PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22237745-1 2012 INTRODUCTION: Renalase is an enzyme released by the kidneys, which breaks down catecholamines in the blood and thus may regulate blood pressure. Catecholamines 79-93 renalase, FAD dependent amine oxidase Homo sapiens 14-22 22626958-2 2012 It has been recently postulated that the loss or reduced levels of renalase in patients with chronic renal disease are, at least in part, responsible for elevated plasma catecholamine levels, which leads to increased CVD. Catecholamines 170-183 renalase, FAD dependent amine oxidase Homo sapiens 67-75 33800219-3 2021 Acknowledging that CKD and CKD progression are associated with increased sympathetic tone, which is implicated in CVR, and that renalase metabolizes catecholamines, we aimed to evaluate the relationship between renalase serum levels (RNLS) and cardiovascular and renal outcomes. Catecholamines 149-163 renalase, FAD dependent amine oxidase Homo sapiens 128-136 22415317-6 2012 Experimental in vitro studies showed that renalase degrades catecholamines and thus may have a significant hemodynamic effect in vivo, for example may decrease cardiac contractility, heart rate, and blood pressure. Catecholamines 60-74 renalase, FAD dependent amine oxidase Homo sapiens 42-50 34200667-1 2021 BACKGROUND/AIMS: Renalase is an enzyme with monoamine oxidase activity that metabolizes catecholamines; therefore, it has a significant influence on arterial blood pressure regulation and the development of cardiovascular diseases. Catecholamines 88-102 renalase, FAD dependent amine oxidase Homo sapiens 17-25 34603559-2 2021 Renalase is a catecholamine-degrading enzyme playing a major role in blood pressure control. Catecholamines 14-27 renalase, FAD dependent amine oxidase Homo sapiens 0-8 34545616-5 2022 It was also put into question whether many physiological discoveries published based on the notion that renalase is secreted into the blood and acts by oxidation of catecholamines can still be considered valid. Catecholamines 165-179 renalase, FAD dependent amine oxidase Homo sapiens 104-112 34156537-1 2021 AIMS: Renalase (RNLS) is an enzyme with monoamine oxidase activity that metabolizes circulating catecholamines. Catecholamines 96-110 renalase, FAD dependent amine oxidase Homo sapiens 6-14 34156537-1 2021 AIMS: Renalase (RNLS) is an enzyme with monoamine oxidase activity that metabolizes circulating catecholamines. Catecholamines 96-110 renalase, FAD dependent amine oxidase Homo sapiens 16-20 34281748-2 2021 Renalase metabolizes catecholamines and have an important role in blood pressure (BP) regulation. Catecholamines 21-35 renalase, FAD dependent amine oxidase Homo sapiens 0-8 32916539-4 2020 Numerous studies have suggested the efficacy of renalase in treating CVD by metabolizing catecholamines in the circulatory system. Catecholamines 89-103 renalase, FAD dependent amine oxidase Homo sapiens 48-56 33578719-4 2021 Renalase metabolises catecholamines and therefore may be involved in the pathogenesis of hypertension and other diseases of the circulatory system. Catecholamines 21-35 renalase, FAD dependent amine oxidase Homo sapiens 0-8 33578719-11 2021 The decreased plasma concentrations of catecholamines may be due to their increased degradation by plasma renalase. Catecholamines 39-53 renalase, FAD dependent amine oxidase Homo sapiens 106-114 32852050-1 2020 Renalase is a recently identified flavoprotein oxidase, secreted mainly by the kidneys, which takes part in the degradation of catecholamines. Catecholamines 127-141 renalase, FAD dependent amine oxidase Homo sapiens 0-8 32338092-1 2020 Renalase is a novel enzyme that can regulate blood pressure by degrading circulating catecholamines. Catecholamines 85-99 renalase, FAD dependent amine oxidase Homo sapiens 0-8 31737132-3 2019 Renalase, a new protein derived from kidneys was demonstrated to metabolize catecholamines and to have a cardioprotective role. Catecholamines 76-90 renalase, FAD dependent amine oxidase Homo sapiens 0-8 31688840-1 2019 INTRODUCTION: