PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12573802-0 2003 Expression of mRNA for PACAP and its receptors in intra- and extra-adrenal human pheochromocytomas and their relationship to catecholamine synthesis. Catecholamines 125-138 adenylate cyclase activating polypeptide 1 Homo sapiens 23-28 12573802-1 2003 PURPOSE: Pituitary adenylate cyclase-activating polypeptide (PACAP), a member of the secretin/glucagons/vasoactive intestinal peptide family, induces the expression of catecholamine-synthesizing enzymes in adrenal medullary cells. Catecholamines 168-181 adenylate cyclase activating polypeptide 1 Homo sapiens 9-59 12573802-1 2003 PURPOSE: Pituitary adenylate cyclase-activating polypeptide (PACAP), a member of the secretin/glucagons/vasoactive intestinal peptide family, induces the expression of catecholamine-synthesizing enzymes in adrenal medullary cells. Catecholamines 168-181 adenylate cyclase activating polypeptide 1 Homo sapiens 61-66 12573802-2 2003 In addition, PACAP and its receptor have been detected in human pheochromocytoma tissues, though it is not yet known whether PACAP enhances the expression of genes encoding catecholamine-synthesizing enzymes. Catecholamines 173-186 adenylate cyclase activating polypeptide 1 Homo sapiens 125-130 12573802-7 2003 CONCLUSION: Our findings support a possible role for PACAP in the regulation of expression of genes encoding catecholamine-synthesizing enzymes in intra-adrenal pheochromocytomas. Catecholamines 109-122 adenylate cyclase activating polypeptide 1 Homo sapiens 53-58 12429744-9 2003 Moreover, PACAP induced catecholamine secretion by chromaffin cells. Catecholamines 24-37 adenylate cyclase activating polypeptide 1 Homo sapiens 10-15 12429744-2 2003 The aim of the present study was to identify PACAP receptor isoforms and to determine whether PACAP can affect intracellular calcium concentration ([Ca(2+)](i)) and catecholamine secretion. Catecholamines 165-178 adenylate cyclase activating polypeptide 1 Homo sapiens 94-99 12429744-10 2003 It is concluded that PACAP-38, through the PAC(1) receptor, acts as a neurotransmitter in human fetal chromaffin cells inducing catecholamine secretion, through nonclassical, recently described, ryanodine/caffeine-sensitive pools, involving a cAMP- and PKA-dependent phosphorylation mechanism. Catecholamines 128-141 adenylate cyclase activating polypeptide 1 Homo sapiens 21-26 11192604-0 2000 Regulation of chromogranin A transcription and catecholamine secretion by the neuropeptide PACAP. Catecholamines 47-60 adenylate cyclase activating polypeptide 1 Homo sapiens 91-96 12050216-6 2002 VIP and PACAP concentration-dependently increased aldosterone and catecholamine secretion from cultured ZG and AM cells. Catecholamines 66-79 adenylate cyclase activating polypeptide 1 Homo sapiens 8-13 12438168-1 2002 Pituitary adenylate cyclase-activating polypeptide (PACAP) is an adrenomedullary cotransmitter that along with acetylcholine is responsible for driving catecholamine and neuropeptide biosynthesis and secretion from chromaffin cells in response to stimulation of the splanchnic nerve. Catecholamines 152-165 adenylate cyclase activating polypeptide 1 Homo sapiens 0-50 12438168-1 2002 Pituitary adenylate cyclase-activating polypeptide (PACAP) is an adrenomedullary cotransmitter that along with acetylcholine is responsible for driving catecholamine and neuropeptide biosynthesis and secretion from chromaffin cells in response to stimulation of the splanchnic nerve. Catecholamines 152-165 adenylate cyclase activating polypeptide 1 Homo sapiens 52-57 12050216-9 2002 The catecholamine response of cultured AM cells to VIP was lowered by VPAC(1)-A and unaffected by PAC(1)-A; conversely, the catecholamine response to PACAP was