamines 191-205 catechol-O-methyltransferase Homo sapiens 102-130 31164811-2 2019 Heritable variation in catecholamine signaling is produced by a common functional polymorphism in the catechol-O-methyltransferase (COMT), with Val carriers exhibiting greater degradation of catecholamines than Met carriers. Catecholamines 191-205 catechol-O-methyltransferase Homo sapiens 132-136 31080692-1 2019 Catechol-O-methyltransferase (COMT) is a model S-adenosyl-l-methionine (SAM) dependent methyl transferase, which catalyzes the methylation of catecholamine neurotransmitters such as dopamine in the primary pathway of neurotransmitter deactivation in animals. Catecholamines 142-155 catechol-O-methyltransferase Homo sapiens 0-28 31080692-1 2019 Catechol-O-methyltransferase (COMT) is a model S-adenosyl-l-methionine (SAM) dependent methyl transferase, which catalyzes the methylation of catecholamine neurotransmitters such as dopamine in the primary pathway of neurotransmitter deactivation in animals. Catecholamines 142-155 catechol-O-methyltransferase Homo sapiens 30-34 30790653-1 2019 The COMT gene encodes for catechol-O-methyl-transferase, an enzyme playing a major role in regulation of synaptic catecholamine neurotransmitters. Catecholamines 114-127 catechol-O-methyltransferase Homo sapiens 26-55 30211780-1 2019 Catechol-O-methyltransferase (COMT) regulates extracellular catecholamines. Catecholamines 60-74 catechol-O-methyltransferase Homo sapiens 0-28 31142902-4 2019 Catechol-O-Methyltransferase (COMT) is an enzyme in the metabolic inactivation of catecholamine and substances containing catecholamines such as dopamine, epinephrine, and norepinephrine. Catecholamines 82-95 catechol-O-methyltransferase Homo sapiens 0-28 31142902-4 2019 Catechol-O-Methyltransferase (COMT) is an enzyme in the metabolic inactivation of catecholamine and substances containing catecholamines such as dopamine, epinephrine, and norepinephrine. Catecholamines 82-95 catechol-O-methyltransferase Homo sapiens 30-34 31142902-4 2019 Catechol-O-Methyltransferase (COMT) is an enzyme in the metabolic inactivation of catecholamine and substances containing catecholamines such as dopamine, epinephrine, and norepinephrine. Catecholamines 122-136 catechol-O-methyltransferase Homo sapiens 0-28 31142902-4 2019 Catechol-O-Methyltransferase (COMT) is an enzyme in the metabolic inactivation of catecholamine and substances containing catecholamines such as dopamine, epinephrine, and norepinephrine. Catecholamines 122-136 catechol-O-methyltransferase Homo sapiens 30-34 30424994-1 2019 OBJECTIVE: Catechol-O-methyltransferase (COMT), a key enzyme in degrading catecholamines associated with the stress response, may influence susceptibility to delirium. Catecholamines 74-88 catechol-O-methyltransferase Homo sapiens 11-39 30424994-1 2019 OBJECTIVE: Catechol-O-methyltransferase (COMT), a key enzyme in degrading catecholamines associated with the stress response, may influence susceptibility to delirium. Catecholamines 74-88 catechol-O-methyltransferase Homo sapiens 41-45 30211780-1 2019 Catechol-O-methyltransferase (COMT) regulates extracellular catecholamines. Catecholamines 60-74 catechol-O-methyltransferase Homo sapiens 30-34 30158547-2 2018 COMT is a protein coding gene located at 22q11.21, and its gene product is a major mammalian enzyme involved in the degradation of catecholamines. Catecholamines 131-145 catechol-O-methyltransferase Homo sapiens 0-4