PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27681312-6 2016 Finally, we found that FoxO1 directly targets and negatively regulates tyrosine hydroxylase (TH) expression, the rate-limiting enzyme of the catecholamine synthesis, delineating a mechanism for the KO phenotypes. Catecholamines 141-154 forkhead box O1 Mus musculus 23-28 25353004-5 2014 FoxO1 favors catecholamine synthesis because it is a potent regulator of the expression of Dbh that encodes the initial and rate-limiting enzyme in the synthesis of these neurotransmitters. Catecholamines 13-26 forkhead box O1 Mus musculus 0-5