Renalase is a novel flavin adenine dinucleotide-dependent amine oxidase with catecholamine-degrading activity. Catecholamines 91-104 renalase, FAD dependent amine oxidase Homo sapiens 14-22 31293181-1 2019 Background: Renalase is kidney-derived molecule initially considered as catecholamine-inactivating enzyme. Catecholamines 72-85 renalase, FAD dependent amine oxidase Homo sapiens 12-20 31156340-2 2019 Renalase metabolizes its catecholamine (CA) substrates, including DA, suggesting that there might be an association between renalase levels and schizophrenia occurrence. Catecholamines 25-38 renalase, FAD dependent amine oxidase Homo sapiens 0-8 30995994-8 2019 Epigenetic analysis and chromatin state models of the implicated 70 kb region of 10q23.31 support active transcription of the gene RNLS in the brain, which encodes a catecholamine metabolising protein. Catecholamines 166-179 renalase, FAD dependent amine oxidase Homo sapiens 131-135 31156340-2 2019 Renalase metabolizes its catecholamine (CA) substrates, including DA, suggesting that there might be an association between renalase levels and schizophrenia occurrence. Catecholamines 25-38 renalase, FAD dependent amine oxidase Homo sapiens 124-132 30304564-2 2019 Renalase is a catecholamine-metabolizing enzyme, which contributes to the occurrence of hypertension. Catecholamines 14-27 renalase, FAD dependent amine oxidase Homo sapiens 0-8 26309615-3 2015 Renalase is a recently discovered protein that expressed in kidney, heart, liver, and brain that metabolizes catecholamines, regulation of blood pressure in humans and animals. Catecholamines 109-123 renalase, FAD dependent amine oxidase Homo sapiens 0-8 30311880-3 2018 Additionally, renalase enzyme destroys catecholamines and mediates the regulation (reduction) of blood pressure. Catecholamines 39-53 renalase, FAD dependent amine oxidase Homo sapiens 14-22 30311880-10 2018 CONCLUSION: SNP elevates NO and renalase levels; thus, administration of renalase preparations, which act in the destruction of catecholamines to contain persistent hypertension that develops in association with catecholamine elevation after CABG surgery, along with SNP and other medications used to lower blood pressure can be an effective therapeutic method to control hypertension. Catecholamines 128-142 renalase, FAD dependent amine oxidase Homo sapiens 73-81 30311880-10 2018 CONCLUSION: SNP elevates NO and renalase levels; thus, administration of renalase preparations, which act in the destruction of catecholamines to contain persistent hypertension that develops in association with catecholamine elevation after CABG surgery, along with SNP and other medications used to lower blood pressure can be an effective therapeutic method to control hypertension. Catecholamines 128-141 renalase, FAD dependent amine oxidase Homo sapiens 73-81 29743680-3 2018 Renalase, released from kidney, metabolizes catecholamines and regulates blood pressure. Catecholamines 44-58 renalase, FAD dependent amine oxidase Homo sapiens 0-8 28372594-1 2017 BACKGROUND: Human renalase (RNLS), a recently identified flavoprotein with oxidoreductase activity, is secreted into blood by kidneys and metabolizes circulating catecholamines. Catecholamines 162-176 renalase, FAD dependent amine oxidase Homo sapiens 18-26 28372594-1 2017 BACKGROUND: Human renalase (RNLS), a recently identified flavoprotein with oxidoreductase activity, is secreted into blood by kidneys and metabolizes circulating catecholamines. Catecholamines 162-176 renalase, FAD dependent amine oxidase Homo sapiens 28-32 27822026-3 2016 Renalase, secreted by the kidney and circulated in blood, may regulate the sympathetic tone by catecholamine degradation and in this way has an impact on cardiovascular and renal complications. Catecholamines 95-108 renalase, FAD dependent amine oxidase Homo sapiens 0-8 27496485-2 2016 Recently chronic kidney disease and renalase metabolism of endogenous catecholamines are thought to make major contribution to the pathogenesis of hypertension. Catecholamines 70-84 