PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16175498-6 2005 In addition the proinflammatory cytokine, IL-6 is also activated, probably via catecholamines. Catecholamines 79-93 interleukin 6 Homo sapiens 42-46 22109853-5 2012 We also demonstrated that tyrosine hydroxylase (TH), the rate-limiting enzyme for synthesis of catecholamine, was reduced after exposure to IL-6, which was accompanied by JAK-STAT3 pathway activation. Catecholamines 95-108 interleukin 6 Homo sapiens 140-144 18234565-6 2008 Baseline values were different between the two groups, but an altered pattern of release was observed for TNFa, IL-6, IL-10 and beta-endorphin levels in patients treated with catecholamines. Catecholamines 175-189 interleukin 6 Homo sapiens 112-116 28817438-11 2019 Mechanistically, we show that macrophages recruited to burn-stressed subcutaneous WAT (sWAT) undergo alternative activation to induce tyrosine hydroxylase expression and catecholamine production mediated by IL-6, factors required for browning of sWAT. Catecholamines 170-183 interleukin 6 Homo sapiens 207-211 20044210-4 2010 Catecholamines and cortisol in plasma and lipopolysaccharide (LPS) stimulated levels of TNF-alpha and IL-6 by peripheral leucocytes were assessed along with severity of obsessive-compulsive symptoms, disgust, and anxiety levels using Visual Analogue Scales prior, during and after a provocation paradigm. Catecholamines 0-14 interleukin 6 Homo sapiens 102-106 14523327-2 2003 Catecholamines, used under clinical conditions to maintain adequate cerebral perfusion pressure, induce a sustained IL-6 release. Catecholamines 0-14 interleukin 6 Homo sapiens 116-120 15607574-3 2005 Physiological concentrations of insulin as well as of catecholamines have been shown to boost adipocyte production of IL-6 dose-dependently. Catecholamines 54-68 interleukin 6 Homo sapiens 118-122 15863947-6 2005 Along with increases in serum catecholamine and urine catecholamine metabolites, his serum interleukin (IL)-6 level was increased to 300 pg/ml, compared with a normal range of 3-12 pg/ml. Catecholamines 30-43 interleukin 6 Homo sapiens 91-109 15863947-6 2005 Along with increases in serum catecholamine and urine catecholamine metabolites, his serum interleukin (IL)-6 level was increased to 300 pg/ml, compared with a normal range of 3-12 pg/ml. Catecholamines 54-67 interleukin 6 Homo sapiens 91-109 12955521-2 2004 Both circulating catecholamine levels and exercise intensity have been related to the exercise-derived IL-6. Catecholamines 17-30 interleukin 6 Homo sapiens 103-107 12955521-4 2004 Therefore, hypoxia offers a unique opportunity to study the effect of catecholamines and intensity on exercise-derived IL-6. Catecholamines 70-84 interleukin 6 Homo sapiens 119-123 12404674-0 2002 Effects of serotonin and catecholamine depletion on interleukin-6 activation and mood in human volunteers. Catecholamines 25-38 interleukin 6 Homo sapiens 52-65 11847483-1 2001 BACKGROUND: Interleukin-6 (IL-6) secretion is suppressed by glucocorticoids and stimulated by catecholamines. Catecholamines 94-108 interleukin 6 Homo sapiens 12-25 12080442-8 2002 Both catecholamines increased IL-6 and leptin secretion. Catecholamines 5-19 interleukin 6 Homo sapiens 30-34 12080442-9 2002 The effects of dexamethasone and catecholamines on IL-6 and leptin were abrogated by RU486 and propranolol, respectively. Catecholamines 33-47 interleukin 6 Homo sapiens 51-55 11847483-1 2001 BACKGROUND: Interleukin-6 (IL-6) secretion is suppressed by glucocorticoids and stimulated by catecholamines. Catecholamines 94-108 interleukin 6 Homo sapiens 27-31 10823386-3 2000 MAIN RESULTS: Catecholamines (epinephrine, norepinephrine, isoproterenol, and dopamine) in general inhibit tumor necrosis factor-alpha (TNF) production and may enhance interleukin-6 (IL-6) and IL-10 production. Catecholamines 14-28 interleukin 6 Homo sapiens 168-181 11084220-1 2000 There are some reports that catecholamines may modulate the production of monocytic cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF alpha). Catecholamines 28-42 interleukin 6 Homo sapiens 102-115 11084220-1 