reduced by both PAC(1)-A and VPAC(1)-A. Catecholamines 124-137 adenylate cyclase activating polypeptide 1 Homo sapiens 150-155 10700013-2 2000 The principal aim of the present study was to determine whether pituitary adenylate cyclase activating peptide (PACAP), which is coreleased with acetylcholine from the splanchnic nerve, can modulate nicotinic receptor-dependent Ca(2+) signaling and catecholamine secretion in porcine adrenal medullary chromaffin (PAMC) cells. Catecholamines 249-262 adenylate cyclase activating polypeptide 1 Homo sapiens 64-110 10700013-2 2000 The principal aim of the present study was to determine whether pituitary adenylate cyclase activating peptide (PACAP), which is coreleased with acetylcholine from the splanchnic nerve, can modulate nicotinic receptor-dependent Ca(2+) signaling and catecholamine secretion in porcine adrenal medullary chromaffin (PAMC) cells. Catecholamines 249-262 adenylate cyclase activating polypeptide 1 Homo sapiens 112-117 11193870-6 2000 These data, together with the observation that PACAP receptors are exclusively located on chromaffin cells, suggest that, in the fetal human adrenal gland, the effect of PACAP on steroid secretion is mediated via the local release of catecholamines. Catecholamines 234-248 adenylate cyclase activating polypeptide 1 Homo sapiens 170-175 8771559-1 1996 Pituitary adenylate cyclase-activating polypeptide (PACAP)i a potent stimulant of catecholamine secretion, increased catecholamine production in cultured porcine adrenal medullary chromaffin cells. Catecholamines 82-95 adenylate cyclase activating polypeptide 1 Homo sapiens 0-50 10515428-3 1999 The mechanism of action for PACAP 1-27 and 1-38 in vivo involves endogenous catecholamines, peptidases and nitric oxide, depending on tissue type. Catecholamines 76-90 adenylate cyclase activating polypeptide 1 Homo sapiens 28-33 8993404-2 1996 Compared to VIP, both PACAP-27 and PACAP-38 demonstrated potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. Catecholamines 144-157 adenylate cyclase activating polypeptide 1 Homo sapiens 22-27 8993404-2 1996 Compared to VIP, both PACAP-27 and PACAP-38 demonstrated potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. Catecholamines 144-157 adenylate cyclase activating polypeptide 1 Homo sapiens 35-40 8993404-3 1996 The differential effects of PACAP peptides on SCG NPY and catecholamine content and secretion coincided with previous studies that activated directly the sympathetic intracellular cyclic AMP-protein kinase A signaling pathway. Catecholamines 58-71 adenylate cyclase activating polypeptide 1 Homo sapiens 28-33 8771559-1 1996 Pituitary adenylate cyclase-activating polypeptide (PACAP)i a potent stimulant of catecholamine secretion, increased catecholamine production in cultured porcine adrenal medullary chromaffin cells. Catecholamines 82-95 adenylate cyclase activating polypeptide 1 Homo sapiens 52-57 8771559-1 1996 Pituitary adenylate cyclase-activating polypeptide (PACAP)i a potent stimulant of catecholamine secretion, increased catecholamine production in cultured porcine adrenal medullary chromaffin cells. Catecholamines 117-130 adenylate cyclase activating polypeptide 1 Homo sapiens 0-50 8771559-1 1996 Pituitary adenylate cyclase-activating polypeptide (PACAP)i a potent stimulant of catecholamine secretion, increased catecholamine production in cultured porcine adrenal medullary chromaffin cells. Catecholamines 117-130 adenylate cyclase activating polypeptide 1 Homo sapiens 52-57 8771559-2 1996 PACAP induced dose-and time-dependent increases in mRNAs for the catecholamine synthesizing enzymes, tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH), with maximal 6- and 4-fold increases occurring at 8-16 h, respectively. Catecholamines 