renalase, FAD dependent amine oxidase Homo sapiens 36-44 27155338-1 2016 BACKGROUND: Renalase is a novel enzyme that degrades circulating catecholamines. Catecholamines 65-79 renalase, FAD dependent amine oxidase Homo sapiens 12-20 26716738-6 2015 Results of the Aliverti"s group on NAD(P)H binding by renalase and weak diaphorase activity of this protein stimulated further studies of renalase as NAD(P)H oxidase catalyzing reaction of catecholamine co-oxidation. Catecholamines 189-202 renalase, FAD dependent amine oxidase Homo sapiens 138-146 26049000-0 2015 Renalase does not catalyze the oxidation of catecholamines. Catecholamines 44-58 renalase, FAD dependent amine oxidase Homo sapiens 0-8 26049000-1 2015 It is widely accepted that the function of human renalase is to oxidize catecholamines in blood. Catecholamines 72-86 renalase, FAD dependent amine oxidase Homo sapiens 49-57 26049000-8 2015 Using time-dependent spectrophotometry we show that the renalase FAD cofactor spectrum is unresponsive to added catecholamines, that adrenochromes are not observed to accumulate in the presence of renalase and that the kinetics of single turnover reactions with 6-dihydroNAD are unaltered by the addition of catecholamines. Catecholamines 308-322 renalase, FAD dependent amine oxidase Homo sapiens 56-64 26016690-1 2015 Despite a lack of convincing in vitro evidence and a number of sound refutations, it is widely accepted that renalase is an enzyme unique to animals that catalyzes the oxidative degradation of catecholamines in blood in order to lower vascular tone. Catecholamines 193-207 renalase, FAD dependent amine oxidase Homo sapiens 109-117 29944173-1 2018 BACKGROUND: Renalase is a catecholamine-metabolising enzyme, but its possible association with atrial fibrillation (AF) remains unknown. Catecholamines 26-39 renalase, FAD dependent amine oxidase Homo sapiens 12-20 29065134-1 2017 Renalase decreases circulating catecholamines concentration and is important in maintaining primary cellular metabolism. Catecholamines 31-45 renalase, FAD dependent amine oxidase Homo sapiens 0-8 28954489-0 2017 Levels of renalase and advanced oxidation protein products with regard to catecholamines in haemodialysed patients. Catecholamines 74-88 renalase, FAD dependent amine oxidase Homo sapiens 10-18 28405891-1 2017 Studies suggest that renalase, a renal catecholamine-inactivating enzyme, plays a major role in the pathogenesis of kidney and cardiovascular diseases in adults. Catecholamines 39-52 renalase, FAD dependent amine oxidase Homo sapiens 21-29 28160962-1 2017 BACKGROUND: Renalase, with possible monoamine oxidase activity, is implicated in degradation of catecholamines; which suggests novel mechanisms of cardiovascular complications in patients with chronic kidney diseases. Catecholamines 96-110 renalase, FAD dependent amine oxidase Homo sapiens 12-20 25900362-2 2016 Throughout the prior decade a consensus belief that renalase is produced predominantly by the kidney and catalytically oxidizes catecholamines in order to lower blood pressure and slow the heart has prevailed. Catecholamines 128-142 renalase, FAD dependent amine oxidase Homo sapiens 52-60 25900362-8 2016 Renalase oxidizes these substrates with rate constants that are up to 10(4)-fold faster than any claimed for catecholamines. Catecholamines 109-123 renalase, FAD dependent amine oxidase Homo sapiens 0-8 25900362-11 2016 The identification of this genuinely catalytic activity for renalase calls for re-evaluation of much of the research of this enzyme, in which definitive links between renalase catecholamine consumption and physiological responses were reported. Catecholamines 176-189 renalase, FAD dependent amine oxidase Homo sapiens 60-68 25900362-11 2016 The identification of this genuinely catalytic activity for renalase calls for re-evaluation of much of the research of this enzyme, in which definitive links between renalase catecholamine consumption and physiological responses were reported. Catecholamines 176-189 renalase, FAD dependent amine oxidase Homo