2000 There are some reports that catecholamines may modulate the production of monocytic cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF alpha). Catecholamines 28-42 interleukin 6 Homo sapiens 117-121 10834930-0 2000 Catecholamines up-regulate lipopolysaccharide-induced IL-6 production in human microvascular endothelial cells. Catecholamines 0-14 interleukin 6 Homo sapiens 54-58 10834930-2 2000 Whereas catecholamines decrease the LPS-induced production of IL-6 by leukocytes, serum levels of IL-6 are dramatically increased by the catecholamine epinephrine in animal endotoxemia models. Catecholamines 8-22 interleukin 6 Homo sapiens 62-66 10834930-4 2000 Furthermore, these catecholamines could even potentiate the LPS-induced IL-6 protein production. Catecholamines 19-33 interleukin 6 Homo sapiens 72-76 10834930-6 2000 The catecholamine-induced IL-6 stimulation is based on increased IL-6 mRNA levels. Catecholamines 4-17 interleukin 6 Homo sapiens 26-30 10834930-6 2000 The catecholamine-induced IL-6 stimulation is based on increased IL-6 mRNA levels. Catecholamines 4-17 interleukin 6 Homo sapiens 65-69 10834930-10 2000 Thus, endothelial cells might be a possible source of increased IL-6 production observed in situations such as stress or septic shock, in which catecholamines are elevated due to endogenous production or exogenous application. Catecholamines 144-158 interleukin 6 Homo sapiens 64-68 10823386-3 2000 MAIN RESULTS: Catecholamines (epinephrine, norepinephrine, isoproterenol, and dopamine) in general inhibit tumor necrosis factor-alpha (TNF) production and may enhance interleukin-6 (IL-6) and IL-10 production. Catecholamines 14-28 interleukin 6 Homo sapiens 183-187 11268388-5 2000 The catecholamines and serotonin also synergistically stimulate IL-6 release in the presence of IL-1 beta. Catecholamines 4-18 interleukin 6 Homo sapiens 64-68 9666567-5 1998 IL-2, IL-3, IL-6, and INF-alpha are able to directly stimulate glucocorticoid production by zona fasciculata and zona reticularis cells, whereas IL-1 exerts an analogous effect through an indirect mechanism involving the stimulation of catecholamine release by chromaffin cells and/or the activation of the intramedullary CRH/ACTH system; again, TNF-alpha depresses glucocorticoid synthesis. Catecholamines 236-249 interleukin 6 Homo sapiens 12-16 10588509-1 1999 Studies performed on healthy volunteers have revealed that catecholamines down-regulate the lipopolysaccharide (LPS)-induced production of tumor necrosis factor (TNF)alpha, interleukin (IL)-6, and IL-1beta. Catecholamines 59-73 interleukin 6 Homo sapiens 173-191 10588509-7 1999 Correspondingly, in blood of patients with prolonged severe sepsis, TNFalpha was reduced by 67.2% (P < 0.0001) and IL-6 was reduced by 32.9% (P < 0.0001); IL-1beta and IL-10 were not modulated by catecholamines in these patients. Catecholamines 202-216 interleukin 6 Homo sapiens 118-122 9629296-6 1998 In addition, catecholamines induce the production of IL-6 by leukocytes of these patients, via triggering of alpha 1-adrenergic receptors. Catecholamines 13-27 interleukin 6 Homo sapiens 53-57 7611579-19 1995 The elevation of the plasma catecholamines immediately after SNP administration should also be taken into account, because an augmentation of the cAMP in various cell types has been proven to result in increased release of IL-6. Catecholamines 28-42 interleukin 6 Homo sapiens 223-227 8982123-2 1996 In healthy individuals, catecholamines can inhibit the production of pro-inflammatory cytokines like interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) via interaction with beta 2-adrenergic receptors. Catecholamines 24-38 interleukin 6 Homo sapiens 101-114 8982123-2 1996 In healthy individuals, catecholamines can inhibit the production of pro-inflammatory cytokines like interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) via interaction with beta 2-adrenergic receptors. Catecholamines 24-38 interleukin 6 Homo sapiens 116-120 8982123-3 1996 In contrast, we show here that catecholamines can stimulate the production of the interleukin-6 (IL-6) in children with the chronic