65-78 adenylate cyclase activating polypeptide 1 Homo sapiens 0-5 7768322-5 1995 The abundance of PACAP and its type I receptors in the adrenal medulla and the results of studies with synthetic PACAP suggest that PACAP is a potent noncholinergic secretogue for catecholamines. Catecholamines 180-194 adenylate cyclase activating polypeptide 1 Homo sapiens 17-22 8550747-0 1996 Pituitary adenylate-cyclase activating peptide enhances aldosterone secretion of human adrenal gland: evidence for an indirect mechanism, probably involving the local release of catecholamines. Catecholamines 178-192 adenylate cyclase activating polypeptide 1 Homo sapiens 0-46 8550747-10 1996 PACAP (10 nmol/L) induced a net rise in catecholamine release by adrenal slices. Catecholamines 40-53 adenylate cyclase activating polypeptide 1 Homo sapiens 0-5 8550747-11 1996 Taken together, our present findings suggest that PACAP indirectly stimulates ALDO secretion by the human adrenal cortex, probably by eliciting the local release of catecholamines by medullary chromaffin cells that are also scattered in the cortical tissue, especially the zona glomerulosa. Catecholamines 165-179 adenylate cyclase activating polypeptide 1 Homo sapiens 50-55 7643128-0 1995 Pituitary adenylate cyclase-activating polypeptide (PACAP) regulation of sympathetic neuron neuropeptide Y and catecholamine expression. Catecholamines 111-124 adenylate cyclase activating polypeptide 1 Homo sapiens 0-50 7643128-0 1995 Pituitary adenylate cyclase-activating polypeptide (PACAP) regulation of sympathetic neuron neuropeptide Y and catecholamine expression. Catecholamines 111-124 adenylate cyclase activating polypeptide 1 Homo sapiens 52-57 7643128-1 1995 Two forms of pituitary adenylate cyclase-activating polypeptide (PACAP), the 38- and 27-amino-acid forms (PACAP38 and PACAP27, respectively), which share amino acid sequence homology with vasoactive intestinal peptide (VIP), were evaluated for their abilities to regulate sympathetic neuron catecholamine and neuropeptide Y (NPY) expression. Catecholamines 291-304 adenylate cyclase activating polypeptide 1 Homo sapiens 65-70 7643128-2 1995 PACAP38 and PACAP27 potently and efficaciously stimulated NPY and catecholamine secretion in primary cultured superior cervical ganglion (SCG) neurons; 100- to 1,000-fold higher concentrations of VIP were required to modulate secretion, suggesting that SCG neurons express the PACAP-selective type I receptor. Catecholamines 66-79 adenylate cyclase activating polypeptide 1 Homo sapiens 0-5 7643128-5 1995 Sympathetic neuron NPY content was decreased, whereas cellular total catecholamine levels were elevated by the PACAP peptides; total NPY and catecholamine levels (secreted plus cellular content) were increased. Catecholamines 69-82 adenylate cyclase activating polypeptide 1 Homo sapiens 111-116 7643128-8 1995 SCG neuronal expression of mRNA encoding the type I PACAP receptor further supported the studies demonstrating that sympathetic neuronal levels of NPY and catecholamine content and secretion and mRNA are differentially regulated by the PACAP peptides. Catecholamines 155-168 adenylate cyclase activating polypeptide 1 Homo sapiens 52-57 7643128-8 1995 SCG neuronal expression of mRNA encoding the type I PACAP receptor further supported the studies demonstrating that sympathetic neuronal levels of NPY and catecholamine content and secretion and mRNA are differentially regulated by the PACAP peptides. Catecholamines 155-168 adenylate cyclase activating polypeptide 1 Homo sapiens 236-241 7768322-5 1995 The abundance of PACAP and its type I receptors in the adrenal medulla and the results of studies with synthetic PACAP suggest that PACAP is a potent noncholinergic secretogue for