sapiens 167-175 27194994-4 2015 Renalase, a novel catecholamine-metabolizing amine oxidase, is synthesized mainly in proximal tubular cells and secreted into urine and blood. Catecholamines 18-31 renalase, FAD dependent amine oxidase Homo sapiens 0-8 25781495-2 2015 Renalase, an amine oxidase secreted by the proximal tubule, not only degrades circulating catecholamines but also protects against renal ischaemia reperfusion injury. Catecholamines 90-104 renalase, FAD dependent amine oxidase Homo sapiens 0-8 25380930-1 2014 INTRODUCTION: Renalase may degrade catecholamines and regulate sympathetic tone and blood pressure. Catecholamines 35-49 renalase, FAD dependent amine oxidase Homo sapiens 14-22 24590362-0 2015 Serum renalase is related to catecholamine levels and renal function. Catecholamines 29-42 renalase, FAD dependent amine oxidase Homo sapiens 6-14 24590362-1 2015 BACKGROUND: Renalase is a kidney-origin monoamine oxidase which can degrade catecholamines and regulate blood pressure and cardiovascular function. Catecholamines 76-90 renalase, FAD dependent amine oxidase Homo sapiens 12-20 24590362-5 2015 Renalase levels were linearly correlated with catecholamine levels (R (2) = 0.817; P < 0.01). Catecholamines 46-59 renalase, FAD dependent amine oxidase Homo sapiens 0-8 26817339-5 2015 There are some factors enhancing the release of renalase: rising catecholamines levels in the circulation and increase in blood pressure. Catecholamines 65-79 renalase, FAD dependent amine oxidase Homo sapiens 48-56 26817339-9 2015 Stimulation of catecholamines degradation, perhaps using recombinant renalase or its analogues, is a new concept in the treatment of hypertension in CKD. Catecholamines 15-29 renalase, FAD dependent amine oxidase Homo sapiens 69-77 25531177-2 2015 There remains a prevailing belief that renalase functions as a hormone, imparting an influence on vascular tone and heart rate by oxidizing circulating catecholamines, chiefly epinephrine. Catecholamines 152-166 renalase, FAD dependent amine oxidase Homo sapiens 39-47 25295465-8 2014 Interestingly, renalase promoter activity was augmented by nicotine and catecholamines; while Sp1 and STAT3 synergistically activated the nicotine-induced effect, Sp1 appeared to enhance epinephrine-evoked renalase transcription. Catecholamines 72-86 renalase, FAD dependent amine oxidase Homo sapiens 15-23 24599883-1 2014 Renalase is a recently described enzyme secreted by the kidney into both plasma and urine, where it was suggested to degrade catecholamines contributing to blood pressure control. Catecholamines 125-139 renalase, FAD dependent amine oxidase Homo sapiens 0-8 25064768-1 2014 The study aimed to evaluate plasma renalase level, a recently discovered kidney-derived catecholamine-metabolizing enzyme in patients after successful repair of aortic coarctation, with special consideration of arterial hypertension in the context of underlying process of arterial remodeling. Catecholamines 88-101 renalase, FAD dependent amine oxidase Homo sapiens 35-43 24742207-1 2014 BACKGROUND AND OBJECTIVES: Renalase, a monoamine oxidase derived from the kidney, can degrade catecholamine (CA) and regulate blood pressure as well as cardiac function. Catecholamines 94-107 renalase, FAD dependent amine oxidase Homo sapiens 27-35 25058146-1 2014 Renalase, a recently discovered enzyme released by the kidneys, breaks down blood-borne catecholamines and may thus regulate blood pressure (BP). Catecholamines 88-102 renalase, FAD dependent amine oxidase Homo sapiens 0-8 23154672-4 2012 On the other hand, renalase, with possible monoamine oxidase activity, which breaks down catecholamines like SSAO, is also expressed in the endothelium as well as in the kidney. Catecholamines 89-103 renalase, FAD dependent amine oxidase Homo sapiens 19-27 25531090-1 2014 BACKGROUND/AIMS: Renalase (gene name RNLS), a recently discovered enzyme with monoamine oxidase activity, is implicated in the degradation of catecholamines. Catecholamines 142-156 renalase, FAD dependent amine oxidase Homo sapiens 17-25 