inflammatory disease polyarticular juvenile rheumatoid arthritis (JRA). Catecholamines 31-45 interleukin 6 Homo sapiens 82-95 8982123-3 1996 In contrast, we show here that catecholamines can stimulate the production of the interleukin-6 (IL-6) in children with the chronic inflammatory disease polyarticular juvenile rheumatoid arthritis (JRA). Catecholamines 31-45 interleukin 6 Homo sapiens 97-101 8843757-0 1996 Exercise stimulates interleukin-6 secretion: inhibition by glucocorticoids and correlation with catecholamines. Catecholamines 96-110 interleukin 6 Homo sapiens 20-33 8843757-1 1996 In experimental animals, stress and catecholamines stimulate endogenous interleukin-6 (IL-6) secretion, whereas glucocorticoids inhibit it. Catecholamines 36-50 interleukin 6 Homo sapiens 72-85 8843757-1 1996 In experimental animals, stress and catecholamines stimulate endogenous interleukin-6 (IL-6) secretion, whereas glucocorticoids inhibit it. Catecholamines 36-50 interleukin 6 Homo sapiens 87-91 8843757-6 1996 These findings suggest that IL-6 secretion is stimulated during exercise, possibly by catecholamines, whereas exogenous glucocorticoids attenuate this effect without affecting the catecholamine levels. Catecholamines 86-100 interleukin 6 Homo sapiens 28-32 8843757-6 1996 These findings suggest that IL-6 secretion is stimulated during exercise, possibly by catecholamines, whereas exogenous glucocorticoids attenuate this effect without affecting the catecholamine levels. Catecholamines 86-99 interleukin 6 Homo sapiens 28-32 8686529-12 1996 The postoperative maximum of IL-6 in plasma could be due to a release of catecholamines. Catecholamines 73-87 interleukin 6 Homo sapiens 29-33 8686529-14 1996 Increased plasma catecholamine concentrations as well as a damage in the blood-brain barrier due to the surgical trauma with a spill-over of IL-6 from brain tissue into plasma could have contributed to this result. Catecholamines 17-30 interleukin 6 Homo sapiens 141-145 8845594-5 1996 Catecholamines also reduced cell proliferation, increased tartrate-resistant acid phosphatase (TRAcP) activity, interleukin 6 (IL-6) production, multi-nuclearity and response to salmon calcitonin (sCT) in undifferentiated FLG 29.1 cells. Catecholamines 0-14 interleukin 6 Homo sapiens 112-125 8845594-5 1996 Catecholamines also reduced cell proliferation, increased tartrate-resistant acid phosphatase (TRAcP) activity, interleukin 6 (IL-6) production, multi-nuclearity and response to salmon calcitonin (sCT) in undifferentiated FLG 29.1 cells. Catecholamines 0-14 interleukin 6 Homo sapiens 127-131 8845594-6 1996 In differentiated FLG 29.1 cells only IL-6 release was induced by catecholamine treatment. Catecholamines 66-79 interleukin 6 Homo sapiens 38-42 25905362-12 2000 In the autonomic nervous system, catecholamines have been found to stimulate IL-6 secretion through a beta-adrenergic mechanism showing the immune effects on endocrine system. Catecholamines 33-47 interleukin 6 Homo sapiens 77-81 32535571-8 2020 Increased concentrations of catecholamines are associated with increased blood levels of proinflammatory cytokines such as IL-6 and TNF-b.the level of CRP may reflect the inflammatory process in the intima of blood vessels. Catecholamines 28-42 interleukin 6 Homo sapiens 123-127 33814251-9 2021 Furthermore, patients in the high IL-6 group significantly more frequently received catecholamine therapy (P = 0.005), venoarterial extracorporeal membrane oxygenation (P = 0.029), and artificial respirator support (P = 0.021) in the acute phase of myocarditis. Catecholamines 84-97 interleukin 6 Homo sapiens 34-38 31686824-2 2019 Aim: The present study investigated associations between plasma IL-6 and plasma catecholamine metabolites in patients with MDD. Catecholamines 80-93 interleukin 6 Homo sapiens 64-68 30836837-8 2019 Post-race catecholamine levels explained 60% of the variance in the IL-6 response (r = 0.77, p = 0.040), which was further increased when the resting autonomic function indices were added to the regression model (R2 > 81%, p < 0.012). Catecholamines 10-23 interleukin 6 Homo sapiens 68-72