catecholamines. Catecholamines 180-194 adenylate cyclase activating polypeptide 1 Homo sapiens 113-118 7768322-5 1995 The abundance of PACAP and its type I receptors in the adrenal medulla and the results of studies with synthetic PACAP suggest that PACAP is a potent noncholinergic secretogue for catecholamines. Catecholamines 180-194 adenylate cyclase activating polypeptide 1 Homo sapiens 113-118 7862259-0 1994 Pertussis toxin pretreatment enhances catecholamine secretion induced by pituitary adenylate cyclase-activating polypeptide in cultured porcine adrenal medullary chromaffin cells: a possible role of the inositol lipid cascade. Catecholamines 38-51 adenylate cyclase activating polypeptide 1 Homo sapiens 73-123 7862259-1 1994 We determined how pertussis toxin (PTX) pretreatment alters PACAP-induced catecholamine secretion in cultured porcine adrenal medullary cells. Catecholamines 74-87 adenylate cyclase activating polypeptide 1 Homo sapiens 60-65 7862259-2 1994 Pretreatment of these cells with PTX (1 ng/ml for 24 h or 10 ng/ml for 6 h) markedly enhanced PACAP-induced catecholamine secretion. Catecholamines 108-121 adenylate cyclase activating polypeptide 1 Homo sapiens 94-99 7862259-4 1994 We examined the role of the phosphoinositol cascade in potentiating the PACAP-induced catecholamine secretion by PTX and found that PACAP-induced accumulation of inositol phosphates in PTX-pretreated cells was significantly greater than that in untreated cells. Catecholamines 86-99 adenylate cyclase activating polypeptide 1 Homo sapiens 72-77 7862259-4 1994 We examined the role of the phosphoinositol cascade in potentiating the PACAP-induced catecholamine secretion by PTX and found that PACAP-induced accumulation of inositol phosphates in PTX-pretreated cells was significantly greater than that in untreated cells. Catecholamines 86-99 adenylate cyclase activating polypeptide 1 Homo sapiens 132-137 7862259-5 1994 Furthermore, removal of extracellular Ca2+ and addition of Ca2+ channel blockers inhibited the catecholamine secretion induced by PACAP in PTX-pretreated cells. Catecholamines 95-108 adenylate cyclase activating polypeptide 1 Homo sapiens 130-135 7862259-6 1994 From these results, we speculate that a PTX-sensitive G-protein tonically inhibits phospholipase C. PTX enhances the PACAP-induced secretion of catecholamine by blocking the action of this inhibitory G-protein. Catecholamines 144-157 adenylate cyclase activating polypeptide 1 Homo sapiens 117-122 8384995-0 1993 Ca(2+)-dependent stimulatory effect of pituitary adenylate cyclase-activating polypeptide on catecholamine secretion from cultured porcine adrenal medullary chromaffin cells. Catecholamines 93-106 adenylate cyclase activating polypeptide 1 Homo sapiens 39-89 8384995-1 1993 Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates catecholamine secretion from cultured porcine adrenal medullary chromaffin cells in a dose-dependent manner with the half-maximal and maximal doses of 30 nM and 1 microM, respectively. Catecholamines 70-83 adenylate cyclase activating polypeptide 1 Homo sapiens 0-50 8384995-1 1993 Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates catecholamine secretion from cultured porcine adrenal medullary chromaffin cells in a dose-dependent manner with the half-maximal and maximal doses of 30 nM and 1 microM, respectively. Catecholamines 70-83 adenylate cyclase activating polypeptide 1 Homo sapiens 52-57 8384995-2 1993 Either removal of extracellular Ca2+ or addition of Gd3+, an inorganic Ca2+ channel blocker, very potently inhibits PACAP-induced catecholamine secretion. Catecholamines 130-143 adenylate cyclase activating polypeptide 1 Homo sapiens 116-121 8384995-3 1993 Both nicardipine (1 microM) and methoxyverapamil (1 