25531090-1 2014 BACKGROUND/AIMS: Renalase (gene name RNLS), a recently discovered enzyme with monoamine oxidase activity, is implicated in the degradation of catecholamines. Catecholamines 142-156 renalase, FAD dependent amine oxidase Homo sapiens 37-41 23964689-3 2013 While it has been widely reported that renalase is the third monoamine oxidase (monoamine oxidase C) that oxidizes circulating catecholamines such as epinephrine, there has been no convincing demonstration of this catalysis in vitro. Catecholamines 127-141 renalase, FAD dependent amine oxidase Homo sapiens 39-47 22969162-3 2013 Renalase may play an important role in the control of blood pressure (BP) by its regulatory function of catecholamine metabolism. Catecholamines 104-117 renalase, FAD dependent amine oxidase Homo sapiens 0-8 23393318-6 2013 Administration of recombinant human renalase reduced plasma catecholamine levels and ameliorated ischemic AKI in wild-type mice. Catecholamines 60-73 renalase, FAD dependent amine oxidase Homo sapiens 36-44 23375328-1 2013 INTRODUCTION: Renalase, an enzyme that cetabolyzes catecholamines, such as circulating adrenaline and noradrenaline, is released by the human kidney to regulate blood pressure. Catecholamines 51-65 renalase, FAD dependent amine oxidase Homo sapiens 14-22 23319980-2 2012 Renalase, with possible monoamine oxidase activity, which breaks down catecholamines like SSAO, is also expressed in the endothelium as well as in the kidney. Catecholamines 70-84 renalase, FAD dependent amine oxidase Homo sapiens 0-8 23107895-1 2012 Renalase is a novel flavoprotein, highly expressed in kidney and heart, which metabolizes catecholamines and catecholamine-like substances via a superoxide (O2(-))-dependent mechanism using nicotinamide adenine dinucleotide (NADH) as a cofactor. Catecholamines 90-104 renalase, FAD dependent amine oxidase Homo sapiens 0-8 23107895-1 2012 Renalase is a novel flavoprotein, highly expressed in kidney and heart, which metabolizes catecholamines and catecholamine-like substances via a superoxide (O2(-))-dependent mechanism using nicotinamide adenine dinucleotide (NADH) as a cofactor. Catecholamines 90-103 renalase, FAD dependent amine oxidase Homo sapiens 0-8 22659670-4 2012 Renalase, as a new biomarker of heart and kidney functional correlation, can lower blood pressure, protect ischemic heart muscle, improve heart function and degrade catecholamine. Catecholamines 165-178 renalase, FAD dependent amine oxidase Homo sapiens 0-8 22227817-4 2012 It was reported that renalase, secreted by the kidney and circulating in the blood, degraded catecholamines and might play a role in the regulation of sympathetic tone and BP. Catecholamines 93-107 renalase, FAD dependent amine oxidase Homo sapiens 21-29 25567503-3 2014 Renalase was first reported to be undetectable in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD), suggesting a causal link between the reduced plasma renalase levels, increased plasma catecholamine, and heightened cardiovascular risk that are well documented in this population. Catecholamines 215-228 renalase, FAD dependent amine oxidase Homo sapiens 0-8 25171187-1 2014 BACKGROUND/AIMS: Renalase is a recently discovered, kidney-specific monoamine oxidase that metabolizes circulating catecholamines. Catecholamines 115-129 renalase, FAD dependent amine oxidase Homo sapiens 17-25 25171187-3 2014 Previous data demonstrated that renalase was mainly secreted from proximal tubules which could be evoked by catecholamines. Catecholamines 108-122 renalase, FAD dependent amine oxidase Homo sapiens 32-40 24137013-1 2014 Renalase, a recently discovered flavoprotein, which is strongly expressed in the kidney and heart, effectively metabolizes catecholamines. Catecholamines 123-137 renalase, FAD dependent amine oxidase Homo sapiens 0-8 25033547-1 2014 Renalase, a recently discovered protein participating in the catecholamine metabolism and belonging to oxidoreductases, possess also antihypertensive and cardioprotective properties, confirmed in several studies on animal