microM), blockers of voltage-dependent Ca2+ channels, are also effective in inhibiting PACAP-induced catecholamine secretion. Catecholamines 153-166 adenylate cyclase activating polypeptide 1 Homo sapiens 139-144 8384995-7 1993 Removal of extracellular Ca2+ enhances PACAP-induced cAMP production but strongly inhibits PACAP-induced catecholamine secretion. Catecholamines 105-118 adenylate cyclase activating polypeptide 1 Homo sapiens 91-96 8384995-10 1993 These results indicate that PACAP activates voltage-dependent Ca2+ channels and phospholipase C as well as adenylate cyclase in cultured porcine adrenal medullary cells and strongly suggest that PACAP-induced catecholamine secretion is mainly mediated by activation of voltage-dependent Ca2+ channels. Catecholamines 209-222 adenylate cyclase activating polypeptide 1 Homo sapiens 28-33 8384995-10 1993 These results indicate that PACAP activates voltage-dependent Ca2+ channels and phospholipase C as well as adenylate cyclase in cultured porcine adrenal medullary cells and strongly suggest that PACAP-induced catecholamine secretion is mainly mediated by activation of voltage-dependent Ca2+ channels. Catecholamines 209-222 adenylate cyclase activating polypeptide 1 Homo sapiens 195-200 1481892-10 1992 These data suggest that responses to PACAP and VIP are mediated by distinct receptors and that pressor responses to PACAP are due to the release of catecholamines from the adrenal gland. Catecholamines 148-162 adenylate cyclase activating polypeptide 1 Homo sapiens 116-121 12097482-2 2002 Calcium influx is required for PACAP-stimulated secretion of catecholamines and neuropeptides. Catecholamines 61-75 adenylate cyclase activating polypeptide 1 Homo sapiens 31-36 24995679-3 2014 PACAP appears to be associated with the "fight-or-flight" response to emergency partly through its effect on adrenal production of cortisol and catecholamines. Catecholamines 144-158 adenylate cyclase activating polypeptide 1 Homo sapiens 0-5 22610912-5 2012 PACAP is responsible for long-term catecholamine secretion using secretory mechanisms different from the rapidly desensitizing depolarization evoked by acetylcholine through nicotinic receptor activation. Catecholamines 35-48 adenylate cyclase activating polypeptide 1 Homo sapiens 0-5 24054157-3 2013 During direct high-frequency stimulation of the splanchnic nerve that is designed to mimic stress, PACAP regulates adrenomedullary catecholamine secretion. Catecholamines 131-144 adenylate cyclase activating polypeptide 1 Homo sapiens 99-104 24054157-4 2013 In addition to transmission, PACAP simultaneously facilitates the biosynthesis of adrenomedullary catecholamines through stimulus-secretion-synthesis coupling. Catecholamines 98-112 adenylate cyclase activating polypeptide 1 Homo sapiens 29-34 22610912-6 2012 PACAP signaling also maintains catecholamine synthesis required for sustained secretion during prolonged stress via induction of the enzymes TH and PNMT, and enhances transcription of additional secreted molecules found in chromaffin cells that alter further secretion through both autocrine and paracrine mechanisms. Catecholamines 31-44 adenylate cyclase activating polypeptide 1 Homo sapiens 0-5 22289055-7 2012 In the periphery, VIP and PACAP play important roles in the control of immunity and inflammation, the control of pancreatic insulin secretion, the release of catecholamines from the adrenal medulla and as co-transmitters in autonomic and sensory neurons. Catecholamines 158-172 adenylate cyclase activating polypeptide 1 Homo sapiens 26-31 16697281-10 2006 VIP and PACAP stimulate the synthesis and release of adrenomedullary catecholamines, and all three subtypes of PACAP/VIP Rs mediate this effect, PAC(1)-Rs being coupled to AC, VPAC(1)-Rs to both AC and PLC, and VPAC(2)-Rs only to PLC. Catecholamines 69-83 adenylate cyclase activating polypeptide 1 Homo sapiens 8-13 19508428-0 2009 PACAP regulates immediate catecholamine release from adrenal chromaffin cells in an activity-dependent manner through a protein kinase C-dependent pathway. Catecholamines 26-39 adenylate cyclase activating polypeptide 1 Homo sapiens 0-5 19508428-7 2009 In this study we utilize native neuronal stimulation of adrenal chromaffin cells in situ and amperometric catecholamine detection to demonstrate that PACAP specifically elicits catecholamine release under elevated splanchnic firing. Catecholamines 106-119 adenylate cyclase activating polypeptide 1 Homo sapiens 150-155 19508428-7 2009 In this study we utilize native neuronal stimulation of adrenal chromaffin cells in situ and amperometric catecholamine detection to demonstrate that PACAP specifically elicits catecholamine release under elevated splanchnic firing. Catecholamines 177-190 adenylate cyclase activating polypeptide 1 Homo sapiens 150-155 19508428-8 2009 Further data reveal that the immediate PACAP-evoked stimulation involves a phospholipase C and protein kinase C-dependent pathway to facilitate calcium influx through a Ni2+ and mibefradil-sensitive calcium conductance that results in catecholamine release. Catecholamines 235-248 adenylate cyclase activating polypeptide 1 Homo sapiens 39-44 18349695-3 2008 PACAP is a neuropeptide involved in neurotransmission in both the peripheral nervous system and central nervous system and is required for catecholamine secretion. Catecholamines 139-152 adenylate cyclase activating polypeptide 1 Homo sapiens 0-5 18048093-4 2008 PACAP also acts as a neurotransmitter to stimulate catecholamine and neuropeptide biosynthesis and release from sympathetic neurons and chromaffin cells, during development and in adulthood. Catecholamines 51-64 adenylate cyclase activating polypeptide 1 Homo sapiens 0-5 17430174-5 2007 At fasting states, PACAP on the one hand promotes feeding behavior by activating neuropeptide Y neurons in the hypothalamic feeding center, arcuate nucleus, and on the other hand stimulates secretion of catecholamine and glucagon and thereby induces lipolysis in adipocytes and glucose output from liver. Catecholamines 203-216 adenylate cyclase activating polypeptide 1 Homo sapiens 19-24 16697281-11 2006 A privotal role in the catecholamine secretagogue action of VIP and PACAP is played by Ca(2+). Catecholamines 23-36 adenylate cyclase activating polypeptide 1 Homo sapiens 68-73 15518890-0 2004 Expression of mRNAs for PACAP and its receptor in human neuroblastomas and their relationship to catecholamine synthesis. Catecholamines 97-110 adenylate cyclase activating polypeptide 1 Homo sapiens 24-29 15518890-1 2004 PURPOSE: Pituitary adenylate cyclase-activating polypeptide (PACAP), a member of the secretin/glucagon/vasoactive intestinal peptide family, induces the expression of catecholamine-synthesizing enzymes in adrenal medullary cells. Catecholamines 167-180 adenylate cyclase activating polypeptide 1 Homo sapiens 9-59 15518890-1 2004 PURPOSE: Pituitary adenylate cyclase-activating polypeptide (PACAP), a member of the secretin/glucagon/vasoactive intestinal peptide family, induces the expression of catecholamine-synthesizing enzymes in adrenal medullary cells. Catecholamines 167-180 adenylate cyclase activating polypeptide 1 Homo sapiens 61-66 15518890-2 2004 In addition, PACAP and its receptor have been detected in human neuroblastoma tissues and cell lines, though it is not yet known whether PACAP enhances the expression of genes encoding catecholamine-synthesizing enzymes. Catecholamines 185-198 adenylate cyclase activating polypeptide 1 Homo sapiens 137-142