models. Catecholamines 61-74 renalase, FAD dependent amine oxidase Homo sapiens 0-8 24266457-2 2013 The consensus belief has been that renalase oxidizes circulating catecholamine neurotransmitters thereby attenuating vascular tone. Catecholamines 65-78 renalase, FAD dependent amine oxidase Homo sapiens 35-43 23964689-3 2013 While it has been widely reported that renalase is the third monoamine oxidase (monoamine oxidase C) that oxidizes circulating catecholamines such as epinephrine, there has been no convincing demonstration of this catalysis in vitro. Catecholamines 127-141 renalase, FAD dependent amine oxidase Homo sapiens 80-99 22812913-1 2012 BACKGROUND: Renalase (gene name RNLS), a recently discovered enzyme with monoamine oxidase activity, is implicated in the degradation of catecholamines. Catecholamines 137-151 renalase, FAD dependent amine oxidase Homo sapiens 12-20 22812913-1 2012 BACKGROUND: Renalase (gene name RNLS), a recently discovered enzyme with monoamine oxidase activity, is implicated in the degradation of catecholamines. Catecholamines 137-151 renalase, FAD dependent amine oxidase Homo sapiens 32-36 22539018-1 2012 UNLABELLED: Renalase, secreted by the kidney, degrades catecholamines and may play a role in the regulation of sympathetic tone and blood pressure. Catecholamines 55-69 renalase, FAD dependent amine oxidase Homo sapiens 12-20 21625261-0 2011 Does renalase degrade catecholamines? Catecholamines 22-36 renalase, FAD dependent amine oxidase Homo sapiens 5-13 22172866-1 2011 INTRODUCTION: Renalase, an enzyme that breaks down catecholamines like adrenaline and noradrenaline in the blood circulation, was discovered in 2005. Catecholamines 51-65 renalase, FAD dependent amine oxidase Homo sapiens 14-22 21996211-1 2011 BACKGROUND: Renalase is an enzyme that catabolizes catecholamines such as adrenaline and noradrenaline in the circulation. Catecholamines 51-65 renalase, FAD dependent amine oxidase Homo sapiens 12-20 17565281-1 2007 PURPOSE OF REVIEW: Renalase is a secreted amine oxidase that metabolizes catecholamines. Catecholamines 73-87 renalase, FAD dependent amine oxidase Homo sapiens 19-27 20975995-1 2010 BACKGROUND: Renalase is a soluble enzyme that metabolizes circulating catecholamines. Catecholamines 70-84 renalase, FAD dependent amine oxidase Homo sapiens 12-20 19471322-2 2009 In this pathway, renalase, a novel secreted amine oxidase that is inactive at baseline, is rapidly turned on ( ~ 10 fold increase) by either a modest increase in blood pressure or by brief surges in plasma catecholamines. Catecholamines 206-220 renalase, FAD dependent amine oxidase Homo sapiens 17-25 19471322-4 2009 Plasma catecholamines not only activate renalase enzymatic activity but also lead to a 3-4 fold stimulation of renalase secretion. Catecholamines 7-21 renalase, FAD dependent amine oxidase Homo sapiens 40-48 19471322-4 2009 Plasma catecholamines not only activate renalase enzymatic activity but also lead to a 3-4 fold stimulation of renalase secretion. Catecholamines 7-21 renalase, FAD dependent amine oxidase Homo sapiens 111-119 18277152-4 2008 Catecholamine administration promotes the secretion of preformed renalase within 5 min. Catecholamines 0-13 renalase, FAD dependent amine oxidase Homo sapiens 65-73 18277152-7 2008 SUMMARY: The renalase pathway is a previously unrecognized mechanism for regulating circulating catecholamines, cardiac function and blood pressure. Catecholamines 96-110 renalase, FAD dependent amine oxidase Homo sapiens 13-21 21073414-0 2010 Renalase, a new secretory enzyme responsible for selective degradation of catecholamines: achievements and unsolved problems. Catecholamines 74-88 renalase, FAD dependent amine oxidase Homo sapiens 0-8 21073414-1 2010 Renalase is a recently discovered secretory enzyme responsible for selective degradation of blood catecholamines. Catecholamines 98-112 renalase, FAD dependent amine oxidase Homo sapiens 0-8 18277152-8 2008 In this pathway, prorenalase is rapidly activated by increased catecholamines and converted to renalase, which in turn degrades catecholamines. Catecholamines 63-77 renalase, FAD dependent amine oxidase Homo sapiens 20-28 18277152-8 2008 In this pathway, prorenalase is rapidly activated by increased catecholamines and converted to renalase, which in turn degrades catecholamines. Catecholamines 128-142 renalase, FAD dependent amine oxidase Homo sapiens 20-28 17216203-1 2007 Renalase, a novel flavin adenine dinucleotide-dependent amine oxidase, is secreted by the kidney, degrades circulating catecholamines, and modulates cardiac function and systemic blood pressure (BP). Catecholamines 119-133 renalase, FAD dependent amine oxidase Homo sapiens 0-8 17565281-4 2007 Parenteral administration of either native or recombinant renalase lowers blood pressure and heart rate by metabolizing circulating catecholamines. Catecholamines 132-146 renalase, FAD dependent amine oxidase Homo sapiens 58-66 17565281-9 2007 SUMMARY: The renalase pathway is a previously unrecognized mechanism for regulating circulating catecholamines, and, therefore, cardiac function, and blood pressure. Catecholamines 96-110 renalase, FAD dependent amine oxidase Homo sapiens 13-21 20409839-7 2007 In vitro studies indicate that renalase is a novel amine oxidase that specifically metabolizes circulating catecholamines including epinephrine and norepinephrine. Catecholamines 107-121 renalase, FAD dependent amine oxidase Homo sapiens 31-39 20409839-9 2007 These results identify renalase as a novel renal hormone that modulates cardiac function and systemic blood pressure by regulating catecholamine levels. Catecholamines 131-144 renalase, FAD dependent amine oxidase Homo sapiens 23-31 15841207-5 2005 Here we report the identification of a novel flavin adenine dinucleotide-dependent amine oxidase (renalase) that is secreted into the blood by the kidney and metabolizes catecholamines in vitro (renalase metabolizes dopamine most efficiently, followed by epinephrine, and then norepinephrine). Catecholamines 170-184 renalase, FAD dependent amine oxidase Homo sapiens 98-106 17385068-0 2007 Renalase, a catecholamine-metabolising enzyme? Catecholamines 12-25 renalase, FAD dependent amine oxidase Homo sapiens 0-8 17385068-4 2007 The catecholamine-metabolising activity of renalase in plasma contrasts with previous investigations where catecholamines were found to be stable in human plasma, provided autoxidation is prevented by an antioxidant. Catecholamines 4-17 renalase, FAD dependent amine oxidase Homo sapiens 43-51 17385068-5 2007 The claim of catecholamine-metabolising activity of renalase was based on the generation of H(2)O(2) during incubation of the enzyme with catecholamines. Catecholamines 13-26 renalase, FAD dependent amine oxidase Homo sapiens 52-60 17385068-5 2007 The claim of catecholamine-metabolising activity of renalase was based on the generation of H(2)O(2) during incubation of the enzyme with catecholamines. Catecholamines 138-152 renalase, FAD dependent amine oxidase Homo sapiens 52-60 17385068-6 2007 Careful inspection and calculations of the data lead to the conclusion that the rate of H(2)O(2) generation is far too low to be ascribed to enzymatic conversion of catecholamines by renalase. Catecholamines 165-179 renalase, FAD dependent amine oxidase Homo sapiens 183-191 16054084-0 2005 Renalase, a catecholamine-metabolizing hormone from the kidney. Catecholamines 12-25 renalase, FAD dependent amine oxidase Homo sapiens 0-8 16054084-2 2005 Renalase appears to be a hormone that metabolizes catecholamines, and its discovery will facilitate our understanding of sympathetic regulation. Catecholamines 50-64 renalase, FAD dependent amine oxidase Homo sapiens 0-8 15841207-5 2005 Here we report the identification of a novel flavin adenine dinucleotide-dependent amine oxidase (renalase) that is secreted into the blood by the kidney and metabolizes catecholamines in vitro (renalase metabolizes dopamine most efficiently, followed by epinephrine, and then norepinephrine). Catecholamines 170-184 renalase, FAD dependent amine oxidase Homo sapiens 195-203